메뉴 건너뛰기




Volumn 11, Issue 5, 2005, Pages 481-486

New antibiotics for the treatment of severe staphylococcal infection in the critically ill patient

Author keywords

Antibiotics; Critically ill; Methicillin resistance; Staphylococcus aureus

Indexed keywords

ANTIBIOTIC AGENT; AZTREONAM; CEFTOBIPROLE; CEFTRIAXONE; DALBAVANCIN; DALFOPRISTIN PLUS QUINUPRISTIN; DAPTOMYCIN; GLYCOPEPTIDE; LINEZOLID; ORITAVANCIN; TEICOPLANIN; TELAVANCIN; TIGECYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN;

EID: 26944452422     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/01.ccx.0000176690.18433.22     Document Type: Review
Times cited : (44)

References (56)
  • 1
    • 3342962524 scopus 로고    scopus 로고
    • Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: Report from the SENTRY Antimicrobial Surveillance Program (North America, 2001)
    • Streit JM, Jones RN, Sader HS, Fritsche TR. Assessment of pathogen occurrences and resistance profiles among infected patients in the intensive care unit: report from the SENTRY Antimicrobial Surveillance Program (North America, 2001). Int J Antimicrob Agents 2004; 24:111-118.
    • (2004) Int J Antimicrob Agents , vol.24 , pp. 111-118
    • Streit, J.M.1    Jones, R.N.2    Sader, H.S.3    Fritsche, T.R.4
  • 2
    • 26944453827 scopus 로고    scopus 로고
    • Annual Report EARSS. 2001. http://www.earss.rivm.nl. 2002.
    • (2001) Annual Report EARSS
  • 3
    • 0031737049 scopus 로고    scopus 로고
    • Nosocomial infections: Prospective survey of incidence in five French intensive care units
    • Legras A, Malvy D, Quinioux AI, et al. Nosocomial infections: prospective survey of incidence in five French intensive care units. Intensive Care Med 1998; 24:1040-1046.
    • (1998) Intensive Care Med , vol.24 , pp. 1040-1046
    • Legras, A.1    Malvy, D.2    Quinioux, A.I.3
  • 4
    • 0027967497 scopus 로고
    • Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes
    • Rello J, Torres A, Ricart M, et al. Ventilator-associated pneumonia by Staphylococcus aureus. Comparison of methicillin-resistant and methicillin-sensitive episodes. Am J Respir Crit Care Med 1994; 150:1545-1549.
    • (1994) Am J Respir Crit Care Med , vol.150 , pp. 1545-1549
    • Rello, J.1    Torres, A.2    Ricart, M.3
  • 5
    • 0037235347 scopus 로고    scopus 로고
    • Comparison of mortality associated with methicillin-resistant and methiollin-susceptible Staphylococcus aureus bacteremia: A meta-analysis
    • Cosgrove SE, Sakoulas G, Perencevich EN, et al. Comparison of mortality associated with methicillin-resistant and methiollin-susceptible Staphylococcus aureus bacteremia: a meta-analysis. Clin Infect Dis 2003; 36:53-59.
    • (2003) Clin Infect Dis , vol.36 , pp. 53-59
    • Cosgrove, S.E.1    Sakoulas, G.2    Perencevich, E.N.3
  • 6
    • 0035992140 scopus 로고    scopus 로고
    • Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials
    • Graffunder EM, Venezia RA. Risk factors associated with nosocomial methicillin-resistant Staphylococcus aureus (MRSA) infection including previous use of antimicrobials. J Antimicrob Chemother 2002; 49:999-1005.
    • (2002) J Antimicrob Chemother , vol.49 , pp. 999-1005
    • Graffunder, E.M.1    Venezia, R.A.2
  • 7
    • 15944419940 scopus 로고    scopus 로고
    • The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: Mortality, length of stay, and hospital charges
    • Cosgrove SE, Qi Y, Kaye KS, et al. The impact of methicillin resistance in Staphylococcus aureus bacteremia on patient outcomes: mortality, length of stay, and hospital charges. Infect Control Hosp Epidemiol 2005; 26:166-174. This is an exceptional study that should be compared by the reader with a previous investigation of the same authors [5].
