메뉴 건너뛰기




Volumn 14, Issue 10, 2005, Pages 1259-1267

Vinflunine: A novel antitubulin agent in solid malignancies

Author keywords

Bladder; Breast; Carcinoma; Lung; Vinflunine

Indexed keywords

ANTHRACYCLINE DERIVATIVE; CAMPTOTHECIN; CAPECITABINE; CARBOPLATIN; CISPLATIN; CREMOPHOR; DOXORUBICIN; FLUOROURACIL; GEMCITABINE; IRINOTECAN; LAXATIVE; LONAFARNIB; MITOMYCIN; NAVELBINE; PACLITAXEL; PLATINUM; POLYSORBATE 80; TAXANE DERIVATIVE; TRASTUZUMAB; TUBULIN; VINFLUNINE;

EID: 27144513351     PISSN: 13543784     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543784.14.10.1259     Document Type: Article
Times cited : (47)

References (39)
  • 2
    • 0034773326 scopus 로고    scopus 로고
    • Vinflunine, the latest vinca alkaloid in clinical development. A review of its preclinical anticancer properties
    • KRUCZYNSKI A, HILL BT: Vinflunine, the latest vinca alkaloid in clinical development. A review of its preclinical anticancer properties. Crit. Rev. Oncol. Hematol. (2001) 40(2):159-173.
    • (2001) Crit. Rev. Oncol. Hematol. , vol.40 , Issue.2 , pp. 159-173
    • Kruczynski, A.1    Hill, B.T.2
  • 3
    • 0032031453 scopus 로고    scopus 로고
    • Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated vinca alkaloid
    • KRUCZYNSKI A, BARRET JM, ETIEVANT C et al.: Antimitotic and tubulin-interacting properties of vinflunine, a novel fluorinated vinca alkaloid. Biochem. Phamacol. (1998) 55:635-648.
    • (1998) Biochem. Phamacol. , vol.55 , pp. 635-648
    • Kruczynski, A.1    Barret, J.M.2    Etievant, C.3
  • 4
    • 0031780236 scopus 로고    scopus 로고
    • A comparison of thermodynamic parameters for vinorelbine and vinflunine induced tubulin self-association by sedimentation velocity
    • LOBERT S, INGRAM JW, HILL B et al.: A comparison of thermodynamic parameters for vinorelbine and vinflunine induced tubulin self-association by sedimentation velocity. Mol. Pharmacol. (1998) 53:908-915.
    • (1998) Mol. Pharmacol. , vol.53 , pp. 908-915
    • Lobert, S.1    Ingram, J.W.2    Hill, B.3
  • 5
    • 42549086057 scopus 로고    scopus 로고
    • Vinflunine and vinorelbine, novel vinca alkaloids that act by modulation of microtubule dynamic instability and treadmilling
    • (Abstract 639)
    • NGAN V, JORDAN MA, WILSON L, HILL BT: Vinflunine and vinorelbine, novel vinca alkaloids that act by modulation of microtubule dynamic instability and treadmilling. Clin. Cancer. Res. (1999) 5:432 (Abstract 639).
    • (1999) Clin. Cancer Res. , vol.5 , pp. 432
    • Ngan, V.1    Jordan, M.A.2    Wilson, L.3    Hill, B.T.4
  • 6
    • 0034665163 scopus 로고    scopus 로고
    • Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules
    • NGAN V, BELLMAN K, PANDA D et al.: Novel actions of the antitumor drugs vinflunine and vinorelbine on microtubules. Cancer Res. (2000) 60:5045-5051.
    • (2000) Cancer Res. , vol.60 , pp. 5045-5051
    • Ngan, V.1    Bellman, K.2    Panda, D.3
  • 7
    • 0035150786 scopus 로고    scopus 로고
    • Anti-vascular effects of vinflunine in the mac 15a transplantable adenocarcinoma model
    • HOLWELL SE, HILL B T, BIBBY M C: Anti-vascular effects of vinflunine in the mac 15a transplantable adenocarcinoma model. Br. J. Cancer (2001) 84:290-295.
    • (2001) Br. J. Cancer , vol.84 , pp. 290-295
    • Holwell, S.E.1    Hill, B.T.2    Bibby, M.C.3
  • 8
    • 0034074044 scopus 로고    scopus 로고
    • In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anti-cancer drugs
    • BARRET J-M, ETIEVANT C, HILL BT: In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anti-cancer drugs. Cancer Chemother. Pharmacol. (2000) 45:471-476.
