Ku antigen binds to Alu family DNA

Journal of Biochemistry

Volumn 123, Issue 1, 1998, Pages 120-127

  Tsuchiya, Takayuki ^a   Saëgusa, Yumiko ^a   Taira, Takahiro ^a   Mimori, Tsuneyo ^b   Iguchi Ariga, Sanae M M ^a   Ariga, Hiroyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KEIO UNIVERSITY   (Japan)

Author keywords

Alu family DNA; Ku antigen

Indexed keywords

ANTIGEN; CHYMOTRYPSIN; DNA BINDING PROTEIN; DNA DIRECTED RNA POLYMERASE III; TRYPSIN;

ALU SEQUENCE; ANTIGEN BINDING; ARTICLE; DNA BINDING; HELA CELL; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; PROTEIN PURIFICATION; RAJI CELL;

EID: 2642708352     PISSN: 0021924X     EISSN: None     Source Type: Journal    
DOI: 10.1093/oxfordjournals.jbchem.a021898     Document Type: Article

References (59)

1. Rohrbaugh, M.L., Johnson III, J.E., James, M.D., and Hardison, R.C. (1985) Transcription unit of the rabbit β1 globin gene. Mol. Cell. Biol. 9, 355-364
2. Allan, M. and Paul, J. (1984) Transcription in vivo of an Alu family member upstream from the human ε-globin gene. Nucleic Acids Res. 12, 1193-1200
3. Aronow, B., Silbiger, R.N., Dusing, M.R., Stock, J.L., Yager, K.L., Potter, S.S., Hutton, J., and Wiginton, D.A. (1992) Functional analysis of the human adenosine deaminase gene thymic regulatory region and its ability to generate position independent transgene expression. Mol. Cell. Biol. 12, 4170-4185
4. Hambor, J.E., Mennone, J., Coon, M.E., Hanke, J.H., and Kavathas, P. (1993) Identification and characterization of an Alu-containing, T-cell-specific enhancer located in the last intron of the human CD8a gene. Mol. Cell. Biol. 13, 7056-7070
5. Brini, A.T., Lee, G.M., and Kinet, J.-P. (1993) Involvement of Alu sequences in the cell-specific regulation of transcription of the g chain of Fc and T cell receptors. J. Biol. Chem. 268, 1355-1361
6. Thorey, I.S., Cecena, G., Reynold, W., and Oshima, R.G. (1993) Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice. Mol. Cell. Biol. 13, 6742-6751
7. Saffer, J.D. and Thurston, S.J. (1989) A negative regulatory element with properties similar to those of enhancers is contained within an Alu sequence. Mol. Cell. Biol. 9, 355-364
8. Sakamoto, K., Fordis, M., Corsici, C.D., Howard, T.H., and Howard, B.H. (1991) Modulation of HeLa cell growth by transfected 7SL RNA and Alu gene sequences. J. Biol. Chem. 266, 3031-3038
9. Tomilin, N.V., Iguchi-Ariga, S.M.M., and Ariga, H. (1990) Transcription and replication silencer element is present within conserved region of human Alu repeats interacting with nuclear protein. FEBS Lett. 263, 69-72
10. Ullu, E., Murphy, S., and Melli, M. (1982) Human 7SL RNA consists of a 140 nucleotide middle repetitive sequence inserted in an Alu sequence. Cell 29, 195-202
11. Duncan, C.H., Jagadeeswaran, P., Wang, R.C., and Weissman, S.M. (1981) Structural analysis of templates and RNA polymerase III transcripts of Alu family sequences interspersed among the human β-globin like genes. Gene 13, 185-196
12. Anachkova, B., Russev, M., and Altmann, H. (1985) Identification of the short dispersed repetitive DNA sequences isolated from the zones of initiation of DNA synthesis in human cells as Alu-elements. Biochem. Biophys. Res. Commun. 128, 101-106
