Avoiding stroke during cerebral arterial occlusion by temporarily blocking neuronal functions in the rabbit

Journal of Stroke and Cerebrovascular Diseases

Volumn 7, Issue 5, 1998, Pages 287-295

  Maynard, Kenneth I ^a   Kawamata, Takakazu ^b   Ogilvy, Christopher S ^a   Perez, Fernando ^c   Arango, Pablo ^d   Ames III, Adelbert ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b TOKYO WOMEN'S MEDICAL UNIVERSITY   (Japan)

^c Hospital Regional de Concepcion Dr Guillermo Grant Benavente   (Chile)

^d PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

Author keywords

Cerebral vascular disease; Focal cerebral ischemia; Metabolic inhibition; Neuroprotection; Stroke

Indexed keywords

EID: 0000460391     PISSN: 10523057     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1052-3057(98)80045-1     Document Type: Article

References (65)

1. Ogilvy C.S., Carter B., Kaplan S., et al. Temporary vessel occlusion for aneurysm surgery: Risk factors for stroke in patients protected by induced hypothermia and hypertension and intravenous mannitol administration. J Neurosurg 84 (1996) 785-791
2. Taylor C.L., Selman W.R., Kiefer S.P., et al. Temporary vessel occlusion during intracranial aneurysm repair. Neurosurgery 39 (1996) 893-906
3. Astrup J. Energy-requiring cell functions in the ischemic brain. J Neurosurg 15 (1982) 482-497
4. Hoff J. Cerebral protection. J Neurosurg 65 (1986) 579-591
5. Barinaga M. Finding new drugs to treat stroke. Science 272 (1996) 664-666
6. Fisher M. Characterizing the target of acute stroke therapy. Stroke 28 (1997) 866-872
7. Grotta J. The current status of neuronal protective therapy: Why have all neuronal protective drugs worked in animals but none so far in stroke patients?. Cerebrovasc Dis 4 (1994) 115-120
8. Kempski O.S. Neuroprotection. Models and basic principles. Anaesthesist 43 suppl 2 (1994) S25-S33
9. Muir K.W., and Lees K.R. Clinical experience with excitatory amino acid antagonist drugs. Stroke 26 (1995) 503-513
10. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia. Part II: Mechanisms of damage and treatment. J Neurosurg 77 (1992) 337-354
11. Cafe C., Torri C., and Marzatico F. Cellular and molecular events of ischemic brain damage. Funct Neurol 8 (1993) 121-133
12. Martin R.L., Lloyd H., and Cowan A.I. The early events of oxygen and glucose deprivation: Setting the scene for neuronal death?. Trends Neurosci 17 (1994) 251-257
13. Siesjo B.K. Pathophysiology and treatment of focal cerebral ischemia. Part I: Pathophysiology. J Neurosurg 77 (1992) 169-194
14. Ames III A. Energy requirements of CNS cells as related to their function and to their vulnerability to ischemia: A commentary based on studies in retina. Can J Physiol Pharmacol 70 (1992) S158-S164
15. Ames III A., Maynard K.I., and Kaplan S. Protection against CNS ischemia by temporary interruption of function-related processes of neurons. J Cereb Blood Flow Metab 15 (1995) 433-439
16. Zager E.L., and Ames III A. Reduction of cellular energy requirements. Screening for agents that may protect against CNS ischemia. J Neurosurg 69 (1988) 568-579
17. Lo E.H., and Steinberg G.K. Effects of hypothermia on evoked potentials, magnetic resonance imaging, and blood flow in focal ischemia in rabbits. Stroke 23 (1992) 889-893
18. Ogilvy C.S., Chu D., and Kaplan S. Mild hypothermia, hypertension and mannitol are protective against infarction during intracranial temporary vessel occlusion. Neurosurgery 38 (1996) 1202-1210
19. Pan Y., Lo E.H., Matsumoto K., et al. Quantitative and dynamic MRI of neuroprotection in experimental stroke. J Neurol Sci 131 (1995) 128-134
