Extracellular signal-regulated kinase mitogen-activated protein kinase activation in the dorsal root ganglion (DRG) and spinal cord after DRG injury in rats

Spine

Volumn 30, Issue 20, 2005, Pages 2252-2256

  Doya, Hideo ^a   Ohtori, Seiji ^a   Takahashi, Kazuhisa ^a   Aoki, Yasuchika ^a   Ino, Hidetoshi ^a   Takahashi, Yuzuru ^a   Moriya, Hideshige ^a   Yamashita, Toshihide ^a  

^a CHIBA UNIVERSITY   (Japan)

Author keywords

Crush injury; Dorsal root ganglion; Extracellular signal regulated kinase

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME INDUCTION; HYPERSENSITIVITY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; INTERVERTEBRAL DISK HERNIA; MALE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RADICULAR PAIN; RAT; SCHWANN CELL; SPINAL CORD INJURY; SPINAL GANGLION;

ANIMALS; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GANGLIA, SPINAL; IMMUNOHISTOCHEMISTRY; LUMBAR VERTEBRAE; MALE; NERVE CRUSH; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; SPINAL CORD; TIME FACTORS; WOUNDS, NONPENETRATING;

EID: 27144458127     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/01.brs.0000182091.53834.08     Document Type: Article

References (14)

1. Hashizume H, Rutkowski MD, Weinstein JN, et al. Central administration of methotrexate reduces mechanical allodynia in an animal model of radiculopathy/sciatica. Pain 2000;87:159-69.
2. Olmarker K, Myers RR. Pathogenesis of sciatic pain: Role of herniated nucleus pulposus and deformation of spinal nerve root and dorsal root ganglion. Pain 1998;78:99-105.
3. Nakamura SI, Myers RR. Injury to dorsal root ganglia alters innervation of spinal cord dorsal horn lamina involved in nociception. Spine 2000;25: 537-42.
4. Howe JF, Loeser JD, Calvin WH. Mechanosensitivity of dorsal root ganglia and chronically injured axons: A physiological basis for the radicular pain of nerve root compression. Pain 1977;3:25-41.
5. Rydevik BL, Myers RR, Powell HC. Pressure increase in the dorsal root ganglion following mechanical compression. Closed compartment syndrome in nerve roots. Spine 1989;14:574-6.
6. Chang L, Karin M. Mammalian MAP kinase signaling cascades. Nature 2001;410:37-40.
7. Ji RR, Baba H, Brenner GJ, et al. Nociceptive-specific activation of ERK in spinal neurons contributes to pain hypersensitivity. Nat Neurosci 1999;2: 1114-9.
8. Kominato Y, Tachibana T, Dai Y, et al. Changes in phosphorylation of ERK and Fos expression in dorsal horn neurons following noxious stimulation in a rat model of neuriris of the nerve root. Brain Res 2003;967:89-97.
9. Dai Y, Iwata K, Fukuoka T, et al. Phosphorylation of extracellular signal-regulated kinase in primary afferent neurons by noxious stimuli and its involvement in peripheral sensitization. J Neurosci 2002;22:7737-45.
10. Chung K, Lee BH, Yoon YW, et al. Sympathetic sprouting in the dorsal root ganglia of the injured peripheral nerve in a rat neuropathic pain model. J Comp Neurol 1996;376:241-52.
11. Ji RR, Befort K, Brenner GJ, et al. ERK MAP kinase activation in superficial spinal cord neurons induces prodynorphin and NK-1 upregulation and contributes to persistent inflammatory pain hypersensitivity. J Neurosci 2002; 22:478-85.
12. Harper AA, Lawson SN. Conduction velocity is related to morphological cell type in rat dorsal root ganglion neurones. J Physiol 1985;359:31-46.
13. Obata K, Yamanaka H, Dai Y, et al. Differential activation of extracellular signal-regulated protein kinase in primary afferent neurons regulates brain-derived neurotrophic factor expression after peripheral inflammation and nerve injury. J Neurosci 2003;23:4117-26.
14. Akassoglou K, Yu WM, Akpinar P, et al. Fibrin inhibits peripheral nerve remyelination by regulating Schwann cell differentiation. Neuron 2002;33: 861-75.