1H NMR Detection of Vitamin C in Human Brain In Vivo

Magnetic Resonance in Medicine

Volumn 51, Issue 2, 2004, Pages 225-229

  Terpstra, Melissa ^a   Gruetter, Rolf ^a  

^a UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

Author keywords

Ascorbic acid; Brain; Human; Magnetic resonance spectroscopy; Vitamin C

Indexed keywords

ASCORBIC ACID; MAGNETIC RESONANCE; MAGNETIC RESONANCE SPECTROSCOPY; METABOLITES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

1H NMR SPECTROSCOPY; ESSENTIAL NUTRIENTS; GLYCEROPHOSPHOCHOLINE; HUMAN; PHOSPHOETHANOLAMINE; RELATIVE INTENSITY; RESONANCE PATTERNS; VITAMIN C;

BRAIN;

ASCORBIC ACID; GLYCEROPHOSPHORYLCHOLINE; INOSITOL; LACTIC ACID; PHOSPHOETHANOLAMINE; PHOSPHORYLCHOLINE;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BRAIN; CLINICAL ARTICLE; FEMALE; HUMAN; HUMAN EXPERIMENT; IN VIVO STUDY; MALE; METABOLITE; NEUROIMAGING; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUTRIENT; PROTON NUCLEAR MAGNETIC RESONANCE; METABOLISM; METHODOLOGY;

ADULT; ASCORBIC ACID; BRAIN; FEMALE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MALE;

EID: 0842285734     PISSN: 07403194     EISSN: None     Source Type: Journal    
DOI: 10.1002/mrm.10715     Document Type: Article

References (17)

1. Davey MW, Van Montagu M, Inze D, Sanmartin M, Kanellis A, Smirnoff N, Benzie IJJ, Strain JJ, Favell D, Fletcher J. Plant L-ascorbic acid: chemistry, function, metabolism, bioavailability and effects of processing. J Sci Food Agric 2000;80:825-860.
2. Rice ME. Ascorbate regulation and its neuroprotective role in the brain. Trends Neurosci 2000;23:209-216.
3. Terpstra M, Henry P-G, Gruetter R. Measurement of reduced glutathione (GSH) in human brain using LCModel: analysis of difference edited spectra. Magn Reson Med 2003;50:19.
4. Terpstra M, Ugurbil K, Gruetter R. Direct in vivo measurement of human cerebral GABA concentration using MEGA-editing at 7 Tesla. Magn Reson Med 2002;47:1009-1012.
5. Adriany G, Gruetter R. A half-volume coil for efficient proton decoupling in humans at 4 tesla. J Magn Reson 1997;125:178-184.
6. Gruetter R, Tkac I. Field mapping without reference scan using asymmetric echo-planar techniques. Magn Reson Med 2000;43:319-323.
7. Tkac I, Starcuk Z, Choi I-Y, Gruetter R. In vivo 1H NMR spectroscopy of rat brain at 1 ms echo time. Magn Reson Med 1999;41:649-656.
8. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R. Simultaneous in vivo spectral editing and water suppression. NMR Biomed 1998;11:266-272.
9. Govindaraju G, Young K, Maudsley A. Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 2000;13:129-153.
10. Willker W, Englemann J, Brand A, Leibfritz D. Metabolite identification in cell extracts and culture media by proton-detected 2D-H,C-NMR spectroscopy. J Magn Res Anal 1996;2:21-32.
11. Provencher SW. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn Reson Med 1993;30:672-679.
12. Behar KL, Rothman DL, Spencer DD, Petroff OAG. Analysis of macromolecule resonances in 1H NMR spectra of human brain. Magn Reson Med 1994;32:294-301.
13. Behar KL, Ogino T. Characterization of macromolecule resonances in the 1H NMR spectrum of rat brain. Magn Reson Med 1993;30:38-44.
14. Henry P-G, Dautry C, Hantraye P, Bloch G. Brain GABA editing without macromolecule contamination. Magn Reson Med 2001;45:517-520.
15. Pfeuffer J, Tkac I, Provencher SW, Gruetter R. Toward an in vivo neurochemical profile: quantification of 18 metabolites in short-echo-time 1H NMR spectra of the rat brain. J Magn Reson 1999;141:104-120.
16. Tkac I, Anderson P, Adriany G, Merkle H, Ugurbil K. In vivo 1H NMR spectroscopy of the human brain at 7 T. Magn Reson Med 2001;46:451-456.
17. Fan TW-M. Metabolite profiling by one- and two-dimensional NMR analysis of complex mixtures. Prog NMR Spectrosc 1996;28:161-219.