Mean corpuscular volume, alcohol flushing, and the predicted risk of squamous cell carcinoma of the esophagus in cancer-free Japanese men

Alcoholism: Clinical and Experimental Research

Volumn 29, Issue 10, 2005, Pages 1877-1883

  Yokoyama, Akira ^a   Yokoyama, Tetsuji ^b   Kumagai, Yoshiya ^c   Kato, Hoichi ^d   Igaki, Hiroyasu ^d   Tsujinaka, Toshimasa ^e   Muto, Manabu ^f   Omori, Tai ^g   Yokoyama, Masako ^h   Watanabe, Hiroshi ⁱ  

^a KURIHAMA NATIONAL HOSPITAL   (Japan)

^b NATIONAL INSTITUTE OF PUBLIC HEALTH   (Japan)

^c Kumagai Satellite Clinic   (Japan)

^d NATIONAL CANCER CENTER HOSPITAL   (Japan)

^e OSAKA NATIONAL HOSPITAL   (Japan)

^f NATIONAL CANCER CENTER HOSPITAL EAST   (Japan)

^g KAWASAKI MUNICIPAL HOSPITAL   (Japan)

^h Mitsukoshi Health and Welfare Foundation   (Japan)

ⁱ KEIO UNIVERSITY   (Japan)

Author keywords

Alcohol; Alcohol flushing; Aldehyde dehydrogenase 2; Esophageal squamous cell carcinoma; Mean corpuscular volume

Indexed keywords

ACETALDEHYDE; ALDEHYDE DEHYDROGENASE ISOENZYME 2;

ADULT; AGED; ALCOHOLISM; ARTICLE; CANCER MORTALITY; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; DIET; ESOPHAGEAL SQUAMOUS CELL CARCINOMA; FLUSHING; GENOTYPE; HIGH RISK POPULATION; HUMAN; JAPAN; MAJOR CLINICAL STUDY; MALE; MEAN CORPUSCULAR VOLUME; MEGALOCYTOSIS; PREDICTION; PRIORITY JOURNAL; QUESTIONNAIRE; SENSITIVITY AND SPECIFICITY; SMOKING; STATISTICAL ANALYSIS;

ADULT; AGED; ALDEHYDE DEHYDROGENASE; CARCINOMA, SQUAMOUS CELL; CASE-CONTROL STUDIES; CENTRAL NERVOUS SYSTEM DEPRESSANTS; DIET; DNA; ERYTHROCYTE INDICES; ESOPHAGEAL NEOPLASMS; ETHANOL; FLUSHING; GENOTYPE; HUMANS; JAPAN; MALE; MIDDLE AGED; QUESTIONNAIRES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RISK ASSESSMENT; SMOKING;

EID: 27644469437     PISSN: 01456008     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.alc.0000183168.98680.aa     Document Type: Article

References (33)