13. Anachkova, B., Todorova, M., Vassilev, L., and Russev, G. (1984) Isolation of short interspersed repetitive DNA sequences present in the regions of initiation of mammalian DNA replication. Eur. J. Biochem. 141, 105-106
14. Ariga, H. (1984) Replication of cloned DNA containing the Alu family sequence during cell extract-promoting simian virus 40 DNA synthesis. Mol. Cell. Biol. 4, 1476-1482
15. Johnson, E.M. and Jelinek, W.R. (1986) Replication of a plasmid bearing a human Alu-family repeat in monkey COS-7 cells. Proc. Natl. Acad. Sci. USA 83, 4660-4664
16. Chen, S.J., Chen, Z., d'Auriol, L., le Conait, M., Grusz, D., and Berger, R. (1989) Ph1+bcr-acute leukemias: implication of Alu sequences in a chromosomal translocation occurring in the new cluster region within the BCR gene. Oncogens 4, 195-202
17. Jagadeeswaran, P., Tuan, D., Forget, B.G., and Weissman, S.M. (1982) A gene deletion ending at the midpoint of a repetitive DNA sequence in one form of hereditary persistence of fetal hemoglobin. Nature 296, 469-470
18. Rogers, J.H. (1985) Oncogene chromosome breakpoints and Alu sequences. Nature 317, 559
19. Calabretta, B., Robberson, D.L., Maizel, A.L., and Saunders, G.F. (1981) mRNA in human cells contains sequences complementary to the Alu family of repeated DNA. Proc. Natl. Acad. Sci. USA 78, 6003-6007
20. Robertson, H.D. and Dickson, E. (1984) Structure and distribution of Alu family sequences or their analogs within heterogeneous nuclear RNA of HeLa, KB, and L cells. Mol. Cell. Biol. 4, 310-316
21. Hess, J.F., Perez-Srable, C., Wu, C.J., Weir, B., Tinoco, I. Jr., and Shen, C.-K.J. (1985) Molecular evolution of the human adult a-globin-like gene region: insertion and deletion of Alu family repeats and non-Alu DNA sequences. J. Mol. Biol. 184, 7-21
22. Elder, J.T., Pan, J., Duncan, C.H., and Weissman, S.M. (1981) Transcriptional analysis of interspersed repetitive polymerase III transcription units in human DNA. Nucleic Acids Res. 12, 3503-3519
23. Perez-Stable, C., Ayres, T.M., and Shen, C.K.J. (1984) Distinctive sequence organization and functional programming of an Alu repeat promoter. Proc. Natl. Acad. Sci. USA 81, 5291-5295
24. Paulson, K.E., Matera, A.G., Deka, N., and Schmid, C.W. (1987) Transcription of a human transposon-like sequence is usually directed by other promoters. Nucleic Acids Res. 15, 5199-5215
25. Jelinek, W.R., Toomey, T.P., Leinwand, L., Duncan, C.H., Biro, P.A., Choudary, P.V., Weissman, S.M., Rubin, C.M., Houck, C.M., Deininger, P.L., and Schmid, C.W. (1980) Ubiquitous, interspersed repeated sequences in mammalian genomes. Proc. Natl. Acad. Sci. USA 77, 1398-1402
26. Chesnokov, I., Bozhkov, V., Popov, B., and Tomilin, N.V. (1991) Binding specificity of human nuclear protein interacting with the Alu-family DNA repeats. Biochem. Biophys. Res. Commun. 178, 613-619
27. Saëgusa, Y., Sato, M., Galli, I., Nakagawa, T., Ono, N., Iguchi-Ariga, S.M.M., and Ariga, H. (1993) Stimulation of SV40 DNA replication and transcription by Alu family sequence. Biochim. Biophys. Acta 1172, 274-282
28. Tomilin, N.V. and Bozhkov, V.M. (1989) Human nuclear protein interacting with a conservative sequence motif of Alu-family DNA repeats. FEBS Lett. 251, 79-83
