Growth hormone-releasing peptide-6 increases insulin-like growth factor-I mRNA levels and activates Akt in RCA-6 cells as a model of neuropeptide Y neurones

Journal of Neuroendocrinology

Volumn 17, Issue 11, 2005, Pages 701-710

  Frago, Laura M ^a   Paneda C ^a   Argente, J ^a   Chowen, J A ^a  

^a HOSPITAL INFANTIL UNIVERSITARIO NIÑO JESÚS   (Spain)

Author keywords

Ghrelin; Hypothalamus; IGF I; Intracellular mechanisms; Neuropeptide Y

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; HISTIDYL DEXTRO TRYPTOPHYLALANYLTRYPTOPHYL DEXTRO PHENYLALANYLLYSINAMIDE; MESSENGER RNA; NEUROPEPTIDE Y; PROTEIN KINASE B; SOMATOMEDIN C;

ANIMAL CELL; ARCUATE NUCLEUS; ARTICLE; CELL CULTURE; CONTROLLED STUDY; EMBRYO; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; HORMONE SYNTHESIS; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; IN VIVO STUDY; INTRACELLULAR SPACE; MALE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN SYNTHESIS; RAT; REAL TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA EXTRACTION; SECOND MESSENGER;

ANIMALS; ARCUATE NUCLEUS; CELL LINE; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HYPOTHALAMUS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; INSULIN-LIKE GROWTH FACTOR I; MALE; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; NEUROPEPTIDE Y; OLIGOPEPTIDES; ONCOGENE PROTEIN V-AKT; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER;

EID: 27644482039     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/j.1365-2826.2005.01347.x     Document Type: Article

References (52)

