Importance of CYP2D3 in polymorphism of diazepam p-hydroxylation in rats

Drug Metabolism and Disposition

Volumn 33, Issue 11, 2005, Pages 1657-1660

  Sakai, Noriaki ^a   Saito, Konomu ^a   Kim, Hyung Sub ^a   Kazusaka, Akio ^a   Ishizuka, Mayumi ^a   Funae, Yoshihiko ^b   Fujita, Shoichi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 HYDROXY DIAZEPAM; 4 HYDROXY DIAZEPAM; CYTOCHROME P450; CYTOCHROME P450 2D; CYTOCHROME P450 2D1; CYTOCHROME P450 2D2; CYTOCHROME P450 2D3; CYTOCHROME P450 2D4; DIAZEPAM; DIAZEPAM DERIVATIVE; ISOENZYME; NORDAZEPAM; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG HYDROXYLATION; DRUG METABOLISM; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME SUBSTRATE; GENETIC POLYMORPHISM; LIVER MICROSOME; MALE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; STRAIN DIFFERENCE;

ALCOHOL OXIDOREDUCTASES; AMINO ACID SEQUENCE; ANIMALS; CYTOCHROME P-450 ENZYME SYSTEM; DIAZEPAM; HYDROXYLATION; KINETICS; MALE; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; MOLECULAR SEQUENCE DATA; POLYMORPHISM, GENETIC; RATS; RATS, WISTAR; RECOMBINANT PROTEINS; SPECIES SPECIFICITY;

AGOUTI; ANIMALIA; RATTUS NORVEGICUS;

EID: 27544506706     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.105.004242     Document Type: Article

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