The conformation of an inhibitor bound to the gastric proton pump

FEBS Letters

Volumn 410, Issue 2-3, 1997, Pages 269-274

  Middleton, David A ^a   Robins, Rachel ^a   Feng, Xiaolong ^b   Levitt, Malcolm H ^b   Spiers, Ian D ^c   Schwalbe, Carl H ^c   Reid, David G ^d   Watts, Anthony ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c ASTON UNIVERSITY   (United Kingdom)

^d GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Drag design; Membrane target; Peptic ulcer; Proton pump; Solid state NMR

Indexed keywords

IMIDAZO[1,2 A]PYRIDINE DERIVATIVE; PROTON PUMP INHIBITOR;

ARTICLE; DRUG CONFORMATION; DRUG DESIGN; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME INHIBITION; PEPTIC ULCER; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

H(+)-K(+)-EXCHANGING ATPASE; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR STRUCTURE; PROTON PUMPS; PYRIDINES; STOMACH;

EID: 0030737976     PISSN: 00145793     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-5793(97)00525-5     Document Type: Article

References (14)

1. Forte J.G., et al. Annu. Rev. Physiol. 42:1980;111.
2. Sachs G. Annu. Rev. Pharmacol. Toxicol. 28:1988;269.
3. Pope A.J., Sachs G. Biochem. Soc. Trans. 20:1992;566.
4. Alberg D.G., Schreiber S.L. Science. 262:1993;248.
5. von Itzstein M., et al. Nature. 363:1993;418.
6. Kaminski J.J., et al. J. Med. Chem. 34:1991;533.
7. Levitt M.H., et al. J. Chem. Phys. 92:1990;6347.
8. Creuzet F., et al. Science. 251:1991;783.
9. Watts A., et al. Mol. Membr. Biol. 12:1995;233.
10. Holl S.M., et al. J. Am. Chem. Soc. 114:1992;4830.
11. McDowell L.M., et al. J. Am. Chem. Soc. 117:1995;12352.
12. Spooner P.J., et al. Proc. Natl. Acad. Sci. USA. 91:1994;3877.
13. Munson K.B., et al. J. Biol. Chem. 266:1991;18976.
14. Keeling D.J., et al. J. Biol. Chem. 10:1989;5552.