Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS)

Modern Pathology

Volumn 18, Issue 11, 2005, Pages 1432-1439

  Chan, Wai S ^a   Wu, Chun ^b   Chow, Sammy C S ^c   Cheung, To ^c   To, Ka Fai ^a   Leung, Wai Keung ^a   Chan, Paul K S ^a   Lee, Kam Cheong ^d   Ng, Ho Keung ^a   Au, Deborah M Y ^c   Lo, Anthony W I ^a,e  

^a CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

^b Abgent Inc   (United States)

^c Century Biotech Limited   (Hong Kong)

^d PRINCESS MARGARET HOSPITAL   (Hong Kong)

^e CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

Coronavirus; Immunohistochemistry; SARS

Indexed keywords

ANIMAL CELL; ARTICLE; CELL TYPE; CONTROLLED STUDY; CORONAVIRUS; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTESTINE; INTESTINE CELL; LUNG ALVEOLUS CELL; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEVERE ACUTE RESPIRATORY SYNDROME; SIGNAL TRANSDUCTION; SURFACE PROPERTY;

ANIMALS; ANTIBODIES, VIRAL; ENTEROCYTES; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LUNG; SARS VIRUS; SEVERE ACUTE RESPIRATORY SYNDROME; VIRAL STRUCTURAL PROTEINS;

EID: 27144482376     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.3800439     Document Type: Article

References (33)

1. WHO. Severe Acute Respiratory Syndrome (SARS) last accessed 2004, August 10.http://www.who.int/csr/sars/en/ 2004.
2. Lee N, Hui D, Wu A, et al. A major outbreak of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003;348:1986-1994.
3. Tsang KW, Ho PL, Ooi GC, et al. A cluster of cases of severe acute respiratory syndrome in Hong Kong. N Engl J Med 2003;348:1977-1985.
4. Zhan J, Chen W, Li C, et al. Digestive system manifestations in patients with severe acute respiratory syndrome. Chin Med J (England) 2003;116:1265-1266.
5. Leung WK, To KF, Chan PK, et al. Enteric involvement of severe acute respiratory syndrome-associated coronavirus infection. Gastroenterology 2003;125:1011-1017.
6. Kuiken T, Fouchier RA, Schutten M, et al. Newly discovered coronavirus as the primary cause of severe acute respiratory syndrome. Lancet 2003;362:263-270.
7. Drosten C, Gunther S, Preiser W, et al. Identification of a novel coronavirus in patients with severe acute respiratory syndrome. N Engl J Med 2003;348:1967-1976.
8. Fouchier RA, Kuiken T, Schutten M, et al. Aetiology: Koch's postulates fulfilled for SARS virus. Nature 2003;423:240.
9. Marra MA, Jones SJ, Astell CR, et al. The genome sequence of the SARS-associated coronavirus. Science 2003;300:1399-1404.
10. Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science 2003;300:1394-1399.
11. Tan YJ, Teng E, Shen S, et al. A novel severe acute respiratory syndrome coronavirus protein, U274, is transported to the cell surface and undergoes endocytosis. J Virol 2004;78:6723-6734.
12. Fielding BC, Tan YJ, Shuo S, et al. Characterization of a unique group-specific protein (U122) of the severe acute respiratory syndrome coronavirus. J Virol 2004;78:7311-7318.
13. Tse GM, To KF, Chan PK, et al. Pulmonary pathological features in coronavirus associated severe acute respiratory syndrome (SARS). J Clin Pathol 2004;57:260-265.
14. Chau TN, Lee KC, Yao H, et al. SARS-associated viral hepatitis caused by a novel coronavirus: report of three cases. Hepatology 2004;39:302-310.
15. Chan PK, To KF, Lo AW, et al. Persistent infection of SARS coronavirus in colonic cells in vitro. J Med Virol 2004;74:1-7.
16. To KF, Tong JH, Chan PK, et al. Tissue and cellular tropism of the coronavirus associated with severe acute respiratory syndrome: an in situ hybridization study of fatal cases. J Pathol 2004;202:157-163.
17. Ding Y, He L, Zhang Q, et al. Organ distribution of severe acute respiratory syndrome (SARS) associated coronavirus (SARS-CoV) in SARS patients: implications for pathogenesis and virus transmission pathways. J Pathol 2004;203:622-630.
18. Cheung OY, Chan JW, Ng CK, et al. The spectrum of pathological changes in severe acute respiratory syndrome (SARS). Histopathology 2004;45:119-124.
19. Nicholls JM, Poon LL, Lee KC, et al. Lung pathology of fatal severe acute respiratory syndrome. Lancet 2003;361(9371):1773-1778.
20. Ding Y, Wang H, Shen H, et al. The clinical pathology of severe acute respiratory syndrome (SARS): a report from China. J Pathol 2003;200:282-289.
21. Franks TJ, Chong PY, Chui P, et al. Lung pathology of severe acute respiratory syndrome (SARS): a study of 8 autopsy cases from Singapore. Hum Pathol 2003;34:743-748.
22. Hwang DM, Chamberlain DW, Poutanen SM, et al. Pulmonary pathology of severe acute respiratory syndrome in Toronto. Mod Pathol 2005;18:1-10.
23. Cui HJ, Tong XL, Li P, et al. Serum hepatic enzyme manifestations in patients with severe acute respiratory syndrome: retrospective analysis. World J Gastroenterol 2004;10:1652-1655.
24. Chan HL, Leung WK, To KF, et al. Retrospective analysis of liver function derangement in severe acute respiratory syndrome. Am J Med 2004;116:566-567.
25. Wong WM, Ho JC, Ooi GC, et al. Temporal patterns of hepatic dysfunction and disease severity in patients with SARS. JAMA 2003;290:2663-2665.
26. To KF, Lo AW. Exploring the pathogenesis of severe acute respiratory syndrome (SARS): the tissue distribution of the coronavirus (SARS-CoV) and its putative receptor, angiotensin-converting enzyme 2 (ACE2). J Pathol 2004;203:740-743.
27. Wang P, Chen J, Zheng A, et al. Expression cloning of functional receptor used by SARS coronavirus. Biochem Biophys Res Commun 2004;315:439-444.
28. Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003;426:450-454.
29. Hofmann H, Geier M, Marzi A, et al. Susceptibility to SARS coronavirus S protein-driven infection correlates with expression of angiotensin converting enzyme 2 and infection can be blocked by soluble receptor. Biochem Biophys Res Commun 2004;319:1216-1221.
30. Yang ZY, Huang Y, Ganesh L, et al. pH-dependent entry of severe acute respiratory syndrome coronavirus is mediated by the spike glycoprotein and enhanced by dendritic cell transfer through DC-SIGN. J Virol 2004;78:5642-5650.
31. Jeffers SA, Tusell SM, Gillim-Ross L, et al. CD209L (L-SIGN) is a receptor for severe acute respiratory syndrome coronavirus. Proc Natl Acad Sci USA 2004;101(44):15748-15753.
32. Hamming I, Timens W, Bulthuis ML, et al. Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis. J Pathol 2004;203:631-637.
33. van Kooyk Y, Geijtenbeek TB. DC-SIGN: escape mechanism for pathogens. Nat Rev Immunol 2003;3:697-709.