Antisense oligodeoxynucleotide complementary to platelet-derived growth factor A-chain messenger RNA inhibits the arterial proliferation in spontaneously hypertensive rats without altering their blood pressures

Journal of Hypertension

Volumn 15, Issue 10, 1997, Pages 1123-1136

  Fukuda, Noboru ^a   Kubo, Atsushi ^a   Watanabe, Yoshiyasu ^a   Nakayama, Tomohiro ^a   Soma, Masayoshi ^a   Izumi, Yoichi ^a   Kanmatsuse, Katsuo ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Antisense; Arterial proliferation; Platelet derived growth factor; Spontaneously hypertensive rat; Vascular smooth muscle

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; MESSENGER RNA; PHOSPHORUS 32; PLATELET DERIVED GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA1;

ALPHA CHAIN; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA; ARTICLE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA CONTENT; DNA SYNTHESIS; GENE MUTATION; GROWTH; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SERUM; SMOOTH MUSCLE FIBER; SPONTANEOUSLY HYPERTENSIVE RAT; SYSTOLIC BLOOD PRESSURE; VASCULAR SMOOTH MUSCLE;

EID: 0030884502     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004872-199715100-00010     Document Type: Article

References (42)

1. Hadrava V, Tremblay J, Hamet P: Abnormalities in growth characteristics of aortic smooth muscle cells in spontaneously hypertensive rats. Hypertension 1989, 13:589-597.
2. Hamet P, Hadrava V, Kruppa U, Tremblay J: Vascular smooth muscle cell hyperresponsiveness to growth factors in hypertension. J Hypertens 1988, 5 (suppl 4):S36-S39.
3. Hamet P, Hadrava V, Kruppa U, Tremblay J: Transforming growth factor β1 expression and effect in aortic smooth muscle cells from spontaneously hypertensive rats. Hypertension 1991, 17:896-901.
4. Fukuda N, Tremblay J, Hamet P: Participation of proteolysis and transforming growth factor β1 activation in growth of cultured smooth muscle cells from spontaneously hypertensive rats. Genet Hypertens 1992, 218:227-229.
5. Mikhail N, Fukuda N, Tremblay J, Hamet P: Platelets, growth factors, and vascular smooth-muscle cells in hypertension and diabetes. J Cardiovasc Pharmacol 1993, 22 (suppl 6):S64-S74.
6. Battegay EJ, Raines EW, Seifert RA, Bowen-Pope DF, Ross R: TGF-β induces bimodal proliferation of connective tissue cells via complex control of an autocrine PDGF loop. Cell 1990, 63:515-524.
7. Walter SV, Hamet P: Enhanced DNA synthesis in heart and kidney of newborn spontaneously hypertensive rats. Hypertension 1986. 8:520-525.
8. Ross R, Raines EW, Bowen-Pope DF: The biology of platelet-derived growth factor. Cell 1986, 46:155-169.
9. Hart CE, Forstrom JW, Kelly JD, Seifert RA, Smith RA, Ross R, et al.: Two classes of PDGF receptor recognize different isoforms of PDGF. Science 1988, 240:1529-1531.
10. Hahn AWH, Resink TJ, Bernhardt J, Ferracin F, Bühler FR: Stimulation of autocrine platelet-derived growth factor AA-homodimer and transforming growth factor β in vascular smooth muscle cells. Biochem Biophys Res Commun 1991, 178:1451-1458.
11. Negoro N, Kanayama Y, Haraguchi M, Umetani N, Nishimura M, Konishi Y, et al.: Blood pressure regulates platelet-derived growth factor A-chain gene expression in vascular smooth muscle cells in vivo: an autocrine mechanism promoting hypertensive vascular hypertrophy. J Clin Invest 1995, 95:1140-1150.
12. Gray GD, Hernandez OM, Hebel D, Root M, Pow-Sang JM, Wickstrom E: Antisense DNA inhibition of tumor growth induced by c-Ha-ras oncogene in nude mice. Cancer Res 1993, 53:577-580
13. Bayever E, Iversen PL, Bishop MR, Sharp JG, Tewary HK, Arneson MA, et al.: Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute mylogenous leukemia and myelodysplastic syndrome: initial results of a phase I trial. Antisense Res Dev 1993, 3:383-390.
14. Alper J: Oligonucleotides surge into clinical trials. Biotechnology 1993, 11:1225.
15. Morishita R, Gibbons GH, Ellison KE, Nakajima M, Zhang L, Kaneda Y, et al.: Single intraluminal delivery of antisense cdc2 kinase and proliferating-cell nuclear antigen oligonucleotides results in chronic inhibition of neointimal hyperplasia. Proc Natl Acad Sci USA 1993, 90:8474-8478.
16. Xia Y, Feng L, Tang WW, Wilson CB: Cloning and expression of rat platelet-derived growth factor A-chain. J Am Soc Nephlol 1992, 3:622-622.
17. Mott RF, Kirkwood TBL: Tests for the statistical significance of protein sequence similarities in data-bank searches. Protein Eng 1990, 4:149-154.
