Antidepressant-like and antinociceptive-like actions of 4-(4′-chlorophenyl)-6-(4″-methylphenyl)-2-hydrazinepyrimidine Mannich base in mice

Pharmacology Biochemistry and Behavior

Volumn 82, Issue 1, 2005, Pages 156-162

  Rodrigues, A L S ^a   Rosa, J M ^a   Gadotti, V M ^a   Goulart, E C ^b   Santos, M M ^b   Silva, A V ^b   Sehnem, B ^c   Rosa, L S ^c   Goncalves R M ^c   Correa R ^c   Santos, A R S ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

^b UNIVERSITY OF SOUTHERN SANTA CATARINA   (Brazil)

^c UNIVERSIDADE DO VALE DO ITAJAÍ   (Brazil)

Author keywords

Antidepressant; Forced swimming test; Mannich base; Monoaminergic system; Writhing test

Indexed keywords

4 (4' CHLOROPHENYL) 6 (4'' METHYLPHENYL) 2 HYDRAZINEPYRIMIDINE; ACETIC ACID; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ALPHA2 ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIDEPRESSANT AGENT; ANTINOCICEPTIVE AGENT; ARGININE; DOPAMINE 2 RECEPTOR BLOCKING AGENT; MANNICH BASE; METHYSERGIDE; NALOXONE; NITRIC OXIDE DONOR; OPIATE ANTAGONIST; SEROTONIN ANTAGONIST; SULPIRIDE; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOPAMINERGIC ACTIVITY; DOSE RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; FEMALE; FORCED SWIMMING TEST; INHIBITION KINETICS; MALE; MOUSE; NEUROPHARMACOLOGY; NONHUMAN; NORADRENERGIC SYSTEM; OPEN FIELD BEHAVIOR; PRIORITY JOURNAL; SEROTONINERGIC SYSTEM; WRITHING TEST;

ABDOMEN; ACETIC ACID; ANALGESICS; ANIMALS; ANTIDEPRESSIVE AGENTS; BEHAVIOR, ANIMAL; FEMALE; HYDRAZINES; MALE; MICE; PYRIMIDINES; SWIMMING;

EID: 26444581321     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2005.08.003     Document Type: Article

References (36)

