Use of altered-specificity binding Oct-4 suggests an absence of pluripotent cell-specific cofactor usage

Nucleic Acids Research

Volumn 33, Issue 18, 2005, Pages 6011-6023

  Smith, Alexander E F ^a   Ford, Kevin G ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

E1A PROTEIN; OCTAMER TRANSCRIPTION FACTOR 4; DNA; DNA BINDING PROTEIN; POU5F1 PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

AMINO TERMINAL SEQUENCE; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CELL DIFFERENTIATION; CONTROLLED STUDY; ENHANCER REGION; HELA CELL; HUMAN; HUMAN CELL; METHODOLOGY; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DNA BINDING; PROTEIN DOMAIN; PROTEIN FAMILY; PROTEIN FUNCTION; TRANSCRIPTION REGULATION; WILD TYPE; AMINO ACID SUBSTITUTION; ANIMAL; CELL LINE; CHEMISTRY; GENETICS; MALE; METABOLISM; PROTEIN TERTIARY STRUCTURE; TRANSACTIVATION; TUMOR CELL LINE;

AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; CELL DIFFERENTIATION; CELL LINE; CELL LINE, TUMOR; DNA; DNA-BINDING PROTEINS; HUMANS; MALE; OCTAMER TRANSCRIPTION FACTOR-3; PLURIPOTENT STEM CELLS; PROTEIN STRUCTURE, TERTIARY; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS;

EID: 27244441000     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gki907     Document Type: Article

References (34)

