Chapter 42 Prefrontal cortex stimulation as antidepressant treatment: mode of action and clinical effectiveness of rTMS

Supplements to Clinical Neurophysiology

Volumn 56, Issue C, 2003, Pages 406-432

  Padberg, Frank ^a   Goldstein Müller, Barbara ^a   Zwanzger, Peter ^a   Möller, Hans Jürgen ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 2642583496     PISSN: 1567424X     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S1567-424X(09)70245-4     Document Type: Article

References (161)

1. Barker A.T., Jalinous R., and Freeston I.L. Noninvasive magnetic stimulation of human motor cortex. Lancet ii (1985) 1106-1107
2. Baxter L.R.J., Schwartz J.M., Phelps M.E., Mazziotta J.C., Guze B.H., Selin C.E., Gerner R.H., and Sumida R.M. Reduction of prefrontal cortex glucose metabolism common to three types of depression. Arch. Gen. Psychiatry 46 (1989) 243-250
3. Belmaker R.H., and Grisaru N. Magnetic stimulation of the brain in animal depression models responsive to ECS. J. ECT 14 (1998) 194-205
4. Ben-Shachar D., Belmaker R.H., Grisaru N., and Klein E. Transcranial magnetic stimulation induces alterations in brain monoamines. J. Neural. Transm. 104 (1997) 191-197
5. Ben-Shachar D., Gazawi H., Riboyad-Levin J., and Klein E. Chronic repetitive transcranial magnetic stimulation alters beta-adrenergic and 5-HT2 receptor characteristics in rat brain. Brain Res. 816 (1999) 78-83
6. Berger M., Vollmann J., Hohagen F., Konig A., Lohner H., Voderholzer U., and Riemann D. Sleep deprivation combined with consecutive sleep phase advance as a fast-acting therapy in depression: an open pilot trial in medicated and unmedicated patients. Am. J. Psychiatry 154 (1997) 870-872
7. Berman R.M., Narasimhan M., Sanacora G., Miano A.P., Hoffman R.E., Hu X.S., Charney D.S., and Boutros N.N. A randomized clinical trial of repetitive transcranial magnetic stimulation in the treatment of major depression. Biol. Psychiatry 47 (2000) 332-337
8. Bonnet J.J., Chagraoui A., Protais P., and Costentin J. Interactions of amineptine with the neuronal dopamine uptake system: neurochemical in vitro and in vivo studies. J. Neural. Transm. 69 (1987) 211-220
9. Borsini F., and Meli A. Is the forced swimming test a suitable model for revealing antidepressant activity?. Psychopharmacology (Berl) 94 (1988) 147-160
10. Boutros N.N., Gueorguieva R., Hoffman R.E., Oren D.A., Feingold A., and Berman R.M. Lack of a therapeutic effect of a 2-week sub-threshold transcranial magnetic stimulation course for treatment-resistant depression. Psychiatry Res. 113 (2002) 245-254
11. Brown A.S., and Gershon S. Dopamine and depression. J. Neural. Transm. Gen. Sect 91 (1993) 75-109
12. Burt T., Lisanby S.H., and Sackeim H.A. Neuropsychiatric applications of transcranial magnetic stimulation: a meta analysis. Int. J. Neuropsychopharmacol. 5 (2002) 73-103
13. Catafau A.M., Perez V., Gironell A., Martin J.C., Kulisevsky J., Estorch M., Carrio I., and Alvarez E. SPECT mapping of cerebral activity changes induced by repetitive transcranial magnetic stimulation in depressed patients. A pilot study. Psychiatry Res. 106 (2001) 151-160
14. Cohrs S., Tergau F., Riech S., Kastner S., Paulus W., Ziemann U., Rüther E., and Hajak G. High-frequency repetitive transcranial magnetic stimulation delays rapid eye movement sleep. Neuro Report 9 (1998) 3439-3443
15. Cohrs S., Tergau F., Korn J., Becker W., and Hajak G. Suprathreshold repetitive transcranial magnetic stimulation elevates thyroid-stimulating hormone in healthy male subjects. J. Nerv. Ment. Dis. 189 (2001) 393-397
16. Conca A., Koppi S., König P., Swoboda E., and Krecke N. Transcranial magnetic stimulation: a novel antidepressive strategy?. Neuropsychobiology 34 (1996) 204-207
