Inhaled nitric oxide: Clinical applications, indications, and toxicology

Canadian Journal of Anaesthesia

Volumn 44, Issue 9, 1997, Pages 973-988

  Troncy, Eric ^a   Francœur, Martin ^a   Blaise, Gilbert ^a  

^a Laboratory of Anæsthesia   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

NITRIC OXIDE;

CHRONIC OBSTRUCTIVE LUNG DISEASE; DRUG TOXICITY; HUMAN; HYPOXEMIA; INHALATION; LUNG EDEMA; PNEUMONIA; PRIORITY JOURNAL; PULMONARY HYPERTENSION; RESPIRATORY DISTRESS; REVIEW;

EID: 2642696807     PISSN: 0832610X     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03011970     Document Type: Review

References (100)

1. Furchgott RF, Zawadzki JV. The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
2. Nathan C. Nitric oxide as a secretory product of mammalian cells. FASEB J 1992; 6: 3051-64.
3. Frostell CG, Blomqvist H, Hedenstierna G, Lundberg J, Zapol WM. Inhaled nitric oxide selectively reverses human hypoxic pulmonary vasoconstriction without causing systemic vasodilation. Anesthesiology 1993; 78: 427-35.
4. Pepke-Zaba J, Higenbottam TW, Dinh-Xuan AT, Stone D, Wallwork J. Inhaled nitric oxide as a cause of selective pulmonary vasodilation in pulmonary hypertension. Lancet 1991; 338: 1173-4.
5. Stoclet JC. The L-arginine-NO pathway and cyclic GMP in the vessel wall. Z Kardiol 1991; 80: 87-90.
6. Goy MF. cGMP: the wayward child of the cyclic nucleotide family. Trends Neurosci 1991; 74: 293-9.
7. Jia L, Bonaventura C, Bonaventura J, Stamler JS. S-nitrosohæmoglobin: a dynamic activity of blood involved in vascular control. Nature 1996; 380: 221-6.
8. Kobzik L, Bredt DS, Lowenstein CJ, et al. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol 1993; 9: 371-7.
9. Gerlach H, Rossaint R, Pappert D, Knorr M, Falke KJ. Autoinhalation of nitric oxide after endogenous synthesis in nasopharynx. Lancet 1994; 343: 518-9.
10. Giaid A, Saleh D. Reduced expression of endothelial nitric oxide synthase in the lungs of patients with pulmonary hypertension. N Engl J Med 1995; 333: 214-21.
11. Barberà JA, Roger N, Roca J, Ravira I, Higenbottam TW, Rodriguez-Roisin R. Worsening of pulmonary gas exchange with nitric oxide inhalation in chronic obstructive pulmonary disease. Lancet 1996; 347: 436-40.
12. Channick RN, Hoch RC, Newhart JW, Johnson FW, Smith CM. Improvement in pulmonary hypertension and hypoxemia during nitric oxide inhalation in a patient with end-stage pulmonary fibrosis. Am J Respir Crit Care Med 1994; 149: 811-4.
13. Rossaint R, Falke KJ, López FA, Slama K, Pison U, Zapol WM. Inhaled nitric oxide for the adult respiratory distress syndrome. N Engl J Med 1993; 328: 399-405.
14. Gerlach H, Rossaint R, Pappert D, Falke KJ. Time-course and dose-response of nitric oxide inhalation for systemic oxygenation and pulmonary hypertension in patients with adult respiratory distress syndrome. Eur J Clin Invest 1993; 23: 499-502.
15. Lowson SM, Rich GF, McArdle PA, Jaidev J, Morris GN. The response to varying concentrations of inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesth Analg 1996; 82: 574-81.
16. Roberts JD, Polaner DM, Lang P, Zapol WM. Inhaled nitric oxide in persistent pulmonary hypertension of the newborn. Lancet 1992; 340: 818-9.
17. Rich GF, Murphy GD Jr, Roos CM, Johns RA. Inhaled nitric oxide. Selective pulmonary vasodilation in cardiac surgical patients. Anesthesiology 1993; 78: 1028-35.
18. Bigatello LM, Hurford WE, Kacmarek RM, Roberts JD Jr, Zapol WM. Prolonged inhalation of low concentrations of nitric oxide in patients with severe adult respiratory distress syndrome. Anesthesiology 1994; 80: 761-70.