    • (2005) Infect Control Hosp Epidemiol , vol.26 , pp. 166-174
    • Cosgrove, S.E.1    Qi, Y.2    Kaye, K.S.3
  • 8
    • 0033732048 scopus 로고    scopus 로고
    • 'Colonization pressure' and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit
    • Merrer J, Santoli F, et al. 'Colonization pressure' and risk of acquisition of methicillin-resistant Staphylococcus aureus in a medical intensive care unit. Infect Control Hosp Epidemiol 2000; 21:718-723.
    • (2000) Infect Control Hosp Epidemiol , vol.21 , pp. 718-723
    • Merrer, J.1    Santoli, F.2
  • 9
    • 0036324252 scopus 로고    scopus 로고
    • Infection in the intensive care unit: Prevention strategies
    • Bonten MJ. Infection in the intensive care unit: prevention strategies. Curr Opin Infect Dis 2002; 15:401-405.
    • (2002) Curr Opin Infect Dis , vol.15 , pp. 401-405
    • Bonten, M.J.1
  • 10
    • 0025669902 scopus 로고
    • Risk factors for Staphylococcus aureus nosocomial pneumonia in critically ill patients
    • Rello J, Quintana E, Ausina V, et ai. Risk factors for Staphylococcus aureus nosocomial pneumonia in critically ill patients. Am Rev Respir Dis 1990; 142: 1320-1324.
    • (1990) Am Rev Respir Dis , vol.142 , pp. 1320-1324
    • Rello, J.1    Quintana, E.2    Ausina, V.3
  • 11
    • 0027367592 scopus 로고
    • Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia
    • Rello J, Ausina V, Ricart M, et al. Impact of previous antimicrobial therapy on the etiology and outcome of ventilator-associated pneumonia. Chest 1993; 104:1230-1235.
    • (1993) Chest , vol.104 , pp. 1230-1235
    • Rello, J.1    Ausina, V.2    Ricart, M.3
  • 12
    • 0026703220 scopus 로고
    • Nosocomial respiratory tract infections in multiple trauma patients. Influence of level of consciousness with implications for therapy
    • Rello J, Ausina V, Castella J, et al. Nosocomial respiratory tract infections in multiple trauma patients. Influence of level of consciousness with implications for therapy. Chest 1992; 102:525-529.
    • (1992) Chest , vol.102 , pp. 525-529
    • Rello, J.1    Ausina, V.2    Castella, J.3
  • 13
    • 0037018951 scopus 로고    scopus 로고
    • The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida
    • Safdar N, Maki DG. The commonality of risk factors for nosocomial colonization and infection with antimicrobial-resistant Staphylococcus aureus, enterococcus, gram-negative bacilli, Clostridium difficile, and Candida. Ann Intern Med 2002; 136:834-844.
    • (2002) Ann Intern Med , vol.136 , pp. 834-844
    • Safdar, N.1    Maki, D.G.2
  • 14
    • 0032437388 scopus 로고    scopus 로고
    • Clinical and epidemiological findings in mechanically-ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia
    • Pujol M, Corbella X, Pena C, et al. Clinical and epidemiological findings in mechanically-ventilated patients with methicillin-resistant Staphylococcus aureus pneumonia. Eur J Clin Microbiol Infect Dis 1998; 17:622-628.
    • (1998) Eur J Clin Microbiol Infect Dis , vol.17 , pp. 622-628
    • Pujol, M.1    Corbella, X.2    Pena, C.3
  • 15
    • 0037083091 scopus 로고    scopus 로고
    • Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: Fitting a model to the data
    • Grundmann H, Hori S, Winter B, et al. Risk factors for the transmission of methicillin-resistant Staphylococcus aureus in an adult intensive care unit: fitting a model to the data. J Infect Dis 2002; 185:481-488.
    • (2002) J Infect Dis , vol.185 , pp. 481-488
    • Grundmann, H.1    Hori, S.2    Winter, B.3
  • 16
    • 0033840740 scopus 로고    scopus 로고
    • Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50
    • Cui L, Murakami H, Kuwahara-Arai K, et al. Contribution of a thickened cell wall and its glutamine nonamidated component to the vancomycin resistance expressed by Staphylococcus aureus Mu50. Antimicrob Agents Chemother 2000; 44:2276-2285.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 2276-2285
    • Cui, L.1    Murakami, H.2    Kuwahara-Arai, K.3
  • 17
    • 0036403740 scopus 로고    scopus 로고
    • The Prevalence and Mechanisms of Vancomycin Resistance in Staphylococcus aureus
    • Walsh TR, Howe RA. The Prevalence and Mechanisms of Vancomycin Resistance in Staphylococcus aureus. Annu Rev Microbiol 2002; 56:657-675.
