The bacterial flagellin gene as a biomarker for detection, population genetics and epidemiological analysis

Microbiology

Volumn 143, Issue 10, 1997, Pages 3071-3084

  Winstanley, Craig ^a,c   Morgan, J Alun W ^b  

^a Institute for Clean Growth and Future Mobility   (United Kingdom)

^b UNIVERSITY OF WARWICK   (United Kingdom)

^c UNIVERSITY OF BRADFORD   (United Kingdom)

Author keywords

Antigenic variation; Detection; Epidemiology; Flagellin; Population genetics

Indexed keywords

FLAGELLIN;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ANTIGENIC VARIATION; BACTERIAL GENE; BACTERIAL GENETICS; CARBOXY TERMINAL SEQUENCE; GENETIC VARIABILITY; MARKER GENE; NONHUMAN; POPULATION GENETICS; PRIORITY JOURNAL; PROTEIN STRUCTURE; REVIEW; SEROTYPE;

BACTERIA (MICROORGANISMS);

EID: 0030780605     PISSN: 13500872     EISSN: None     Source Type: Journal    
DOI: 10.1099/00221287-143-10-3071     Document Type: Review

References (84)

1. Aizawa, S.-I. (1996). Flagellar assembly in Salmonella typhimurium. Mol Microbiol 19, 1-5.
2. Allison, C. & Hughes, C. (1991). Bacterial swarming: an example of prokaryotic differentiation and multicellular behaviour. Sci Prog 75, 403-422.
3. Allison, C., Coleman, N., Jones, P. L. & Hughes, C. (1992). The ability of Proteus mirabilis to invade human urothelial cells is coupled to motility and swarming differentiation. Infect Immun 60, 4740-4746.
4. Alm, R. A., Guerry, P., Power, M. E. & Trust, T. J. (1992). Variation in antigenicity and molecular weight of Campylobacter coli VC167 flagellin in different backgrounds. J Bacteriol 174, 4230-4238.
5. Alm, R. A., Guerry, P. & Trust, T. J. (1993). Distribution and polymorphism of the flagellin genes from isolates of Campylobacter coli and Campylobacter jejuni. J Bacteriol 175, 3051-3057.
6. Bahrani, F. K., Johnson, D. E., Robbins, D. & Mobley, H. L. T. (1991). Proteus mirabilis flagella and MR/P fimbriae: isolation, purification, N-terminal analysis, and serum antibody response following experimental urinary tract infection. Infect Immun 59, 3574-3580.
7. Behammer, W., Shao, Z., Mages, W., Rachel, R., Stetter, K.-O. & Schmitt, R. (1995). Flagellar structure and hyperthermophily: analysis of a single flagellin gene and its product in Aquifex pyrophilus. J Bacteriol 177, 6630-6637.
8. Belas, R. (1994). Expression of multiple flagellin-encoding genes of Proteus mirabilis. J Bacteriol 176, 7169-7181.
9. Belas, R. (1996). Proteus mirabilis and other swarming bacteria. In Bacteria as Multicellular Organisms, pp. 183-219. Edited by J. A. Shapiro & M. Dworkin. Oxford: Oxford University Press.
10. Brunham, R. C., Plummer, F. A. & Stephens, R. S. (1993). Bacterial antigenic variation, host immune response, and pathogen-host coevolution. Infect Immun 61, 2273-2276.
11. Charon, N. W., Greenberg, E. P., Koopman, M. B. H. & Limberger, R. J. (1992). Spirochete chemotaxis, motility, and the structure of the spirochetal periplasmic flagella. Res Microbiol 143, 597-603.
12. Cheng, K., Smyth, R. L., Govan, J. R. W., Doherty, C., Winstanley, C., Denning, N., Heaf, D. P., van Seane, R. & Hart, C. A. (1996). Spread of a β-lactam-resistant Pseudomonas aeruginosa in a cystic fibrosis clinic. Lancet 348, 639-642.
13. Denning, N., Morgan, J. A. W., Whipps, J. M., Saunders, J. R. & Winstanley, C. (1997). The flagellin gene as a stable marker for detection of Pseudomonas fluorescens SBW25. Lett Appl Microbiol 24, 198-202.
