Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists

Journal of Medicinal Chemistry

Volumn 48, Issue 22, 2005, Pages 6803-6812

  Buck, Ildiko M ^a   Black, James W ^a   Cooke, Tracey ^a   Dunstone, David J ^a   Gaffen, John D ^a   Griffin, Eric P ^a   Harper, Elaine A ^a   Hull, Robert A D ^a   Kalindjian, S Barret ^a   Lilley, Elliot J ^a   Linney, Ian D ^a   Low, Caroline M R ^a   McDonald, Iain M ^a   Pether, Michael J ^a   Roberts, Sonia P ^a   Shankley, Nigel P ^a,b   Shaxted, Mark E ^a   Steel, Katherine I M ^a   Sykes, David A ^a   Tozer, Matthew J ^a,c   Watt, Gillian F ^a,d   Walker, Martin K ^a   Wright, Laurence ^a   Wright, Paul T ^a   more..

^a James Black Foundation   (United Kingdom)

^b JOHNSON AND JOHNSON PHARMACEUTICAL RESEARCH AND DEVELOPMENT   (United States)

^c MEDIVIR AB   (Sweden)

^d UCB PHARMA   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

3 [[5 (ADAMANTAN 1 YLOXYMETHYL) 2 CYCLOHEXYL 1H IMIDAZOLE 4 CARBONYL]AMINO]BENZOIC ACID; 6 [[(1 ADAMANTYLMETHYL)AMINO]CARBONYL] 5 [[1 [[(3,5 DICARBOXYPHENYL)AMINO]CARBONYL] 2 PHENYLETHYLAMINO]CARBONYL]INDOLE; BICYCLO COMPOUND; CHOLECYSTOKININ B RECEPTOR ANTAGONIST; IMIDAZOLE DERIVATIVE; JB 95008; PENTAGASTRIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DOG; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG METABOLISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HEPATOBILIARY SYSTEM; HYDROPHILICITY; MOLECULAR MODEL; NONHUMAN; RAT; RECEPTOR AFFINITY; STOMACH ACID SECRETION; STRUCTURE ANALYSIS;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; CEREBRAL CORTEX; DOGS; FEMALE; GASTRIC ACID; IMIDAZOLES; INFUSIONS, INTRAVENOUS; MICE; MODELS, MOLECULAR; PENTAGASTRIN; PYRROLES; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; RADIOLIGAND ASSAY; RECEPTOR, CHOLECYSTOKININ B;

EID: 27444436448     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0490686     Document Type: Article

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