The journey towards elucidating the anti-HCMV activity of alkylated bicyclic furano pyrimidines

Nucleosides, Nucleotides and Nucleic Acids

Volumn 24, Issue 5-7, 2005, Pages 643-645

  Kelleher, M R ^a   McGuigan, C ^a   Bidet, O ^a   Carangio, A ^a   Weldon, H ^a   Andrei, G ^b   Snoeck, R ^b   De Clercq, E ^b   Balzarini, J ^b  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Antiviral; Furanopyrimidines; Human Cytomegalovirus

Indexed keywords

ALKYL GROUP; ANTIVIRUS AGENT; BICYCLO COMPOUND; PYRIMIDINE DERIVATIVE;

ALKYLATION; ANTIVIRAL ACTIVITY; CONFERENCE PAPER; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; HUMAN CYTOMEGALOVIRUS; NONHUMAN; STRUCTURE ACTIVITY RELATION; VARICELLA ZOSTER VIRUS;

ANTIVIRAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; DRUG DESIGN; FURANS; HUMANS; MODELS, CHEMICAL; PHOSPHORYLATION; PYRIMIDINE NUCLEOSIDES; PYRIMIDINES;

HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 5;

EID: 26644433205     PISSN: 15257770     EISSN: 15322335     Source Type: Journal    
DOI: 10.1081/NCN-200060122     Document Type: Conference Paper

References (7)

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4. McGuigan, C.; Barucki, H.; Blewett, S.; Carangio, A.; Erichsen, J.T.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Extremely potent and selective inhibition of Varicella-Zoster virus (VZV) by bicyclic furo pyrimidine nucleosides with aryl side-chains. J. Med. Chem. 2000, 43, 4993-4997.
5. McGuigan, C.; Pathirana, R.; Snoeck, R.; Andrei, G.; De Clercq, E.; Balzarini, J. Discovery of a new family of inhibitors of human cytomegalovirus (HCMV) based upon lipophilic alkyl furano pyrimidine dideoxy nucleosides. J. Med. Chem. 2004, 47, 1847-1851.
6. Kelleher, M.R.; Bidet, O.; Carangio, A.; McGuigan, C.; Weldon, H.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. Synthesis and biological evaluation of bicyclic furano pyrimidine nucleosides as inhibitors of human cytomegalovirus. Antivir. Res. 2003, 57, pp. A69, 100.
7. Kelleher, M.R.; Bidet, O.; Carangio, A.; McGuigan, C.; Weldon, H.; Andrei, G.; Snoeck, R.; De Clercq, E.; Balzarini, J. In Synthesis and biological evaluation of N- and O-alkylated bicyclic furanopyrimidines as non-nucleosidic inhibitors of human cytomegalovirus, Presented at the XVI International Roundtable, Minneapolis, Minnesota.