Thiamethoxam induced mouse liver tumors and their relevance to humans Part 2: Species differences in response

Toxicological Sciences

Volumn 86, Issue 1, 2005, Pages 48-55

  Green, Trevor ^a   Toghill, Alison ^a   Lee, Robert ^a   Waechter, Felix ^a   Weber, Edgar ^a,c   Peffer, Richard ^b   Noakes, James ^a   Robinson, Mervyn ^a  

^a JEALOTT S HILL INTERNATIONAL RESEARCH CENTRE   (United Kingdom)

^b SYNGENTA CROP PROTECTION   (United States)

^c DSM NUTRITIONAL PRODUCTS LTD   (Switzerland)

Author keywords

Hepatotoxicity; Metabolism; Species differences; Thiamethoxam

Indexed keywords

INSECTICIDE; THIAMETHOXAM; UNCLASSIFIED DRUG; CARCINOGEN; NITRO DERIVATIVE; OXAZINE DERIVATIVE; PESTICIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL DEATH; CELL PROLIFERATION; CONTROLLED STUDY; DIETARY INTAKE; EXPOSURE; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; LIVER CARCINOGENESIS; LIVER CELL; LIVER INJURY; LIVER TUMOR; MALE; METABOLITE; MOUSE; NONHUMAN; SPECIES DIFFERENCE; ANIMAL; CHEMICALLY INDUCED DISORDER; DIET; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY;

ANIMALS; CARCINOGENS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIET; HUMANS; LIVER NEOPLASMS, EXPERIMENTAL; MASS SPECTROMETRY; MICE; NITRO COMPOUNDS; OXAZINES; PESTICIDES; SPECIES SPECIFICITY;

EID: 26944495351     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfi125     Document Type: Article

References (16)

1. Dolbeare, F. (1995a). Bromodeoxymidine: A diagnostic tool in biology and medicine, Part I: Historical perspectives, histochemical methods and cell kinetics. Histochem. J. 27(5), 339-369.
2. Dolbeare, F. (1995b). Bromodeoxymidine: A diagnostic tool in biology and medicine, Part II: Oncology, chemotherapy and carcinogenesis. Histochem. J. 27(12), 923-964.
3. Dolbeare, F. (1996). Bromodeoxymidine: A diagnostic tool in biology and medicine, Part III. Proliferation in normal, injured and diseased tissue, growth factors, differentiation, DNA replication sites and in situ hybridization. Histochem. J. 28(8), 531-575.
4. Dunn, O. J. (1964). Multiple comparisons using rank sums. Technometrics 6, 241-252.
5. Dunnett, C. W. (1955). A multiple comparison procedure for comparing several treatments with a control. J. Amer. Stat. Assoc. 50, 1096-1121.
6. EPA (2003). Draft Final Guidelines for Carcinogen Risk Assessment, U.S. Environmental Protection Agency, Washington DC.
7. Gad, S. C., and Weil, C. S. (1986). Statistics and Experimental Design for Toxicologists. The Telford Press, Caldwell, NJ.
8. Gavrieli, Y., Sherman, Y., and Ben-Sasson, S. A. (1992). Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. J. Cell Biol. 119, 493-501.
9. Green, T, Toghill, A., Lee, R., Waechter, F., Weber, E., and Noakes, J. (2005). Thiamethoxam induced mouse liver tumors and their relevance to humans. Part 1: Mode of action studies in the mouse. Toxicol. Sci. 86, 36-47.
10. ILSI (2003): Meek, M. E., Bucher, J. R., Cohen, S. M., Dellarco, V., Hill, R. N., Lehman-McKeeman, L. D., Longfellow, D., Pastoor, T., Seed, J., and Patton, D. E. (2003). A framework for human relevance analysis of information on carcinogenic modes of action. Crit. Rev. Toxicol. 33(6), 591-653.
11. Kruskal, W. H., and Wallis, W. A. (1952). Use of ranks in one-criterion variance analysis. J. Amer. Stat. Assoc. 47, 583-621.
12. Lake, B. G. (1987). Preparation and characterisation of microsomal fractions for studies of xenobiotic metabolism. In Biochemical Toxicology, A Practical Approach (K. Snell and B. Mullock, Eds.), pp. 183-215. Oxford IRL Press, Oxford, U.K.
13. Leatherbarrow, R. J. (1998). GraFit Version 4.0. Erithacus Software Ltd, Staines, U.K.
14. Lowry, O., Rosebrough, N., Farr, A., and Randall, R. (1951). Protein measurement with the folin phenol reagent. J. Biol. Chem. 193, 265-275.
15. Maienfisch, P., Huerlimann, H., Rindlisbacher, A., Gsell, L., Dettwiler, H., Haettenschwiler, J., Sieger, E., and Walti, M. (2001). The discovery of thiamethoxam: A second generation neonicotinoid. Pest. Management Sci. 57, 165-176.
16. McKillop, D., Wild, M. J., Butters, C. J., and Simcock, C. (1998). Effects of propofol on human hepatic microsomal cytochrome P450 activities. Xenobiotica 2, 845-853.