19. Ichinose F, Adrie C, Hurford WE, Zapol WM. Prolonged pulmonary vasodilator action of inhaled nitric oxide by zaprinast in awake lambs. J Appl Physiol 1995; 78: 1288-95.
20. Kinsella JP, Torielli F, Ziegler JW, Ivy DD, Abman SH. Dipyridamole augmentation of response to nitric oxide (Letter). Lancet 1995; 346: 647-8.
21. Puybasset L, Rouby J-J, Mourgeon E, et al. Factors influencing cardiopulmonary effects of inhaled nitric oxide in acute respiratory failure. Am J Respir Crit Care Med 1995; 152: 318-28.
22. Henrichsen T, Goldman AP, Macrae DJ. Inhaled nitric oxide can cause severe systemic hypotension (Letter). J Pediatrics 1996; 129: 183.
23. Payen DM, Gatecel C, Plaisance P. Almitrine effect on nitric oxide inhalation in adult respiratory distress syndrome (Letter). Lancet 1993; 341: 1664.
24. Germann P, Pöschl G, Balassa A, et al. Additional benefit of combined nitric oxide inhalational and gravitational therapy in patients with isolated ARDS. Anesthesiology 1994; 81: A266.
25. Tsao PS, Lewis NP, Alpert S, Cooke JP. Exposure to shear stress alters endothelial adhesiveness. Role of nitric oxide. Circulation 1995; 92: 3513-9.
26. Van Dervort AL, Yan L, Madara PJ, et al. Nitric oxide regulates endotoxin-induced TNF-α production by human neutrophils. J Immunol 1994; 152: 4102-9.
27. Taylor-Robinson AW, Liew FY, Severn A, et al. Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. Eur J Immunol 1994; 24: 980-4.
28. 2 - lipoxygenase pathway in rat alveolar macrophages. In: Moncada S, Stamler J, Gross S, Higgs EA (Eds.). The Biology of Nitric Oxide - Part 5. London: Portland Press, 1996: 110.
29. Maulik N, Engelman DT, Watanabe M, et al. Nitric oxide/carbon monoxide. A molecular switch for myocardial preservation during ischemia. Circulation 1996; 94[Suppl.II]: II398-406.
30. Beckman JS. The physiological and pathological chemistry of nitric oxide. In: Lancaster J Jr (Ed.). Nitric Oxide: Principles and Actions. San Diego: Academic Press, 1996: 1-82.
31. Kubes P, Granger DN. Nitric oxide modulates microvascular permeability. Am J Physiol 1992; 262: H611-5.
32. Suttorp N, Hippenstiel S, Fuhrmann M, Krüll M, Podzuweit T. Role of nitric oxide and phosphodiesterase isoenzyme II for reduction of endothelial hyperpermeability. Am J Physiol 1996; 270: C778-85.
33. Belvisi M, Barnes PJ, Larkin S, et al. Nitric oxide synthase activity is elevated in inflammatory lung disease in humans. Eur J Pharmacol 1995; 283: 255-8.
34. Estrada C, Gómez C, Martín C, Moncada S, Gonzáles C. Nitric oxide mediates tumor necrosis factor-α cytotoxicity in endothelial cells. Biochem Biophys Res Commun 1992; 186: 475-82.
35. Finkel MS, Oddis CV, Jacob TD, Watkins SC, Hattler BG, Simmons RL. Negative inotropic effects of cytokines on the heart mediated by nitric oxide. Science 1992; 257: 387-9.
36. Radi R, Beckman JS, Bush KM, Freeman BA. Peroxynitrite-induced membrane lipid peroxidation: the cytotoxic potential of superoxide and nitric oxide. Arch Biochem Biophys 1991; 288: 481-7.
37. Noronha-Dutra AA, Epperlein MM, Woolf N. Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide-mediated killing. FEBS 1993; 321: 59-62.
38. Benzing A, Geiger K. Inhaled nitric oxide lowers pulmonary capillary pressure and changes longitudinal distribution of pulmonary vascular resistance in patients with acute lung injury. Acta Anaesthesiol Scand 1994; 38: 640-5.
39. Chollet-Martin S, Gatecel C, Kermarrec N, Gougerot-Pocidalo M-A, Payen DM. Alveolar neutrophil functions and cytokine levels in patients with the adult respiratory distress syndrome during nitric oxide inhalation. Am J Respir Crit Care Med 1996; 153: 985-90.
40. Garat C, Adnot S, Rezaiguia S, Meignan S, Jayr C. Effect of inhaled nitric oxide on 100% oxygen induced lung injury in intact rats. Anesthesiology 1994; 81: A1455.