    • (2002) Annu Rev Microbiol , vol.56 , pp. 657-675
    • Walsh, T.R.1    Howe, R.A.2
  • 18
    • 0037024849 scopus 로고    scopus 로고
    • Staphylococcus aureus resistant to vancomycin - United States, 2002
    • Centers for Disease Control and Prevention. Staphylococcus aureus resistant to vancomycin - United States, 2002. Morb Mortal Wkly Rep 2002; 51:565-567.
    • (2002) Morb Mortal Wkly Rep , vol.51 , pp. 565-567
  • 19
    • 0031566835 scopus 로고    scopus 로고
    • Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin
    • Hiramatsu K, Aritaka N, Hanaki H, et al. Dissemination in Japanese hospitals of strains of Staphylococcus aureus heterogeneously resistant to vancomycin. Lancet 1997; 350:1670-1673.
    • (1997) Lancet , vol.350 , pp. 1670-1673
    • Hiramatsu, K.1    Aritaka, N.2    Hanaki, H.3
  • 20
  • 21
    • 0027499255 scopus 로고
    • Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients
    • Lamer C, de Beco V, Soler P, et al. Analysis of vancomycin entry into pulmonary lining fluid by bronchoalveolar lavage in critically ill patients. Antimicrob Agents Chemother 1993; 37:281-286.
    • (1993) Antimicrob Agents Chemother , vol.37 , pp. 281-286
    • Lamer, C.1    De Beco, V.2    Soler, P.3
  • 22
    • 10344245591 scopus 로고    scopus 로고
    • Recent advances in the treatment of infections due to resistant Staphylococcus aureus
    • Anstead GM, Owens AD. Recent advances in the treatment of infections due to resistant Staphylococcus aureus. Curr Opin Infect Dis 2004; 17:549-555.
    • (2004) Curr Opin Infect Dis , vol.17 , pp. 549-555
    • Anstead, G.M.1    Owens, A.D.2
  • 23
    • 21744455460 scopus 로고    scopus 로고
    • The need for new therapeutic agents: What is the pipeline?
    • Shah PM. The need for new therapeutic agents: what is the pipeline? Clin Microbiol Infect 2005; 11(Suppl 3):36-42.
    • (2005) Clin Microbiol Infect , vol.11 , Issue.SUPPL. 3 , pp. 36-42
    • Shah, P.M.1
  • 24
    • 15744372279 scopus 로고    scopus 로고
    • Mechanisms of action of newer antibiotics for Gram-positive pathogens
    • Hancock RE. Mechanisms of action of newer antibiotics for Gram-positive pathogens. Lancet Infect Dis 2005; 5:209-218. The author presents a complete review on the mechanisms of action and resistance of gram-positive microorganisms to the newer antibiotics and a brief overview on the factors contributing to resistance development.
    • (2005) Lancet Infect Dis , vol.5 , pp. 209-218
    • Hancock, R.E.1
  • 25
    • 0034018950 scopus 로고    scopus 로고
    • In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against staphylococci and enterococci, including vancomycin-intermediate and -resistant strains
    • Rybak MJ, Herhberger E, Moldovan T, et al. In vitro activities of daptomycin, vancomycin, linezolid, and quinupristin-dalfopristin against staphylococci and enterococci, including vancomycin-intermediate and -resistant strains. Antimicrob Agents Chemother 2000; 44:1062-1066.
    • (2000) Antimicrob Agents Chemother , vol.44 , pp. 1062-1066
    • Rybak, M.J.1    Herhberger, E.2    Moldovan, T.3
  • 27
    • 20144385743 scopus 로고    scopus 로고
    • Pharmacokinetic studies of linezolid and teicoplanin in the critically ill
    • Whitehouse T, Cepeda JA, Shulman R, et al. Pharmacokinetic studies of linezolid and teicoplanin in the critically ill. J Antimicrob Chemother 2005; 55: 333-340. An interesting study covering the issue of linezolid pharmacokinetics in critically ill patients and showing that renal adjustment by a dosage of 600 mg every 12 his not required in these patients.
