Using altered specificity Oct-1 and Oct-2 mutants to analyze the regulation of immunoglobulin gene transcription

EMBO Journal

Volumn 16, Issue 23, 1997, Pages 7105-7117

  Shah, Pratik C ^a   Bertolino, Eric ^a   Singh, Harinder ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

Altered specificity mutant; Expression screening; Immunoglobulin gene transcription; Octamer binding protein; POU domain

Indexed keywords

HISTONE; MUTANT PROTEIN; OCTAMER TRANSCRIPTION FACTOR 1; OCTAMER TRANSCRIPTION FACTOR 2; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ARTICLE; B LYMPHOCYTE; CELL MATURATION; CELL TYPE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOGLOBULIN GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DNA BINDING; TRANSCRIPTION REGULATION;

EID: 0030710206     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.23.7105     Document Type: Article

References (60)

1. Bergman, Y., Rice, D., Grosschedl, R. and Baltimore, D. (1984) Two regulatory elements for immunoglobulin kappa light chain gene expression. Proc. Natl Acad. Sci. USA, 81, 7041-7045.
2. Brass, A.L., Kehrli, E., Eisenbeis, C.F., Storb, U. and Singh, H. (1996) Pip, a lymphoid-restricted IRF, contains a regulatory domain that is important for autoinhibition and ternary complex formation with the Ets factor. PU.1. Genes Dev., 10, 2335-2347.
3. Clerc, R.G., Corcoran, L.M., LeBowitz, J.H., Baltimore, D. and Sharp, P.A. (1988) The B-cell-specific Oct-2 protein contains POU box-and homeo box-type domains. Genes Dev., 2, 1570-1581.
4. Corcoran, L.M. and Karvelas, M. (1994) Oct-2 is required early in T cell-independent B cell activation for G1 progression and for proliferation. Immunity, 1, 635-645.
5. Corcoran, L.M., Karvelas, M., Nossal, G.J., Ye, Z.S., Jacks, T. and Baltimore, D. (1993) Oct-2, although not required for early B-cell development, is critical for later B-cell maturation and for postnatal survival. Genes Dev., 7, 570-582.
6. Cormack, B.P. and Strahl, K. (1993) Regional codon randomization: defining a TATA-binding protein surface required for RNA polymerase III transcription. Science, 262, 244-248.
7. Dariavach, P., Williams, G.T., Campbell, K., Pettersson, S. and Neuberger, M.S. (1991) The mouse IgH 3′-enhancer. J. Immunol., 21, 1499-1504.
8. Das, G. and Herr, W. (1993) Enhanced activation of the human histone H2B promoter by an Oct-1 variant generated by alternative splicing. J. Biol. Chem., 268, 25026-25032.
9. Dreyfus, M., Doyen, N. and Rougeon, F. (1987) The conserved decanucleotide from the immunoglobulin heavy chain promoter induces a very high transcriptional activity in B-cells when introduced into an heterologous promoter. EMBO J., 6, 1685-1690.
10. Falkner, F.G. and Zachau, H.G. (1984) Correct transcription of an immunoglobulin kappa gene requires an upstream fragment containing conserved sequence elements. Nature, 310, 71-74.
11. Feldhaus, A.L., Klug, C.A., Arvin, K.L. and Singh, H. (1993) Targeted disruption of the Oct-2 locus in a B cell provides genetic evidence for two distinct cell type-specific pathways of octamer element-mediated gene activation. EMBO J., 12, 2763-2772.
12. Fletcher, C., Heintz, N. and Roeder, R.G. (1987) Purification and characterization of OTF-1, a transcription factor regulating cell cycle expression of a human histone H2b gene. Cell, 51, 773-781.
13. Glaser, S.M., Yelton, D.E. and Huse, W.D. (1992) Antibody engineering by codon-based mutagenesis in a filamentous phage vector system. J. Immunol., 149, 3903-3913.
14. Grosschedl, R. and Baltimore, D. (1985) Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell, 41, 885-897.
15. Gstaiger, M., Knoepfel, L., Georgiev, O., Schaffner, W. and Hovens, C.M. (1995) A B-cell coactivator of octamer-binding transcription factors. Nature, 373, 360-362.
16. Hanes, S.D. and Brent, R. (1989) DNA specificity of the bicoid activator protein is determined by homeodomain recognition helix residue 9. Cell, 57, 1275-1283.
