The lrp gene and its role in type I fimbriation in Citrobacter rodentium

Journal of Bacteriology

Volumn 187, Issue 20, 2005, Pages 7009-7017

  Cordone, Angela ^a   Mauriello, Emilia M F ^a   Pickard, Derek J ^b   Dougan, Gordon ^b   De Felice, Maurilio ^a   Ricca, Ezio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LEUCINE RESPONSIVE REGULATORY PROTEIN; REGULATOR PROTEIN; UNCLASSIFIED DRUG; VIRULENCE FACTOR;

ARTICLE; BACTERIUM PILUS; CITROBACTER RODENTIUM; FIMAICDFGH OPERON; FIMBRIA; GASTROINTESTINAL INFECTION; GENE; GENE EXPRESSION REGULATION; GENE LOCUS; IN VIVO STUDY; LEE ISLAND; LRP GENE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPERON; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REPRESSOR GENE; SEQUENCE HOMOLOGY; STRUCTURAL GENE; TRANSCRIPTION REGULATION;

CITROBACTER RODENTIUM; DNA-BINDING PROTEINS; ESCHERICHIA COLI PROTEINS; FIMBRIAE, BACTERIAL; GENE EXPRESSION REGULATION, BACTERIAL; LEUCINE-RESPONSIVE REGULATORY PROTEIN; MUTATION; OPERON; PHENOTYPE; TRANSCRIPTION FACTORS; VIRULENCE; VIRULENCE FACTORS;

BACTERIA (MICROORGANISMS); CITROBACTER RODENTIUM; ENTEROBACTERIA; ESCHERICHIA COLI; MURINAE;

EID: 26444568677     PISSN: 00219193     EISSN: None     Source Type: Journal    
DOI: 10.1128/JB.187.20.7009-7017.2005     Document Type: Article

References (28)