    • (2005) J Antimicrob Chemother , vol.55 , pp. 333-340
    • Whitehouse, T.1    Cepeda, J.A.2    Shulman, R.3
  • 28
    • 0035112879 scopus 로고    scopus 로고
    • Linezolid (PNU-100766) versus Vancomycin in the Treatment of Hospitalized Patients with Nosocomial Pneumonia: A Randomized. Double-Blind, Multicenter Study
    • Rubinstein E, Cammarata SK, Oliphant TH, et al. Linezolid (PNU-100766) versus Vancomycin in the Treatment of Hospitalized Patients with Nosocomial Pneumonia: A Randomized. Double-Blind, Multicenter Study. Clin Infect Dis 2001; 32:402-412.
    • (2001) Clin Infect Dis , vol.32 , pp. 402-412
    • Rubinstein, E.1    Cammarata, S.K.2    Oliphant, T.H.3
  • 29
    • 0037364869 scopus 로고    scopus 로고
    • Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia
    • Wunderink RG, Cammarata SK, Oliphant TH, et al. Continuation of a randomized, double-blind, multicenter study of linezolid versus vancomycin in the treatment of patients with nosocomial pneumonia. Clin Ther 2003; 25: 980-992.
    • (2003) Clin Ther , vol.25 , pp. 980-992
    • Wunderink, R.G.1    Cammarata, S.K.2    Oliphant, T.H.3
  • 30
    • 0242552187 scopus 로고    scopus 로고
    • Linezolid vs Vancomycin. Analysis of two Double-Blind Studies of Patients with Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia
    • Wunderink RG, Rello J, Cammarata SK, et al. Linezolid vs Vancomycin. Analysis of two Double-Blind Studies of Patients with Methicillin-Resistant Staphylococcus aureus Nosocomial Pneumonia. Chest 2003; 124:1789-1797.
    • (2003) Chest , vol.124 , pp. 1789-1797
    • Wunderink, R.G.1    Rello, J.2    Cammarata, S.K.3
  • 31
    • 1642350291 scopus 로고    scopus 로고
    • Clinical cure and survival in gram-positive ventilator-associated pneumonia. Retrospective analysis of two double-blind studies comparing linezolid with vancomycin
    • Kollef MH, Rello J, Cammarata SK, et al. Clinical Cure and Survival in Gram-positive Ventilator-associated Pneumonia. Retrospective Analysis of Two Double-blind Studies Comparing Linezolid with Vancomycin. Intensive Care Med 2004; 30:388-394. Here is an excellent investigation that supports the superiority of linezolid in VAP by MRSA. This study is a retrospective analysis of 544 VAP patients. When only MRSA cases were taken into account, linezolid was associated with significantly higher rates of clinical cure (62.2% versus 21.2. p = 0.001), survival (84.1% versus 61.7%, p = 0.02), and eradication (60.5% versus 22.9%, p = 0.001), compared to vancomycin.
    • (2004) Intensive Care Med , vol.30 , pp. 388-394
    • Kollef, M.H.1    Rello, J.2    Cammarata, S.K.3
  • 32
    • 0036604489 scopus 로고    scopus 로고
    • Linezolid versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections
    • Stevens DL, Herr D, Lampins H, et al. and the Linezolid MRSA Study Group: Linezolid versus Vancomycin for the Treatment of Methicillin-Resistant Staphylococcus aureus Infections. Clin Infect Dis 2002; 34:1481-1490.
    • (2002) Clin Infect Dis , vol.34 , pp. 1481-1490
    • Stevens, D.L.1    Herr, D.2    Lampins, H.3
  • 33
    • 10744231747 scopus 로고    scopus 로고
    • Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: A randomized, double-blind, multicentre study
    • Cepeda JA, Whitehouse T, Cooper B, et al. Linezolid versus teicoplanin in the treatment of Gram-positive infections in the critically ill: a randomized, double-blind, multicentre study. J Antimicrob Chemother 2004; 53:345-355. The study shows that linezolid is associated with a significantly lower colonization rate by MRSA in comparison to teicoplanin in critically ill patients with gram-positive infection.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 345-355
    • Cepeda, J.A.1    Whitehouse, T.2    Cooper, B.3
  • 34
    • 1642451852 scopus 로고    scopus 로고
    • Linezolid for treatment of ventilator-associated pneumonia: A cost-effective alternative to vancomycin
    • Shorr AF, Susla GM, Kollef MH. Linezolid for treatment of ventilator-associated pneumonia: a cost-effective alternative to vancomycin. Crit Care Med 2004; 32: 137-143.
