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Volumn 122, Issue 17, 2000, Pages 4032-4038

Unsymmetrical azo initiators increase efficiency of radical generation in aqueous dispersions, liposomal membranes, and lipoproteins

Author keywords

[No Author keywords available]

Indexed keywords

AZO COMPOUND; LIPOPROTEIN; LIPOSOME; LOW DENSITY LIPOPROTEIN; PEROXY RADICAL; RADICAL; SCAVENGER; URIC ACID;

EID: 0034600255     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja9934605     Document Type: Article
Times cited : (29)

References (39)
  • 18
    • 0343935199 scopus 로고    scopus 로고
    • note
    • In TTAB micelles the presence of methyl linoleate with α-TOH and no initiator caused significant antioxidant consumption. Thus, methyl linoleate was excluded from these experiments.
  • 19
    • 0343935200 scopus 로고    scopus 로고
    • note
    • Preliminary experiments have been carried out measuring the rates of initiator decomposition in molecular aggregates such as micelles and liposomes by nitrogen evolution. These preliminary studies suggest that the assumption of a common rate of decomposition for C-0, C-8, C-12, and C-16 is reasonable. To be submitted for publication: S. M. Culbertson, N. A. Porter, L. R. C. Barclay, and M. Vinqvist.
  • 20
    • 0342629120 scopus 로고    scopus 로고
    • note
    • If the micelle captures urate because of charge effects, urate will compete effectively for lipophilic peroxyl radicals. C-0 decomposes in the aqueous phase where UA can scavenge a large fraction of the free radicals before partitioning into the lipid phase.
  • 22
    • 0343935193 scopus 로고    scopus 로고
    • note
    • The initiators C-8, C-12, and C-16 primarily decompose in the lipid aggregate where both free radicals generated can be quickly scavenged by α-TOH in the immediate vicinity.
  • 23
    • 0342629134 scopus 로고    scopus 로고
    • note
    • 5 Our experience with the antioxidant DPPD implicated it did not function the same as α-TOH in micelles and liposomes tested. In fact, results suggest that there is an interconnection (possibly a regeneration of uryl radical) between UA and DPPD across the aqueous/lipid interface (data not shown).


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.