Characterization of mechanisms of interleukin-6 gene repression by estrogen receptor

Journal of Steroid Biochemistry and Molecular Biology

Volumn 60, Issue 1-2, 1997, Pages 11-17

  Kurebayashi, Shogo ^a   Miyashita, Yoshihiro ^a   Hirose, Takahisa ^a   Kasayama, Soji ^a   Akira, Shizuo ^b   Kishimoto, Tadamitsu ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b HYOGO COLLEGE OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4 HYDROXYTAMOXIFEN; ANTIESTROGEN; ESTRADIOL; ESTROGEN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6;

ANIMAL CELL; ARTICLE; CELL LINE; CONTROLLED STUDY; CYTOCHEMISTRY; DELETION MUTANT; ELECTROPHORETIC MOBILITY; GENE REPRESSION; HUMAN; MONKEY; MUTANT; NONHUMAN; OSTEOPOROSIS; PROMOTER REGION; PROTEIN ANALYSIS; PROTEIN ISOLATION; PROTEIN MODIFICATION; PROTEIN PROTEIN INTERACTION;

ANIMALS; BINDING SITES; CCAAT-ENHANCER-BINDING PROTEINS; COS CELLS; DNA-BINDING PROTEINS; ESTRADIOL; ESTROGEN ANTAGONISTS; GENE EXPRESSION REGULATION; GENES, REPORTER; INTERLEUKIN-6; LUCIFERASES; MUTATION; NF-KAPPA B; NUCLEAR PROTEINS; PLASMIDS; PROMOTER REGIONS (GENETICS); RECEPTORS, ESTROGEN; RECOMBINANT PROTEINS; TAMOXIFEN; TRANSFECTION;

EID: 0030976857     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(96)00175-6     Document Type: Article

References (31)

