Probing the agonist binding pocket in the nicotinic acetylcholine receptor: A high-resolution solid-state NMR approach

Biochemistry

Volumn 37, Issue 30, 1998, Pages 10854-10859

  Williamson, P T F ^a   Grobner G ^a   Spooner, P J R ^a   Miller, K W ^b   Watts, A ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; ACETYLCHOLINESTERASE; NICOTINIC AGENT; NICOTINIC RECEPTOR;

ANIMAL TISSUE; ARTICLE; BINDING SITE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; TORPEDO;

ACETYLCHOLINE; ANIMALS; BINDING SITES; BUNGAROTOXINS; CARBON ISOTOPES; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; MAGNETIC RESONANCE SPECTROSCOPY; PERCHLORIC ACID; RECEPTORS, NICOTINIC; TIME FACTORS; TORPEDO;

ANIMALIA; TORPEDO NOBILIANA;

EID: 2642642085     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi980390q     Document Type: Article

References (28)

1. Stroud, R. M., McCarthy, M. P., and Schuster, M. (1990) Biochemistry 29, 11009-11023.
2. Unwin, N. (1995) Nature 373, 37-43.
3. Smith, S. O. (1993) Curr. Opin. Struct. Biol. 3, 755-759.
4. Smith, S. O., Aschheim, K., and Groesbeek, M. (1996) Q. Rev. Biophys. 29, 395-449.
5. Griffiths, J. M., and Griffin, R. G. (1993) Anal. Chim. Acta 283, 1081-1101.
6. Middleton, D. A., Robins, R., Feng, X. L., Levitt, M. H., Spiers, I. D., Schwalbe, C. H., Reid, D. G., and Watts, A. (1997) FEBS Lett. 410, 269-274.
7. Watts, A., Ulrich, A. S., and Middleton, D. A. (1995) Mol. Membr. Biol. 72, 233-246.
8. Peersen, O. B., and Smith, S. O. (1993) Concepts Magn. Reson. 5, 303-317.
9. Pines, A., Gibby, M. G., and Waugh, J. S. (1973) J. Chem. Phys. 59, 569-590.
10. Spooner, P. J. R., Rutherford, N. G., Watts, A., and Henderson, P. J. F. (1994) Proc. Natl. Acad. Sci. U.S.A. 91, 3877-3881.
11. Höfle, G., Steglich, W., and Vorbrügger, H. (1978) Angew. Chem., Int. Ed. Engl. 17, 569-583.
12. Neubig, R. R., and Cohen, J. B. (1979) Biochemistry 18, 5464-5475.
13. Braswell, L. M., Miller, K. W., and Sauter, J. F. (1984) Br. J. Pharmacol. 83, 305-311.
14. Spooner, P. J. R. (1998) Biophys. J. (submitted for publication).
15. Williamson, M. P. (1993) J. Magn. Reson. Ser. B 101, 63-71.
16. Asakura, T., Taoka, K., Demura, M., and Williamson, M. P. (1995) J. Biomol. NMR 6, 227-236.
17. Haugh, C. W., and Mallion, R. B. (1972) Org. Magn. Reson. 4, 203-228.
18. Raves, M. L., Harel, M., Pang, Y. P., Silman, T., Kozikowski, A. P., and Sussman, J. L. (1997) Nat. Struct. Biol. 4, 57-63.
19. Boyd, N. D. (1980) Biochemistry 19, 5353-5358.
20. Galzi, J. L., Revah, F., Bessis A., and Changeux, J. P. (1991) Annu, Rev. Pharmacol. 31, 37-72.
21. Luginbühl, P., Szyperski, T., and Würthrich, K. (1995) J. Magn. Reson. (B) 109, 229-233.
22. Sussman, J. L., and Silman, I. (1992) Curr. Opin. Struct. Biol. 2, 721-729.
23. Cohen, J. B., Sharp, S. D., and Liu, W. S. (1991) J. Biol. Chem., 266, 23354-23364.
24. Abramson, S. N., Trischman, J. A., Tapiolas, D. M., Harold, E. E., Fenical, W., and Taylor, P. (1991) J. Med. Chem. 24, 1798-1804.
25. Dougherty, D. A., and Stauffer D. A. (1990) Science 250, 1558-1560.
26. Tsigelny, I., Suguyama, N., Sine, S. M., and Taylor, P. (1997) Biophys. J. 73, 52-66.
27. Slichter, C. P. (1990) in Principles of Magnetic Resonance (3rd ed.), Springer-Verlag,
28. Rankin, S. Ph.D. Thesis, University of Oxford, Oxford, UK, 1996.