17. Herr, W. and Cleary, M.A. (1995) The POU domain: versatility in transcriptional regulation by a flexible two-in-one DNA-binding domain. Genes Dev., 9, 1679-1693.
18. Hill, C.S., Marais, R., John, S., Wynne, J., Dalton, S. and Treisman, R. (1993) Functional analysis of a growth factor-responsive transcription factor complex. Cell, 73, 395-406.
19. Jenuwein, T. and Grosschedl, R. (1991) Complex pattern of immunoglobulin μ gene expression in normal and transgenic mice: nonoverlapping regulatory sequences govern distinct tissue specificities. Genes Dev., 5, 932-943.
20. Junker, S., Pedersen, S., Schreiber, E. and Matthias, P. (1990) Extinction of an immunoglobulin kappa promoter in cell hybrids is mediated by the octamer motif and correlates with suppression of Oct-2 expression. Cell, 61, 467-474.
21. Kemler, I., Bucher, E., Seipel, K., Muller-Immergluck, M.M. and Schaffner, W. (1991) Promoters with the octamer DNA motif (ATGCAAAT) can be ubiquitous or cell type-specific depending on binding affinity of the octamer site and Oct-factor concentration. Nucleic Acids Res., 19, 237-242.
22. Kim, U., Qin, X.F., Gong, S., Stevens, S., Luo, Y., Nussenzweig, M. and Roeder, R.G. (1996) The B-cell-specific transcription coactivator OCA-B/OBF-1/Bob-1 is essential for normal production of immunoglobulin isotypes. Nature, 383, 542-547.
23. Kingsley, C. and Winoto, A. (1992) Cloning of GT box-binding proteins: a novel Sp1 multigene family regulating T-cell receptor gene expression. Mol. Cell. Biol., 12, 4251-4261.
24. Kissinger, C.R., Liu, B.S., Martin-Blanco, E., Kornberg, T.B. and Pabo, C.O. (1990) Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: a framework for understanding homeodomain-DNA interactions. Cell, 63, 579-590.
25. Klein, C. and Struhl, K. (1994) Increased recruitment of TATA-binding protein to the promoter by transcriptional activation domains in vivo. Science, 266, 280-282.
26. Klemm, J.D., Rould, M.A., Aurora, R., Herr, W. and Pabo, C.O. (1994) Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules. Cell, 77, 21-32.
27. LaBella, F., Sive, H.L., Roeder, R.G. and Heintz, N. (1988) Cell-cycle regulation of a human histone H2b gene is mediated by the H2b subtype-specific consensus element. Genes Dev., 2, 32-39.
28. Lieberson, R., Ong, J., Shi, X. and Eckhardt, L.A. (1995) Immunoglobulin gene transcription ceases upon deletion of a distant enhancer. EMBO J., 14, 6229-6238.
29. Luo, Y. and Roeder, R.G. (1995) Cloning, functional characterization, and mechanism of action of the B-cell-specific transcriptional coactivator OCA-B. Mol. Cell. Biol., 15, 4115-4124.
30. Luo, Y., Fujii, H., Gerster, T. and Roeder, R.G. (1992) A novel B cell-derived coactivator potentiates the activation of immunoglobulin promoters by octamer-binding transcription factors. Cell, 71, 231-241.
31. H gene promoter that includes a functional consensus sequence. Cell, 41, 479-487.
32. Miller, C.L., Feldhaus, A.L., Rooney, J.W., Rhodes, L.D., Sibley, C.H. and Singh, H. (1991) Regulation and a possible stage-specific function of Oct-2 during pre-B-cell differentiation. Mol. Cell. Biol., 11, 4885-4894.
33. Mittal, V., Cleary, M.A., Herr, W. and Hernandez, N. (1996) The Oct-1 POU-specific domain can stimulate small nuclear RNA gene transcription by stabilizing the basal transcription complex SNAPC. Mol. Cell. Biol., 16, 1955-1965.
34. Muller, M.M., Ruppert, S., Schaffner, W. and Matthias, P. (1988) A cloned octamer transcription factor stimulates transcription from lymphoid-specific promoters in non-B cells. Nature, 336, 544-551.
35. Murphy, S., Moorefield, B. and Pieler, T. (1989) Common mechanisms of promoter recognition by RNA polymerases II and III. Trends Genet., 5, 122-126.
36. Pettersson, S., Cook, G.P., Bruggemann, M., Williams, G.T. and Neuberger, M.S. (1990) A second B cell-specific enhancer 3′ of the immunoglobulin heavy-chain locus. Nature, 344, 165-168.