1. Green S., Walter P., Kumar V., Krust A., Bornert J. M., Argos P. and Chambon P.: Human oestrogen receptor cDNA: sequences, expression and homology to v-erb-A. Nature 320 (1986) 134-139.
2. Evans R. M.: The steroid and thyroid hormone receptor super-family. Science 240 (1988) 889-895.
3. Beato M.: Gene regulation by steroid hormones. Cell 56 (1989) 335-344.
4. Kumar V., Green S., Stack G., Berry M., Jin J. R. and Chambon P.: Functional domains of the human estrogen receptor. Cell 51 (1987) 941-951.
5. Tora L., White J., Brou C., Tasset D., Webster N., Scheer E. Chambon P.: The human estrogen receptor has two independent non-acidic transcriptional activation functions. Cell 59 (1989) 477-487.
6. Sakai D. D., Helms S., Carlstedt-Duke J., Gustafsson J.Å., Rottman F. M. and Yamamoto K. R.: Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev. 2 (1988) 1144-1154.
7. Schule R., Rangarajian P., Kliewer S., Ransone L. J., Bolado J., Yang N., Verma I. M. and Evans R. M.: Functional antagonism between oncoprotein c-Jun and the glucocorticoid receptor. Cell 62 (1990) 1217-1227.
8. Komm B. S., Terpening C. M., Benz D. J., Graeme K. A., Gallegos A., Korc M., Greene G. L., O'Malley B. W. and Haussler M. R.: Estrogen binding, receptor mRNA, and biological response in osteoblast-like osteosarcoma cells. Science 241 (1988) 81-84.
9. Ernst M., Heath J. K. and Rodan G. A.: Estradiol effects on proliferation, messenger ribonucleic acid for collagen and insulin-like growth factor-I, and parathyroid hormone-stimulated adenylate cyclase activity in osteoblastic cells from calvariae and long bones. Endocrinology 125 (1989) 825-833.
10. Oursler M. J., Cortese C., Keeting P. E., Anderson M. A., Bonde S. K., Riggs B. L. and Spelsberg T. C.: Modulation of transforming growth factor-β production in normal human osteoblast-like cells by 17β-estradiol and parathyroid hormone. Endocrinology 129 (1991) 3313-3320.
11. Girasole G., Jilka R. L., Passeri G., Boswell S., Boder G., Williams D. C. and Manolagas S. C.: 17β-estradiol inhibits interleukin-6 production by bone marrow-derived stromal cells and osteoblasts in-vitro: a potential mechanism for the antios-teoporotic effect of estrogens. J. Clin. Invest. 89 (1992) 883-891.
12. Jilka R. L., Hangoc G., Girasole G., Passeri G., Williams D. C., Abrams J. S., Boyce B., Broxmeyer H. and Manolagas S. C.: Increased osteoclast development after estrogen loss: mediation by interleukin-6. Science 257 (1992) 88-91.
13. Ray A., Sassone-Corsi P. and Sehgal P. B.: A multiple cytokine- and second messenger-responsive element in the enhancer of the human interleukin-6 gene: similarities with c-fos gene regulation. Molec. Cell. Biol. 9 (1989) 5537-5547.
14. Akira S., Isshiki H., Sugita T., Tanabe O., Kinoshita S., Nishio Y., Nakajima T., Hirano T. and Kishimoto T.: A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J. 9 (1990) 1897-1906.
15. Ray A., Perfontaine K. E. and Ray P.: Down-modulation of interleukin-6 gene expression by 17β-estradiol in the absence of high affinity DNA binding by the estrogen receptor. J. Biol. Chem. 269 (1994) 12940-12946.
16. Drouin J., Sun Y. L., Chamberland M., Gauthier Y., De Lean A., Nemer M. and Schmidt T. J.: Novel glucocorticoid receptor complex with DNA element of the hormone-repressed POMC gene. EMBO J. 12 (1993) 145-156.
17. Pottratz S. T., Bellido T., Mocharla H., Crabb D. and Manolagas S. C.: 17β-estradiol inhibits expression of human interleukin-6 promoter-reporter constructs by a receptor-dependent mechanism. J. Clin. Invest. 93 (1994) 944-950.
18. Stein B. and Yang M. X.: Repression of the interleukin-6 promoter by estrogen receptor is mediated by NF-κB and C/EBPβ. Molec. Cell Biol. 15 (1995) 4971-4979.
19. Kinoshita S., Akira S. and Kishimoto T.: A member of C/EBP family, NF-IL6β, forms a heterodimer and transcriptionally synergizes with NF-IL6. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 1473-1476.
20. Matsusaka T., Fujikawa K., Nishio Y., Mukaida N., Matsushima K., Kishimoto T. and Akira S.: Transcription factors NF-IL6 and NF-κB synergistically activate transcription of the inflammatory cytokines, interleukin 6 and interleukin 8. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 10193-10197.
21. Schreiber E., Matthias P., Müller M. M. and Schaffner W.: Rapid detection of octamer binding proteins with "mini-extracts", prepared from a small number of cells. Nucl. Acids Res. 17 (1989) 6419.
22. Berry M., Metzger D. and Chambon P.: Role of the two activating domains of the oestrogen receptor in the cell-type and promoter-context dependent agonistic activity of the anti-oestrogen 4-hydroxytamoxifen. EMBO J. 9 (1990) 2811-2818.
23. Ray A. and Prefontaine K. E.: Physical association and functional antagonism between the p65 subunit of transcription factor NF-κB and the glucocorticoid receptor. Proc. Natl. Acad. Sci. U.S.A. 91 (1994) 752-756.
24. Nishio Y., Isshiki H., Kishimoto T. and Akira S.: A nuclear factor for interleukin-6 expression (NF-IL6) and glucocorticoid receptor synergistically activate transcription of rat α1-acid glycoprotein gene via direct protein-protein interaction. Molec. Cell. Biol. 13 (1993) 1854-1862.
25. Mukaida N., Morita M., Ishikawa Y., Rice N., Okamoto S., Kasahara T. and Matsushima K.: Novel mechanism of glucocorticoid-mediated gene repression. J. Biol. Chem. 269 (1994) 13289-13295.
26. Auphan N., DiDonato J. A., Rosette C., Helmberg A. and Karin M.: Immunosuppression by glucocorticoids: inhibition of NF-κB activity through induction of I-κB synthesis. Science 270 (1995) 286-290.
27. Lin Y., Yao S., Veach R. A., Torgerson T. R. and Hawiger J.: Inhibition of nuclear translocation of transcription factor NF-κ-B by a synthetic peptide containing cell membrane-permeable motif and nuclear localization sequence. J. Biol. Chem. 270 (1995) 14255-14258.
28. Love R. R., Mazess R. B., Barden H. S., Epstein S., Newcomb P. A., Jordan V. C., Carbone P. P. and DeMets D. L.: Effects of tamoxifen on bone mineral density in post-menopausal women with breast cancer. N. Engl. J. Med. 326 (1992) 852-856.
29. Caldenhoven E., Liden J., Wissink S., Van de Stolpe A., Raaijmakers J., Koenderman L., Okert S., Gustafsson J.Å. and Van der Saag P. T.: Negative cross-talk between relA and the glucocorticoid receptor: a possible mechanism for the anti-inflammatory action of glucocorticoids. Molec. Endocr. 9 (1995) 401-412.
30. Butta A., MacLenman K., Flanders K. C., Sacks N. P. M., Smith I., Mckinna A., Dowsett M., Wakefield L. M., Sporn M. B., Baum M. and Colletta A. A.: Induction of transforming growth factor b1 in human breast cancer in vivo following tamoxifen treatment. Cancer Res. 52 (1992) 4261-4264.
31. Scheinman R. I., Gualberto A., Jewell C. M., Cidlowski J. A. Baldwin A.S. Jr: Characterization of mechanisms involved in transrepression of NF-κB by activated glucocorticoid receptors. Molec. Cell. Biol. 15 (1995) 943-953.