1. Brinkman, A. B., T. J. Ettema, W. M. de Vos, and J. van der Oost. 2003. The Lrp family of transcriptional regulators. Mol. Microbiol. 48:287-294.
2. Calvo, J. M., and R. G. Matthews. 1994. The leucine-responsive regulatory protein, a global regulator of metabolism in Escherichia coli. Microbiol. Rev. 58:466-490.
3. Camacho, E. M., and J. Casadesus. 2002. Conjugal transfer of the virulence plasmid of Salmonella enterica is regulated by the leucine-responsive regulatory protein and DNA adenine methylation. Mol. Microbiol. 44:1589-1598.
4. Datsenko, K. A., and B. L. Wanner. 2000. One-step inactivation of chromosomal genes in Escherichia coli K-12 using PCR products. Proc. Natl. Acad. Sci. USA 97:6640-6645.
5. Ernsting, B. R., M. R. Atkinson, A. J. Ninfa, and R. G. Matthews. 1992. Characterization of the regulon controlled by the leucine-responsive regulatory protein in Escherichia coli. J. Bacteriol. 174:1109-1118.
6. Friedberg, D., M. Midkiff, and J. M. Calvo. 2001. Global versus local regulatory roles for Lrp-related proteins: Haemophilus influenzae as a case study. J. Bacteriol. 183:4004-4011.
7. Gally, D. L., T. J. Rucker, and I. C. Blomfield. 1994. The leucine-responsive regulatory protein binds to the fim switch to control phase variation of type 1 fimbrial expression in Escherichia coli K-12. J. Bacteriol. 176:5665-5672.
8. Hay, N. A., D. J. Tipper, D. Gygi, and C. Hughes. 1997. A nonswarming mutant of Proteus mirabilis lacks the Lrp global transcriptional regulator. J. Bacteriol. 179:4741-4746.
9. Hess, P., A. Altenhofer, S. A. Khan, N. Daryab, K. S. Kim, J. Hacker, and T. A. Oelschlaeger. 2004. A Salmonella fim homologue in Citrobacter freundii mediates invasion in vitro and crossing of the blood-barrier in the rat pup model. Infect. Immun. 72:5298-5307.
10. Hung, S. P., P. Baldi, and G. W. Hatfield. 2002. Global gene expression profiling in Escherichia coli K12. The effects of leucine-responsive regulatory protein. J. Biol. Chem. 277:40309-40323.
11. Jafri, S., S. Evoy, K. Cho, H. G. Craighead, and S. C. Winans. 1999. An Lrp-type transcriptional regulator from Agrobacterium tumefaciens condenses more than 100 nucleotides of DNA into globular nucleoprotein complexes. J. Mol. Biol. 288:811-824.
12. Luperchio, S. A., and D. B. Schauer. 2001. Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia. Microbes Infect. 3:333-340.
13. Madhusudhan, K. T., N. Huang, and J. R. Sokatch. 1995. Characterization of BkdR DNA binding in the expression of the bkd operon of Pseudomonas putida. J. Bacteriol. 177:636-641.
14. Mahan, M. J., D. M. Heithoff, R. L. Sinsheimer, and D. A. Low. 2000. Assessment of bacterial pathogenesis by analysis of gene expression in the host. Annu. Rev. Genet. 34:139-164.
15. Marshall, D. G., B. J. Sheehan, and C. J. Dorman. 1999. A role for the leucine-responsive regulatory protein and integration host factor in the regulation of the Salmonella plasmid virulence (spv) locus in Salmonella typhimurium. Mol. Microbiol. 34:134-145.
16. Napoli, A., J. van der Oost, C. W. Sensen, R. L. Charlebois, M. Rossi, and M. Ciaramella. 1999. An Lrp-like protein of the hyperthermophilic archacon Sulfolobus solfataricus which binds to its own promoter. J. Bacteriol. 181: 1474-1480.
17. Newman, E. B., and R. Lin. 1995. Leucine-responsive regulatory protein: a global regulator of gene expression in E. coli. Annu. Rev. Microbiol. 49:747-775.
18. Platko, J. V., D. A. Willins, and J. M. Calvo. 1990. The ilvIH operon of Escherichia coli is positively regulated. J. Bacteriol. 172:4563-4570.
19. Roesch, P. L., and I. C. Blomfield. 1998. Leucine alters the interaction of the leucine-responsive regulatory protein (Lrp) with the fim switch to stimulate site-specific recombination in Escherichia coli. Mol. Microbiol. 27:751-761.
20. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N. Y.
21. Schwan, W. R., H. S. Seifert, and J. L. Duncan. 1992. Growth conditions mediate differential transcription of fim genes involved in phase variation of type I pili. J. Bacteriol. 174:2367-2375.
22. Sohanpal, B. K., H. D. Kulasekara, A. Bonnen, and I. C. Blomfield. 2001. Orientational control of fimE expression in Escherichia coli Mol. Microbiol. 42:483-494.
23. Stentebjerg-Olsen, B., T. Chakraborty, and P. Klemm. 2000. FimE-catalyzed off-to-on inversion of the type I fimbrial phase variation and insertion sequence recruitment in an Escherichia coli K-12 fimB strain. FEMS Microbiol. Lett. 182:319-325.
24. Tani, T. H., A. Khodursky, R. M. Blumenthal, P. O. Brown, and R. G. Matthews. 2002. Adaptation to famine: a family of stationary-phase genes revealed by microarray analysis. Proc. Natl. Acad. Sci. USA 99:13471-13476.
25. Wang, Q., J. Wu, D. Friedberg, J. Plakto, J. Calvo. 1994. Regulation of the Escherichia coli lrp gene. J. Bacteriol. 176:1831-1839.
26. Wiles, S., S. Clare, J. Harker, A. Huett, D. Young, G. Dougan, and G. Frankel. 2004. Organ specificity, colonization and clearance dynamics in vivo following oral challenges with the murine pathogen Citrobacter rodentium. Cell Microbiol. 6:963-972.
27. Willins, D. A., C. W. Ryan, J. V. Platko, and J. M. Calvo. 1991. Characterization of Lrp, and Escherichia coli regulatory protein that mediates a global response to leucine. J. Biol. Chem. 266:10768-10774.
28. Wilson, K. J., R. A. Jefferson, and S.G. Hughes. 1992. The Escherichia coli gus operon: induction and expression of the gus operon in E. coli and the occurrence and use of GUS in other bacteria, p. 7-23. In S. R. Gallagher (ed.), GUS protocols: using the GUS gene as a reporter of gene expression. Academic Press, Inc., San Diego, Calif.