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 471-476
    • Barret, J.-M.1    Etievant, C.2    Hill, B.T.3
  • 9
    • 27144434642 scopus 로고    scopus 로고
    • Synergistic effects of the farnesyltransferase inhibitor SCH-66336 and novel vinca alkaloids in A549 non-small cell lung cancer cells in vitro
    • (Abstract A269)
    • ETIEVANT C, BARRET JM, CABROL N et al.: Synergistic effects of the farnesyltransferase inhibitor SCH-66336 and novel vinca alkaloids in A549 non-small cell lung cancer cells in vitro. Proc. Am. Cancer Res. (2003) 9:116 (Abstract A269).
    • (2003) Proc. Am. Cancer Res. , vol.9 , pp. 116
    • Etievant, C.1    Barret, J.M.2    Cabrol, N.3
  • 10
    • 27144533305 scopus 로고    scopus 로고
    • Vinflunine and radiation: A promising radiosensitizing combination?
    • (Abstract 5606)
    • SIMONTHSENS C, KORST AE, DE POOTER CM et al.: Vinflunine and radiation: a promising radiosensitizing combination? Proc. Am. Assoc. Cancer Res. (2004) 45:6-12 (Abstract 5606).
    • (2004) Proc. Am. Assoc. Cancer Res. , vol.45 , pp. 6-12
    • Simonthsens, C.1    Korst, A.E.2    De Pooter, C.M.3
  • 11
    • 0031912695 scopus 로고    scopus 로고
    • Preclinical in vivo antitumour activity of vinflunine, a novel fluorinated vinca alkaloid
    • KRUCZYNSKI A, COLPAERT F, TARAYRE JP et al.: Preclinical in vivo antitumour activity of vinflunine, a novel fluorinated vinca alkaloid. Cancer Chemother. Pharmacol. (1998) 41:437-447.
    • (1998) Cancer Chemother. Pharmacol. , vol.41 , pp. 437-447
    • Kruczynski, A.1    Colpaert, F.2    Tarayre, J.P.3
  • 12
    • 27144489811 scopus 로고    scopus 로고
    • Marked antitumour activity of vinflunine, a new fluorinated vinca-alkaloid, in murine and human experimental tumors
    • KRUCZYNSKI A, RICOME C, ASTRUC J et al.: Marked antitumour activity of vinflunine, a new fluorinated vinca-alkaloid, in murine and human experimental tumors. Ann. Oncol. (1998) 9(2):38.
    • (1998) Ann. Oncol. , vol.9 , Issue.2 , pp. 38
    • Kruczynski, A.1    Ricome, C.2    Astruc, J.3
  • 13
    • 0033105721 scopus 로고    scopus 로고
    • Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts
    • HILL B, FIEBIG H, WAUD WR et al.: Superior in vivo experimental antitumour activity of vinflunine, relative to vinorelbine, in a panel of human tumour xenografts. Eur. J. Cancer (1999) 35(3):512-520.
    • (1999) Eur. J. Cancer , vol.35 , Issue.3 , pp. 512-520
    • Hill, B.1    Fiebig, H.2    Waud, W.R.3
  • 14
    • 27144467580 scopus 로고    scopus 로고
    • Definite antitumour activity of vinflunine, a novel fluorinated vinca alkaloid, against human tumour xenografts
    • KRUCZYNSKI A, ASTRUC J, RICOME C et al.: Definite antitumour activity of vinflunine, a novel fluorinated vinca alkaloid, against human tumour xenografts. Contrib. Oncol. Basel, Karger (1999) 54:369-378.
    • (1999) Contrib. Oncol. Basel, Karger , vol.54 , pp. 369-378
    • Kruczynski, A.1    Astruc, J.2    Ricome, C.3
  • 15
    • 0035986530 scopus 로고    scopus 로고
    • Higher antitumor activity of vinflunine than vinorelbine against an orthoptic murine model of transitional cell carcinoma of the bladder
    • BONFIL RD, RUSSO DM, BINDA MM et al.: Higher antitumor activity of vinflunine than vinorelbine against an orthoptic murine model of transitional cell carcinoma of the bladder. Urol. Oncol. (2002) 7:159-166.
    • (2002) Urol. Oncol. , vol.7 , pp. 159-166
    • Bonfil, R.D.1    Russo, D.M.2    Binda, M.M.3
  • 16
    • 0031820395 scopus 로고    scopus 로고
    • Vinflunine (20′, 20′-difluoro-3′,4′-dihydrovinorelbine) a novel vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro
    • ETIEVANT C, BARRET JM, KRUCZYNSKI A et al.: Vinflunine (20′, 20′-difluoro-3′,4′-dihydrovinorelbine) a novel vinca alkaloid, which participates in P-glycoprotein (Pgp)-mediated multidrug resistance in vivo and in vitro. Investig. New Drugs (1998) 16:3-17.
