Role of cytokines in development of Th1 and Th2 cells

Chemical Immunology

Volumn 63, Issue , 1996, Pages 1-13

  O'Garra, Anne ^a   Murphy, Kenneth ^b  

^a MERCK RESEARCH LABORATORIES   (United States)

^b WASHINGTON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERLEUKIN 12; INTERLEUKIN 4; INTERLEUKIN RECEPTOR;

CELL COMMUNICATION; HELPER CELL; IMMUNE RESPONSE; INFECTION; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION;

EID: 0030007259     PISSN: 10150145     EISSN: None     Source Type: Journal    
DOI: 10.1159/000319475     Document Type: Review

References (88)

1. Sher A, Coffiman RL: Regulation of immunity to parasites by T cells and T cell-derived cytokines. Am Rev Immunol 1992;10:385-409.
2. Mosmann TR, Cherwinski H, Bond MW, Giedlin MA, Coffman RL: Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J Immunol 1986;136:2348-2357.
3. Mosmann TR, Coffman RL: Heterogeneity of cytokine secretion patterns and functions of helper T cells. Adv Immunol 1989;46:111-147.
4. Scott P, Natovitz P, Coffman RL, Pearce E, Sher A: Immunoregulation of cutaneous leishmaniasis: T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens. J Exp Med 1988;168:1675-1684.
5. Heinzel FP, Sadick MD, Holaday BJ, Coffman RL, Locksley RM: Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. J Exp Med 1989;169:59-72
6. Belosevic M, Finbloom DS, Meide PHVD, Slayter MV, Nacy CA: Administration of monoclonal anti-IFN-γ antibodies in vivo abrogates natural resistance of C3H/HeN mice to infection with Leishmanta major. J Immunol 1989;143:266-274.
7. Fowell D, McKnight AJ, Powrie F, Dyke R, Mason D: Subsets of CD4+ T cells and their roles in the induction and prevention of autoimmunity. Immunol Rev 1991;123:37-64.
8. Fowell D, Mason D: Evidence that the T cell repertoiie of normal rats contains cells with the potential to cause diabetes: Characterization of the CD4+ T cell subset that inhibits this autoimmune potential. J Exp Med 1993;177:627-636.
9. Powrie F, Coffman RL: Cytokine regulation of T-cell function: Potential for therapeutic intervention. Immunol Today 1993;14:270-274.
10. O'Garra A. Murphy K: T-cell subsets in autoimmunity. Curr Opin Immunol 1995;5:880-886.
11. Mosmann TR, Bond MW, Coffman RL, Ohara J, Paul WE: T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci USA 1986;83:5654-5658.
12. H2 subsets: Doubt no more. Immunol Today 1991;12:256-257
13. Parronchi P, Macchia D, Piccinni M-P, et al: Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production. Proc Natl Acad Sci USA 1991;88
14. Yssel H, Johnson KE, Schneider P, et al: T cell activation epitopes of the house dust mite allergen Der p I J Immunol 1992;148:738-745.
15. Wierenga EA, Snoek M, et al: Evidence for compartmentalization of functional subsets of CD4+ T lymphocytes in atopic patients. J Immunol 1990;144:4651-4656.
16. Fiorentino DF, Bond MW, Mosmann TR: Two types of mouse helper T cell. IV Th2 clones secrete a factor that inhibits cytokine production by Th1 clones J Exp Med 1989;170:2081-2095.
17. Fiorentino DF, Zlotnik A, Vieira P, et al: IL-10 acts on the antigen-presenting cell to inhibit cytokine production by Th1 cells, J Immunol 1991;146:3444-3451.
18. de Waal Malefyt R, Haanen J, Yssel H, et al: IL-10 and v-IL-10 strongly reduce antigen specific human T cell responses by diminishing the antigen presenting capacity of monocytes via down-regulation of class II MHC expression. J Exp Med 1991;174:915-924.
19. Powrie F, Coffman R: IL-4 and IL-10 inhibit DTH and IFN-γ production. Eur J Immunol 1993; 23:2223-2229.
20. Parish CR: The relationship between humoral and cell-mediated immunity. Transplant Rev 1972; 13:35-66.
21. Katsura Y: Cell-mediated and humoral immune responses in mice. III. Dynamic balance between delayed-type hypersensitivety and antibody response. Immunology 1977;32:227-235.
22. Asherson GL, Stone SH: Selective and specific inhibition of 24-hour skin reactions in the guinea pig. I. Immune deviation: Description of the phenomenon and the effect of splenectomy Immunology 1965;9:205-217.