1. Schwartz MW, Woods SC, Porter D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671.
2. Druce MR, Small CJ, Bloom SR. Minireview: gut peptides regulating satiety. Endocrinology 2004; 145: 2660-2665.
3. Ukkola O. Peripheral regulation of food intake: new insights. J Endocrinol Invest 2004; 27: 96-98.
4. Casanueva FF, Dieguez C. Neuroendocrine regulation and actions of leptin. Front Neuroendocrinol 1999; 20: 317-363.
5. Kojima M, Hosoda H, Date Y, Nakazato M, Matsuo H, Kangawa K. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999; 402: 656-660.
6. Kalra SP, Kalra PS. Neuropeptide Y. A physiological orexigen modulated by the feedback action of ghrelin and leptin. Endocine 2003; 22: 49-55.
7. Frago LM, Pañeda C, Dickson SL, Hewson AK, Argente J, Chowen JA. Growth hormone (GH) and GH-releasing peptide-6 increase brain insulin-like growth factor-I expression and activate intracellular signaling pathways involved in neuroprotection. Endocrinology 2002; 143: 4113-4122.
8. Cardona-Gómez GP, Méndez P, DonCarlos LL, Azcoitia I, García-Segura LM. Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection. Brain Res Brain Res Rev 2001; 37: 320-334.
9. Feldman EL, Sullivan KA, Kim B, Russel JW. Insulin-like growth factors regulate neuronal differentiation and survival. Neurobiol Dis 1997; 4: 201-214.
10. Cardona-Gómez GP, Méndez P, García-Segura LM. Synergistic interaction of estradiol and insulin-like growth factor-I activation of PI3K/Akt signalling in the adult rat hypothalamus. Brain Res Mol Brain Res 2002; 107: 80-88.
11. Baldanzi G, Filigheddu N, Cutrupi S, Catapano F, Bonissoni S, Fubin A, Malan D, Baj G, Granata R, Broglio F, Papotti M, Surico N, Bussolini F, Isgaard J, Deghenghi R, Sinigaglia F, Prat M, Muccioli G, Ghigo E, Granziani A. Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERD1/2 and PI 3-kinase/AKT. J Cell Biol 2002; 159: 1029-1037.
12. Kim MS, Yoon CY, Jang PG, Park YJ, Shin CS, Park HS, Ryu JW, Le YK, Park JY, Lee KU, Kim SY, Lee HK, Kim YB, Park KS. The mitogenic and anti-apoptotic actions of ghrelin in 3T3-L1 adipocytes. Mol Endocrinol 2004; 18: 2291-2301.
13. Mazzocchi G, Neri G, Ruciuski M, Rebuffat P, Spinazzi R, Malendowicz LK, Nussdorfer GG. Ghrelin enhances the growth of cultured human adrenal zona glomerulosa cells by exerting MAPK-mediated proliferogenic and antiapoptotic effects. Peptides 2004; 25: 1269-1277.
14. Gottero C, Broglio F, Prodam F, Destefanis S, Bellone S, Benso A, Gauna C, Arvat E, Van der Lely AJ, Ghigo E. Ghrelin: a link between eating disorders, obesity and reproduction. Nutr Neurosci 2004; 7: 255-270.
15. Van der Lely A, Tschöp M, Heiman ML, Ghigo E. Biological, physiological, pathophysiological and pharmacological aspects of ghrelin. Endocr Rev 2004; 25: 426-457.
16. Kamegai J, Minami S, Sugihara H, Hasegawa O, Higuchi H, Wakabayashi I. Growth hormone receptor gene is expressed in neuropeptide Y neurons in hypothalamic arcuate nucleus of rats. Endocrinology 1996; 137: 2109-2112.
17. Kamegai J, Tamura H, Shimizu T, Ishii S, Sugihara H, Wakabayashi I. Chronic central infusion of ghrelin increases hypothalamic neuropeptide Y and Agouti-related protein mRNA levels and body weight in rats. Diabetes 2001; 50: 2438-2443.
18. Tannenbaum GS, Lapointe M, Beaudet A, Howard AD. Expression of growth hormone secretagogue-receptors by growth hormone-releasing hormone neurons in the mediobasal hypothalamus. Endocrinology 1998; 139: 4420-4423.
19. Seoane LM, Lopez M, Tovar S, Casanueva FF, Señaris R, Dieguez C. Agouti-related peptide, neuropeptide Y, and somatostatin-producing neurons are targets for ghrelin actions in the rat hypothalamus. Endocrinology 2003; 144: 544-551.
20. Dickson SL, Luckman SM. Induction of c-fos messenger ribonucleic acid in neuropeptide Y and growth hormone (GH)-releasing factor neurons in the rat arcuate nucleus following systemic injection of the GH secretagogue, GH-releasing peptide-6. Endocrinology 1997; 138: 771-777.
21. Sun Y, Wang P, Zheng H, Smith RG. Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci USA 2004; 1001: 4679-4684.
22. Willensen MG, Kristensen P, Romer J. Co-localization of growth hormone secretagogue receptor and NPY mRNA in the arcuate nucleus of the rat. Neuroendocrinology 1999; 70: 306-316.
23. LeRoith D, Bondy C, Yakar S, Liu JL, Butler A. The somatomedin hypothesis: 2001. Endocr Rev 2001; 22: 53-74.
24. Chan YY, Steiner RA, Clifton DK. Regulation of hypothalamic neuropeptide-Y neurons by growth hormone in the rat. Endocrinology 1996; 137: 1319-1325.
25. Grinspoon S, Miller KK, Herzog DB, Grieco KA, Klibanski A. Effects of estrogen and recombinant human insulin-like growth factor I on ghrelin secretion in severe undernutrition. J Clin Endocrinol Metab 2004; 89: 3988-3993.
26. Méndez P, Azcoitia I, García-Segura LM. Estrogen receptor alpha forms estrogen-dependent multimolecular complexes with insulin-like growth factor receptor and phosphatidylinositol 3-kinase in the adult rat brain. Brain Res Brain Mol Res 2003; 112: 170-176.
27. Pong SS, Chaung LY, Dean DC, Nargund RP, Patchett AA, Smith RG. Identification of a new G-protein-linked receptor for growth hormone secretagogues. Mol Endocrinol 1996; 10: 57-61.
