Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 639-641

  Kelleher, M R ^a   McGuigan, C ^b   Andrei, G ^b   Snoeck, R ^b   De Clercq, E ^b   Balzarini, J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b NONE

Author keywords

Antiviral; Furanopyrimidines; Human Cytomegalovirus

Indexed keywords

ANTIVIRUS AGENT; BICYCLO COMPOUND; FURAN DERIVATIVE; PYRIMIDINE DERIVATIVE;

ALKYLATION; ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DRUG CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; HUMAN CYTOMEGALOVIRUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VIRUS INHIBITION; VIRUS STRAIN;

ANTIVIRAL AGENTS; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; FURANS; HUMANS; LUNG; MODELS, CHEMICAL; PYRIMIDINES;

HUMAN HERPESVIRUS 5;

EID: 26644467738     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060118     Document Type: Conference Paper

References (7)

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6. McGuigan, C.; Pathirana, R.; Snoeck, R.; Andrei, G.; De Clercq, E.; Balzarini, J. Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides: action via a novel non-nucleosidic mechanism. J. Med. Chem. 2004, 47, 1847-1851.
7. Kelleher, M.R.; Bidet, O.; Carangio, A.; McGuigan, C.; Weldon, H.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Synthesis and biological evaluation of bicyclic furano pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antivir. Res. 2003, 57(A69), 100.