Design and evaluation of dihydroxytetrahydro-1H-pyrrolo[2,1-c ]-[1,4]benzothiazines as conformationally restricted transition-state inhibitors of β-ribosidases

Journal of Organic Chemistry

Volumn 70, Issue 22, 2005, Pages 9013-9016

  Gao, Li ^a   Hollingsworth, Rawle I ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CARBOHYDRATES; ELECTRON TRANSITIONS; NITROGEN COMPOUNDS; STRUCTURE (COMPOSITION);

Β-RIBOSIDASES; IMINOPENTITOL SUBSTRUCTURES; NUCLEOSIDE HYDROLASES; THERAPEUTICS;

ENZYMES;

BACTERIAL ENZYME; BENZOTHIAZINE DERIVATIVE; BETA RIBOSIDASE; DIHYDROXY 2,3,3A,4 TETRAHYDRO 1H PYRROLO[2,1 C][1,4]BENZOTHIAZINE; DIHYDROXYHEXAHYDRO 1H PYRROLO[1,4]THIAZINE; DIHYDROXYTETRAHYDRO 1H PYRROLO[2,1 C][1,2]BENZOTHIAZINE DERIVATIVE; HEXAHYDRO BIS TRIMETHYLACETOXY 1H PYRROLO[1,4]THIAZIN 6 ONE; PURINE NUCLEOSIDE PHOSPHORYLASE; RIBOSE; UNCLASSIFIED DRUG;

ARTICLE; CARBOHYDRATE METABOLISM; CHIRALITY; DRUG CONFORMATION; DRUG DESIGN; DRUG SYNTHESIS; ENZYME INHIBITION; STEREOCHEMISTRY;

CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ENZYME INHIBITORS; HYDROGEN; HYDROXYLATION; MODELS, MOLECULAR; MOLECULAR CONFORMATION; N-GLYCOSYL HYDROLASES; PURINE-NUCLEOSIDE PHOSPHORYLASE; STEREOISOMERISM; THIAZINES;

EID: 27444440551     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo050374g     Document Type: Article

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