14. DeShazer, D., Brett, P. J., Carlyon, R. & Woods, D. E. (1997). Mutagenesis of Burkholderia pseudomallei with Tn5-OT182: isolation of motility mutants and molecular characterization of the flagellin structural gene. J Bacteriol 179, 2116-2125.
15. Doig, P. & Trust, T. J. (1994). Identification of surface-exposed outer-membrane antigens of Helicobacter pylori. Infect Immun 62, 4526-4533.
16. Doig, P., Kinsella, N., Guerry, P. & Trust, T. J. (1996). Characterization of a post-translational modification of Campylobacter flagellin: identification of a sero-specific glycosyl moiety. Mol Microbiol 19, 379-387.
17. Driks, A., Bryan, R., Shapiro, L. & DeRosier, D. J. (1989). The organization of the Caulobacter crescentus flagellar filament. J Mol Biol 206, 627-636.
18. Forbes, K. J., Fang, Z. & Pennington, T. H. (1995). Allelic variation in the Helicobacter pylori flagellin genes flaA and flaB: its consequences for strain typing schemes and population structure. Epidemiol Infect 114, 257-266.
19. Fuerst, J. A. & Perry, J. W. (1988). Demonstration of lipopolysaccharide on sheathed flagella of Vibrio cholerae O : 1 by protein A-gold immunoelectron microscopy. J Bacteriol 170, 1488-1494.
20. Fukunaga, M. & Koreki, Y. (1996). A phylogenetic analysis of Borrelia burgdorferi sensu lato isolates associated with Lyme disease in Japan by flagellin gene sequence determination. Int J Syst Bacteriol 46, 416-421.
21. Ge, Y. & Charon, N. W. (1997). An unexpected flaA homolog is present and expressed in Borrelia burgdorferi. J Bacteriol 179, 552-556.
22. Geis, G., Leying, H., Suerbaum, S., Mai, U. & Opferkuch, W. (1989). Ultrastructure and chemical analysis of Campylobacter pylori flagella. J Clin Microbiol 27, 436-441.
23. Gray, D. I. & Kroll, R. G. (1995). Polymerase chain reaction amplification of the flaA gene for the rapid identification of Listeria spp. Lett Appl Microbiol 20, 65-68.
24. Guerry, P., Alm, R. A., Power, M. E., Logan, S. M. & Trust, T. J. (1991). Role of two flagellin genes in Campylobacter motility. J Bacteriol 173, 4757-4764.
25. Guerry, P., Doig, P., Alm, R. A., Burr, D. H., Kinsella, N. & Trust, T. J. (1996). Identification and characterization of genes required for post-translational modification of Campylobacter coli VC167 flagellin. Mol Microbiol 19, 369-378.
26. Harshey, R. M. (1994). Bees aren't the only ones: swarming in Gram-negative bacteria. Mol Microbiol 13, 389-394.
27. Homma, M., Fujita, H., Yamaguchi, S. & Iino, T. (1987). Regions of Salmonella typhimurium flagellin essential for its polymerization and excretion. J Bacteriol 169, 291-296.
28. Iino, T. (1977). Genetics of structure and function of bacterial flagella. Annu Rev Genet 11, 161-182.
29. Jank, B., Doblhoff-Dier, O., van der Plas, J. & Habermann, B. (1995). Sequence motifs in a flagellin of Pseudomonas putida. Microbiology 141, 1491-1492.
30. Jarrell, K. F., Bayley, D. P. & Kostyukova, A. S. (1996). The archaeal flagellum: a unique motility structure. J Bacteriol 178, 5057-5064.
31. Josenhans, C., Labigne, A. & Suerbaum, S. (1995). Comparative ultrastructural and functional studies of Helicobacter pylori and Helicobacter mustelae flagellin mutants: both flagellin subunits, FlaA and FlaB, are necessary for full motility in Helicobacter species. J Bacteriol 177, 3010-3020.
32. Joys, T. M. (1988). The flagellar filament protein. Can J Microbiol 34, 452-458.
