Autistic effector T cells in mice with a point mutation in the LAT adaptor fail to respond to Listeria monocytogenes infection

International Immunology

Volumn 17, Issue 7, 2005, Pages 951-957

  Prinz, Immo ^a,b   Kursar, Mischo ^a,b   Mittrücker, Hans Willi ^b   Aguado, Enrique ^b,c   Steinhoff, Ulrich ^b   Kaufmann, Stefan H E ^b   Malissen, Bernard ^a  

^a CENTRE D IMMUNOLOGIE DE MARSEILLE LUMINY   (France)

^b MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^c UNIVERSITY OF MURCIA   (Spain)

Author keywords

LatY136F mutation; Linker for activation of T cells (LAT); Listeria monocytogens; Signal transduction; T cell activation; Th1 Th2 cells

Indexed keywords

CD4 ANTIGEN; CD8 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 4; LAT PROTEIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANTIGEN SPECIFICITY; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EFFECTOR CELL; LISTERIA MONOCYTOGENES; LISTERIOSIS; MOUSE; MOUSE STRAIN; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION; TH1 CELL; TH2 CELL; WILD TYPE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; LYMPHOCYTE ACTIVATION; MEMBRANE PROTEINS; MICE; MICE, MUTANT STRAINS; PHOSPHOPROTEINS; POINT MUTATION; T-LYMPHOCYTES;

EID: 26444497181     PISSN: 09538178     EISSN: 14602377     Source Type: Journal    
DOI: 10.1093/intimm/dxh276     Document Type: Article

References (17)

1. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R. P. and Samelson, L. E. 1998. LAT. the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell92:83.
2. Zhang, W., Irvin, B. J., Trible, R. P., Abraham, R. T. and Samelson, L. E. 1999. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT deficient Jurkat cell line. Int. Immunol. 11:943.
3. Lin, J. and Weiss, A. 2001. Identification of the minimal tyrosine residues required for linker for activation of T cell function. J. Biol. Chem. 276:29588.
4. Zhang, W., Trible, R. P., Zhu, M., Liu, S. K., McGlade, C. J. and Samelson, L. E. 2000. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J. Biol. Chem. 275:23355.
5. Zhang, W., Sommers, C. L., Burshtyn, D. N. et al. 1999. Essential role of LAT in T cell development. Immunity 10:323.
6. Aguado, E., Richelme, S., Nunez-Cruz, S. et al. 2002. Induction of T helper type 2 immunity by a point mutation in the LAT adaptor. Science 296:2036.
7. Sommers, C. L., Park, C. S., Lee, J. et al. 2002. A LAT mutation that inhibits T cell development yet induces lymphoproliferation. Science 296:2040.
8. Kaufmann, S. H. 1993. Immunity to intracellular bacteria. Annu. Rev. Immunol. 11:129.
9. Mittrucker, H. W., Kohler, A. and Kaufmann, S. H. 2000. Substantial in vivo proliferation of CD4(+) and CD8(+) T lymphocytes during secondary Listeria monocytogenes infection. Eur. J. Immunol. 30:1053.
10. Foulds, K. E., Zenewicz, L. A., Shedlock, D. J., Jiang, J., Troy, A. E. and Shen, H. 2002. Cutting edge: CD4 and CD8 T cells are intrinsically different in their proliferative responses. J. Immunol. 168:1528.
11. Mittrucker, H. W., Kursar, M., Kohler, A., Hurwitz, R. and Kaufmann, S. H. 2001. Role of CD28 for the generation and expansion of antigen-specific CD8(+) T lymphocytes during infection with Listeria monocytogenes. J. Immunol. 167:5620.
12. Skoberne, M., Schenk, S., Hof, H. and Geginat, G. 2002. Cross-presentation of Listeria monocytogenes-derived CD4 T cell epitopes. J. Immunol. 169:1410.
13. Grogan, J. L. and Locksley, R. M. 2002. T helper cell differentiation: on again, off again. Curr. Opin. Immunol. 14:366.
14. Ho, I. C. and Glimcher, L. H. 2002. Transcription: Tantalizing times for T cells. Cell 109(Suppl.):S109.
15. Murphy, K. M. and Reiner, S. L. 2002. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2:933.
16. Dennehy, K. M., Kerstan, A., Bischof, A., Park, J. H., Na, S. Y. and Hunig, T. 2003. Mitogenic signals through CD28 activate the protein kinase Ctheta-NF-kappaB pathway in primary peripheral T cells. Int. Immunol. 15:655.
17. Vivier, E. and Malissen, B. 2005. Innate and adaptive immunity: specificities and signaling hierarchies revisited. Nat. Immunol. 6:17.