In vitro cytopathic effects of mycotoxin T-2 on human peripheral blood T lymphocytes

Toxicology Letters

Volumn 160, Issue 1, 2005, Pages 60-68

  Vlata, Zaharenia ^a   Porichis, Filippos ^a   Tzanakakis, George ^b   Tsatsakis, Aristidis ^b   Krambovitis, Elias ^a  

^a INSTITUTE OF MOLECULAR BIOLOGY AND BIOTECHNOLOGY   (Greece)

^b UNIVERSITY OF CRETE   (Greece)

Author keywords

CD3; CD4; CD45RA; CD45RO; CD8; T lymphocytes; T 2 toxin

Indexed keywords

CD4 ANTIGEN; CD45 ANTIGEN; CD8 ANTIGEN; PHYTOHEMAGGLUTININ; T 2 TOXIN;

APOPTOSIS; ARTICLE; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; EXPOSURE; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TOXICITY;

APOPTOSIS; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, IMMUNOLOGIC; FLOW CYTOMETRY; HUMANS; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; NECROSIS; PHYTOHEMAGGLUTININS; T-2 TOXIN; T-LYMPHOCYTE SUBSETS; T-LYMPHOCYTES;

EID: 27144530245     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2005.06.006     Document Type: Article

References (40)

1. H.A. Atkinson, and K. Miller Inhibitory effect of deoxynivalenol 3-acetyldeoxynivalenol and zearalenone on induction of rat and human lymphocyte proliferation Toxicol. Lett. 23 1984 215 221
2. S. Baritaki, G.N. Tzanakakis, J. Alifragis, A. Zafiropoulos, R.I. Tashmukhamedov, A. Tsatsakis, M.I. Shtilman, A.K. Rizos, and E. Krambovitis Light scattering and in vitro biocompatibility studies of poly(vinyl pyrrolidone) derivatives with amino-acid-dependent groups J. Biomed. Mater. Res. 63 2002 830 837
3. S. Baritaki, A. Zafiropoulos, M. Sioumpara, M. Politis, D.A. Spandidos, and E. Krambovitis Ionic interaction of the HIV-1 V3 domain with CCR5 and deregulation of T lymphocyte function Biochem. Biophys. Res. Commun. 298 2002 574 580
4. J.W. Bennett, and M. Klich Mycotoxins Clin. Microbiol. Rev. 16 2003 497 516
5. L. Berek, I.B. Petri, A. Mesterhazy, J. Teren, and J. Molnar Effects of mycotoxins on human immune functions in vitro Toxicol. In Vitro 15 2001 25 30
6. D.E. Corrier Mycotoxicosis: mechanisms of immunosuppression Vet. Immunol. Immunopathol. 30 1991 73 87
7. D.E. Corrier, and R.L. Ziprin Immunotoxic effects of T-2 mycotoxin on cell-mediated resistance to Listeria monocytogenes infection Vet. Immunol. Immunopathol. 14 1987 11 21
8. D.E. Corrier, R.L. Ziprin, and H.H. Mollenhauer Modulation of cell-mediated resistance to listeriosis in mice given T-2 toxin Toxicol. Appl. Pharmacol. 89 1987 323 331
9. C. Dive, C.D. Gregory, D.J. Phipps, D.L. Evans, A.E. Milner, and A.H. Wyllie Analysis and discrimination of necrosis and apoptosis (programmed cell death) by multiparameter flow cytometry Biochim. Biophys. Acta 1133 1992 275 285
10. J.H. Forsell, J.R. Kateley, T. Yoshizawa, and J.J. Pestka Inhibition of mitogen-induced blastogenesis in human lymphocytes by T-2 toxin and its metabolites Appl. Environ. Microbiol. 49 1985 1523 1526
11. M.I. Gyongyossy-Issa, and G.G. Khachatourians Interaction of T-2 toxin and murine lymphocytes and the demonstration of a threshold effect on macromolecular synthesis Biochim. Biophys. Acta 844 1985 167 173
12. M.A. Hayes, J.E. Bellamy, and H.B. Schiefer Subacute toxicity of dietary T-2 toxin in mice: morphological and hematological effects Can. J. Comp. Med. 44 1980 203 218
13. S.D. Holladay, B.L. Blaylock, C.E. Comment, J.J. Heindel, and M.I. Luster Fetal thymic atrophy after exposure to T-2 toxin: selectivity for lymphoid progenitor cells Toxicol. Appl. Pharmacol. 121 1993 8 14
14. S.D. Holladay, B.J. Smith, and M.I. Luster B lymphocyte precursor cells represent sensitive targets of T2 mycotoxin exposure Toxicol. Appl. Pharmacol. 131 1995 309 315
15. J.A. Holme, E. Morrison, J.T. Samuelsen, R. Wiger, M. Lag, P.E. Schwarze, A. Bernhoft, and M. Refsnes Mechanisms involved in the induction of apoptosis by T-2 and HT-2 toxins in HL-60 human promyelocytic leukemia cells Cell Biol. Toxicol. 19 2003 53 68
16. P.S. Holt, D.E. Corrier, and J.R. DeLoach Suppressive and enhancing effect of T-2 toxin on murine lymphocyte activation and interleukin 2 production Immunopharmacol. Immunotoxicol. 10 1988 365 385
17. B.J. Hughes, B.B. Jarvis, and R.P. Sharma Effects of macrocyclic trichothecene congeners on the viability and mitogenesis of murine splenic lymphocytes Toxicol. Lett. 50 1990 57 67