33. Kelly-Wintenberg, K., South, S. L. & Montie, T. C. (1993). Tyrosine phosphate in a-and b-type flagellins of Pseudomonas aeruginosa. J Bacteriol 172, 2458-2461.
34. Khan, S. (1993). Gene to ultrastructure: the case of the flagellar basal body. J Bacteriol 175, 2169-2174.
35. Kilger, G. & Grimont, P. A. D. (1993). Differentiation of Salmonella phase 1 flagellar antigen types by restriction of the amplified fliC gene. J Clin Microbiol 31, 1108-1110.
36. Kuwajima, G. (1988). Construction of a minimum-size functional flagellin of Escherichia coli. J Bacteriol 170, 3305-3309.
37. Lagacé, J., Peloquin, L., Kermani, P. & Montie, T. C. (1995). IgG subclass responses to Pseudomonas aeruginosa a-and b-type flagellins in patients with cystic fibrosis: a prospective study. J Med Microbiol 43, 270-276.
38. Limberger, R. J., Slivienski, L. L., Yelton, D. B. & Charon, N. W. (1992). Molecular genetic analysis of a class B periplasmic-flagellum gene of Treponema phagedenis. J Bacteriol 174, 6404-6410.
39. Lövgren, A., Zhang, M.-Y., Engström, Å. & Landén, R. (1993). Identification of two expressed flagellin genes in the insect pathogen Bacillus thuringiensis subsp. alesti. J Gen Microbiol 139, 21-30.
40. Lu, Z., Murray, K. S., van Cleave, V., LaVallie, E. R., Stahl, M. L. & McCoy, J. M. (1995). Expression of thioredoxin reductase random peptide libraries on the Escherichia coli cell surface as functional fusions to flagellin: a system designed for exploring protein-protein interactions. Bio/Technology 13, 366-372.
41. Luke, C. J. & Penn, C. W. (1995). Identification of a 29 kDa flagellar sheath protein in Helicobacter pylori using a murine monoclonal antibody. Microbiology 141, 597-604.
42. McCarter, L. L. (1995). Genetic and molecular characterization of the polar flagellum of Vibrio parahaemolyticus. J Bacteriol 177, 1595-1609.
43. McGee, K., Horstedt, P. & Milton, D. L. (1996). Identification and characterization of additional flagellin genes from Vibrio anguillarum. J Bacteriol 178, 5188-5198.
44. Macnab, R. M. (1992). Genetics and biogenesis of bacterial flagella. Annu Rev Genet 26, 131-158.
45. Macnab, R. M. (1996). Flagella and motility. In Escherichia coli and Salmonella: Cellular and Molecular Biology, 2nd edn, pp. 123-145. Edited by F. C. Neidhardt and others. Washington, DC: American Society for Microbiology.
46. Mahenthiralingham, E., Campbell, M. E. & Speert, D. P. (1994). Nonmotility and phagocytic resistance of Pseudomonas aeruginosa isolates from chronically colonized patients with cystic fibrosis. Infect Immun 62, 596-605.
47. Masten, B. J. & Joys, T. M. (1993). Molecular analysis of the Salmonella g flagellar antigen complex. J Bacteriol 175, 5359-5365.
48. Minnich, S. A., Ohta, N., Taylor, N. & Newton, A. (1988). Role of the 25-, 27-, and 29-kilodalton flagellins in Caulobacter crescentus cell motility: method for construction of deletion and Tn5 insertion mutants by gene replacement. J Bacteriol 170, 3953-3960.
49. Moens, S., Michiels, K., Keijers, V., van Leuven, F. & Vanderleyden, J. (1995a). Cloning, sequencing and phenotypic analysis of laf1, encoding the flagellin of the lateral flagella of Azospirillum brasilense Sp7. J Bacteriol 177, 5419-5426.
50. Moens, S., Michiels, K. & Vanderleyden, J. (1995b). Glycosylation of the flagellin of the polar flagellum of Azospirillum brasilense, a Gram-negative nitrogen-fixing bacterium. Microbiology 141, 2651-2657.
