Potential effect of inter-genic action on peak bone mass (PBM) in Chinese females

Acta Genetica Sinica

Volumn 32, Issue 10, 2005, Pages 1003-1010

  Deng, Fei Yan ^a   Long, Ji Rong ^b   Lei, Shu Feng ^a   Li, Miao Xin ^a   Deng, Hong Wen ^a,b  

^a HUNAN NORMAL UNIVERSITY   (China)

^b CREIGHTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Analysis of variance; Gene; Interaction; Peak bone mass (PBM)

Indexed keywords

ALPHA2 GLYCOPROTEIN; COLLAGEN TYPE 1; COLLAGEN TYPE 1 ALPHA 2; ESTROGEN RECEPTOR ALPHA; INTERLEUKIN 6; OSTEOCALCIN; PARATHYROID HORMONE; PROTEIN ALPHA2 HS GLYCOPROTEIN; UNCLASSIFIED DRUG; VITAMIN D RECEPTOR;

ADULT; ARTICLE; BONE DENSITY; BONE MASS; CHINESE; DUAL ENERGY X RAY ABSORPTIOMETRY; ENVIRONMENTAL FACTOR; ETHNOLOGY; FEMALE; GENE INTERACTION; GENE LOCUS; GENETIC POLYMORPHISM; GENOTYPE; HEREDITY; HUMAN; POLYMERASE CHAIN REACTION; PREMENOPAUSE; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ABSORPTIOMETRY, PHOTON; ADULT; ALLELES; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PROTEINS; BONE DENSITY; CHINA; COLLAGEN; ESTROGEN RECEPTOR ALPHA; FEMALE; FEMUR; GENE FREQUENCY; GENOTYPE; HUMANS; INTERLEUKIN-6; LUMBAR VERTEBRAE; OSTEOCALCIN; PARATHYROID HORMONE; POLYMERASE CHAIN REACTION; POLYMORPHISM, GENETIC; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; RECEPTORS, CALCITRIOL; YOUNG ADULT;