1. Okamoto,K., Okazawa,H., Okuda,A., Sakai,M., Muramatsu,M. and Hamada,H. (1990) A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell, 60, 461-472.
2. Rosner,M.H., Vigano,M.A., Ozato,K., Timmons,P.M., Poirier,F., Rigby,P.W. and Staudt,L.M. (1990) A POU-domain transcription factor in early stem cells and germ cells of the mammalian embryo. Nature, 345, 686-692.
3. Scholer,H.R., Dressler,G.R., Balling,R., Rohdewohld,H. and Gruss,P. (1990a) Oct-4: A germline-specific transcription factor mapping to the mouse t-complex. EMBO J., 9, 2185-2195.
4. Shimazaki,T., Okazawa,H., Fujii,H., Ikeda,M., Tamai,K., McKay,R.D., Muramatsu,M. and Hamada,H. (1993) Hybrid cell extinction and re-expression of Oct-3 function correlates with differentiation potential. EMBO J., 12, 4489-4498.
5. Niwa,H., Masui,S., Chambers,I., Smith,A.G. and Miyazaki,J. (2002) Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Mol. Cell. Biol., 22, 1526-1536.
6. Nichols,J., Zevnik,B., Anastassiadis,K., Niwa,H., Klewe-Nebenius,D., Chambers,I., Scholer,H. and Smith,A. (1998) Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct-4. Cell, 95, 379-391.
7. Scholer,H.R., Ruppert,S., Suzuki,N., Chowdhury,K. and Gruss,P. (1990b) New type of POU domain in germ line-specific protein Oct-4. Nature, 344, 435-439.
8. Scholer,H.R., Ciesiolka,T. and Gruss,P. (1991) A nexus between Oct-4 and E1A: Implications for gene regulation in embryonic stem cells. Cell, 66, 291-304.
9. Brehm,A., Ohbo,K., Zwerschke,W., Botquin,V., Jansen-Durr,P. and Scholer,H.R. (1999) Synergism with germ line transcription factor Oct-4: viral oncoproteins share the ability to mimic a stem cell-specific activity. Mol. Cell. Biol., 19, 2635-2643.
10. La Thangue,N.B. and Rigby,P.W. (1987) An adenovirus E1A-like transcription factor is regulated during the differentiation of murine embryonal carcinoma stem cells. Cell, 49, 507-513.
11. Berk,A.J., Boyer,T.G., Kapanidis,A.N., Ebright,R.H., Kobayashi,N.N., Horn,P.J., Sullivan,S.M., Koop,R., Surby,M.A. and Triezenberg,S.J. (1998) Mechanisms of viral activators. Cold Spring Harb. Symp. Quant. Biol., 63, 243-252.
12. Frisch,S.M. and Mymryk,J.S. (2002) Adenovirus-5 E1A: Paradox and paradigm. Nature Rev. Mol. Cell Biol., 3, 441-452.
13. Niwa,H., Miyazaki,J. and Smith,A.G. (2000) Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genet., 24, 372-376.
14. Niwa,H. (2001) Molecular mechanism to maintain stem cell renewal of ES cells. Cell Struct. Funct., 26, 137-148.
15. Brehm,A., Ohbo,K. and Scholer,H. (1997) The carboxy-terminal transactivation domain of Oct-4 acquires cell specificity through the POU domain. Mol Cell. Biol., 17, 154-162.
16. Pomerantz,J.L. and Sharp,P.A. (1994) Homeodomain determinants of major groove recognition. Biochemistry, 33, 10851-10858.
17. Walker,S., Hayes,S. and O'Hare,P. (1994) Site-specific conformational alteration of the Oct-1 POU domain-DNA complex as the basis for differential recognition by Vmw65 (VP16). Cell, 79, 841-852.
18. Shah,P.C., Bertolino,E. and Singh,H. (1997) Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription. EMBO J., 16, 7105-7117.
19. McBurney,M.W., Jones-Villeneuve,E.M., Edwards,M.K. and Anderson,P.J. (1982) Control of muscle and neuronal differentiation in a cultured embryonal carcinoma cell line. Nature, 299, 165-1657.
20. Luckow,B. and Schutz,G. (1987) CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res., 15, 5490.
21. Smith,A. (2003) Characterization of Oct-4 function and assessment of potential relationships between Oct-4 and E1A-like cofactors specific to undifferentiated EC cells. Thesis, King's College London, London, UK.
22. Meijer,D., Graus,A. and Grosveld,G. (1992) Mapping the transactivation domain of the Oct-6 POU transcription factor. Nucleic Acids Res., 20, 2241-2247.
23. Gstaiger,M., Knoepfel,L., Georgiev,O., Schaffner,W. and Hovens,C.M. (1995) A B-cell coactivator of octamer-binding transcription factors. Nature, 373, 360-362.
24. Nishimoto,M., Fukushima,A., Okuda,A. and Muramatsu,M. (1999) The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol. Cell. Biol., 19, 5453-5465.
25. Butteroni,C., De Felici,M., Scholer,H.R. and Pesce,M. (2000) Phage display screening reveals an association between germline-specific transcription factor Oct-4 and multiple cellular proteins. J. Mol. Biol., 304, 529-40.
26. Guo,Y., Costa,R., Ramsey,H., Starnes,T., Vance,G., Robertson,K., Kelley,M., Reinbold,R., Scholer,H. and Hromas,R. (2002) The embryonic stem cell transcription factors Oct-4 and FoxD3 interact to regulate endodermal-specific promoter expression. Proc. Natl Acad. Sci. USA, 99, 3663-3667.
27. Aurora,R. and Herr,W. (1992) Segments of the POU domain influence one another's DNA-binding specificity. Mol. Cell. Biol., 12, 455-467.
28. Botquin,V., Hess,H., Fuhrmann,G., Anastassiadis,C., Gross,M.K., Vriend,G. and Scholer,H.R. (1998) New POU dimer configuration mediates antagonistic control of an osteopontin preimplantation enhancer by Oct-4 and Sox-2. Genes Dev., 12, 2073-2090.
29. Scholer,H.R., Balling,R., Hatzopoulos,A.K., Suzuki,N. and Gruss,P. (1989) Octamer binding proteins confer transcriptional activity in early mouse embryogenesis. EMBO J., 8, 2551-2557.
30. Vigano,M.A. and Staudt,L.M. (1996) Transcriptional activation by Oct-3: evidence for a specific role of the POU-specific domain in mediating functional interaction with Oct-1. Nucleic Acids Res., 24, 2112-2118.
31. Veenstra,G.J., Mathu,M.T. and Destree,O.H. (1999) The Oct-1 POU domain directs developmentally regulated nuclear translocation in Xenopus embryos. Biol. Chem., 380, 253-2357.
32. Imagawa,M., Miyamoto,A., Shirakawa,M., Hamada,H. and Muramatsu,M. (1991) Stringent integrity requirements for both transactivation and DNA-binding in a trans-activator, Oct-3. Nucleic Acids Res., 19, 4503-4508.
33. Atanasoski,S., Schreiber,E., Fontana,A. and Herr,W. (1997) N-Oct 5 is generated by in vitro proteolysis of the neural POU-domain protein N-Oct3. Oncogene, 14, 1287-1294.
34. Gerster,T., Matthias,P., Thali,M., Jiricny,J. and Schaffner,W. (1987) Cell type-specificity elements of the immunoglobulin heavy chain gene enhancer. EMBO J., 6, 1323-1330.