51. Mohran, Z. S., Guerry, P., Lior, H., Murphy, J. R., Elgendy, A. M., Mikhail, M. M. & Oyofo, B. A. (1996). Restriction fragment length polymorphism of flagellin genes of Campylobacter jejuni and/or Campylobacter coli isolates from Egypt. J Clin Microbiol 34, 1216-1219.
52. Morgan, J. A. W., Winstanley, C., Pickup, R. W. & Saunders, J. R. (1991). Rapid immunocapture of Pseudomonas putida cells from lake water by using bacterial flagella. Appl Environ Microbiol 57, 503-509.
53. Nachamkin, I. & Yang, X. H. (1989). Human antibody response to Campylobacter jejuni flagellin protein and a synthetic N-terminal flagellin peptide. J Clin Microbiol 27, 2195-2198.
54. Nachamkin, I., Bohachick, K. & Patton, C. M. (1993). Flagellin gene typing of Campylobacter jejuni by restriction fragment length polymorphism analysis. J Clin Microbiol 31, 1531-1536.
55. Namba, K., Yamashita, I. & Vonderviszt, F. (1989). Structure of the core and central channel of bacterial flagella. Nature 342, 648-654.
56. Newton, S. M. C., Jacob, C. O. & Stocker, B. A. D. (1989). Immune response to cholera toxin epitope inserted in Salmonella flagellin. Science 244, 70-72.
57. Noppa, L., Burman, N., Sadziene, A., Barbour, A. G. & Bergström, S. (1995). Expression of the flagellin gene in Borrelia is controlled by an alternative σ factor. Microbiology 141, 85-93.
58. Norris, S. J. & the Treponema pallidum polypeptide research group (1993). Polypeptides of Treponema pallidum: progress toward understanding their structural, function, and immunologic roles. Microbiol Rev 57, 750-779.
59. Olsen, G. J., Woese, C. R. & Overbeek, R. (1994). The winds of (evolutionary) change: breathing new life into microbiology. J Bacteriol 176, 1-6.
60. Oyofo, B. A. & Rollins, D. M. (1993). Efficacy of filter types for detecting Campylobacter jejuni and Campylobacter coli in environmental water samples by polymerase chain reaction. Appl Environ Microbiol 59, 4090-4095.
61. Penn, C. W. & Luke, C. J. (1992). Bacterial flagellar diversity and significance in pathogenesis. FEMS Microbiol Lett 100, 331-336.
62. Picken, R. N. (1992). Polymerase chain reaction primers and probes derived from flagellin gene sequences for specific detection of the agents of Lyme disease and North American relapsing fever. J Clin Microbiol 30, 99-114.
63. Pleier, E. & Schmitt, R. (1991). Expression of two Rhizobium meliloti flagellin genes and their contribution to the complex filament structure. J Bacteriol 173, 2077-2085.
64. Rasiah, C., Schiltz, E., Reichert, J. & Vogt, A. (1992). Purification and characterization of a tryptic peptide of Borrelia burgdorferi flagellin, which reduces cross-reactivity in immunoblots and ELISA. J Gen Microbiol 138, 147-154.
65. Rasmussen, O. F., Skouboe, P., Dons, L., Rossen, L. & Olsen, J. E. (1995). Listeria monocytogenes exists in at least three evolutionary lines: evidence from flagellin, invasive associated protein and listeriolysin O genes. Microbiology 141, 2053-2061.
66. Rasmussen, H. N., Olsen, J. E., Jorgensen, K. & Rasmussen, O. F. (1996). Detection of Campylobacter jejuni and Camp. coli in chicken faecal samples by PCR. Lett Appl Microbiol 23, 363-366.
67. Schuster, S. C., Bauer, M., Kellermann, J., Lottspeich, F. & Baeuerlein, E. (1994). Nucleotide sequence of the Wolinella succinogenes flagellin, which contains in the antigenic domain two conserved regions also present in Campylobacter spp. and Helicobacter pylori. J Bacteriol 176, 5151-5155.