    • (2004) Crit Care Med , vol.32 , pp. 137-143
    • Shorr, A.F.1    Susla, G.M.2    Kollef, M.H.3
  • 35
    • 0034885097 scopus 로고    scopus 로고
    • Hematologic effects of antimicrobials: Focus on the oxazolidinone linezolid
    • Kuter DJ, Tillotson GS. Hematologic effects of antimicrobials: focus on the oxazolidinone linezolid. Pharmacotherapy 2001; 21:1010-1013.
    • (2001) Pharmacotherapy , vol.21 , pp. 1010-1013
    • Kuter, D.J.1    Tillotson, G.S.2
  • 36
    • 0346848723 scopus 로고    scopus 로고
    • Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: Comparative analysis of linezolid and vancomycin use
    • Nasraway SA, Shorr AF, Kuter DJ, et al. Linezolid does not increase the risk of thrombocytopenia in patients with nosocomial pneumonia: comparative analysis of linezolid and vancomycin use. Clin Infect Dis 2003; 37:1609-1616.
    • (2003) Clin Infect Dis , vol.37 , pp. 1609-1616
    • Nasraway, S.A.1    Shorr, A.F.2    Kuter, D.J.3
  • 37
    • 4544302794 scopus 로고    scopus 로고
    • Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infections
    • Raad I, Hachem R, Hanna H, et al. Prospective, randomized study comparing quinupristin-dalfopristin with linezolid in the treatment of vancomycin-resistant Enterococcus faecium infections. J Antimicrob Chemother 2004; 53:646-649.
    • (2004) J Antimicrob Chemother , vol.53 , pp. 646-649
    • Raad, I.1    Hachem, R.2    Hanna, H.3
  • 38
    • 18844432844 scopus 로고    scopus 로고
    • Trends in linezolid susceptibility patterns in 2002: Reprot from the worldide Zyvox Annual Appraisal of Potency and Spectrum Program
    • Ross JE, Anderegg TR, Sader HS, et al. Trends in linezolid susceptibility patterns in 2002: Reprot from the worldide Zyvox Annual Appraisal of Potency and Spectrum Program. Diagn Microbiol Infect Dis 2005; 42:53-58.
    • (2005) Diagn Microbiol Infect Dis , vol.42 , pp. 53-58
    • Ross, J.E.1    Anderegg, T.R.2    Sader, H.S.3
  • 39
    • 0037076032 scopus 로고    scopus 로고
    • Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium
    • Herrero IA, Issa NC, Patel R. Nosocomial spread of linezolid-resistant, vancomycin-resistant Enterococcus faecium. N Engl J Med 2002; 346:867-869.
    • (2002) N Engl J Med , vol.346 , pp. 867-869
    • Herrero, I.A.1    Issa, N.C.2    Patel, R.3
  • 40
    • 0035857967 scopus 로고    scopus 로고
    • Infections due to vancomycin-resistant Enterococcus faecius resistant to linezolid
    • Gonzales RD, Schreckenberger PC, Graham MB, et al. Infections due to vancomycin-resistant Enterococcus faecius resistant to linezolid. Lancet 2001; 357:1179.
    • (2001) Lancet , vol.357 , pp. 1179
    • Gonzales, R.D.1    Schreckenberger, P.C.2    Graham, M.B.3
  • 41
    • 0034021097 scopus 로고    scopus 로고
    • Treatment of gram-positive nosocomial pneumonia. Prospective randomized comparison of quinupristin/dancomycin
    • Fagon JY, Patrick H, Haas DW, et al. and the Nosocomial Pneumonia Group: Treatment of Gram-positive Nosocomial Pneumonia. Prospective Randomized Comparison of Quinupristin/Dancomycin. Am J Respir Crit Care Med 2000; 161:753-762.