18. Uyer RP, Phillips LR, Egan W, Regan JB, Beaucage SL: The automated synthesis of sulfur-containing oligodeoxyribonucleotides using 3H-1,2-benzodithiol-3-one 1,1-dioxide as a sulfur transfer agent. J Org Chem 1990, 55:4693-4698.
19. Ross R: The smooth muscle cell - II. Growth of smooth muscle in culture and formation of elastic fibers. J Cell Biol 1971, 50:172-186.
20. Franks DJ, Plamondon J, Hamet P: An increase in adenylate cyclase activity precedes DNA synthesis in cultured vascular smooth muscle cells. J Cell Physiol 1984, 119:41-45.
21. Nakamura T, Takeshita I, Inamura T, Tashima T, Fukui V: Expression of the B-chain of platelet-derived growth factor and proliferation activity of human brain tumors. Neurol Med Chir (Tokyo) 1993, 33:205-211.
22. Laemmli UJ: Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970, 227:680-685.
23. Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheet: procedure and some applications. Proc Natl Acad Sci USA 1979, 76:4350-4354.
24. Mocharla H, Mocharla R, Hocks ME: Coupled reverse transcriptase-polymerase chain reaction (RT-PCR) as a sensitive and rapid method for isozyme genotyping. Gene 1990, 93:271-275.
25. Chan YL, Lin A, McNally J, Pelleg D, Meyuhas O, Wool I: The primary structure of rat ribosomal protein L19. J Biol Chem 1987, 262:1111-1115.
26. Lowry OH, Rosebrough NJ, Farr AL, Randall J: Protein measurement with the folin phenol reagent. J Biol Chem 1951, 193:265-275.
27. Danscher G, Nörgaard JUR: Light microscopic visualization of colloidal gold on resin-embedded tissue. J Histochem Cytochem 1983, 31:1394-1398.
28. Antoniades HN: Human platelet-derived growth factor (PDGF): purification of PDGF-I and PDGF-II and separation of their reduced subunits. Proc Natl Acad Sci USA 1981, 78:7314-7317.
29. Nilsson J, Sjölund M, Palmberg L, Thyberg J, Heldin C: Arterial smooth muscle cells in primary culture produce a platelet-derived growth factor-like protein. Proc Natl Acad Sci USA 1985, 82:4418-4422.
30. Inoue M: Antisense RNA: its functions and applications in gene regulation [review]. Gene 1988, 72:25-34.
31. Walder RY, Walder JA: Role of RNase H in hybrid-arrested translation by antisense oligonucleotides. Proc Natl Acad Sci USA 1988, 85:5011-5015.
32. Munroe SH: Antisense RNA inhibits splicing of pre-mRNA in vitro. EMBO J 1988, 7:2523-2532.
33. Wellstein A, Zugmaier G, Califano J, Kern F, Paik S, Lippman M: Tumor growth dependent on Kaposi's sarcoma derived fibroblast growth factor inhibited by pentosan polysulfate. J Natl Cancer Inst 1991, 83:716-720.
34. Perez JR, Li Y, Stein CA, Majumder S, Van Oorschot A, Narayanan R: Sequence-independent induction of Sp1 transcription factor activity by phosphore thioate oligodeoxynucleotides. Proc Natl Acad Sci USA 1994, 91:5957-5961.
35. Burgess TL, Fisher EF, Ross SL, Bready JV, Qian Y, Bayewitch LA, et al.: The antiproliferative activity of c-myb and c-myc antisense oligonucleotides in smooth muscle cells is caused by a nonantisense mechanism. Proc Natl Acad Sci USA 1995, 92:4051-4055.
36. Wanger RW: Gene inhibition using antisense oligodeoxynucleotides. Nature 1994, 372:333-335.
37. Majack RA, Majesky MW, Goodman LV: Role of PDGF-A expression in the control of vascular smooth muscle cell growth by transforming growth factor-β. J Cell Biol 1990, 111:239-247.
38. Goodman LV, Majack RA: Vascular smooth muscle cells express distinct transforming growth factor-β receptor phenotypes as a function of cell density in culture. J Biol Chem 1989, 264:5241-5244.
39. Fukuda N, Kubo A, Izumi Y, Soma M, Kammatsuse K: Characteristics and expression of transforming growth factor-β receptor subtypes on vascular smooth muscle cells from spontaneously hypertensive rats. J Hypertens 1995, 13:831-837.
40. Resink TJ, Scott-Burden T, Hahn AWA, Rouge M, Hosang M, Powell JS, et al.: Specific growth stimulation of cultured smooth muscle cells from spontaneously hypertensive rats by platelet-derived growth factor A-chain homodimer. Cell Regulation 1990, 1:821-831.
41. Kitami Y, Inui H, Uno S, Inagami T: Molecular structure and transcriptional regulation of the gene for the platelet-derived growth factor alpha receptor in cultured vascular smooth muscle cells. J Clin Invest 1995, 96:558-567.
42. Yakubov LA, Deeva EA, Zarytova VF, Ivanova EM, Ryte AS, Yurchenko LY, et al.: Mechanism of oligonucleotide uptake by cells: involvement of specific receptor? Proc Natl Acad Sci USA 1989, 86:6454-6458.