20. Sakas D.E., Crowell R.M., and Zervas N.T. Effects of lecithin-emulsified perfluorochemical compounds in ischemic brain injury. Biotechnology 22 (1994) 83-89
21. Tomlinson F.H., Anderson R.E., and Meyer F.B. Acidic foci within the ischemia penumbra of the New Zealand white rabbit. Stroke 24 (1993) 2030-2039
22. Yamamoto K., Yoshimine T., and Yanagihara T. Cerebral ischemia in rabbit: A new experimental model with immuno-histochemical investigation. J Cereb Blood Flow Metab 5 (1985) 529-536
23. Lee J.S., Hamilton M.G., and Zabramski J.M. Variation in the anatomy of the rabbit cervical carotid artery. Stroke 25 (1994) 501-503
24. Neuwelt E.A., Maravilla K.R., Frenkel E.P., et al. Osmotic blood-brain barrier disruption. Computerized tomographic monitoring of chemotherapeutic agent delivery. J Clin Invest 64 (1979) 684-688
25. Little J.R. Treatment of acute focal cerebral ischemia with intermittent, low-dose mannitol. Neurosurgery 5 (1979) 687-691
26. Yoshimoto T., Sakamoto T., Watanabe T., et al. Experimental cerebral infarction. Part 3: Protective effect of mannitol in thalamic infarction in dogs. Stroke 9 (1978) 217-218
27. Bederson J.B., Pitts L.H., Germano S.M., et al. Evaluation of 2,3,5-triphenyltetrazolium chloride as a stain for the detection and quantification of experimental cerebral infarction in rats. Stroke 17 (1986) 1304-1308
28. Swanson R.A., Morton N.T., Tsao-Wu G., et al. A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metabol 10 (1990) 290-293
29. 2+ exchanger. J Neurosci 12 (1992) 430-439
30. Weber M.L., and Taylor C.P. Damage from glucose and oxygen deprivation in hippocampal slices is prevented by tetrodotoxin, lidocaine and phenytoin without blockade of action potentials. Brain Res 664 (1994) 167-177
31. Hartley D.M., and Choi D.W. Delayed rescue of N-methyl-D-aspartate receptor-mediated neuronal injury in cortical culture. J Pharmacol Exp Ther 250 (1989) 752-758
32. Schurr A., Payne R.S., and Rigor B.M. Synergism between diltiazem and MK801 but not APV in protecting hippocampal slices against hypoxic damage. Brain Res 684 (1995) 233-236
33. Tombaugh G.C., and Sapolsky R.M. Mild acidosis protects hippocampal neurons from injury induced by oxygen and glucose deprivation. Brain Res 506 (1990) 343-345
34. Izumi Y., Roussel S., Pinard E., et al. Reduction of infarct volume by magnesium after middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab 11 (1991) 1025-1030
35. Schmitt H.J., Barth G.R., and Thierauf P. Neuronal protection by intraischemic brain perfusion: An electron microscopy study in the rat. J Neurosurg Anesthesiol 6 (1994) 265-274
36. Simpson J.I., Eide T.R., Schiff G.A., et al. Intrathecal magnesium sulfate protects the spinal cord from ischemic injury during thoracic aortic cross-clamping. Anesthesiology 81 (1994) 1493-1499
37. 2+ protect against irreversible damage during CNS ischemia. Stroke 15 (1984) 695-698
38. Manev H., Bertolino M., and DeErausquin G. Amiloride blocks glutamate-operated cationic channels and protects neurons in culture from glutamate-induced death. Neuropharmacology 29 (1990) 1103-1110
39. Weiss R.G., Lakatta E.G., and Gernstenblith G. Effects of amiloride on metabolism and contractility during reoxgenation in perfused rat hearts. Circ Res 66 (1990) 1012-1022
40. Yang G.-Y., and Betz A.L. Reperfusion-induced injury to the blood-brain barrier after middle cerebral artery occlusion in rats. Stroke 25 (1994) 1658-1665
41. Aronowski J., Strong R., and Grotta J.C. Reperfusion injury: Demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab 17 (1997) 1048-1056