29. Dignam, J.D., Lebovitz, R.M., and Roeder, R.G. (1983) Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei. Nucleic Acids Res. 11, 1475-1489
30. Westin, G., Gerster, T., Müller, M.M., Schaffner, G., and Schaffner, W. (1987) OVEC, a versatile system to study transcription in mammalian cells and cell-free extracts. Nucleic Acids Res. 15, 6787-6797
31. Mimori, T., Akizuki, M., Yamagata, H., Inada, S., Yoshida, S., and Homma, M. (1981) Characterization of a high molecular weight acidic nuclear protein recognized by autoantibodies in sera from patients with polymyositis-scleroderma overlap. J. Clin. Invest. 68, 611-620
32. Mimori, T., Hardin, J.A., and Steitz, J.A. (1986) Characterization of the DNA-binding protein antigen Ku recognized by autoantibodies from patients with rheumatic disorders. J. Biol. Chem. 261, 2274-2278
33. Schreiber, E., Matthias, P., Muller, M.M., and Schaffner, W. (1988) Identification of a novel lymphoid specific octamer binding protein (OTF-2B) by proteolytic clipping bandshift assay (PCBA). EMBO J. 7, 4221-4229
34. Siebenlist, U. and Gilbert, W. (1980) Contacts between Escherichia coli RNA polymerase and an early promoter of phage T7. Proc. Natl. Acad. Sci. USA 77, 122-126
35. Maxam, A.M. and Gilbert, W. (1980) Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol. 65, 499-560
36. Mimori, T., Ohsone, Y., Hama, N., Suwa, A., Akizuki, M., Homma, M., Griffith, A.J., and Hardin, J.A. (1990) Isolation and characterization of cDNA encoding the 80-kDa subunit protein of the human autoantigen Ku (p70/p80) recognized by autoantibodies from patients with scleroderma-polymyositis overlap syndrome. Proc. Natl. Acad. Sci. USA 87, 1777-1781
37. Griffith, A.J., Craft, J., Evans, J., Mimori, T., and Hardin, J.A. (1992) Nucleotide sequence and genomic structure analyses of the p70 subunit of the human Ku autoantigen: evidence for a family of genes encoding Ku (p70)-related polypeptides. Mol. Biol. Rep. 16, 91-97
38. Reeves, W.H. and Sthoeger, Z.M. (1989) Molecular cloning of cDNA encoding the p70 (Ku) lupus autoantigen. J. Biol. Chem. 264, 5047-5052
39. Yaneva, M., Wen, J., Ayala, A., and Cook, R. (1989) cDNA-derived amino acid sequence of the 86-kDa subunit of the Ku antigen. J. Biol. Chem. 264, 13407-13411
40. Zdzienicka, M.Z. (1995) Mammalian mutants defective in the response to ionizing radiation-induced DNA damage. Mutat. Res. 336, 203-213
41. Troelstra, C. and Jaspers, N.G.J. (1994) Recombination and repair. Ku starts at the end. Curr. Biol. 4, 1149-1151
42. Errami, A., Smider, V., Rathmell, W.K., He, D.M., Hendrickson, E.A., Zdzienicka, M.Z., and Chu, G. (1996) Ku86 defines the genetic defect and restores X-ray resistance and V(D)J recombination to complementation group 5 hamster cell mutants. Mol. Cell. Biol. 16, 1519-1526
43. He, D.M., Lee, S.E., and Hendrickson, E.A. (1996) Restoration of X-ray and etoposide resistance, Ku-end binding activity and V(D)J recombination to the Chinese hamster sxi-3 mutant by a hamster Ku86 cDNA. Mutat. Res. 363, 43-56
44. Zhu, C., Bogue, M.A., Lim, D.S., Hasty, P., and Roth, D.B. (1996) Ku86-deficient mice exhibit severe combined immunodeficiency and defective processing of V(D)J recombination intermediates. Cell 86, 379-389