    • (1998) Investig. New Drugs , vol.16 , pp. 3-17
    • Etievant, C.1    Barret, J.M.2    Kruczynski, A.3
  • 17
    • 0034918410 scopus 로고    scopus 로고
    • Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro
    • ETIÉVANT C, KRUCZYNSKI A, BARRET JM et al.: Markedly diminished drug resistance-inducing properties of vinflunine (20′,20′-difluoro-3′,4′-dihydrovinorelbine) relative to vinorelbine, identified in murine and human tumour cells in vivo and in vitro. Cancer Chemother. Pharmacol. (2001) 48(1):62-70.
    • (2001) Cancer Chemother. Pharmacol. , vol.48 , Issue.1 , pp. 62-70
    • Etiévant, C.1    Kruczynski, A.2    Barret, J.M.3
  • 19
    • 3943102041 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic study of vinflunine given on days 1 and 8 every 3 weeks
    • (Abstract)
    • ZORZA G, JOHNSON P, JUDSON I et al.: A Phase I pharmacokinetic study of vinflunine given on days 1 and 8 every 3 weeks. Proc. Am. Soc. Clin. Oncol. (2001) 20:2070 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2070
    • Zorza, G.1    Johnson, P.2    Judson, I.3
  • 20
    • 3943095303 scopus 로고    scopus 로고
    • A Phase I pharmacokinetic study of vinflunine given on a weekly schedule
    • (Abstract)
    • PUOZZO C, VERMORKEN JB, BAUER J et al.: A Phase I pharmacokinetic study of vinflunine given on a weekly schedule. Proc. Am. Soc. Clin. Oncol. (2001) 20:2107 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2107
    • Puozzo, C.1    Vermorken, J.B.2    Bauer, J.3
  • 21
    • 0037819331 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumors
    • BENNOUNA J, FUMOLEAU P, ARMAND JP et al.: Phase I and pharmacokinetic study of the new vinca alkaloid vinflunine administered as a 10-min infusion every 3 weeks in patients with advanced solid tumors. Ann. Oncol. (2003) 14:630-637.
    • (2003) Ann. Oncol. , vol.14 , pp. 630-637
    • Bennouna, J.1    Fumoleau, P.2    Armand, J.P.3
  • 22
    • 4243813549 scopus 로고    scopus 로고
    • Phase I study of vinflunine given as a 10 minute intravenous (i.v.) infusion on a weekly schedule in patients (patients) with advanced solid tumours
    • (Abstract)
    • DELORD JP, STUPP R, PINEL MC et al.: Phase I study of vinflunine given as a 10 minute intravenous (i.v.) infusion on a weekly schedule in patients (patients) with advanced solid tumours. Proc. Am. Soc. Clin. Oncol. (2001) 20:441 (Abstract).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 441
    • Delord, J.P.1    Stupp, R.2    Pinel, M.C.3
  • 23
    • 27144447846 scopus 로고    scopus 로고
    • Phase I study of vinflunine given as a 10-minute infusion on days 1 and 8 every 3 weeks in patients with solid malignancies
    • (Abstract 88b)
    • JOHNSON P, O'DONNELL A, PINEL MC et al.: Phase I study of vinflunine given as a 10-minute infusion on days 1 and 8 every 3 weeks in patients with solid malignancies. Proc. Am. Soc. Clin. Oncol. (2001) 20:2100 (Abstract 88b).
    • (2001) Proc. Am. Soc. Clin. Oncol. , vol.20 , pp. 2100
    • Johnson, P.1    O'Donnell, A.2    Pinel, M.C.3
  • 24
    • 27144495909 scopus 로고    scopus 로고
    • Phase I study of i.v. vinflunine given on a weekly schedule in previously untreated patients with advanced solid tumours
    • (Abstract 887)
    • VERMORKEN JB, STUPP R, NGUYEN L et al.: Phase I study of i.v. vinflunine given on a weekly schedule in previously untreated patients with advanced solid tumours. Proc. Am. Soc. Clin. Oncol. (2003) 22:221 (Abstract 887).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 221
    • Vermorken, J.B.1    Stupp, R.2    Nguyen, L.3
  • 25
    • 2942550368 scopus 로고    scopus 로고
    • Preliminary results of a Phase II study testing intravenous (IV) vinflunine (VFL) as second line therapy in patients with advanced transitional cell cancer (TCC) of the bladder
    • (Abstract 1571)
    • BUI B, THEODORE C, CULINE S et al.: Preliminary results of a Phase II study testing intravenous (IV) vinflunine (VFL) as second line therapy in patients with advanced transitional cell cancer (TCC) of the bladder. Proc. Am. Soc. Clin. Oncol. (2003) 22:391 (Abstract 1571).