23. Maggi E, Prete GD, Macchia D. et al: Profiles of lymphokine activities and helper function for IgE in human T cell clones. Eur J Immunol 1988;18:1045-1050.
24. Maggi E, Parronchi P, Manetti R, et al: Reciprocal regulatory effects of IFN-gamma and IL-4 on the in vitro development of human Th1 and Th2 clones. J Immunol 1992;148:2142.
25. Yssel H, Shanafelt M-C, Soderberg C, Schneider PV, Anzola J, Peltz G B burgdorferi activates a TH1-like T cell subset in lyme arthritis, J Exp Med 1991;174:593-601.
26. Haanen JBG, Malefijt RdW, Res PCM, et al: Selection of a human Th1-like T cell subset by mycobacteria J Exp Med 1991;174:583-592.
27. Salgame P, Abrams JS, Clayberger C, et al: Differing lymphokine profiles of functional subsets of human CD4 T and CD8 T cell clones. Science 1991;254:279-282.
28. Yamamura M, Uyemura K, Deans RJ, et al: Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 1991;254:277-279
29. de Vries JE, de Waal Malefyt R, Yssel H, Roncarolo M-G, Spits H: Do human TH1 and TH2 CD4+ clones exist? CD4+ T-cell subsets: Differentiation and Function Res Immunol 1991,142:59-63.
30. Andersson U, Andersson J, Lindfors A, Wagner K, Möller G, Hewsser CH: Simultaneous production of interleukin 2, interleukin 4 and interferon-γ by activated human blood lymphocytes. Eur J Immunol 1990;20:1591-1596.
31. Kelso A, Gough NM: Coexpression of granulocyte-macrophage colony-stimulating factor, γ interferon. and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones Proc Natl Acad Sci USA 1988;85.9189-9193.
32. Firestein GS, Roeder WD, Laxer JA, et al: A new murine CD4+ cell subset with an unrestricted cytokine profile. J Immunol 1989;143:518-525.
33. Openshaw P, Murphy E, Hosken NA, et al: Heterogeneity of intracellular cytokine synthesis at the single cell level in polarized T helper 1 and T helper 2 populations. J Exp Med 1995:in press.
34. Kamogawa Y, Minasi L-aE, Carding SR, Bottomly K, Flavell RA: The relationship of IL-4 and IFN-γ-producing T cells studied by lineage ablation of IL-4 producing cells Cell 1993;75:985-995.
35. Fernandez-Botran R, Sanders VM, Mosmann TR, Vitetta ES: Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells J Exp Med 1988;168:543-558.
36. Gajewski TF, Schell SR, Nau G, Fitch FW: Regulation of T-cell activation: Differences among T cell subsets. Immunol Rev 1989;111.79-110.
37. Secrist H, DeKruyff RH. Umetsu DT Interleukin 4 production by CD4+ T cells from allergic individuals is modulated by antigen concentration and antigen presenting cell type.J Exp Med 1995; 181:1081-1089
38. Swain SL, Weinberg AD, English M, Huston G: IL-4 directs the development of Th2-like helper effectors. J Immunol 1990;145:3796-3806.
39. Le Gros G, Ben-Sasson S, Seder R, Finkelman FD, Pal WE. Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4 producing cells. J Exp Med 1990,172:921-929.
40. Hsieh C-S, Heimberger AB, Gold JS, O'Garra A, Murphy K. Differential regulation of T helper phenotype development by IL-4 and IL-10 in an αβ-transgenic system. Proc Natl Acad Sci USA 1992;89:6065-6069.
41. Hsieh C-S, Macatonia SE, Tripp CS, Wolf SF, O'Garra A, Murphy KM: Development of Th1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science 1993;260:547-549.
42. Seder RA, Paul WE, Davis MM, Fazekas de St Groth B: The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 1992;176.1091-1098.
43. Seder RA, Gazzinelli R, Sher A, Paul WE: Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon γ production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci USA 1993,90 10188-10192.
44. Manetti R, Parronchi P, Guidizi MG, et al; Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing cells. J Exp Med 1993;177:1199-1204
45. Romagnani S. Regulatory role of IL-4 and other cytokines on the function and development of human T cell clones. Res Immunol Immunobiol IL-4 1993;144:625-628.
46. Swain SL, Bradley LM, Croft M, et al: Helper T-cell subsets: Phenotype, function and the role of lymphokines in regulating their development. Immunol Rev 1991;123.115-144.