1. J.F. Cryan, A. Markou, and I. Lucki Assessing antidepressant activity in rodents: recent developments and future needs Trends Pharmacol Sci 23 2002 238 245
2. S.R. Currie, and J. Wang Chronic back pain and major depression in the general Canadian population Pain 107 2004 54 60
3. G. Da Silva, A. Matteussi, A.R.S. Santos, J.B. Calixto, and A.L.S. Rodrigues Evidence for dual effects of nitric oxide in the forced swimming test and in the tail suspension test in mice Neuroreport 11 2000 3699 3702
4. J.R. Dimmock, and P. Kumar Anticancer and cytotoxic properties of Mannich bases Curr Med Chem 4 1997 1 22
5. J.R. Dimmock, K.M. Advikolanu, H.E. Scott, M.J. Duffy, R.S. Reid, and J.W. Quail Evaluation of cytotoxicity of some Mannich bases of various aryl and arylidene ketones and their corresponding arylhydrazones J Pharm Sci 81 1992 1147 1152
6. J.R. Dimmock, N.M. Kandepu, M. Hetherington, J.W. Quail, U. Pugazhenthi, and A.M. Sudom Cytotoxic activities of Mannich bases of chalcones and related compounds J Med Chem 41 1998 1014 1026
7. A.S. Elhwuegi Central monoamines and their role in major depression Prog Neuropsychopharmacol Biol Psychiatry 28 2004 435 451
8. E. Erciyas, H.I. Erkaleli, and G. Cosar Antimicrobial evaluation of some styryl ketone derivatives and related thiol adducts J Pharm Sci 83 1994 545 548
9. H. Fillion, M. Porte, M.H. Bartoli, Z. Bouaziz, M. Berlion, and J. Villard Synthesis of Mannich bases of 5-hydroxynapthalene-1,8-carbolactone as potential antifungal or antitumor agents Chem Pharm Bull 39 1991 493 495
10. M. Gul, H.I. Gul, J. Vepsalainen, E. Erciyas, and O. Hanninen Cytotoxic activities of mono and bis Mannich bases derived from acetophenone against Renca and Jurkat cells Pharm Acta Helv 74 2000 393 398
11. H.I. Gul, U. Calis, and J. Vepsalainen Synthesis and evaluation of anticonvulsant activities of some bis Mannich bases and corresponding piperidinols Arzneimittelforschung 52 2002 863 869
12. M. Gutierrez, A. Ortega-Alvaro, J. Gibert-Rahola, and J.A. Mico Interactions of acute morphine with chronic imipramine and fluvoxamine treatment on the antinociceptive effect in arthritic rats Neurosci Lett 352 2003 37 40
13. A.J. Harkin, K.H. Bruce, B. Craft, and I.A. Paul Nitric oxide synthase inhibitors have antidepressant-like properties in mice: 1. Acute treatments are active in the forced swim test Eur J Pharmacol 372 1999 207 213
14. M. Maes, H.Y. Meltzer, P. D'Hondt, P. Cosyns, and P. Blockx Effects of serotonin precursors on the negative feedback effects of glucocorticoids on hypothalamic-pituitary-adrenal axis function in depression Psychoneuroendocrinology 20 1995 149 167
15. H. Meltzer, B. Bastani, K. Jayathilake, and M. Maes Fluoxetine, but not tricyclic antidepressants, potentiates the 5-hydroxytryptophan-mediated increase in plasma cortisol and prolactin secretion in subjects with major depression or with obsessive compulsive disorder Neuropsychopharmacology 17 1997 1 11
16. M.J. Millan Descending control of pain Prog Neurobiol 66 2002 355 474
17. J.B. Murray Depression in Parkinson's disease J Psychol 130 1996 659 667
18. C.J. Murray, and A.D. Lopez Global mortality, disability, and the contribution of risk factors: Global Burd. Dis. Study Lancet 349 1997 1436 1442
19. 2 receptor antagonist sulpiride causes long-lasting serotonin release Eur J Pharmacol 363 1998 29 34
20. M.F. O'Neill, D.J. Osborne, S.M. Woodhouse, and M.W. Conway Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice J Psychopharmacol 15 2001 18 22
21. M.J. Owens, and C.B. Nemeroff Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter Clin Chem 40 1994 288 295
22. S.N. Pandeya, D. Sriram, G. Nath, and E. de Clercq Synthesis and antimicrobial activity of Schiff and Mannich bases of isatin and its derivatives with pyrimidine Il Farmaco 54 1999 624 628
23. S.N. Pandeya, D. Sriram, G. Nath, and E. de Clercq Synthesis, antibacterial, antifungal and anti-HIV evaluation of Schiff and Mannich bases of isatin and its derivatives with triazole Arzneimittelforschung 50 2000 55 59
24. R.V. Parsey, M.A. Oquendo, Y. Zea-Ponce, J. Rodenhiser, L.S. Kegeles, and M. Pratap Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression Biol Psychiatry 50 2001 313 322
25. T. Pincus, A.C.C. Williams, S. Vogel, and A. Field The development and testing of the depression, anxiety, and positive outlook scale (DAPOS) Pain 109 2004 181 188
26. R.D. Porsolt, A. Bertin, and M. Jalfre Behavioral despair in mice: a primary screening test for antidepressants Arch Int Pharmacodyn Ther 229 1977 327 336
27. A.L. Rodrigues, J.B. Rocha, C.F. Mello, and D.O. Souza Effect of perinatal lead exposure on rat behavior in open-field and two-way avoidance tasks Pharmacol Toxicol 79 1996 150 156
28. M.O. Rojas-Corrales, J. Casas, M.R. Moreno-Brea, J. Gibert-Rahola, and J.A. Mico Antinociceptive effects of tricyclic antidepressants and their noradrenergic metabolites Eur Neuropsychopharmacol 13 2003 355 363
29. A.O. Rosa, J. Lin, J.B. Calixto, A.R.S. Santos, and A.L.S. Rodrigues Involvement of NMDA receptors and l-arginine-nitric oxide pathway in the antidepressant-like effects of zinc in mice Behav Brain Res 144 2003 87 93
30. A.R. Santos, O.G. Miguel, R.A. Yunes, and J.B. Calixto Antinociceptive properties of the new alkaloid, cis-8, 10-di-N-propyllobelidiol hydrochloride dihydrate isolated from Siphocampylus verticillatus: evidence for the mechanism of action J Pharmacol Exp Ther 289 1999 417 426
31. V.P. Singh, N.K. Jain, and S.K. Kulkarni On the antinociceptive effect of fluoxetine, a selective serotonin reuptake inhibitor Brain Res 915 2001 218 226
32. S.K. Sridhar, and A. Ramesh Synthesis and pharmacological activities of hydrazones, Schiff and Mannich bases of isatin derivatives Biol Pharm Bull 24 2001 1149 1152
33. V. Volke, G. Wegener, M. Bourin, and E. Vasar Antidepressant- and anxiolytic-like effects of selective neuronal NOS inhibitor 1-(2- trifluoromethylphenyl)-imidazole in mice Behav Brain Res 18:140 2003 141 147
34. P. Willner Animal models of depression: validity and applications Adv Biochem Psychopharmacol 49 1995 19 41
35. D.T. Wong, and F.P. Bymaster Dual serotonin and noradrenaline uptake inhibitor class of antidepressants - potential for greater efficacy or just hype? Prog Drug Res 58 2002 169 222
36. A.D. Zomkowski, L. Hammes, J. Lin, J.B. Calixto, A.R. Santos, and A.L. Rodrigues Agmatine produces antidepressant-like effects in two models of depression in mice Neuroreport 13 2002 387 391