    • (2003) Proc. Am. Soc. Clin. Oncol. , vol.22 , pp. 391
    • Bui, B.1    Theodore, C.2    Culine, S.3
  • 26
    • 27144515689 scopus 로고    scopus 로고
    • A Phase II study testing intravenous (IV) vinflunine as second line therapy in patients with advanced transitional cell cancer (TCC) of the bladder
    • (Abstract)
    • CULINE S, THEODORE C, DESANTIS M et al.: A Phase II study testing intravenous (IV) vinflunine as second line therapy in patients with advanced transitional cell cancer (TCC) of the bladder. Eur. J. Oncol. (2003) 5:844 (Abstract).
    • (2003) Eur. J. Oncol. , vol.5 , pp. 844
    • Culine, S.1    Theodore, C.2    Desantis, M.3
  • 27
    • 0003486931 scopus 로고
    • World Health Organization: World Health Organization publication, Geneva
    • WORLD HEALTH ORGANIZATION: WHO handbook for reporting results of cancer treatment. World Health Organization publication, Geneva (1979).
    • (1979) WHO Handbook for Reporting Results of Cancer Treatment
  • 28
    • 33644969346 scopus 로고    scopus 로고
    • Phase II study of i.v. vinflunine as second line in patients with metastatic breast cancer after anthracycline-taxane failure
    • (Abstract 542)
    • FUMOLEAU P, CAMPONE M, VOROBIOF D et al.: Phase II study of i.v. vinflunine as second line in patients with metastatic breast cancer after anthracycline-taxane failure. Proc. Am. Soc. Clin. Oncol. (2004) 23:12 (Abstract 542).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 12
    • Fumoleau, P.1    Campone, M.2    Vorobiof, D.3
  • 29
    • 27144521255 scopus 로고    scopus 로고
    • Preliminary results of a Phase II study of intravenous vinflunine as second line therapy in patients with metastatic breast cancer after anhracycline-taxane based regimen failure
    • (Abstract 355)
    • CAMPONE M, VOROBIOF D, CORTES-FUNES H: Preliminary results of a Phase II study of intravenous vinflunine as second line therapy in patients with metastatic breast cancer after anhracycline-taxane based regimen failure. Breast Cancer Res. Treat. (2003) 82(Suppl. 1S):85 (Abstract 355).
    • (2003) Breast Cancer Res. Treat. , vol.82 , Issue.SUPPL. 1S , pp. 85
    • Campone, M.1    Vorobiof, D.2    Cortes-Funes, H.3
  • 30
    • 27144440192 scopus 로고    scopus 로고
    • Phase II study of IV vinflunine (VFL) as second line treatment of patients (patients) with advanced non-small-cell lung cancer (NSCLC) previously treated with a platinum based regimen. Final results
    • (Abstract 7139)
    • BENNOUNA J, TAN EH, O'BRIEN M et al.: Phase II study of IV vinflunine (VFL) as second line treatment of patients (patients) with advanced non-small-cell lung cancer (NSCLC) previously treated with a platinum based regimen. Final results. Proc. Am. Soc. Clin. Oncol. (2004) 23:648 (Abstract 7139).
    • (2004) Proc. Am. Soc. Clin. Oncol. , vol.23 , pp. 648
    • Bennouna, J.1    Tan, E.H.2    O'Brien, M.3
  • 31
    • 27144434511 scopus 로고    scopus 로고
    • Interim results of the Phase II study of vinflunine (VFL) in malignant pleural mesothelioma (MPM)
    • (Abstract 7171)
    • TALBOT J, MARGERY G, DABUIS G et al.: Interim results of the Phase II study of vinflunine (VFL) in malignant pleural mesothelioma (MPM). Proc. Am. Soc. Clin. Oncol. (2005) (Abstract 7171).
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Talbot, J.1    Margery, G.2    Dabuis, G.3
  • 32
    • 27144550898 scopus 로고    scopus 로고
    • Vinflunine and cisplatin combination in first line treatment of advanced non-small-cell lung cancer. Final results of a Phase II study. Proceedings of the 11th World Conference on Lung Cancer
    • (Abstract P-574)
    • SOUQUET P J, RAMLAU R, SUN X et al.: Vinflunine and cisplatin combination in first line treatment of advanced non-small-cell lung cancer. Final results of a Phase II study. Proceedings of the 11th World Conference on lung cancer. Lung Cancer (2005) 49(2) (Abstract P-574).
