Selective imidazoline I2 ligands do not show antidepressant-like activity in the forced swim test in mice

Journal of Psychopharmacology

Volumn 15, Issue 1, 2001, Pages 18-22

  O'Neill, Michael F ^a   Osborne, David J ^a   Woodhouse, Sandra M ^a   Conway, Michael W ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

BDF 8082; BU224; BU239; Clonidine; Forced swim test; Imidazoline receptors; Mice

Indexed keywords

2 (2 IMIDAZOLIN 2 YL)QUINOLINE; ANTIDEPRESSANT AGENT; CLONIDINE; IMIDAZOLE DERIVATIVE; LIGAND; TRICYCLIC ANTIDEPRESSANT AGENT; 2 (2 IMIDAZOLIN 2 YL)QUINOXALINE; 4 CHLORO 2 (2 IMIDAZOLINE)ISOINDOLINE; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; AMINE OXIDASE (FLAVIN CONTAINING); BDF 8082; IDAZOXAN; IMIDAZOLINE I2 RECEPTOR; IMIPRAMINE; UNCLASSIFIED DRUG; YOHIMBINE;

ANIMAL; ARTICLE; BRAIN; FEMALE; METABOLISM; MOUSE; MOUSE STRAIN; PSYCHOLOGICAL ASPECT; SWIMMING; ANIMAL EXPERIMENT; ANIMAL TISSUE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG BRAIN LEVEL; DRUG EFFECT; FORCED SWIMMING TEST; IMMOBILIZATION; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMALS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BRAIN; CLONIDINE; FEMALE; IMIDAZOLES; LIGANDS; MICE; MICE, INBRED STRAINS; SWIMMING;

EID: 0034745152     PISSN: 02698811     EISSN: None     Source Type: Journal    
DOI: 10.1177/026988110101500104     Document Type: Article

References (19)

1. Clonidine as a sensitizing agent in the forced swimming test for revealing antidepressant activity
2. Clinical and biochemical aspects of depressive disorders: II. Transmitter/receptor theories
3. Clonidine causes antidepressant-like effects in rats by activating alpha 2-adrenoceptors outside the locus coeruleus
4. The role of serotonin and dopamine in brain in the anti-depressant-like effect of clonidine in the forced swimming test
5. 2 receptors
6. 'Seeing through a glass darkly': Casting light on imidazoline 'I' sites
7. 2-adrenoceptors in the ventrolateral medulla
8. Heterogeneity of imidazoline binding sites: Proposed I-1 and I-2 subtypes
9. Pharmacologic characterization of imidazoline receptor proteins identified by immunologic techniques and other methods
10. Mechanism of action of antidepressant medications
11. Imidazoline receptors and human brain disorders
12. Affinity and selectivity for BU224 and BU239 for rabbit brain non-adrenoceptor idazoxan binding sites (I-2-sites)
13. The central bioavailability of selective imidazoline2 site ligands BU224 and BU239
14. Functional studies of specific Imidazoline-2 receptor Ligands
15. Behavioural despair in rats: A new model sensitive to antidepressant treatments
16. 2 specific ligands in vitro
17. The stimulatory effect of clonidine through imidazoline receptors on locus coeruleus noradrenergic neurones is mediated by excitatory amino acids and modulated by serotonin
18. Animal models as simulations of depression
19. No evidence for functional imidazoline receptors on locus coeruleus neurons