Increased expression and processing of ADAM 12 (meltrin-α) in osteolysis associated with aseptic loosening of total hip replacement implants

Journal of Rheumatology

Volumn 32, Issue 10, 2005, Pages 1943-1950

  Ma, Guofeng ^a   Ainola, Mari ^b   Liljeström, Mikko ^b   Santavirta, Seppo ^a   Poduval, Praseet ^a   Zhao, Desheng ^a   Chen, Tong ^a   Konttinen, Yrjö T ^a  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

ADAM 12; Cell fusion; Giant cell; Osteoclast; Synovial membrane; Total hip replacement

Indexed keywords

DISINTEGRIN; MELTRIN ALPHA; MESSENGER RNA; METALLOPROTEINASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN ADAM 12; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CELL FUSION; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; GIANT CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOFLUORESCENCE; MALE; MONONUCLEAR CELL; MULTINUCLEAR CELL; MYOBLAST; NUCLEOTIDE SEQUENCE; OSTEOLYSIS; PRIORITY JOURNAL; PROSTHESIS LOOSENING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; STAINING; SYNOVIUM; TOTAL HIP PROSTHESIS; WESTERN BLOTTING;

ADAM PROTEINS; AGED; AGED, 80 AND OVER; ARTHROPLASTY, REPLACEMENT, HIP; BONE RESORPTION; CARRIER PROTEINS; CELLS, CULTURED; FEMALE; GIANT CELLS; HIP PROSTHESIS; HUMANS; LEUKOCYTES, MONONUCLEAR; MACROPHAGE COLONY-STIMULATING FACTOR; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE PROTEINS; MIDDLE AGED; MONOCYTES; OSTEOCLASTS; OSTEOLYSIS; PROSTHESIS FAILURE; RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; RNA, MESSENGER;

EID: 26444506230     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Tipper JL, Ingham E, Hailey JL, et al. Quantitative analysis of polyethylene wear debris, wear rate and head damage in retrieved Chamley hip prostheses. J Mater Sci Mater Med 2000;11:117-24.
2. Goodman SB, Lind M, Song Y, Smith RL. In vitro, in vivo, and tissue retrieval studies on particulate debris. Clin Orthop 1998;352:25-34.
3. Lassus J, Salo J, Jiranek WA, et al. Macrophage activation results in bone resorption. Clin Orthop 1998;352:7-15.
4. Jiranek WA, Machado M, Jasty M, et al. Production of cytokines around loosened cemented acetabular components. Analysis with immunohistochemical techniques and in situ hybridization. J Bone Joint Surg Am 1993;75:863-79.
5. Itonaga I, Sabokbar A, Murray DW, Athanasou NA. Effect of osteoprotegerin and osteoprotegerin ligand on osteoclast formation by arthroplasty membrane derived macrophages. Ann Rheum Dis 2000;59:26-31.
6. Childs LM, Paschalis EP, Xing L, et al. In vivo RANK signaling blockade using the receptor activator of NF-kappa-B:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res 2002;17:192-9.
7. Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res 2002;20:169-73.
8. Ma J, Chen T, Mandelin J, et al. Regulation of macrophage activation. Cell Mol Life Sci 2003;60:2334-46.
9. Wolfsberg TG, Primakoff P, Myles DG, White JM. ADAM, a novel family of membrane proteins containing a disintegrin and metalloprotease domain: multipotential functions in cell-cell and cell-matrix interactions. J Cell Biol 1995;131:275-8.
10. Zolkiewska A. Disintegrin-like/cysteine-rich region of ADAM 12 is an active cell adhesion domain. Exp Cell Res 1999;252:423-31.
11. Eto K, Puzon-McLaughlin W, Sheppard D, Sehara-Fujisawa A, Zhang XP, Takada Y. RGD-independent binding of integrin alpha-9-beta-1 to the ADAM-12 and -15 disintegrin domains mediates cell-cell interaction. J Biol Chem 2000;275:34922-30.
12. Iba K, Albrechtsen R, Gilpin BJ, Loechel F, Wewer UM. Cysteine-rich domain of human ADAM 12 (meltrin α) supports tumor cell invasion. Am J Pathol 1999;154:1489-501.
13. Iba K, Albrechtsen R, Gilpin B, et al. The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta-1 integrin-dependent cell spreading. J Cell Biol 2000;149:1143-56.
14. Huovila AP, Almeida EA, White JM. ADAMs and cell fusion. Curr Opin Cell Biol 1996;8:692-9.
15. Kang Q, Cao Y, Zolkiewska A. Direct interaction between the cytoplasmic tail of ADAM 12 and the Src homology 3 domain of p85-alpha activates phosphatidylinositol 3-kinase in C2C12 cells. J Biol Chem 2001;276:24466-72.
16. Galliano MF, Huet C, Frygelius J, Polgren A, Wewer UM, Engvall E. Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha-actinin-2, is required for myoblast fusion. J Biol Chem 2000;275:13933-9.
17. Cao Y, Kang Q, Zolkiewska A. Metalloprotease-disintegrin ADAM 12 interacts with alpha-actinin-1. Biochem J 2001;357:353-61.
18. Kawaguchi N, Sundberg C, Kveiborg M, et al. ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta-1 integrin function. J Cell Sci 2003;116:3893-904.
19. Paloneva J, Mandelin J, Kiialainen A, et al. DAP12/TREM2 deficiency results in impaired osteoclast differentiation and osteoporotic features. J Exp Med 2003;198:669-75.
20. Mandelin J, Liljestrom M, Li TF, et al. Pseudosynovial fluid from loosened total hip prosthesis induces osteoclast formation. J Biomed Mater Res B Appl Biomater 2005;74:582-8.
21. Tian BL, Wen JM, Zhang M, Xie D, Xui RB, Luo CJ. The expression of ADAM 12 (meltrin α) in human giant cell tumours of bone. J Clin Pathol Mol Pathol 2002;55:394-7.
22. Abe E, Mocharla H, Yamate T, Taguchi Y, Manolagas SC. Meltrin-α, a fusion protein involved in multinucleated giant cell and osteoclast formation. Calcif Tissue Int 1999;64:508-15.
23. Farber A, Chin R, Song Y, Huie P, Goodman S. Chronic antigen-specific immune-system activation may potentially be involved in the loosening of cemented acetabular components. J Biomed Mater Res 2001;55:433-41.
24. Hallab NJ, Anderson S, Stafford T, Giant T, Jacobs JJ. Lymphocyte responses in patients with total hip arthroplasty. J Orthop Res 2005;23:384-91.
25. Weyand CM, Geisler A, Brack A, Bolander ME, Goronzy JJ. Oligoclonal T-cell proliferation and interferon-gamma production in periprosthetic inflammation. Lab Invest 1998;78:677-85.
26. Wilder RL. Integrin alpha V beta 3 as a target for treatment of rheumatoid arthritis and related rheumatic diseases. Ann Rheum Dis 2002;61 Suppl 2:96-9.
27. Becherer JD, Blobel CP. Biochemical properties and functions of membrane-anchored metalloprotease-disintegrin proteins (ADAMs). Curr Top Dev Biol 2003;54:101-23.
28. Seals DF, Courtneidge SA. The ADAMs family of metalloproteases: multidomain proteins with multiple functions. Genes Dev 2003;17:7-30.
29. Yagami-Hiromasa T, Sato T, Kurisaki T, Kamijo K, Nabeshima Y, Fujisawa-Sehara A. A metalloprotease-disintegrin participating in myoblast fusion. Nature 1995;377:652-6.