Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in wistar rats

Clinical and Experimental Pharmacology and Physiology

Volumn 26, Issue 10, 1999, Pages 815-816

  Cheng, Juei Tang ^a,b   Wang, Chia Jane ^a   Hsu, Feng Lin ^a  

^a NATIONAL CHENG KUNG UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Adenosine A1 receptors; Antagonist; Blood pressure; Paeoniflorin; Wistar rat

Indexed keywords

8 (4 SULFOPHENYL)THEOPHYLLINE; 8 CYCLOPENTYLTHEOPHYLLINE; ADENOSINE A1 RECEPTOR; GUANETHIDINE; PAEONIFLORIN;

ARTICLE; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG RECEPTOR BINDING; HYPOTENSION; INTRAVENOUS DRUG ADMINISTRATION; MALE; NONHUMAN; PLANT ROOT; RAT; RECEPTOR INTRINSIC ACTIVITY;

EID: 0032828075     PISSN: 03051870     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1681.1999.03132.x     Document Type: Article

References (7)

1. 1. Hsu FL, Lai CW, Cheng JT. Antihyperglycemic effects of paeoniflorin and 8-debenzoylpaeoniflorin, glucosides from the root of Paeonia lactiflora. Planta Med. 1997; 63: 323-5.
2. 2. Lai CW, Hsu FL, Cheng JT. Stimulatory effect of paeoniflorin on adenosine A-1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUTT4) in isolated rat white adipocytes. Life Sci. 1998; 62: 1591-5.
3. 3. Ohta FL, Ni JW, Matsumoto K, Watanabe H. Paeony and its major constituent, paeoniflorin, improve radial maze performance impaired by scopolamine in rats. Pharmacol. Biochem. Behav. 1993; 45: 719-23.
4. 4. Chang TK, Hsu FL, Cheng JT. Punicalagin-induced release of norepinephrine reverses orthostatic hypotension in rats. Phytother. Res. 1994; 8: 348-51.
5. 5. Bunag RD, Butterfield J. Tailcuff blood pressure measurement without external preheating in awake rats. Hypertension 1982; 4: 898-903.
6. 6. Armstrong J, Eloura A. Effects of clonidine and guanethidine on peripheral sympathetic nerve function in pithed rat. Br. J. Pharmacol. 1973; 47: 850-3.
7. 7. Etrsniuk G, von Borstel RW, Wurtman RJ, Antagonism of the candiovascular effects of adenosine by taffeine or 8-(p-sulfophenyl)theophylline. J. Pharmacol Exp. Ther. 1987; 240: 428-32.