Chronic morphine treatment promotes specific Th2 cytokine production by murine T cells in vitro via a Fas/Fas ligand-dependent mechanism

Journal of Immunology

Volumn 175, Issue 8, 2005, Pages 4999-5005

  Greeneltch, Kristy M ^a,b   Kelly Welch, Ann E ^a   Shi, Yufang ^c   Keegan, Achsah D ^a  

^a HOLLAND LABORATORY   (United States)

^b GEORGE WASHINGTON UNIVERSITY SCHOOL OF MEDICINE AND HEALTH SCIENCES   (United States)

^c RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; FAS ANTIGEN; FAS LIGAND; GAMMA INTERFERON; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; MESSENGER RNA; MORPHINE; T LYMPHOCYTE RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND;

ANIMAL CELL; ARTICLE; ASTHMA; AUTOIMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEMALE; HOMEOSTASIS; IMMUNE RESPONSE; LYMPHOCYTE DIFFERENTIATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

EID: 26844559667     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.175.8.4999     Document Type: Article

References (41)

1. Mosmann, T. R., H. Cherwinski, M. W. Bond, M. A. Giedlin, and R. L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136: 2348-2357.
2. + T cells. Annu. Rev. Immunol. 12: 635-673.
3. Swain, S. L., D. T. McKenzie, R. W. Dutton, S. L. Tonkonogy, and M. English. 1988. The role of IL4 and IL5: characterization of a distinct helper T cell subset that makes IL4 and IL5 (Th2) and requires priming before induction of lymphokine secretion. Immunol. Rev. 102: 77-105.
4. O'Garra, A., and K. Murphy. 1996. Role of cytokines in development of Th1 and Th2 cells. Chem. Immunol. 63: 1-13.
5. Szabo, S. J., B. M. Sullivan, S. L. Peng, and L. H. Glimcher. 2003. Molecular mechanisms regulating Th1 immune responses. Annu. Rev. Immunol. 21: 713-758.
6. Glimcher, L. H., and K. M. Murphy. 2000. Lineage commitment in the immune system: the T helper lymphocyte grows up. Genes Dev. 14: 1693-1711.
7. Ansel, K. M., D. U. Lee, and A. Rao. 2003. An epigenetic view of helper T cell differentiation. Nat. Immunol. 4: 616-623.
8. Murphy, K. M., W. Ouyang, J. D. Farrar, J. Yang, S. Ranganath, H. Asnagli, M. Afkarian, and T. L. Murphy. 2000. Signaling and transcription in T helper development. Annu. Rev. Immunol. 18: 451-494.
9. Murphy, K. M., and S. L. Reiner. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2: 933-944.
10. Stanulis, E. D., S. D. Jordan, J. A. Rosecrans, and M. P. Holsapple. 1997. Disruption of Th1/Th2 cytokine balance by cocaine is mediated by corticosterone. Immunopharmacology 37: 25-33.
11. H2 differentiation. Surgery 130: 304-309.
12. Sacerdote, P., V. E. di San Secondo, G. Sirchia, B. Manfredi, and A. E. Panerai. 1998. Endogenous opioids modulate allograft rejection time in mice: possible relation with Th1/Th2 cytokines. Clin. Exp. Immunol. 113: 465-469.
13. Sacerdote, P., L. Gaspani, and A. E. Panerai. 2000. The opioid antagonist naloxone induces a shift from type 2 to type 1 cytokine pattern in normal and skin-grafted mice. Ann. NY Acad. Sci. 917: 755-763.
14. Roy, S., J. Wang, S. Gupta, R. Charboneau, H. H. Loh, and R. A. Barke. 2004. Chronic morphine treatment differentiates T helper cells to Th2 effector cells by modulating transcription factors GATA 3 and T-bet. J. Neuroimmunol. 147: 78-81.
15. Oberg, H. H., B. Lengl-Janssen, D. Kabelitz, and O. Janssen. 1997. Activation-induced T cell death: resistance or susceptibility correlate with cell surface fas ligand expression and T helper phenotype. Cell. Immunol. 181: 93-100.
16. Ramsdell, F., M. S. Seaman, R. E. Miller, K. S. Picha, M. K. Kennedy, and D. H. Lynch. 1994. Differential ability of Th1 and Th2 T cells to express Fas ligand and to undergo activation-induced cell death. Int. Immunol. 6: 1545-1553.
17. Varadhachary, A. S., S. N. Perdow, C. Hu, M. Ramanarayanan, and P. Salgame. 1997. Differential ability of T cell subsets to undergo activation-induced cell death. Proc. Natl. Acad. Sci. USA 94: 5778-5783.
18. Zhang, X., T. Brunner, L. Carter, R. W. Dutton, P. Rogers, L. Bradley, T. Sato, J. C. Reed, D. Green, and S. L. Swain. 1997. Unequal death in T helper cell (Th)1I and Th2 effectors: Th1, but not Th2, effectors undergo rapid Fas/FasL-mediated apoptosis. J. Exp. Med. 185: 1837-1849.
19. Suda, T., T. Okazaki, Y. Naito, T. Yokota, N. Arai, S. Ozaki, K. Nakao, and S. Nagata. 1995. Expression of the Fas ligand in cells of T cell lineage. J. Immunol. 154: 3806-3813.
