Does carvedilol impair insulin sensitivity in heart failure patients without diabetes?

Journal of Cardiac Failure

Volumn 11, Issue 8, 2005, Pages 590-594

  Ferrua, Stefania ^a   Bobbio, Marco ^a,c   Catalano, Elisa ^b   Grassi, Giorgio ^a   Massobrio, Nicola ^b   Pinach, Silvia ^a   Rossi, Claudio ^b   Veglio, Massimo ^b   Trevi, Gian Paolo ^a  

^a MOLINETTE HOSPITAL   (Italy)

^b Valdese Hospital Turin   (Italy)

^c Div Universitaria di Cardiologia   (Italy)

Author keywords

Blockers; Metabolism; Oral glucose tolerance test

Indexed keywords

CARVEDILOL; GLUCOSE; GLYCOSYLATED HEMOGLOBIN; INSULIN; LIPID; LIPOPROTEIN;

ADULT; AGED; ARTICLE; CALCULATION; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG EFFECT; EVALUATION; FEMALE; GLUCOSE BLOOD LEVEL; HEART FAILURE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; INSULIN SENSITIVITY; MALE; MAXIMUM ALLOWABLE CONCENTRATION; METABOLISM; ORAL GLUCOSE TOLERANCE TEST; PARAMETERS OF MEASUREMENT AND ANALYSIS; PRIORITY JOURNAL; PROGNOSIS; STATISTICAL SIGNIFICANCE;

ADRENERGIC BETA-ANTAGONISTS; AGED; BIOLOGICAL MARKERS; BLOOD GLUCOSE; CARBAZOLES; DOSE-RESPONSE RELATIONSHIP, DRUG; FASTING; FEMALE; FOLLOW-UP STUDIES; GLUCOSE TOLERANCE TEST; HEART FAILURE, CONGESTIVE; HUMANS; INSULIN; MALE; MIDDLE AGED; PROPANOLAMINES; RESEARCH DESIGN; TREATMENT OUTCOME; VENTRICULAR DYSFUNCTION, LEFT;

EID: 26844531968     PISSN: 10719164     EISSN: 15328414     Source Type: Journal    
DOI: 10.1016/j.cardfail.2005.06.431     Document Type: Article

References (24)