41. Van Obbergh LJ, Charbonneau M, Blaise G. Combination of inhaled nitric oxide with i.v. nitroglycerin or with a prostacyclin analogue in the treatment of experimental pulmonary hypertension. Br J Anaesth 1996; 77: 227-31.
42. Malmros C, Blomquist S, Dahm P, Mårtensson L, Thörne J. Nitric oxide inhalation decreases pulmonary platelet and neutrophil sequestration during extracorporeal circulation in the pig. Crit Care Med 1996; 24: 845-9.
43. Samama CM, Diaby M, Fellahi J-L, et al. Inhibition of platelet aggregation by inhaled nitric oxide in patients with acute respiratory distress syndrome. Anesthesiology 1995; 83: 56-65.
44. Friese RS, Fullerton DA, McIntyre RC Jr, et al. NO prevents neutrophil-mediated pulmonary vasomotor dysfunction in acute lung injury. J Surg Res 1996; 63: 23-8.
45. Stamler JS, Jaraki O, Osborne J, et al. Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 1992; 89: 7674-7.
46. Troncy E, Jacob E, Peres da Silva E, et al. Comparison of the effect of inhaled nitric oxide and intravenous nitroglycerine on hypoxia-induced pulmonary hypertension in pigs. Eur J Anaesthesiol 1996; 13: 521-9.
47. Kelly RA, Balligand J-L, Smith TW. Nitric oxide and cardiac function. Circ Res 1996; 79: 363-80.
48. Shah NS, Nakayama DK, Jacob TD, et al. Efficacy of inhaled nitric oxide in a porcine model of adult respiratory distress syndrome. Arch Surg 1994; 129: 158-64.
49. Albert J, Wallén NH, Bröijersén A, Frosteil C, Hjemdahl P. Effects of inhaled nitric oxide compared with aspirin on platelet function in vivo in healthy subjects. Clin Sci 1996; 91: 225-31.
50. Troncy E, Francœur M, Salazkin I, Vinay P, Blaise GA. Systemic effect of inhaled nitric oxide: modification of renal hemodynamics in pigs. In: Moncada S, Stamler J, Gross S, Higgs EA (Eds.). The Biology of Nitric Oxide - Part 5. London: Portland Press, 1996: 319.
51. McQueston JA, Kinsella JP, Ivy DD, McMurtry IF, Abman SH. Chronic pulmonary hypertension in utero impairs endothelium-dependent vasodilation. Am J Physiol 1995; 268: H288-94.
52. Kinsella JP, Neish SR, Ivy DD, Shaffer E, Abman SH. Clinical responses to prolonged treatment of persistent pulmonary hypertension of the newborn with low doses of inhaled nitric oxide. J Pediatr 1993; 123: 103-8.
53. Okamoto K, Sato T, Kurose M, Kukita I, Fujii H, Taki K. Successful use of inhaled nitric oxide for treatment of severe hypoxemia in an infant with total anomalous pulmonary venous return. Anesthesiology 1994; 81: 256-9.
54. Haydar A, Malhère T, Mauriat P, et al. Inhaled nitric oxide for postoperative pulmonary hypertension in patients with congenital heart defects (Letter). Lancet 1992; 340: 1545.
55. Mertes PM, Pinelli G, Hubert T, et al. Impact of nitric oxide inhalation on right ventricular failure after implantation of Novacor left ventricular assist system. J Thorac Cardiovasc Surg 1995; 109: 1251.
56. Gries A, Motsch J, Böttiger B, Mieck U, Bode C, Dörsam J. Inhaled nitric oxide reduces platelet activation in acute pulmonary embolism in pigs. Br J Anaesth 1995; 74[Suppl.II]: (A412).
57. Sitbon O, Brenot F, Denjean A, et al. Inhaled nitric oxide as a screening vasodilator agent in primary pulmonary hypertension. A dose-response study and comparison with prostacyclin. Am J Respir Crit Care Med 1995; 151: 384-9.
58. Adnot S, Kouyoumdjian C, Defouilloy C, et al. Hemodynamic and gas exchange responses to infusion of acetylcholine and inhalation of nitric oxide in patients with chronic obstructive lung disease and pulmonary hypertension. Am Rev Respir Dis 1993; 148: 310-6.