1. Bosron WF, Li TK (1986) Genetic polymorphism of human liver alcohol and aldehyde dehydrogenases and their relationship to alcohol metabolism and alcoholism. Hepatology 6:502-510.
2. Chalmers DM, Levi AJ, Chanarin I, North W, Meade TW (1979) Mean cell volume in a working population: the effects of age, smoking, alcohol and oral contraception. Br J Haematol 43:631-636.
3. Chao YC, Wang LS, Hsieh TY, Chu CW, Chang FY, Chu HC (2000) Chinese alcoholic patients with esophageal cancer are genetically different from alcoholics with acute pancreatitis and liver cirrhosis. Am J Gastroenterol 95:2958-2964.
4. Cheng KK, Day NE (1996) Nutrition and esophageal cancer. Cancer Causes Control 7:33-40.
5. Choi SW, Mason JB (2000) Folate and carcinogenesis: an integrated scheme. J Nutr 130:129-132.
6. Enomoto N, Takase S, Yasuhara M, Takada A (1991) Acetaldehyde metabolism in different aldehyde dehydrogenase-2 genotypes. Alcohol Clin Exp Res 15:141-144.
7. Fang JL, Vaca CE (1997) Detection of DNA adducts of acetaldehyde in peripheral white blood cells of alcohol abusers. Carcinogenesis 18:627-632.
8. Harada S, Zhang S (1993) New strategy for detection of ALDH2 mutant. Alcohol Alcohol 28(Suppl):11-13.
9. Hashimoto Y, Nakayama T, Futamura A, Omura M, Nakahara K (2002) Erythrocyte mean cell volume and genetic polymorphism of aldehyde dehydrogenase 2 in alcohol drinkers. Blood 99:3487-3488.
10. Hillman RS, Steinberg SE (1982) The effects of alcohol on folate metabolism. Annu Rev Med 33:345-354.
11. International Agency for Research on Cancer (1985) Allyl compounds, aldehydes, epoxides and peroxides, in IARC Monographs on the Evaluation on the Carcinogenic Risk of Chemicals to Humans. Vol. 36, pp 101-132, IARC, Lyon.
12. International Agency for Research on Cancer (1986) Tobacco smoking, in IARC Monographs on the Evaluation on the Carcinogenic Risk of Chemicals to Humans. Vol. 38, pp 83-126, IARC, Lyon.
13. International Agency for Research on Cancer (1999) Re-evaluation of some organic chemicals, hydrazine and hydrogen peroxide, in IARC Monographs on the Evaluation on the Carcinogenic Risks to Humans. Vol. 71, pp 319-335, IARC, Lyon.
14. Latvala J, Parkkila S, Melkko J, Niemela O (2001) Acetaldehyde adducts in blood and bone marrow of patients with ethanol-induced erythrocyte abnormalities. Mol Med 7:401-405.
15. Makuuchi H (2001) Endoscopic mucosal resection for mucosal cancer in the esophagus. Gastrointest Endosc Clin N Am 11:445-458.
16. Matsuo K, Hamajima N, Shinoda M, Hatooka S, Inoue M, Takezaki T, Tajima K (2001) Gene-environment interaction between an aldehyde dehydrogenase-2 (ALDH2) polymorphism and alcohol consumption for the risk of esophageal cancer. Carcinogenesis 22:913-916.
17. Morimoto K, Takeshita T (1996) Low Km aldehyde dehydrogenase (ALDH2) polymorphism, alcohol-drinking behavior, and chromosome alterations in peripheral lymphocytes. Environ Health Perspect 104(Suppl 3):563-567.
18. Nomura F, Itoga S, Tamura M, Harada S, Iizuka Y, Nakai T (2000) Biological markers of alcoholism with respect to genotypes of low-Km aldehyde dehydrogenase (ALDH2) in Japanese subjects. Alcohol Clin Exp Res 24(Suppl 4):30S-33S.
19. Seppa K, Laippala P, Saarni M (1991) Macrocytosis as a consequence of alcohol abuse among patients in general practice. Alcohol Clin Exp Res 15:871-876.
20. Shaw S, Jayatilleke E, Herbert V, Colman N (1989) Cleavage of folates during ethanol metabolism: Role of acetaldehyde/xanthine oxidase-generated Superoxide. Biochem J 257:277-280.
21. Takeshita T, Morimoto K (2000) Accumulation of hemoglobin-associated acetaldehyde with habitual alcohol drinking in the atypical ALDH2 genotype. Alcohol Clin Exp Res 24:1-7.
22. Vaughan TL, Davis S, Kristal A, Thomas DB (1995) Obesity, alcohol, and tobacco as risk factors for cancers of the esophagus and gastric cardia: adenocarcinoma versus squamous cell carcinoma. Cancer Epidemiol Biomark Prev 4:85-92.
23. Wickramasinghe SN, Malik F (1986) Acetaldehyde causes a prolongation of the doubling time and an increase in the modal volume of cells in culture. Alcohol Clin Exp Res 10:350-354.
24. Wu A, Chanarin I, Levi AJ (1974) Macrocytosis of chronic alcoholism. Lancet 1:829-830.
25. Yokoyama A, Kato H, Yokoyama T, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Fukuda H, Yoshimizu H (2002) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and glutathione S-transferase M1 and drinking, smoking, and diet in Japanese men with esophageal squamous cell carcinoma. Carcinogenesis 23:1851-1859.
26. Yokoyama A, Muramatsu T, Ohmori T, Higuchi S, Hayashida M, Ishii H (1996) Esophageal cancer and aldehyde dehydrogenase-2 genotypes in Japanese males. Cancer Epidemiol Biomark Prev 5:99-102.
27. Yokoyama A, Muramatsu T, Ohmori T, Yokoyama T, Okuyama K, Takahashi H, Hasegawa Y, Higuchi S, Maruyama K, Shirakura K, Ishii H (1998) Alcohol-related cancers and aldehyde dehydrogenase-2 in Japanese alcoholics. Carcinogenesis 19:1383-1387.
28. Yokoyama A, Ohmori T (2003) Genetic polymorphisms of alcohol and aldehyde dehydrogenases and risk for esophageal and head and neck cancers. Jpn J Clin Oncol 33:111-121.
29. Yokoyama A, Ohmori T, Makuuchi H, Maruyama K, Okuyama K, Takahashi H, Yokoyama T, Yoshino K, Hayashida M, Ishii H (1995) Successful screening for early esophageal cancer in alcoholics using endoscopy and mucosa iodine staining. Cancer 76:928-934.
30. Yokoyama A, Yokoyama T, Muramatsu T, Omori T, Matsushita S, Higuchi S, Maruyama K (2003a) Macrocytosis, a new predictor for esophageal squamous cell carcinoma in Japanese men. Carcinogenesis 24:1773-1778.
31. Yokoyama M, Yokoyama A, Yokoyama T, Hamana G, Funazu K, Kondo S, Yamashita T, Yoshimizu H, Nakamura H (2003b) Mean corpuscular volume and the aldehyde dehydrogenase-2 genotype in male Japanese workers. Alcohol Clin Exp Res 27:1395-1401.
32. Yokoyama T, Saito K, Lwin H, Yoshiike N, Yamamoto A, Matsushita Y, Date C, Tanaka H (2005) Epidemiological evidence that acetaldehyde plays a significant role in the development of decreased serum folate concentration and elevated mean corpuscular volume in alcohol drinker. Alcohol Clin Exp Res 29:622-630.
33. Yokoyama T, Yokoyama A, Kato H, Tsujinaka T, Muto M, Omori T, Haneda T, Kumagai Y, Igaki H, Yokoyama M, Watanabe H, Yoshimizu H (2003c) Alcohol flushing, alcohol and aldehyde dehydrogenase genotypes, and risk for esophageal squamous cell carcinoma in Japanese men. Cancer Epidemiol Biomark Prev 12:1227-1233.