18. Z. Islam, M. Nagase, T. Yoshizawa, K. Yamauchi, and N. Sakato T-2 toxin induces thymic apoptosis in vivo in mice Toxicol. Appl. Pharmacol. 148 1998 205 214
19. V. Jagadeesan, C. Rukmini, M. Vijayaraghavan, and P.G. Tulpule Immune studies with T-2 toxin: effect of feeding and withdrawal in monkeys Food Chem. Toxicol. 20 1982 83 87
20. J. Jason, and K.L. Inge Mitogen-induced modulation of CD3, CD4, and CD8(1) Hum. Immunol. 61 2000 202 211
21. A. Johannisson, B. Bjokhag, W. Hansson, I.L. Gadhasson, and A. Thuvander Effects of four trichothecene mycotoxins on activation marker expression and cell proliferation of human lymphocytes in culture Cell Biol. Toxicol. 15 1999 203 215
22. F.A. Meky, L.J. Hardie, S.W. Evans, and C.P. Wild Deoxynivalenol-induced immunomodulation of human lymphocyte proliferation and cytokine production Food Chem. Toxicol. 39 2001 827 836
23. T. Nagata, H. Suzuki, N. Ishigami, J. Shinozuka, K. Uetsuka, H. Nakayama, and K. Doi Development of apoptosis and changes in lymphocyte subsets in thymus, mesenteric lymph nodes and Peyer's patches of mice orally inoculated with T-2 toxin Exp. Toxicol. Pathol. 53 2001 309 315
24. D. Parent-Massin Haematotoxicity of trichothecenes Toxicol. Lett. 153 2004 75 81
25. J.C. Paucod, S. Krivobok, and D. Vidal Immunotoxicity testing of mycotoxins T-2 and patulin on Balb/c mice Acta Microbiol. Hung. 37 1990 331 339
26. J.J. Pestka, H.R. Zhou, Y. Moon, and Y.J. Chung Cellular and molecular mechanisms for immune modulation by deoxynivalenol and other trichothecenes: unraveling a paradox Toxicol. Lett. 153 2004 61 73
27. S. Robbana-Barnat, C. Lafarge-Frayssinet, H. Cohen, G.A. Neish, and C. Frayssinet Immunosuppressive properties of deoxynivalenol Toxicology 48 1988 155 166
28. Y. Rosenstein, and C. Lafarge-Frayssinet Inhibitory effect of Fusarium T2-toxin on lymphoid DNA and protein synthesis Toxicol. Appl. Pharmacol. 70 1983 283 288
29. S. Sehata, N. Kiyosawa, T. Makino, F. Atsumi, K. Ito, T. Yamoto, M. Teranishi, Y. Baba, K. Uetsuka, H. Nakayama, and K. Doi Morphological and microarray analysis of T-2 toxin-induced rat fetal brain lesion Food Chem. Toxicol. 42 2004 1727 1736
30. R.P. Sharma Immunotoxicity of mycotoxins J. Dairy Sci. 76 1993 892 897
31. V.I. Shifrin, and P. Anderson Trichothecene mycotoxins trigger a ribotoxic stress response that activates c-Jun N-terminal kinase and p38 mitogen-activated protein kinase and induces apoptosis J. Biol. Chem. 274 1999 13985 13992
32. B.J. Smith, S.D. Holladay, and B.L. Blaylock Hematopoietic alterations after exposure to T-2 mycotoxin Toxicon 32 1994 1115 1123
33. D.L. Sudakin Trichothecenes in the environment: relevance to human health Toxicol. Lett. 143 2003 97 107
34. A. Thuvander, C. Wikman, and I. Gadhasson In vitro exposure of human lymphocytes to trichothecenes: individual variation in sensitivity and effects of combined exposure on lymphocyte function Food Chem. Toxicol. 37 1999 639 648
35. R.S. Tomar, B.R. Blakley, and W.E. De Coteau In vitro effects of T-2 toxin on the mitogen responsiveness and antibody-producing ability of human lymphocytes Toxicol. Lett. 40 1988 109 117
36. Y. Ueno, K. Umemori, E. Niimi, S. Tanuma, S. Nagata, M. Sugamata, T. Ihara, M. Sekijima, K. Kawai, and I. Ueno Induction of apoptosis by T-2 toxin and other natural toxins in HL-60 human promyelotic leukemia cells Nat. Toxins. 3 1995 129 137
37. J. Wang, D.W. Fitzpatrick, and J.R. Wilson Effect of T-2 toxin on blood-brain barrier permeability monoamine oxidase activity and protein synthesis in rats Food Chem. Toxicol. 36 1998 955 961
38. R. Yarom, Y. Sherman, R. More, I. Ginsburg, R. Borinski, and B. Yagen T-2 toxin effect on bacterial infection and leukocyte functions Toxicol. Appl. Pharmacol. 75 1984 60 68
39. N. Yoshino, M. Takizawa, H. Akiba, H. Okumura, F. Tashiro, M. Honda, and Y. Ueno Transient elevation of intracellular calcium ion levels as an early event in T-2 toxin-induced apoptosis in human promyelotic cell line HL-60 Nat. Toxins 4 1996 234 241
40. A. Zafiropoulos, E. Andersson, E. Krambovitis, and C.A. Borrebaeck Induction of antigen-specific isotype switching by in vitro immunization of human naive B lymphocytes J. Immunol. Methods 200 1997 181 190