59. Dupuy PM, Shore SA, Drazen JM, Frostell C, Hill WA, Zapol WM. Bronchodilator action of inhaled nitric oxide in guinea pigs. J Clin Invest 1992; 90: 421-8.
60. Sanna A, Kurtansky A, Veriter C, Stånescu D. Bronchodilator effect of inhaled nitric oxide in healthy men. Am J Respir Crit Care Med 1994; 150: 1702-4.
61. Högman M, Frostell CG, Hedenström H, Hedenstierna G. Inhalation of nitric oxide modulates adult human bronchial tone. Am Rev Respir Dis 1993; 148: 1474-8.
62. Ashbaugh DG, Bigelow DB, Petty TL, Levine BE. Acute respiratory distress in adults. Lancet 1967; 2: 319-23.
63. Bernard GR, Artigas A, Brigham KL, et al. The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am J Respir Crit Care Med 1994; 149: 818-24.
64. Petros AJ, Marshall JC, van Saene HKF. Should morbidity replace mortality as an endpoint for clinical trials in intensive care? Lancet 1995; 345: 986-7.
65. Rossaint R, Slama K, Steudel W, et al. Effects of inhaled nitric oxide on right ventricular function in severe acute respiratory distress syndrome. Intensive Care Med 1995; 21: 197-203.
66. Fierobe L, Brunet F, Dhainaut J-F, et al. Effect of inhaled nitric oxide on right ventricular function in adult respiratory distress syndrome. Am J Respir Crit Care Med 1995; 151: 1414-9.
67. Wenstone R, Wilkes RG. Clinical management of ARDS (Editorial). Br J Anaesth 1994; 72: 617-9.
68. McIntyre RC Jr, Moore FA, Moore EE, Piedalue F, Haenel JS, Fullerton DA. Inhaled nitric oxide variably improves oxygenation and pulmonary hypertension in patients with acute respiratory distress syndrome. J Trauma 1995; 39: 418-25.
69. Murray JF, Matthay MA, Luce JM, Flick MR. An expanded definition of the adult respiratory distress syndrome. Am Rev Respir Dis 1988; 138: 720-3.
70. Puybasset L, Rouby JJ, Mourgeon E, et al. Inhaled nitric oxide in acute respiratory failure: dose-response curves. Intensive Care Med 1994; 20: 319-27.
71. Walmrath D, Schneider T, Schermuly R, Olschewski H, Grimminger F, Seeger W. Direct comparison of inhaled nitric oxide and aerosolized prostacyclin in acute respiratory distress syndrome. Am J Respir Crit Care Med 1996; 153: 991-6.
72. Blaise G, Charneau S, Francœur M, et al. Inhaled NO and ARDS: effect on oxygenation, systemic and pulmonary hemodynamics and on mortality. Can J Anaesth 1995; 42[Suppl.II]: A65 A.
73. Rossaint R, Gerlach H, Schmidt-Ruhnke H, et al. Efficacy of inhaled nitric oxide in patients with severe ARDS. Chest 1995; 107: 1107-15.
74. Wysocki M, Delclaux C, Roupie E, et al. Additive effect on gas exchange of inhaled nitric oxide and intravenous almitrine bismesylate in the adult respiratory distress syndrome. Intensive Care Med 1994; 20: 254-9.
75. Lu Q Mourgeon E, Law-Koune JD, et al. Dose-response curves of inhaled nitric oxide with and without intravenous almitrine in nitric oxide-responding patients with acute respiratory distress syndrome. Anesthesiology 1995; 83: 929-43.
76. Young JD, Brampton WJ, Knighton JD, Finfer SR. Inhaled nitric oxide in acute respiratory failure in adults. Br J Anaesth 1994; 73: 499-502.
77. Puybasset L, Stewart T, Rouby J-J, et al. Inhaled nitric oxide reverses the increase in pulmonary vascular resistance induced by permissive hypercapnia in patients with acute respiratory distress syndrome. Anesthesiology 1994; 80: 1254-67.
78. Gerlach H, Pappert D, Lewandowski K, Rossaint R, Falke KJ. Long-term inhalation with evaluated low doses of nitric oxide for selective improvement of oxygenation in patients with adult respiratory distress syndrome. Intensive Care Med 1993; 19: 443-9.
79. Levy B, Bollaert P-E, Bauer P, Nace L, Audibert G, Larcan A. Therapeutic optimization including inhaled nitric oxide in adult respiratory distress syndrome in a polyvalent intensive care unit. J Trauma 1995; 38: 370-4.