37. Pomerantz, J.L. and Sharp, P.A. (1994) Homeodomain determinants of major groove recognition. Biochemistry, 33, 10851-10858.
38. Rebar, E.J. and Pabo, C.O. (1994) Zinc finger phage: affinity selection of fingers with new DNA-binding specificities. Science, 263, 671-673.
39. Roberts, S.G. and Green, M.R. (1995) Dichotomous regulators. Nature, 375, 105-106.
40. Schaffner, W. (1989) How do different transcription factors binding the same DNA sequence sort out their jobs? Trends Genet., 5, 37-39.
41. Scholer, H.R. (1991) Octamania: the POU factors in murine development. Trends Genet., 7, 323-329.
42. Schubart, D.B., Rolink, A., Kosco-Vilbois, M.H., Botteri, F. and Matthias, P. (1996) B-cell-specific co-activator OBF-1/OCA-B/Bob1 required for immune response and germinal centre formation. Nature, 383, 538-542.
43. Schier, A.F. and Gehring, W.J. (1992) Direct homeodomain-DNA interaction in the autoregulation of the fushi tarazu gene. Nature, 356, 804-807.
44. Serwe, M. and Sablitzky, F. (1993) V(D)J recombination in B cells is impaired but not blocked by targeted deletion of the immunoglobulin heavy chain intron enhancer. EMBO J., 12, 2321-2327.
45. Simon, M.C. (1995) Gotta have GATA. Nature Genet., 11, 9-11.
46. Singh, H. (1993) Specific recognition site probes for isolating genes encoding DNA-binding proteins. Methods Enzymol., 218, 551-567.
47. Singh, H., Sen, R., Baltimore, D. and Sharp, P.A. (1986) A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature, 319, 154-158.
48. Staudt, L.M., Singh, H., Sen, R., Wirth, T., Sharp, P.A. and Baltimore, D. (1986) A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature, 323, 640-643.
49. Staudt, L.M., Clerc, R.G., Singh, H., LeBowitz, J.H., Sharp, P.A. and Baltimore, D. (1988) Cloning of a lymphoid-specific cDNA encoding a protein binding the regulatory octamer DNA motif. Science, 241, 577-580.
50. Strubin, M. and Struhl, K. (1992) Yeast and human TFIID with altered DNA-binding specificity for TATA elements. Cell, 68, 721-730.
51. Strubin, M., Newell, J.W. and Matthias, P. (1995) OBF-1, a novel B cell-specific coactivator that stimulates immunoglobulin promoter activity through association with octamer-binding proteins. Cell, 80, 497-506.
52. Tanaka, M. and Herr, W. (1990) Differential transcriptional activation by Oct-1 and Oct-2: interdependent activation domains induce Oct-2 phosphorylation. Cell, 60, 375-386.
53. Tjian, R. and Maniatis, T. (1994) Transcriptional activation: a complex puzzle with few easy pieces. Cell, 77, 5-8.
54. Treisman, J., Gonczy, P., Vashishtha, M., Harris, E. and Desplan, C. (1989) A single amino acid can determine the DNA binding specificity of homeodomain proteins. Cell, 59, 553-562.
55. Verrijzer, C.P., Alkema, M.J., van Weperen, W.W., Van Leeuwen, H.C., Strating, M.J. and van der Vliet, P.C. (1992) The DNA binding specificity of the bipartite POU domain and its subdomains. EMBO J., 11, 4993-5003.
56. Voss, J.W., Wilson, L. and Rosenfeld, M.G. (1991) POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter. Genes Dev., 5, 1309-1320.
57. Wang, Z.F., Tisovec, R., Debry, R.W., Frey, M.R. Matera, A.G. and Marzluff, W.F. (1996) Characterization of the 55-kb mouse histone gene cluster on chromosome 3. Genome Res., 6, 688-701.
58. Wirth, T., Staudt, L. and Baltimore, D. (1987) An octamer oligonucleotide upstream of a TATA motif is sufficient for lymphoid-specific promoter activity. Nature, 329, 174-178.
59. Zou, Y.R., Takeda, S. and Rajewsky, K. (1993) Gene targeting in the Ig kappa locus: efficient generation of lambda chain-expressing B cells, independent of gene rearrangements in Ig kappa. EMBO J., 12, 811-820.
60. Zwilling, S., Annweiler, A. and Wirth, T. (1994) The POU domains of the Oct-1 and Oct-2 transcription factors mediate specific interactions with TBP. Nucleic Acids Res., 22, 1655-1662.