47. Swain SL: IL-4 dictates T-cell differentiation. 53rd Forum Immunol Res. Immunology 1993;144: 567-651.
48. Sadick MD, Heinzel FP, Holaday BJ, Pa RT, Dawkins RS, Locksley RM: Cure of leishmaniasis with anti-interleukin 4 monoclonal antibody: Evidence for a T-cell-dependent, interferon gamma-independent mechanism. J Exp Med 1990;171:115.
49. Chatelain R, Varkila K, Coffman RL. IL-4 induces a Th2 response in Leishmania major-infected mice. J Immunol 1992;148:1182.
50. Romani LA, Mencacci U, Grohmann MS, Mosci P, Puccetti P, Bistoni F: Neutralizing antibody to interleukin 4 induces systemic protection and T helper type 1-associated immunity in murine candidiasis, J Exp Med 1992;176:19.
51. Kopf M, Le Gros G, Bachmann M, Lamers MC, Bluethmann H, Kohler G: Disruption of the murine IL-4 gene blocks Th2 cytokine responses. Nature 1993;362:245-248.
52. Macatonia SE, Hsieh C-S, Murphy KM, O'Garra A. Dendntic cells and macrophages are required for Th1 development of CD4H+ T cells from αβ TCR transgenic mice: IL-12 substitution for macrophages to stimulate IFN-γ production is IFN-γ-dependent. Int Immunol 1993;5:1119-1128.
53. Manetti R, Gerosa F, Giudici MG, et al: Interleukin-12 induces stable priming for interferon-γ (IFN-γ) production during differentiation of human T helper (Th) cells and transient IFN-γ production in established Th2 cell clones. J Exp Med 1994,179:1273-1283.
54. D'Andrea A, Rengaraju M, Valiante NM, et al: Production of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells. J Exp Med 1992;176:1387-1398.
55. Kobayashi M, Fitz L, Ryan M, et al: Identification and purification of natural killer cell stimulatory factor (NKSF), a cytokine with multiple biologic effects on human lymphocytes. J Exp Med 1989; 170:827-845.
56. Tripp CS, Wolf SE, Unanue ER: Interleukin-12 and tumor necrosis factor α are costimulators of interferon-γ production by natural killer cells in severe combined immunodeficiency mice with listeriosis, and interleukin 10 is a physiologic anatagonist. Proc Natl Acad Sci USA 1993;90:3725-3729.
57. Gazzmelli RT, Hieny S, Wynn TA, Wolf S, Sher A: Interleukin 12 is required for the T-lymphocyte-independent induction of interferon γ by an intracellular parasite and induces resistance in T-cell deficient hosts Proc Natl Acad Sci USA 1993,90:6115-6119.
58. Sypek JP, Chung CL, Mayor SEH, et al. Resolution of cutaneous leishmaniasis: Interleukin 12 initiates a protective T helper type 1 immune response. J Exp Med 1993;177:1797-1802.
59. Heinzel FP, Schoenhaut DS, Rerko RM, LE, Gately MK: Recombinant interleukin 12 cures mice infected with Leishinania major. J Exp Med 1993,177:1505-1509.
60. Chan SH, Perussia B, Gupta JW, et al: Induction of interferon gamma production by natural killer cell stimulatory factor: Characterization of the responder cells and synergy with other inducers. J Exp Med 1991;173.869-879.
61. Scott P: IFN-gamma modulates the early development of Th1 and Th2 responses in a murine model of leishmaniasis. J Immunol 1991;147:3149.
62. Hsieh C-S, Macatonia SE, O'Garra A, Murphy KM: Pathogen-induced Th1 phenotype development in CD4+ αβ-TCR transgenic T cells is macrophage dependent. Int Immunol 1993;5:371-382.
63. Parronchi P, De Carli M, Manetti R, et al: IL-4 and IFN (α and γ) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones. J Immunol 1992; 149:2977-2983
64. Gollob KJ, Nagelkerken L, Coffman RL: Endogenous retroviral superantigen presentation by B cells induces the development of type 1 CD4+ T helper lymphocytes. Eur J Immunol 1993;23: 2565-2571.
65. Wang ZE, Reiner SL, Zheng S, Dalton DK, Locksley RM: CD4+ effector cells default to the Th2 pathway in interferon-γ-deficient mice infected with Leishmania major J Exp Med 1994,179: 1367-1371.
66. Swihart K, Fruth U, Messmer N, et al: Mice from a genetically resistant background lacking the interferon γ receptor are susceptible to infection with Leishmania major but mount a polarized T helper cell 1-type CD4+ T cell response. J Exp Med 1995;181:961-971.