42. Chi C.P., Rosenthal M., and Sick T. Ion leakage is reduced during anoxia in turtle brain: A potential survival strategy. Am J Physiol 257 (1989) R1562-R1564
43. Hochachka P.W. Defence strategies against hypoxia and hypothermia. Science 231 (1986) 234-241
44. Michenfelder J.D., and Theye R.A. The effects of anesthesia and hypothermia on canine cerebral ATP and lactate during anoxia produced by decapitation. Anesthesiology 33 (1973) 430-439
45. Wright R.L., and Ames III A. Measurement of maximal permissible cerebral ischemia and a study of its pharmacologic prolongation. J Neurosurg 21 (1964) 567-574
46. Buchan A., and Pulsinelli W.A. Hypothermia but not the N-methyl-D-aspartate antagonist, MK801, attenuates neuronal damage in gerbils subjected to transient global ischemia. J Neurosci 10 (1990) 311-316
47. Busto R., Dietrich W.D., Globus M.Y., et al. Small differences in intraischemic brain temperature critically determine the extent of ischemic neuronal injury. J Cereb Blood Flow Metab 7 (1987) 729-738
48. Field II J., Fuhrman F.A., and Martin A.W. Effects of temperature on the oxygen consumption of brain tissue. J Neurophysiol 7 (1944) 117-126
49. Lust W.D., Wheaton A.B., Feussner G., et al. Metabolism in the hamster brain during hibernation and arousal. Brain Res 489 (1989) 12-20
50. Ridenour T.R., Warner D.S., Todd M.M., et al. Mild hypothermia reduces infarct size resulting from temporary but not permanent focal ischemia in rats. Stroke 23 (1992) 733-738
51. Xue D., Huang Z.-G., Smith K.E., et al. Immediate or delayed mild hypothermia prevents focal cerebral infarction. Brain Res 587 (1992) 66-72
52. Nehls D.G., Todd M.M., Spetzler R.F., et al. A comparison of the cerebral protective effects of isofluorane and barbiturates during temporary focal ischemia in primates. Anesthesiology 66 (1987) 453-464
53. Theye R.A., and Michenfelder J.D. The effect of halothane on canine cerebral metabolism. Anesthesiology 29 (1968) 1107-1112
54. Astrup J., Sorensen P.M., and Sorensen H.R. Inhibition of cerebral oxygen and glucose consumption in the dog by hypothermia, pentobarbital and lidocaine. Anesthesiology 55 (1981) 263-268
55. Michenfelder J.D. Cerebral protection by thiopental during hypoxia. Anesthesiology 39 (1973) 510-517
56. Nillson L., and Siesjo B.K. The effect of pentobarbitone anaesthesia on blood flow and oxygen consumption in the rat brain. Acta Anaesthesiol Scand Supply 57 (1975) 18-24
57. Todd M.M., and Warner D.S. A comfortable hypothesis reevaluated. Cerebral metabolic depression and brain protection during ischemia. Anesthesiology 76 (1992) 161-164
58. Gorman C. Damage control. Time 148 (1996) 31-35
59. Obrenovitch T.P. The ischemic penumbra: Twenty years on. Cerebrovasc Brain Metab Rev 7 (1995) 297-323
60. 31P nuclear magnetic resonance study in unanesthetized neonatal rats. Pediatr Res 42 (1997) 700-708
61. Jonas S. Prophylactic pharmacologic neuroprotection against focal cerebral ischemia. Ann N Y Acad Sci 765 (1995) 21-25
62. Baumgartner W.A., Silverberg G.D., Ream A.K., et al. Reappraisal of cardiopulmonary bypass with deep hypothermia and circulatory arrest for complex neurosurgical operations. Surgery 94 (1983) 242-249
63. Pacult A., Gratzick G., Voegele D., et al. Surgical clipping of difficult intracranial aneurysms using deep hypothermia and total circulatory arrest. South Med J 86 (1993) 898-902
64. Robinson J.R., and Spetzler R.F. Cardiac bypass and hypothermia in the treatment of complex aneurysms. West J Med 162 (1995) 256
65. Williams M.D., Ranier W.G., Fieger Jr. H.G., et al. Cardiopul-monary bypass, profound hypothermia, and circulatory arrest for neurosurgery. Ann Thorac Surg 52 (1991) 1069-1074