1. T.W. Gress, F.J. Nieto, E. Shahar, M.R. Wofford, F.L. Brancati for the Atherosclerosis Risk in Communities Study Hypertension and antihypertensive therapy as risk factors for type 2 diabetes mellitus N Engl J Med 342 2000 905 912
2. P. Micossi, G. Pollavini, U. Raggi, M.C. Librenti, B. Garimberti, and P. Beggi Effects of metoprolol and propranolol on glucose tolerance and insulin secretion in diabetes mellitus Horm Metab Res 16 1984 59 63
3. T. Pollare, H. Lithell, I. Selinus, and C. Berne Sensitivity to insulin during treatment with atenolol and metoprolol: a randomised, double blind study of effects on carbohydrate and lipoprotein metabolism in hypertensive patients BMJ 298 1989 1152 1157
4. T. Pollare, H.O. Lithell, I. Selinus, and C. Berne Application of prazosin is associated with an increase of insulin sensitivity in obese patients with hypertension Diabetologia 31 1988 415 420
5. M.R. Bristow, E.M. Gilbert, W.T. Abraham, K.F. Adams, M.B. Fowler, R.E. Hershberger for the MOCHA Investigators Carvedilol produces dose-related improvements in left ventricular function and survival in subjects with chronic heart failure Circulation 94 1996 2807 2816
6. M. Packer, M.R. Bristow, J.N. Cohn, W.S. Colucci, M.B. Fowler, E.M. Gilbert for the US Carvedilol Heart Failure Study Group The effect of carvedilol on morbidity and mortality in patients with chronic heart failure N Engl J Med 334 1996 1349 1355
7. Australia/New Zealand Heart Failure Research Collaborative Group Randomised, placebo-controlled trial of carvedilol in patients with congestive heart failure due to ischaemic heart disease Lancet 349 1997 375 380
8. M. Packer, A.J.S. Coats, M.B. Fowler, H.A. Katus, H. Krum, and P. Mohacsi Effect of carvedilol on survival in severe chronic heart failure N Engl J Med 344 2001 1651 1658
9. P.A. Poole-Wilson, K. Swedberg, J.D. Cleland, A. Di Lenarda, P. Hanrath, and M. Komajda Carvedilol Or Metoprolol European Trial Investigators. Comparison of carvedilol and metoprolol on clinical outcomes in patients with chronic heart failure in the Carvedilol Or Metoprolol European Trial (COMET): randomized controlled trial Lancet 362 2003 7 13
10. Bruno A, Ruiu G, Leso A. HOMA e definizione di sindrome metabolica nella popolazione italiana [abstract]. 18th Congresso Nazionale SID, Il diabete 2000;12 (Suppl 1):48.
11. F. Belfiore, S. Iannello, and G. Volpicelli Insulin sensitivity indices calculated from basal and OGTT-induced insulin, glucose, and FFA levels Mol Gen Metab 63 1998 134 141
12. M. Matsuda, and R.A. De Fronzo Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycemic insulin clamp Diabetes Care 22 1999 1462 1470
13. J.W. Swan, S.D. Anker, C. Walton, I.F. Godsland, A.L. Clark, and F. Leyva Insulin resistance in chronic heart failure: relation to severity and etiology of heart failure J Am Coll Cardiol 30 1997 527 532
14. L.W.E. Sabelis, P.J. Senden, M.L. Zonderland, A. van de Wiel, J.P. Wielders, and I.A. Huisveld Determinants of insulin sensitivity in chronic heart failure Eur J Heart Failure 5 2003 759 765
15. J. Refsgaard, C. Thomsen, F. Andreasen, and O. Gøtzsche Carvedilol does not alter the insulin sensitivity in patients with congestive heart failure Eur J Heart Fail 4 2002 445 453
16. M. Pietilä, K. Malminiemi, R. Huupponen, J. Rouru, K. Pulkki, and E. Pere Celiprolol augments the effect of physical exercise on insulin sensitivity and serum lipid levels in chronic heart failure Eur J Heart Fail 2 2000 81 90
17. S. Jacob, K. Rett, M. Wicklmayr, B. Agrawal, H.J. Augustin, and G.J. Dietze Differential effect of chronic treatment with two beta-blocking agents on insulin sensitivity: the carvedilol-metoprolol study J Hypertens 14 1996 489 494
18. D. Giugliano, R. Acampora, R. Marfella, N. De Rosa, P. Ziccardi, and R. Ragone Metabolic and cardiovascular effects of carvedilol and atenolol in non-insulin-dependent diabetes mellitus and hypertension- a randomized, controlled trial Ann Intern Med 126 1997 955 959
19. B. Agrawal, and U. Stienen Long-term effect of carvedilol on lipids and blood glucose: a metaanalysis approach [abstract] Can J Cardiol 11 1995 62D
20. M. Gajdoš, V. Spustová, J. šmid, J. Opatrný, and R. Dzúrik Carvedilol does not impair insulin sensitivity and plasma lipid levels [abstract] Eur Heart J 17 1996 343
21. Bobbio M, Ferrua S, Opasich C, Porcu M, Lucci D, Scherillo M, et al.; BRING-UP Investigators. on behalf of BRING-UP Investigators. Survival and hospitalization in heart failure patients with or without diabetes treated with beta blockers. J Card Fail 2003;9:192-202.
22. S. Nodari, M. Metra, A. Dei Cas, and L. Dei Cas Efficacy and tolerability of the long-term administration of carvedilol in patients with chronic heart failure with and without concomitant diabetes mellitus Eur J of Heart Fail 5 2003 803 809
23. MERIT-HF Study Group Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet 353 1999 2001 2007
24. CIBIS II Investigators and Committees The Cardiac Insufficiency Bisoprolol Study II (CIBIS II): a randomised trial Lancet 353 1999 9 13