Slow-MAS NMR: A new technology for in vivo metabolomic studies

Drug Discovery Today: Technologies

Volumn 2, Issue 3, 2005, Pages 291-294

  Wind, Robert A ^a   Hu, Jian Z ^a   Majors, Paul D ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACCURACY; BIOMEDICAL TECHNOLOGY ASSESSMENT; BIOTECHNOLOGY; HUMAN; IN VIVO STUDY; LIVER; LOCALIZED MAGIC ANGLE TURNING NUCLEAR MAGNETIC RESONANCE; MAGNETISM; MEDICAL RESEARCH; MEDICAL TECHNOLOGY; METABOLOMICS; METHODOLOGY; MOUSE STRAIN; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTON NUCLEAR MAGNETIC RESONANCE; RADIOFREQUENCY; REVIEW; SENSITIVITY ANALYSIS; SIGNAL DETECTION; SLOW MAGIC ANGLE SPINNING NUCLEAR MAGNETIC RESONANCE;

EID: 27244458364     PISSN: 17406749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ddtec.2005.08.009     Document Type: Review

References (33)

1. 1H MR spectroscopy for clinical use J. Progr. NMR Spectrosc. 31 1997 155-195
2. 19F NMR spectra of suspended leukemic cells NMR Biomed. 6 1993 125-129
3. J.L. Boxerman et al. Susceptibility effects in whole body experiments I.R. Young ed. In Methods in Biomedical Magnetic Resonance and Spectroscopy 2000 John Wiley 654-661
4. F.J. Cooke et al. Quantitative proton magnetic resonance spectroscopy of the cervical spinal cord Magn. Reson. Med. 51 2004 1122-1128
5. A. Ericsson et al. Measurements of magnetic-field variations in the human brain using a 3D-FT multiple gradient-echo technique Magn. Reson. Med. 33 1995 171-177
6. D.C. Ailion Lung and mediastinum: A discussion of relevant NMR physics I.R. Young ed. In Methods in Biomedical Magnetic Resonance and Spectroscopy 2000 John Wiley 400-408
7. S. Serafini et al. Comparison of fMRI and PEPSI during language processing in children Magn. Reson. Med. 45 2001 217-225
8. A. Schwarcz et al. Localized proton MRS of cerebral metabolite profiles in different mouse strains Magn. Reson. Med. 49 2003 822-827
9. R. Gruetter Automated localized in vivo adjustment of all first- and second-order shim coils Magn. Reson. Med. 29 1993 804-811
10. 1H NMR detection of Vitamin C in human brain in vivo Magn. Res. Med. 51 2004 225-229
11. A.N. Garroway Magic-angle sample spinning of liquids J. Magn. Reson. 49 1982 168-171
12. D.L. VanderHart Magnetic susceptibility & high resolution NMR of liquids & solids D.M. Grant and R.K. Harris eds. In Encyclopedia of Magnetic Resonance 1996 John Wiley 2938-2946
13. L.L. Cheng et al. Quantitative neuropathology by high resolution magic angle spinning proton magnetic resonance spectroscopy Proc. Natl. Acad. Sci. U S A 94 1997 6408-6413
14. 1H NMR spectroscopy of intact liver tissue Magn. Reson. Med. 50 2003 925-930
15. A.S. Zektzer et al. Improved signal to noise in HR-MAS TOCSY studies of prostate tissues using rotor synchronized adiabatic pulses Magn. Reson. Med. 53 2005 41-48
16. 1H NMR spectroscopy in organs and tissues using slow magic angle spinning Magn. Reson. Med. 46 2001 213-218
17. 1H NMR spectroscopy in rat liver using magic angle turning at a 1 Hz spinning rate Magn. Reson. Med. 47 2002 829-836
18. J.Z. Hu and R.A. Wind The evaluation of different MAS techniques at low spinning rates in aqueous samples and in the presence of magnetic susceptibility gradients J. Magn. Reson. 159 2002 92-100
19. 1H NMR spectroscopy in a live mouse subjected to 1.5 Hz magic angle spinning Magn. Reson. Med. 50 2003 1113-1119
20. R.A. Wind and J.Z. Hu Magnetic susceptibility effects in nuclear magnetic resonance spectroscopy of biological objects Recent Res. Dev. Magn. Magn. Mater. 1 2003 147-169
21. R.A. Wind and J.Z. Hu Proton NMR in biological objects submitted to magic angle spinning P.J. Worsfold et al. eds. In Encyclopedia of Analytical Science 2nd edn 2005 Elsevier 333-342
22. S.G. Cho et al. Chronic hepatisis: In vivo proton MR spectroscopic evaluation of the liver and correlation with histopathologic findings Radiology 221 2001 740-746
23. A. Rosi et al. 1H-MRS lipid signal modulation and morphological and ultrastructural changes related to tumor cell proliferation Magn. Reson. Med. 42 1999 248-257
24. L.M. Foley et al. In vivo image-guided 1H-magnetic resonance spectroscopy of the serial development of hepatocarcinogenesis in an experimental animal model Biochim. Biophys. Acta 1526 2001 230-236
25. R. Katz-Brull et al. Decreases in free cholesterol and fatty acid unsaturation in renal cell carcinoma demonstrated by breath-hold magnetic resonance spectroscopy Am. J. Physiol. Renal Physiol. 288 2005 F637-F641
26. N.J. Waters et al. NMR and pattern recognition studies on the time-related metabolic effects of a-naphthylisothiocyanate on liver, urine, and plasma in the rat: An integrative metabonomic approach Chem. Res. Toxicol. 14 2001 1401-1412
27. M. Coen et al. An integrated metabonomic study of acetaminophen toxicity in the mouse using NMR spectroscopy Chem. Res. Toxicol. 16 2003 295-303
28. J.C. Lindon et al. Toxicological applications of magnetic resonance Progr. NMR Spectrosc. 45 2004 109-143
29. F.G. Blankenberg et al. Detection of apoptotic cell death by proton NMR spectroscopy Blood 87 1996 1951-1956
30. 1H MRS detects polyunsaturated fatty acid accumulation during gene therapy of glioma: Implications for the in vivo detection of apoptosis Nat. Med. 5 1999 1323-1327
31. 1H NMR visible lipids in the life and death of cells TIBS 25 2000 357-362
32. J.R. Espina et al. Detection of in vivo biomarkers of phospholipidosis using NMR-based metabonomic approaches Magn. Reson. Chem. 39 2001 559-565
33. B.E. Miller and G.E.R. Hook Stimulation of surfactant phospholipid biosynthesis in the lungs of rats treated with silica Biochem. J. 253 1988 659-665