80. Wysocki M, Vignon Ph, Roupie E, et al. Improvement in right ventricular function with inhaled nitric oxide in patients with the adult respiratory distress syndrome (ARDS) and permissive hypercapnia. Am Rev Respir Dis 1993; 147: A350.
81. Mira JP, Monchi M, Brunet F, Fierobe L, Dhainaut JF, Dinh-Xuan AT. Lack of efficacy of inhaled nitric oxide in ARDS (Letter). Intensive Care Med 1994; 7: 532.
82. Levy B, Bollaert PE, Larcan A. Inhaled nitric oxide is often efficient in severe ARDS (Letter). Intensive Care Med 1995; 21: 864.
83. Ricou B, Suter PM. Variable effects of nitric oxide (NO) in ARDS patients. Am Rev Respir Dis 1993; 147: A350.
84. Monchi M, Fierobe L, Mira JP, et al. Predictive factors of inhaled nitric oxide inefficiency in ARDS patients. Am J Respir Crit Care Med 1994; 149: A423.
85. ○) on oxygenation and hemodynamic parameters in the acute respiratory distress syndrome (ARDS). Responders versus non responders? Am J Respir Crit Care Med 1994; 149: A424.
86. Steltzer H, Fridrich P, Koc D, Hiesmayr M, Krafft P, Hammerle AF. Prolonged inhalation of nitric oxide in patients with septic acute respiratory distress syndrome (ARDS): effects on hæmodynamics and oxygenation in responders and non-responders. Br J Anæsth 1995; 74[Suppl.II]: 124(A410).
87. Krafft P, Fridrich P, Fitzgerald RD, Koc D, Steltzer H. Effectiveness of nitric oxide inhalation in septic ARDS. Chest 1996; 109: 486-93.
88. Miller OI, Tang SF, Keech A, Celermajer DS. Rebound pulmonary hypertension on withdrawal from inhaled nitric oxide (Letter). Lancet 1995; 346: 51-2.
89. Adatia I, Perry S, Landzberg M, Moore P, Thompson JE, Wessel DL. Inhaled nitric oxide and hemodynamic evaluation of patients with pulmonary hypertension before transplantation. J Am Coll Cardiol 1995; 25: 1656-64.
90. Semigran MJ, Cockrill BA, Kacmarek R, et al. Hemodynamic effects of inhaled nitric oxide in heart failure. J Am Coll Cardiol 1994; 24: 982-8.
91. Borland CDR, Higenbottam TW. A simultaneous single breath measurement of pulmonary diffusing capacity with nitric oxide and carbon monoxide. Eur Respir J 1989; 2: 56-63.
92. Persson MG, Wiklund NP, Gustafsson LE. Endogenous nitric oxide in single exhalations and the change during exercise. Am Rev Respir Dis 1993; 148: 1210-4.
93. Kharitonov SA, Yates D, Barnes PJ. Increased nitric oxide in exhaled air of normal human subjects with upper respiratory tract infections. Eur Resp J 1995; 8: 295-7.
94. Lundberg JON, Rinder J, Weitzberg E, Lundberg JM, Alving K. Nasally exhaled nitric oxide in humans originates mainly in the paranasal sinuses. Acta Physiol Scand 1994; 152: 431-2.
95. Frawley JP, Calandra JE, Fredrick WG, et al. Emergency exposure limits - Statement of general principles - Nitrogen dioxide. Industrial Hygiene Journal 1964; 25: 578-82.
96. Szabó C. The pathophysiological role of peroxynitrite in shock, inflammation, and ischemia-reperfusion injury. Shock 1996; 6: 79-88.
97. Dickstein ML, Burkhoff D. A theoretic analysis of the effect of pulmonary vasodilation on pulmonary venous pressure: implications for inhaled nitric oxide therapy. J Heart Lung Transplant 1996; 15: 715-21.
98. Wessel DL, Adatia I, Thompson JE, Hickey PR. Delivery and monitoring of inhaled nitric oxide in patients with pulmonary hypertension. Crit Care Med 1994; 22: 930-8.
99. Dyar O, Young JD, Xiong L, Howell S, Johns E. Dose-response relationship for inhaled nitric oxide in experimental pulmonary hypertension in sheep. Br J Anaesth 1993; 71: 702-8.
100. Frostell C. Nitric oxide inhalation - future drug or an invitation to disaster? Pediatr Anaesth 1994; 4: 147-50.