17. Conca A., Konig P., and Hausmann A. Transcranial magnetic stimulation induces 'pseudoabsence seizure'. Acta Psychiatr. Scand. 101 (2001) 246-248
18. Conca A., Peschina W., Konig P., Fritzsche H., and Hausmann A. Effect of chronic repetitive transcranial magnetic stimulation on regional cerebral blood flow and regional cerebral glucose uptake in drug treatment-resistant depressives. A brief report. Neuropsychobiology 45 (2002) 27-31
19. Counter S.A. Neurobiological effects of extensive transcranial electromagnetic stimulation in an animal model. Electroencephalogr. Clin. Neurophysiol. 89 (1993) 341-348
20. Cumming P., Brown E., Damsma G., and Fibiger H. Formation and clearance of interstitial metabolites of dopamine and serotonin in the rat striatum: an in vivo microdialysis study. J. Neurochem. 59 (1992) 1905-1914
21. Czéh B., Welt T., Fischer A.K., Erhardt A., Schmitt W., Müller M.B., Toschi N., Fuchs E., and Keck M.E. Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: Effects on stress hormone levels and adult hippocampal neurogenesis. Biol. Psychiatry 52 (2002) 1057-1065
22. Dannon P.N., and Grunhaus L. Effect of electroconvulsive therapy in repetitive transcranial magnetic stimulation non-responder MDD patients: a preliminary study. Int. J. Neuropsycho-pharmacol. 4 (2001) 265-268
23. Dannon P.N., Dolberg O.T., Schreiber S., and Grunhaus L. Three and six-month outcome following courses of either ECT or rTMS in a population of severely depressed individuals-preliminary report. Biol. Psychiatry 51 (2002) 687-690
24. De Boer T., and Ruigt G.S.F. The selective alpha-2-adrenoceptor antagonist mirtazapine (Org 3770) enhances noradrenergic and 5-HT1A-mediated serotonergic neurotransmission. CNS Drugs 4 Suppl. (1995) 29-38
25. Dearing M.J. Mood effects of prefrontal repetitive high-frequency TMS in healthy volunteers. CNS Spectrums 2 (1992) 53 and 68
26. Dolberg O.T., Schreiber S., and Grunhaus L. Transcranial magnetic stimulation-induced switch into mania: a report of two cases. Biol. Psychiatry 49 (2001) 468-470
27. Drevets W.C. Functional anatomical abnormalities in limbic and prefrontal cortical structures in major depression. Prog. Brain. Res. 126 (2000) 413-431
28. Eichhammer P., Kharraz A., Wiegand R., Langguth B., Frick U., Aigner J.M., and Hajak G. Sleep deprivation in depression stabilizing antidepressant effects by repetitive transcranial magnetic stimulation. Life Sci. 70 (2002) 1741-1749
29. Ella R., Zwanzger P., Stampfer R., Preuss U., Müller-Siecheneder F., Möller H.-J., and Padberg F. Switch to mania after slow rTMS of the right prefrontal cortex. J. Clin. Psychiatry 63 (2002) 249
30. Eschweiler G.W., Wegerer C., Schlotter W., Spandl C., Stevens A., Bartels M., and Buchkremer G. Left prefrontal activation predicts therapeutic effects of repetitive transcranial magnetic stimulation (rTMS) in major depression. Psychiatry Res. 99 (2000) 161-172
31. Eschweiler G.W., Plewnia C., and Bartels M. Welche depressiven Patienten profitieren von präfrontaler transkranieller Magnetstimulation (rTMS)? Which patients with major depression benefit from prefrontal repetitive magnetic stimulation? [article in German]. Fortschr. Neurol. Psychiatr. 69 (2001) 402-409
32. Figiel G., Epstein C., McDonald W., Amazon-Leece J., Figiel L., Saldivia A., and Glover S. The use of rapid-rate transcranial magnetic stimulation (rTMS) in refractory depressed patients. J. Neuropsychiatry Clin. Neurosci. 10 (1998) 20-25
33. Fleischmann A., Prolov K., Abarbanel J., and Belmaker R.H. The effect of transcranial magnetic stimulation of rat brain on behavioral models of depression. Brain Res. 699 (1995) 130-132
34. Fox P., Ingham R., George M.S., Mayberg H., Ingham J., Roby J., Martin C., and Jerabek P. Imaging human intra-cerebral connectivity by PET during TMS. Neuro Report 8 (1997) 2787-2791