    • (2000) Am J Respir Crit Care Med , vol.161 , pp. 753-762
    • Fagon, J.Y.1    Patrick, H.2    Haas, D.W.3
  • 42
    • 0035984793 scopus 로고    scopus 로고
    • Resistance to quinupristin-dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus
    • Malbruny B, Canu A, Bozdogan B, et al. Resistance to quinupristin- dalfopristin due to mutation of L22 ribosomal protein in Staphylococcus aureus. Antimicrob Agents Chemother 2002; 46:2200-2207.
    • (2002) Antimicrob Agents Chemother , vol.46 , pp. 2200-2207
    • Malbruny, B.1    Canu, A.2    Bozdogan, B.3
  • 43
    • 0037340692 scopus 로고    scopus 로고
    • Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogen cellected in the SECURE study (Europe) during 2000-2001
    • Critchley IA, Draghi DC, Sahrm DF, et al. Activity of daptomycin against susceptible and multidrug-resistant Gram-positive pathogen cellected in the SECURE study (Europe) during 2000-2001. J Antimiorob Chemother 2003; 51:639-649.
    • (2003) J Antimiorob Chemother , vol.51 , pp. 639-649
    • Critchley, I.A.1    Draghi, D.C.2    Sahrm, D.F.3
  • 44
    • 1542407276 scopus 로고    scopus 로고
    • A comprehensive review of the pharmacology of daptomycin
    • Fenton C, Keating GM, Cuuran MP. A comprehensive review of the pharmacology of daptomycin. Drugs 2004; 64:445-455.
    • (2004) Drugs , vol.64 , pp. 445-455
    • Fenton, C.1    Keating, G.M.2    Cuuran, M.P.3
  • 45
    • 2942665465 scopus 로고    scopus 로고
    • The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections
    • Arbeit RD, Maki D, Tally FP, et al. The safety and efficacy of daptomycin for the treatment of complicated skin and skin-structure infections. Clin Infect Dis 2004; 38:1673-1681.
    • (2004) Clin Infect Dis , vol.38 , pp. 1673-1681
    • Arbeit, R.D.1    Maki, D.2    Tally, F.P.3
  • 46
    • 0038262639 scopus 로고    scopus 로고
    • In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterocovvi and staphylococci with diminished susceptibility to glycopeptide
    • Cercenado E, Cercenado S, Gomez JA, Bouza E. In vitro activity of tigecycline (GAR-936), a novel glycylcycline, against vancomycin-resistant enterocovvi and staphylococci with diminished susceptibility to glycopeptide. J Antimicrob Chemother 2003; 52:138-139.
    • (2003) J Antimicrob Chemother , vol.52 , pp. 138-139
    • Cercenado, E.1    Cercenado, S.2    Gomez, J.A.3    Bouza, E.4
  • 47
    • 2942571341 scopus 로고    scopus 로고
    • Results of a multicenter, randomized, open-label efficacy and safety study of two doses of tigecycline for complicated skin and skin-structure infections in hospitalized patients
    • Postier RG, Green SL, Klein SR, et al. Results of a multicenter, randomized, open-label efficacy and safety study of two doses of tigecycline for complicated skin and skin-structure infections in hospitalized patients. Clin Ther 2004; 26:704-714.
    • (2004) Clin Ther , vol.26 , pp. 704-714
    • Postier, R.G.1    Green, S.L.2    Klein, S.R.3
  • 48
    • 0346452266 scopus 로고    scopus 로고
    • The clinical response to tigecycline in the treatment of complicated intra-abdominal infections in hospitalised patients. A phase 2 clinical trial
    • Chicago, IL, USA. Abstract L739
    • Murray J, Wilson S, Klein S, et al. The clinical response to tigecycline in the treatment of complicated intra-abdominal infections in hospitalised patients. A phase 2 clinical trial [abstract]. 43rd International Conference Antimicrobial Agents Chemotherapy 2003. Chicago, IL, USA. Abstract L739 2005.