45. Blier, P.R., Griffith, A.J., Craft, J., and Hardin, J.A. (1993) Binding of Ku protein to DNA. Measurement of affinity for ends and demonstration of binding to nicks. J. Biol. Chem. 268, 7594-7601
46. Csordás-Tóth, É., Marusic, L., Ochem, A., Patthy, A., Pongor, S., Giacca, M., and Falaschi, A. (1993) Interactions of USF and Ku antigen with a human DNA region containing a replication origin. Nucleic Acids Res. 21, 3257-3263
47. Mimori, T. and Hardin, J.A. (1986) Mechanism of interaction between Ku protein and DNA. J. Biol. Chem. 261, 10375-10379
48. Genersch, E., Eckerskorn, C., Lottspeich, F., Herzog, C., Kühn, K., and Pöschl, E. (1995) Purification of the sequence-specific transcription factor CTCBF, involved in the control of human collagen IV genes: subunits with homology to Ku antigen. EMBO J. 14, 791-800
49. Kim, D., Ouyang, H., Yang, S.-H., Nussenzweug, A., Burgman, P., and Li, G.C. (1995) A constitutive heat shock element-binding factor is immunologically identical to the Ku autoantigen. J. Biol. Chem. 270, 15277-15284
50. Knuth, M.K., Gunderson, S.I., Thompson, N.B., Strasheim, L.A., and Burgess, R.R. (1990) Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter. J. Biol. Chem. 265, 17911-17920
51. Li, G.C., Yang, S.-H., Kim, D., Nussenzweig, A., Ouyang, H., Wei, J., Burgman, P., and Li, L. (1995) Suppression of heat-induced hsp70 expression by the 70-kDa subunit of the human Ku autoantigen. Proc. Natl. Acad. Sci. USA 92, 4512-4516
52. Niu, H. and Jacob, S.T. (1994) Enhancer 1 binding factor (E1BF), a Ku-related protein, is a growth-regulated RNA polymerase I transcription factor: association of a repressor activity with purified E1BF from serum-deprived cells. Proc. Natl. Acad. Sci. USA 91, 9101-9105
53. 2 major breakpoint region is a sequence-and cell-cycle-specific binding site of the Ku antigen. Proc. Natl. Acad. Sci. USA 92, 10137-10141
54. Tuteja, N., Tuteja, R., Ochem, A., Taneja, P., Huang, N.W., Simoncsits, A., Susie, S., Rahman, K., Marusic, L., Chen, J., Zhang, J., Wang, S., Pongor, S., and Falaschi, A. (1994) Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen. EMBO J. 13, 4991-5001
55. Dvir, A., Peterson, S., Knuth, M.W., Lu, H., and Dynan, W.S. (1992) Ku autoantigen is the regulatory component of a template-associated protein kinase that phosphorylates RNA polymerase II. Proc. Natl. Acad. Sci. USA 89, 11920-11924
56. Gottlieb, T.M. and Jackson, S.P. (1993) The DNA-dependent protein kinase: requirement for DNA ends and association with Ku antigen. Cell 72, 131-142
57. Suwa, A., Hirakata, M., Takeda, Y., Jesch, S.A., Mimori, T., and Hardin, J.A. (1994) DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA. Proc. Natl. Acad. Sci. USA 91, 6904-6908
58. Giffin, W., Torrance, H., Rodda, D.J., Prefontaine, G.G., Pope, L., and Hache, R.J.G. (1996) Sequence-specific DNA binding by Ku autoantigen and its effects on transcription. Nature 380, 265-268
59. Okumura, K., Sakaguchi, G., Takagi, S., Naito, K., Mimori, T., and Igarashi, H. (1996) Sp1 family proteins recognize the U5 repressive element of the long terminal repeat of human T cell leukemia virus type I through binding to the CACCC core motif. J. Biol. Chem. 271, 12944-12950