28. Howard AD, Feighner SD, Cully DF, Arena JP, Liberator PA, Rosenblum CI, Hamelin M, Hreniuk DL, Palyha OC, Anderson J, Paress PS, Diaz C, Chou M, Liu KK, McKee KK, Pong SS, Chaung LY, Elbrecht A, Dashkevicz M, Heavens R, Rigby M, Sirinathsinghji DJ, Dean DC, Melillo DG, Patchett AA, Nargund R, Griffin PR, DeMartino JA, Gupta SK, Schaeffer JM, Smith RG, Van der Ploeg LH. A receptor in pituitary and hypothalamus that functions in growth hormone release. Science 1996; 273: 974-977.
29. Guan XM, Yu H, Palyha OC, McKee KK, Feighner SD, Sirinathsinghji DJ, Smith RG, van der Ploeg LH, Howard AD. Distribution of mRNA encoding the growth hormone secretagogue receptor in brain and peripheral tissues. Brain Res Mol Brain Res 1997; 48: 23-29.
30. Torres-Alemán I, Naftolin F, Robbins RJ. Trophic effects of basic fibroblast growth factor on fetal rat hypothalamic cells: interactions with insulin-like growth factor 1. Dev Brain Res 1990; 52: 253-257.
31. Torres-Alemán I, Naftolin F, Robbins R. Growth promoting effects of IGF-I on fetal hypothalamic cell lines under serum-free culture conditions. Int J Dev Neurosci 1989; 7: 195-202.
32. Rasmussen JE, Torres-Alemán I, MacLusky NJ, Naftolin F, Robbins RJ. The effects of estradiol on the growth patterns of estrogen receptor-positive hypothalamic cell lines. Endocrinology 1990; 126: 235-240.
33. Loudes C, Faivre-Bauman A, Tixier-Vidal A. Techniques for culture of hypothalamic neurons. Meth Enzymol 1983; 103: 313-334.
34. Kurihara S, Hakuno F, Takahashi S. Insulin-like growth factor-I-dependent signal transduction pathway leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y. the roles of MAP kinase pathway and PI 3-kinase pathway. Endocr J 2000; 47: 739-751.
35. Vincent AM, Feldman EL. Control of cell survival by IGF signaling pathways. Growth Horm IGF Res 2002; 12: 193-197.
36. Fernández-Galaz MC, Torres-Alemán I, García-Segura LM. Endocrine-dependent accumulation of IGF-I by hypothalamic glia. Neuroreport 1996; 8: 373-377.
37. Reinhardt RR, Bondy CA. Insulin-like growth factors cross the blood-brain barrier. Endocrinology 1994; 135: 1753-1761.
38. Settembrini B, Figueroa J, Gallardo M, Chiocchio S. Growth hormone (GH) but not IGF-I secretion is stimulated in aged rats by chronic hexarelin and GHRP-6 administration. Endocr Regul 1998; 32: 17-26.
39. Conley LK, Gaillard RC, Giustina A, Brogan RS, Wehrenberg WB. Effects of repeated doses and continuous infusions of the growth hormone-releasing peptide hexarelin in conscious male rats. J Endocrinol 1998; 158: 367-375.
40. Shoba LN, Newman M, Liu W, Lowe WL Jr. LY 294002, an inhibitor of phosphatidylinositol 3-kinase, inhibits GH-mediated expression of the IGF-I gene in rat hepatocytes. Endocrinology 2001; 142: 3980-3986.
41. McDonald AJ. Coexistence of somatostatin with neuropeptide Y, but not with cholecystokinin or vasoactive intestinal peptide, in neurons of the rat amygdala. Brain Res 1989; 500: 37-45.
42. Figueredo-Cardenas G, Morello M, Sancesario G, Bernardi G, Reiner A. Colocalization of somatostatin, neuropeptide Y, neuronal nitric oxide synthase and NADPH-diaphorase in striatal interneurons in rats. Brain Res 1996; 735: 317-324.
43. Ciofi P, Croix D, Tramu G. Colocalization of GHRF and NPY immunoreactivities in neurons of the infundibular area of the human brain. Neuroendocrinology 1988; 47: 469-472.
44. Conti AC, Raghupathi R, Trojanowski JQ, McIntosh TK. Experimental brain injury induces regionally distinct apoptosis during the acute and delayed post-traumatic period. J Neurosci 1998; 18: 5663-5672.
45. Lucassen PJ, Muller MB, Hosboer F, Bauer J, Holtrop A, Wouda J, Hoogendijk WJ, De Kloet ER, Swaab DF. Hippocampal apoptosis in major depression is a minor event and absent from subareas at risk for glucocorticoid overexposure. Am J Pathol 2001; 158: 453-468.
46. Biebl M, Cooper CM, Winkler J, Kuhn HG. Analysis of neurogenesis and programmed cell death reveals a self-renewing capacity in the adult rat brain. Neurosci Lett 2000; 291: 17-20.
47. Badger TM, Millard WJ, McCormick GF, Bower CY, Martin JB. The effects of growth hormone (GH)-releasing peptides on GH secretion in perfused pituitary cells of adult male rats. Endocrinology 1984; 115: 1432-1438.
48. Sakoda H, Gotoh Y, Katagiri H, Kurakawa M, Ono H, Onishi Y, Motonobu A, Ogihara T, Fujishiro M, Fukushima Y, Abe M, Shojima N, Kikuchi M, Oka Y, Hirai H, Asano T. Differing roles of Akt and SGK in glucose metabolism, DNA synthesis and oncogenic activity. J Biol Chem 2003; 278: 25802-25807.
49. Nyberg F. Growth hormone in the brain, characteristics of specific brain targets for the hormone and their functional significance. Front Neuroendocrinol 2000; 21: 330-348.
50. van Dam PS, Aleman A, de Vries WR, Deijen JB, van der Veen EA, de Haan EH, Koppeschaar HP. Growth hormone, insulin-like growth factor I and cognitive function in adults. Growth Horm IGF Res 2000; 10 (Suppl. B): S69-S73.
51. Wang Q, Liu L, Pei L, Ju W, Ahmadian G, Lu J, Wang Y, Liu F, Wang YT. Control of synaptic strength, a novel function of Akt. Neuron 2003; 38: 915-928.
52. Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004; 304: 110-115.