    • (2005) 43rd International Conference Antimicrobial Agents Chemotherapy 2003
    • Murray, J.1    Wilson, S.2    Klein, S.3
  • 49
    • 20944431809 scopus 로고    scopus 로고
    • Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin
    • Kosowska K, Hoellman DB, Lin G, et al. Antipneumococcal activity of ceftobiprole, a novel broad-spectrum cephalosporin. Antimicrob Agents Chemother 2005; 49:1932-1942.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 1932-1942
    • Kosowska, K.1    Hoellman, D.B.2    Lin, G.3
  • 50
    • 14744278669 scopus 로고    scopus 로고
    • Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus
    • Chambers HF. Evaluation of ceftobiprole in a rabbit model of aortic valve endocarditis due to methicillin-resistant and vancomycin-intermediate Staphylococcus aureus. Antimicrob Agents Chemother 2005; 49:884-888.
    • (2005) Antimicrob Agents Chemother , vol.49 , pp. 884-888
    • Chambers, H.F.1
  • 51
    • 3342877329 scopus 로고    scopus 로고
    • Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria
    • Hegde SS, Reyes N, Wiens T, et al. Pharmacodynamics of telavancin (TD-6424), a novel bactericidal agent, against gram-positive bacteria. Antimicrob Agents Chemother 2004; 48:3043-3050.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 3043-3050
    • Hegde, S.S.1    Reyes, N.2    Wiens, T.3
  • 52
    • 21144449191 scopus 로고    scopus 로고
    • Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria
    • Stryjewski ME, O'Riordan WD, Lau WK, et al. Telavancin versus standard therapy for treatment of complicated skin and soft-tissue infections due to gram-positive bacteria. Clin Infect Dis 2005; 40:1601-1607.
    • (2005) Clin Infect Dis , vol.40 , pp. 1601-1607
    • Stryjewski, M.E.1    O'Riordan, W.D.2    Lau, W.K.3
  • 53
    • 0347709911 scopus 로고    scopus 로고
    • Phase 3 trial comparing 3-7 days of orintavancin vs. 10-14 days of vancomycin/cephalexin in the treatment of patients with complicated skin and skin tructure infections(cSSSI)
    • Chicago, IL, USA. Abstract L-739
    • Giamarellou H, O'Riordan W, Harris H, et al. Phase 3 trial comparing 3-7 days of orintavancin vs. 10-14 days of vancomycin/cephalexin in the treatment of patients with complicated skin and skin tructure infections(cSSSI) [abstract]. 43rd International Conference Antimicrobial Agents Chemotherapy 2003. Chicago, IL, USA. Abstract L-739 2003.
    • (2003) 43rd International Conference Antimicrobial Agents Chemotherapy 2003
    • Giamarellou, H.1    O'Riordan, W.2    Harris, H.3
  • 54
    • 1242270459 scopus 로고    scopus 로고
    • Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates
    • Streit JM, Fritsche TR, Sader HS, Jones RN. Worldwide assessment of dalbavancin activity and spectrum against over 6,000 clinical isolates. Diagn Microbiol Infect Dis 2004; 48:137-143.
    • (2004) Diagn Microbiol Infect Dis , vol.48 , pp. 137-143
    • Streit, J.M.1    Fritsche, T.R.2    Sader, H.S.3    Jones, R.N.4
  • 55
    • 1442300060 scopus 로고    scopus 로고
    • Activities of dalbavancin in vitro and in a rabbit model of experimental endocarditis due to Staphylococcus aureus with or without reduced susceptibility to vancomycin and teicoplanin
    • Lefort A, Pavie J, Garry L, et al. Activities of dalbavancin in vitro and in a rabbit model of experimental endocarditis due to Staphylococcus aureus with or without reduced susceptibility to vancomycin and teicoplanin. Antimicrob Agents Chemother 2004; 48:1061-1064.
    • (2004) Antimicrob Agents Chemother , vol.48 , pp. 1061-1064
    • Lefort, A.1    Pavie, J.2    Garry, L.3
  • 56
    • 13444257356 scopus 로고    scopus 로고
    • Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens
    • Raad I, Darouiche R, Vazquez J, et al. Efficacy and safety of weekly dalbavancin therapy for catheter-related bloodstream infection caused by gram-positive pathogens. Clin Infect Dis 2005; 40:374-380. This phase 2 trial reports promising results of the novel drug dalbavancin in a single dosage in comparison to vancomycin in patients who have a catheter-related infection by gram-positive bacteria.
    • (2005) Clin Infect Dis , vol.40 , pp. 374-380
    • Raad, I.1    Darouiche, R.2    Vazquez, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.