EID: 26944470371     PISSN: 03794172     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Liu Z, Piao J, Pang L, Qing X, Nan S, Pan Z, Wang X, Li F, Liu J, Cheng X. The diagnostic criteria for primary osteoporosis and the incidence of osteoporosis in China. J Bone Miner Metab, 2002, 20(4): 181-189.
2. Dequeker J, Nijs J, Verstraeten A, Geusens P, Gevers G. Genetic determinants of bone mineral content at the spine and radius: A twin study. Bone, 1987, 8(4): 207-209.
3. Slemeda S W, Christian J C C, Williams C J, Norton J A, Johnston Jr. C C. Genetic determinants of bone mass in adult woman: A reevaluation of the twin model and the potential importance of gene interaction on heritability estimates. J Bone Miner Res, 1991, 6(6): 561-567.
4. Rubin L A, Hawker G A, Peltekova V D, Fielding L J, Ridout R, Cole D E. Determinants of peak bone mass: clinical and genetic analyses in a young female Canadian cohort. J Bone Miner Res, 1999, 14(4): 633-643.
5. Ho N C, Jia L, Driscoll C C, Gutter E M, Francomano C A. A skeletal gene database. J Bone Miner Res, 2000, 15(11): 2095-2122.
6. Niu T, Xu X. Candidate genes for osteoporosis. Therapeutic implications. Am J Pharmacogenomics, 2001, 1(1): 11-19.
7. Subramaniam M, Colvard D, Keeting P E, Rasmussen K, Riggs B L, Spelsberg T C. Glucocorticoid regulation of alkaline phosphatase, osteocalcin, and proto-oncogenes in normal human osteoblast-like cells. J Cell Biochem, 1992, 50 (4): 411-424.
8. Rifas L, Kenney J S, Marcelli M, Pacifici R, Cheng S L, Dawson L L, Avioli L V. Production of interleukin-6 in human osteoblasts and human bone marrow stromal cells: evidence that induction by interleukin-1 and tumor necrosis factor-alpha is not regulated by ovarian steroids. Endocrinology, 1995, 136(9): 4056-4067.
9. Tanaka S, Haji M, Takayanagi R, Tanaka S, Sugioka Y, Nawata H. 1, 25-Dihydroxyvitamin D3 enhances the enzymatic activity and expression of the messenger ribonucleic acid for aromatase cytochrome P450 synergistically with dexamethasone depending on the vitamin D receptor level in cultured human osteoblasts. Endocrinology, 1996, 137(5): 1860-1869.
10. Willing M, Sowers M, Aron D, Clark M K, Burns T, Bunten C, Crutchfield M, D'Agostino D, Jannausch M. Bone mineral density and its change in white women: estrogen and vitamin D receptor genotypes and their interaction. J Bone Miner Res, 1998, 13(4): 695-705.
11. Deng H W, Li J, Li J L, Johnson M, Gong G, Davis K M, Recker R R. Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes. Hum Genet, 1998, 103(5): 576-585.
12. Patel M S, Cole D E, Smith J D, Hawker G A, Wong B, Trang H, Vieth R, Meltzer P, Rubin L A. Alleles of the estrogen receptor alpha-gene and an estrogen receptor cotranscriptional activator gene, amplified in breast cancer-1 (AIB1), are associated with quantitative calcaneal ultrasound. J Bone Miner Res, 2000, 15(11): 2231-2239.
13. Nasu M, Sugimoto T, Kaji H, Chihara K. Estrogen modulates osteoblast proliferation and function regulated by parathyroid hormone in osteoblastic SaOS-2 cells: role of insulin-like growth factor (IGF)-I and IGF-binding protein-5. J Endocrinol, 2000, 167(2): 305-313.
14. Uitterlinden A G, Weel A E, Burger H, Fang Y, van Duijn C M, Hofman A, van Leeuwen J P, Pols H A. Interaction between the vitamin D receptor gene and collagen type I alpha I gene in susceptibility for fracture. J Bone Miner Res, 2001, 16(2): 379-385.
15. Garcia-Giralt N, Nogues X, Enjuanes A, Puig J, Mellibovsky L, Bay-Jensen A, Carreras R, Balcells S, Diez-Perez A, Grinberg D. Two new single-nucleotide polymorphisms in the COL1A1 upstream regulatory region and their relationship to bone mineral density. J Bone Miner Res, 2000, 17 (3): 384-393.
16. Willing M C, Torner J C, Burns T L, Janz K F, Marshall T, Gilmore J, Deschenes S P, Warren J J, Levy S M. Gene polymorphisms, bone mineral density and bone mineral content in young children: the Iowa bone development study. Osteoporos Int, 2003, 14(8): 650-658.
17. Chiba S, Un-No M, Neer R M, Okada K, Serge G V, Lee K. Parathyroid hormone induces interleukin-6 gene expression in bone stromal cells of young rats. J Vet Med Sci, 2002, 64 (7): 641-644.