35. Fujiki M., and Steward O. High frequency transcranial magnetic stimulation mimics the effects of ECS in upregulating astroglial gene expression in the murine CNS. Brain Res. Mol. Brain. Res. 44 (1997) 301-308
36. Garcia-Toro M., Mayol A., Arnillas H., Capllonch I., Ibarra O., Crespi M., Mico J., Lafau O., and Lafuente L. Modest adjunctive benefit with transcranial magnetic stimulation in medication-resistant depression. J. Affect. Disord. 64 (2001) 271-275
37. Garcia-Toro M., Pascual-Leone A., Romera M., Gonzalez A., Mico J., Ibarra O., Arnillas H., Capllonch I., Mayol A., and Tormos J.M. Prefrontal repetitive transcranial magnetic stimulation as add on treatment in depression. J. Neurol. Neurosurg. Psychiatry 71 (2001) 546-548
38. George M.S., Wassermann E.M., Williams W.A., Callahan A., Ketter T.A., Basser P., Hallett M., and Post R.M. Daily left prefrontal repetitive transcranial magnetic stimulation (rTMS) improves mood in depression. Neuro Report 6 (1995) 1-6
39. George M.S., Wassermann E.M., Williams W.A., Steppel J., Pascual-Leone A., Basser P., Hallett M., and Post R.M. Changes in mood and hormone levels after rapid-rate transcranial magnetic stimulation (rTMS) of the prefrontal cortex. J. Neuropsychiatry Clin. Neurosci. 8 (1996) 172-180
40. George M.S., Speer A.M., Wassermann E.M., Kimbrell T.A., William W.A., Kellner C.H., Risch S.C., Stallings L., and Post R.M. Repetitive TMS as a probe of mood in health and disease. CNS Spectrums 2 (1997) 39-44
41. George M.S., Wassermann E.M., Kimbrell T.A., Little J.T., Williams W.E., Danielson A.L., Greenberg B.D., Hallett M., and Post R.M. Mood improvement following daily left prefrontal repetitive transcranial magnetic stimulation in patients with depression: A placebo-controlled crossover trial. Am. J. Psychiatry 154 (1997) 1752-1756
42. George M.S., Lisanby S.H., and Sackeim H.A. Transcranial magnetic stimulation. Arch. Gen. Psychiatry 56 (1999) 300-311
43. George M.S., Nahas Z., Molloy M., Speer A.M., Oliver N.C., Li X.B., Arana G.W., Risch S.C., and Ballenger J.C. A controlled trial of daily left prefrontal cortex TMS for treating depression. Biol. Psychiatry 48 (2000) 962-970
44. Golden R.N., Rudorfer M.V., Sherer M.A., Linnoila M., and Potter W.Z. Bupropion in depression. I. Biochemical effects and clinical response. Arch. Gen. Psychiatry 45 (1988) 139-143
45. Grisaru N., Yarovslavsky U., Abarbanel J., Lamberg T., and Belmaker R.H. Transcranial magnetic stimulation in depression and schizophrenia. European Neuropsychopharmacology 4 (1994) 287-288
46. Grisaru N., Bruno R., and Pridmore S. Effect on the emotions of healthy individuals of slow repetitive transcranial magnetic stimulation applied to the prefrontal cortex. J. ECT 17 (2001) 184-189
47. Grunhaus L., Dannon P.N., Schreiber S., Dolberg O.H., Amiaz R., Ziv R., and Lefkifker E. Repetitive transcranial magnetic stimulation is as effective as electroconvulsive therapy in the treatment of nondelusional major depressive disorder: an open study. Biol. Psychiatry 47 (2000) 314-324
48. Grunhaus L., Schreiber S., Dolberg O.T., Polak D., and Dannon P.N. A randomized controlled comparison of electroconvulsive therapy and repetitive transcranial magnetic stimulation in severe and resistant nonpsychotic major depression. Biol. Psychiatry 53 (2003) 324-331
49. Gur E., Lerer B., and Newman M.E. Chronic electroconvulsive shock and 5-HT autoreceptor activity in rat brain: an in vivo microdialysis study. J. Neurol. Transm. 104 (1997) 795-804
50. Gur E., Lerer B., Dremencov E., and Newman M.E. Chronic repetitive transcranial magnetic stimulation induces subsensitivity of presynaptic serotonergic autoreceptor activity in rat brain. Neuroreport 11 (2000) 2925-2929