20. Watanabe, N., H. Arase, K. Kurasawa, I. Iwamoto, N. Kayagaki, H. Yagita, K. Okumura, S. Miyatake, and T. Saito. 1997. Th1 and Th2 subsets equally undergo Fas-dependent and -independent activation-induced cell death. Eur. J. Immunol. 27: 1858-1864.
21. Zhang, X. R., L. Y. Zhang, S. Devadas, L. Li, A. D. Keegan, and Y. F. Shi. 2003. Reciprocal expression of TRAIL and CD95L in Th1 and Th2 cells: role of apoptosis in T helper subset differentiation. Cell Death Differ. 10: 203-210.
22. Roberts, A. I., S. Devadas, X. Zhang, L. Zhang, A. Keegan, K. Greeneltch, J. Solomon, L. Wei, J. Das, E. Sun, et al. 2003. The role of activation-induced cell death in the differentiation of T-helper-cell subsets. Immunol. Res. 28: 285-293.
23. Yin, D., R. A. Mufson, R. Wang, and Y. Shi. 1999. Fas-mediated cell death promoted by opioids. Nature 397: 218.
24. Eisenstein, T. K., J. J. Meissler, Jr., J. L. Bussiere, T. J. Rogers, E. B. Geller, and M. W. Adler. 1995. Mouse strain differences in in vivo and in vitro immunosuppressive effects of opioids. Adv. Exp. Med. Biol. 373: 115-121.
25. Bussiere, J. L., M. W. Adler, T. J. Rogers, and T. K. Eisenstein. 1992. Differential effects of morphine and naltrexone on the antibody response in various mouse strains. Immunopharmacol. Immunotoxicol. 14: 657-673.
26. Peng, X., D. M. Mosser, M. W. Adler, T. J. Rogers, J. J. Meissler, Jr., and T. K. Eisenstein. 2000. Morphine enhances interleukin-12 and the production of other pro-inflammatory cytokines in mouse peritoneal macrophages. J. Leukocyte Biol. 68: 723-728.
27. Kraus, J., C. Borner, E. Giannini, K. Hickfang, H. Braun, P. Mayer, M. R. Hoehe, A. Ambrosch, W. Konig, and V. Hollt. 2001. Regulation of μ-opioid receptor gene transcription by interleukin-4 and influence of an allelic variation within a STAT6 transcription factor binding site. J. Biol. Chem. 276: 43901-43908.
28. Sharma, K., R. X. Wang, L. Y. Zhang, D. L. Yin, X. Y. Luo, J. C. Solomon, R. F. Jiang, K. Markos, W. Davidson, D. W. Scott, et al. 2000. Death the Fas way: regulation and pathophysiology of CD95 and its ligand. Pharmacol. Ther. 88: 333-347.
29. 2+ signaling. J. Pharmacol. Exp. Ther. 302: 1002-1012.
30. Taylor, D. A., and W. W. Fleming. 2001. Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids. J. Pharmacol. Exp. Ther. 297: 11-18.
31. Narita, M., M. Makimura, Y. Feng, B. Hoskins, and I. K. Ho. 1994. Influence of chronic morphine treatment on protein kinase C activity: comparison with butorphanol and implication for opioid tolerance. Brain Res. 650: 175-179.
32. Li, M. D., K. McAllen, and B. M. Sharp. 1999. Regulation of δ opioid receptor expression by anti-CD3-ε, PMA, and ionomycin in murine splenocytes and T cells. J. Leukocyte Biol. 65: 707-714.
33. Sharp, B. M., M. D. Li, S. G. Matta, K. McAllen, and N. A. Shahabi. 2000. Expression of δ opioid receptors and transcripts by splenic T cells. Ann. NY Acad. Sci. 917: 764-770.
34. Sharp, B. M., D. J. McKean, K. McAllen, and N. A. Shahabi. 1998. Signaling through δ opioid receptors on murine splenic T cells and stably transfected Jurkat cells. Ann. NY Acad. Sci. 840: 420-424.
35. Shahabi, N. A., W. Heagy, and B. M. Sharp. 1996. β-Endorphin enhances concanavalin-A-stimulated calcium mobilization by murine splenic T cells. Endocrinology 137: 3386-3393.
36. Singhal, P. C., P. Sharma, A. A. Kapasi, K. Reddy, N. Franki, and N. Gibbons. 1998. Morphine enhances macrophage apoptosis. J. Immunol. 160: 1886-1893.
37. Singhal, P. C., A. A. Kapasi, N. Franki, and K. Reddy. 2000. Morphine-induced macrophage apoptosis: the role of transforming growth factor-β. Immunology 100: 57-62.
38. Nair, M. P., S. A. Schwartz, R. Polasani, J. Hou, A. Sweet, and K. C. Chadha. 1997. Immunoregulatory effects of morphine on human lymphocytes. Clin. Diagn. Lab. Immunol. 4: 127-132.
39. Peterson, P. K., B. M. Sharp, G. Gekker, B. Jackson, and H. H. Balfour, Jr. 1991. Opiates, human peripheral blood mononuclear cells, and HIV. Adv. Exp. Med. Biol. 288: 171-178.
40. Tashkin, D. P. 2001. Airway effects of marijuana, cocaine, and other inhaled illicit agents. Curr. Opin. Pulm. Med. 7: 43-61.
41. Cygan, J., M. Trunsky, and T. Corbridge. 2000. Inhaled heroin-induced status asthmaticus: five cases and a review of the literature. Chest 117: 272-275.