18. Turner R T, Colvard D S, Spelsberg T C. Estrogen inhibition of periosteal bone formation in rat long bones: downregulation of gene expression for bone matrix proteins. Endocrinology, 1990, 127(3): 1346-1351.
19. Kurebayashi S, Miyashita Y, Hirose T, Kasayama S, Akira S, Kishimoto T. Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor. J Steroid Biochem Mol Biol, 1997(1-2), 60: 11-17.
20. Angeli A, Dovio A, Sartori M L, Masera R G, Ceoloni B, Prolo P, Racca S, Chiappelli F. Interactions between glucocorticoids and cytokines in the bone microenvironment. Ann N Y Acad Sci, 2002, 966: 97-107.
21. Lei S F, Liu Y Z, Deng F Y, Li Y M, Li M X, Deng H W. Association and linkage analyses of interleukin-6 gene 634C/G polymorphism and bone phenotypes in Chinese. J Bone Miner Metab, 2005, 23(4): 323 -328.
22. Qin Y J, Shen H, Huang Q R, Zhao L J, Zhou Q, Li M X, He J W, Mo X Y, Lu J H, Recker R R, Deng H W. Estrogen receptor α gene polymorphisms and peak bone density (PBD) in Chinese nuclear families. J Bone Miner Res, 2003, 18(6): 1028-1035.
23. Liu X H, Liu Y J, Jiang D K, Li Y M, Li M X, Qin Y J, Jian W X, Zhou Q, Deng H W. No evidence for linkage and/or association of human alpha2-HS glycoprotein gene with bone mineral density variation in Chinese nuclear families. Calcif Tissue Int, 2003, 73(3): 244-250.
24. Zhou X G, Li M X, Jian W X, Lei S F, Mo X Y, Qin Y J, Zhou Q, Liu Y Z, Deng H W. Parathyroid hormone (PTH) gene and bone mineral density/content in Chinese. Biochem Biophys Res Commun, 2003, 307(3): 666-671.
25. Deng F Y, Liu M Y, Li M X, Lei S F, Qin Y J, Zhou Q, Zhao L J, Liu Y J, Deng H W. Tests of linkage and association of the COL1A2 gene with bone phenotypes variation in Chinese nuclear families. Bone, 2003, 33(4): 614 -619.
26. Yao W J, Wu C H, Wang S T, Chang C J, Chiu N T, Yu C Y. Differential changes in regional bone mineral density in healthy Chinese: age-related and sex-dependent. Calcif Tissue Int, 2001, 68(6): 330-336.
27. QIN Ming-Wei, YU Wei, MENG Xun-Wu, XING Xiao-Ping, XU Ling. Normal spinal changes of bone mineral density in 445 individuals; assessment by quantitative computed tomography Zhongguo. Acta Academiae Medicinae Sinica, 1996, 18(6): 439-443.
28. LU Sheng-Dong, eds. Current Protocols for Molecular Biology. 2nd edition. Beijing: Xiehe Medical University Press in China, 1999, 102-103.
29. Lei S F, Deng F Y, Li M X, Dvornyk V, Deng H W. Bone mineral density in elderly Chinese: Effects of age, gender, weight, height, and body mass index. J Bone Miner Metab, 2004, 22(1): 71-78.
30. Liu Y Z, Liu Y J, Recker R R, Deng H W. Molecular studies of identification of genes for osteoporosis: the 2002 update. J Endocrinol, 2003, 177(2): 147-196.
31. Nishimura R, Moriyama K, Yasukawa K, Mundy G R, Yoneda T. Combination of interleukin-6 and soluble interleukin-6 receptors induces differentiation and activation of JAK-STAT and MAP kinase pathways in MG-63 human osteoblastic cells. J Bone Miner Res, 1998, 13(5): 777-785.
32. Manglagas S C, Jilka R L. Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis. N Engl J Med, 1995, 332(5): 305-311.
33. Pacifici R. Estrogen, cytokines, and pathogenesis of postmenopausal osteoporosis. J Bone Miner Res, 1996, 11(8): 1043-1051.
34. Girasole G, Jilka R L, Passeri G, Boswell S, Boder G, Williams D C, Manolagas S C. 17 beta-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in vitro: a potential mechanism for the antiosteoporotic effect of estrogens. J Clin Invest, 1992, 89 (3): 883-891.
35. Abrahamsen B, Bonnevie-Nielsen V, Ebbesen E N, Gram J, Beck-Nielsen H. Cytokines and bone loss in a 5-year longitudinal study-hormone replacement therapy suppresses serum soluble interleukin-6 receptor and increases interleukin-1-receptor antagonist: the danish osteoporosis prevention Study. J Bone Miner Res, 2000, 15(8): 1545-1554.
36. Stein B, Yang M X. Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-kappa B and C/EBP beta. Mol Cell Biol, 1995, 15(9): 4971-4979.
37. Pederson L, Kremer M, Foged N T, Winding B, Ritchie C, Fitzpatrick L A, Oursler M J. Evidence of a correlation of estrogen receptor level and avian osteoclast estrogen responsiveness. J Bone Miner Res, 1997, 12(5): 742-752.
38. Camp N J, Farnham J M. Correcting for multiple analyses in genomewide linkage studies. Ann Hum Genet, 2001, 65 (Pt 6): 577-582.