67. Wenner CA, Macatonia SA, O'Garra A, Murphy KM: Common roles for IFNα and IFNγ in promoting Th1 differentiation induced by IL-12. J Immunol 1996; in press.
68. Bradley LM, Duncan DD, Tonkonogy S, Swain SL: Characterization of antigen-specific CD4+ effector T cells in vivo. Immunization results in a transient population of Mel-14-, CD4RB - helper cells that secretes interleukin 2(IL-2), IL-3, IL-4 and interferon γ. J Exp Med 1991;174-547-559.
69. Bendelac A, Schwartz RH: CD4+ and CD8+ T cells acquire specific lymphokine secretion potentials during thymic maturation. Nature 1991;353:68-71.
70. Macatoma SE, Hosken NA, Litton M, et al: Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells J Immunol 1995;154:5071-5079.
71. Hosken NA, Shibuya K, Heath AW, Murphy KM, O'Garra A: The effect of antigen dose on CD4+ T cell phenotype development in a αβ-TCR-transgenic mouse model. J Exp Med 1995;182: 1579-1584.
72. Schmitz J, Assenmacher M, Radbruch A: Regulation of T helper cell cytokine expression. Functional dichotomy of antigen presenting cells. Eur J Immunol 1993;23:191-199.
73. Swain SL, Huston G, Tonkonogy S, Weinberg AD: Transforming growth factor beta and IL-4 cause helper T cell precursors to develop into distinct effector help cells that differ in lymphokine secretion pattern and cell surface phenotype J Immunol 1991;147:2991.
74. Nagelkerken L, Gollob K, Tielmans M, Coffman RL: Role of transforming growth factor β in the preferential induction of Th1 cells by staphyococcal enterotoxin B. Eur J Immunol 1993;23.2306.
75. Sad S, Mosmann TR. A single IL-2-secreting precursor CD4 T cell can develop into either a Th1 or Th2 secreting phenotype. J Immunol 1994;153:3514-3522
76. Barral-Netto M, Barral A, Brownell CE, et al: Transforming growth factor-β in leishmanial infection: A parasite escape mechanism. Science 1992;257:545-548.
77. Miller A, Lider O, Roberts A, Sporn MB, Weiner HL: Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor β after antigen-specific triggering. Proc Natl Acad Sci USA 1992;89:421-425.
78. Santambrogio L, Hochwald GM, Saxena B, et al: Studies on the mechanisms by which transforming growth factor-β (TGF-β) protects against allergic encephalomyelitis. J Immunol 1993;151 1116-1127.
79. Oswald JP, Gazzinelli RT, Sher A, James SL: 11-10 synergizes with IL-4 and TGF-β to inhibit macrophage cytotoxic activity J Immunol 1992;in press
80. Arthur RP, Mason D: T cells that help B cell responses to soluble antigen are distinguishable from those producing interleukin 2 on mitogenic or allogeneic stimulation J Exp Med 1986,163.744-786.
81. Kim J, Woods A, Becker-Dunn E, Bottomly K: Distinct functional phenotypes of cloned Iarestricted helper T cells. J Exp Med 1985;162:188-201
82. 2 specific T cell clones from human allergic and non-allergic individuals; Cytokine patterns change in response to the antigen concentration. Eur J Immunol 1992,22: 1357.
83. Pfeiffer C, Murray J, Madri J, Bottomly K: Selective activation of Th1- and Th2-like cells in vivo. Response to human collagen IV. Immunol Rev 1991;123:65-84
84. Jacobson NG, Szabo SJ, Weber-Nordt RM, et al: Interleukin 12 signalling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (stat)3 and Stat4. J Exp Med 1995;18:1755-1762.
85. Darnell JE, Kerr IM, Stark GR Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Science 1994;264:1415-1421.
86. Yamamoto K, Quelle FW, Thierefelder WE, et al: Sat4, a novel gamma interferon activation site-binding protein expressed in early mycloid differentiation. Mol Cell Biol 1994;14.4342-4349.
87. Zhong Z, Wen Z, Darnell JE Jr: Stat3 and stat4: Members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci USA 1994;91:4806-4810.
88. Chua AO, Chizzonite R, Desai BB, et al: Expression cloning of a human IL-12 receptor component: A new member of the cytokine receptor superfamily with strong homology to gp130. J Immunol 1994;153 128-136