68. Selander, R. K., Li, J., Boyd, E. F., Wang, F.-S. & Nelson, K. (1994). DNA sequence analysis of the genetic structure of populations of Salmonella enterica and Escherichia coli. In Bacterial Diversity and Systematics, pp. 17-49. Edited by F. G. Priest, A. Ramos-Cormenzana & B. J. Tindall. New York: Plenum.
69. Silverman, M. & Simon, M. (1980). Phase variation: genetic analysis of switching mutants. Cell 19, 845-854.
70. Smith, N. H., Beltran, P. & Selander, R. K. (1990). Recombination of Salmonella phase 1 flagellin genes generates new serovars. J Bacteriol 172, 2209-2216.
71. Sjoblad, R. D., Emala, C. W. & Doetsch, R. N. (1983). Bacterial flagellar sheaths: structures in search of a function. Cell Motil 3, 93-103.
72. Tamura, Y., Kijima, M., Ohishi, K., Takahashi, T., Suzuki, S. & Nakamura, M. (1992). Antigenic analysis of Clostridium chauvoei flagella with protective and non-protective monoclonal antibodies. J Gen Microbiol 138, 537-542.
73. Tamura, Y., Kijima-Tanaka, M., Aoki, A., Ogikubo, Y. & Takahashi, T. (1995). Reversible expression of motility and flagella in Clostridium chauvoei and their relationship to virulence. Microbiology 141, 605-610.
74. Thomas, L. M., Long, K. A., Good, R. T., Panaccio, M. & Widders, P. R. (1997). Genotypic diversity among Campylobacter jejuni isolates in a commercial broiler flock. Appl Environ Microbiol 63, 1874-1877.
75. Tomashow, L. S. & Rittenberg, S. C. (1985). Isolation and composition of sheathed flagella from Bdellovibrio bacteriovorus 109J. J Bacteriol 163, 1047-1054.
76. Tominaga, A., Mahmoud, M. A.-H., Mukaihara, T. & Enomoto, M. (1994). Molecular characterization of intact, but cryptic, flagellin genes in the genus Shigella. Mol Microbiol 12, 277-285.
77. Trachtenberg, S. & DeRosier, D. J. (1992). A three-start helical sheath on the flagellar filament of Caulobacter crescentus. J Bacteriol 174, 6198-6206.
78. Wassenaar, T. M., Fry, B. N. & van der Zeijst, B. A. M. (1995). Variation of the flagellin gene locus of Campylobacter jejuni by recombination and horizontal gene transfer. Microbiology 141, 95-101.
79. Way, J. S., Josephson, K. L., Pillai, S. D., Abbaszadegan, M., Gerba, C. P. & Pepper, I. L. (1993). Specific detection of Salmonella spp. by multiplex polymerase chain reaction. Appl Environ Microbiol 59, 1473-1479.
80. Wei, L.-N. & Joys, T. M. (1985). Covalent structure of three phase-1 flagellar filament proteins of Salmonella. J Mol Biol 186, 791-803.
81. Whittam, T. S. (1995). Genetic population structure and pathogenicity in enteric bacteria. In Population Genetics of Bacteria (Society for General Microbiology Symposium 52), pp. 217-245. Edited by S. Baumberg, J. P. W. Young, E. M. H. Wellington & J. R. Saunders. Cambridge: Cambridge University Press.
82. Wilson, D. R. & Beveridge, T. J. (1993). Bacterial flagellar filaments and their component flagellins. Can J Microbiol 39, 451-472.
83. Winstanley, C., Morgan, J. A. W., Pickup, R. W. & Saunders, J. R. (1994). Molecular cloning of two Pseudomonas flagellin genes and basal body structural genes. Microbiology 140, 2019-2031.
84. Winstanley, C., Coulson, M. A., Wepner, B., Morgan, J. A. W. & Hart, C. A. (1996). Flagellin gene and protein variation amongst clinical isolates of Pseudomonas aeruginosa. Microbiology 142, 2145-2151.