    • (2005) Lung Cancer , vol.49 , Issue.2
    • Souquet, P.J.1    Ramlau, R.2    Sun, X.3
  • 33
    • 0034594628 scopus 로고    scopus 로고
    • New guidelines to evaluate the response to treatment in solid tumors
    • THERASSE P, ARBRUCK SG, EISENHAUER E et al.: New guidelines to evaluate the response to treatment in solid tumors. J. Natl. Cancer Inst. (2000) 92:205-216.
    • (2000) J. Natl. Cancer Inst. , vol.92 , pp. 205-216
    • Therasse, P.1    Arbruck, S.G.2    Eisenhauer, E.3
  • 34
    • 44449086184 scopus 로고    scopus 로고
    • Vinflunine (VFL) in combination with gemcitabine (GEM) for treatment of advanced non-small cell lung cancer (NSCLC) in chemontsnaive patients (patients): Preliminary results of a Phase I and pharmacokinetic study
    • (Abstract 7266)
    • LEMARIÉ E, BENNOUNA J, GROSSI F et al.: Vinflunine (VFL) in combination with gemcitabine (GEM) for treatment of advanced non-small cell lung cancer (NSCLC) in chemontsnaive patients (patients): preliminary results of a Phase I and pharmacokinetic study. Proc. Am. Soc. Clin. Oncol. (2005) (Abstract 7266).
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Lemarié, E.1    Bennouna, J.2    Grossi, F.3
  • 35
    • 41549114752 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of vinflunine (VFL) in combination with carboplatin (CBDCA) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonthsnaive patients (patients): Final results
    • (Abstract 7271)
    • TOURANI JM, PINEL MC, PLANCHARD D et al.: Phase I and pharmacokinetic study of vinflunine (VFL) in combination with carboplatin (CBDCA) for treatment of advanced non-small cell lung cancer (NSCLC) in chemonthsnaive patients (patients): final results. Proc. Am. Soc. Clin. Oncol. (2005) (Abstract 7271).
    • (2005) Proc. Am. Soc. Clin. Oncol.
    • Tourani, J.M.1    Pinel, M.C.2    Planchard, D.3
  • 36
    • 0034074044 scopus 로고    scopus 로고
    • In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anti-cancer drugs
    • BARRET JM, ETIEVANT C, HILL BT: In vitro synergistic effects of vinflunine, a novel fluorinated vinca alkaloid, in combination with other anti-cancer drugs. Cancer Chemother. Pharmacol. (2000) 45:471-476.
    • (2000) Cancer Chemother. Pharmacol. , vol.45 , pp. 471-476
    • Barret, J.M.1    Etievant, C.2    Hill, B.T.3
  • 37
    • 27144434642 scopus 로고    scopus 로고
    • Synergistic effects of the farnesyltransferase inhibitor SCH-66336 and novel vinca alkaloids in A549 non-small cell lung cancer cells in vitro
    • (Abstract A269)
    • ETIEVANT C, BARRET JM, CABROL N et al.: Synergistic effects of the farnesyltransferase inhibitor SCH-66336 and novel vinca alkaloids in A549 non-small cell lung cancer cells in vitro. Clin. Cancer Res. (2003) 9:116 (Abstract A269).
    • (2003) Clin. Cancer Res. , vol.9 , pp. 116
    • Etievant, C.1    Barret, J.M.2    Cabrol, N.3
  • 38
    • 27144504311 scopus 로고    scopus 로고
    • Markedly augmented in vivo experimental antitumour activity with vinflunine, the most recent vinca alkaloid to show activity in Phase I clinical trials, when combined with DNA damaging anticancer agents
    • KRUCZYNSKI A, RICOME C, ASTRUC J et al.: Markedly augmented in vivo experimental antitumour activity with vinflunine, the most recent vinca alkaloid to show activity in Phase I clinical trials, when combined with DNA damaging anticancer agents. Proc. Am. Assoc. Cancer Res. (2002) 43:268.
    • (2002) Proc. Am. Assoc. Cancer Res. , vol.43 , pp. 268
    • Kruczynski, A.1    Ricome, C.2    Astruc, J.3
  • 39
    • 0842311660 scopus 로고    scopus 로고
    • Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in transplantable routine adenocarcinoma model
    • SHNYDER SD, COOPER PA, GYSELINCK N et al.: Vinflunine potentiates the activity of cisplatin but not 5-fluorouracil in transplantable routine adenocarcinoma model. Anticancer Res. (2003) 23:4815-4820.
    • (2003) Anticancer Res. , vol.23 , pp. 4815-4820
    • Shnyder, S.D.1    Cooper, P.A.2    Gyselinck, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.