51. Hallett M. Transcranial magnetic stimulation: a tool for mapping the central nervous system. Electroencephalogr. Clin. Neurophysiol. 46 Suppl. (1996) 43-51
52. Hamilton M. A rating scale for depression. J. Neurol. Neurosurg. Psychiatry 23 (1960) 56-62
53. Herwig U., Padberg F., Unger J., Spitzer M., and Schonfeldt-Lecuona C. Transcranial magnetic stimulation in therapy studies: examination of the reliability of "standard" coil positioning by neuronavigation. Biol. Psychiatry 50 (2001) 58-61
54. Hoffman R.E., and Cavus I. Slow transcranial magnetic stimulation, long-term depotentiation, and brain hyperexcitability disorders. Am. J. Psychiatry 159 (2002) 1093-1102
55. Höflich G., Kasper S., Hufnagel A., Ruhrmann S., and Möller H.-J. Application of transcranial magnetic stimulation in treatment of drug-resistant major depression. Human Psychopharmacology 8 (1993) 361-365
56. Holsboer F. Stress, hypercortism and corticosteroid receptors in depression: implications for therapy. J. Affect. Disord. 62 (2001) 77-91
57. Holsboer F., and Barden N. Antidepressants and hypothalamic-pituitary-adrenocortical regulation. Endocr. Rev. 17 (1996) 187-205
58. Janicak P.G., Dowd S.M., Martis B., Alam D., Beedle D., Krasuski J., Strong M.J., Sharma R., Rosen C., and Viana M. Repetitive transcranial magnetic stimulation vs. electroconvulsive therapy for major depression: Preliminary results of a randomized trial. Biol. Psychiatry 51 (2002) 659-667
59. Jenkins J., Shajahan P.M., Lappin J.M., and Ebmeier K.P. Right and left prefrontal transcranial magnetic stimulation at 1 Hz does not affect mood in healthy volunteers. BMC Psychiatry 2 (2002) 1
60. Juckel G., Mendlin A., and Jacobs B.L. Electrical stimulation of rat medial prefrontal cortex enhances forebrain serotonin output: implications for electroconvulsive therapy and transcranial magnetic stimulation in depression. Neuropsychopharmacology 21 (1999) 391-398
61. Kapur S., and Mann J.J. Role of the dopaminergic system in depression. Biol. Psychiatry 32 (1992) 1-17
62. Karreman M., Westerink B.H., and Moghaddam B. Excitatory amino acid receptors in the ventral tegmental area regulate dopamine release in the ventral striatum. J. Neurochem. 67 (1996) 601-607
63. Keck M.E., Engelmann M., Müller M.B., Henniger M.S.H., Hermann B., Rupprecht R., Neumann I.D., Toschi N., Landgraf R., and Post A. Repetitive transcranial magnetic stimulation induces active coping strategies and attenuates the neuroendocrine stress response in rats. J. Psychiatr. Res. 34 (2000) 265-276
64. Keck M.E., Sillaber I., Ebner K., Welt T., Toschi N., Kaehler S.T., Singewald N., Philippu A., Elbel G.K., Wotjak C.T., Holsboer F., Landgraf R., and Engelmann M. Acute transcranial magnetic stimulation of frontal brain regions selectively modulates the release of vasopressin, biogenic amines and amino acids in the rat brain. Eur. J. Neurosci. 12 (2000) 3713-3720
65. Keck M.E., Welt T., Post A., Müller M.B., Toschi N., Wigger A., Landgraf R., Holsboer F., and Engelmann M. Neuroendocrine and behavioral effects of repetitive transcranial magnetic stimulation in a psychopathological animal model are suggestive of antidepressant-like effects. Neuropsycho-pharmacology 24 (2001) 337-349
66. Keck M.E., Welt T., Müller M.B., Erhardt A., Ohl F., Toschi N., Holsboer F., and Sillaber I. Repetitive transcranial magnetic stimulation increases the release of dopamine in the mesolimbic and mesostriatal system. Neuropharmacology 43 (2002) 101-109
67. Khan A., Khan S., and Brown W.A. Are placebo controls necessary to test new antidepressants and anxiolytics?. Int. J. Neuropsychopharm. 5 (2002) 193-197
68. Kimbrell T.A., Little J.T., Dunn R.T., Frye M.A., Greenberg B.D., Wassermann E.M., Repella J.D., Danielson A.L., Willis M.W., Benson B.E., Speer A.M., Osuch E., George M.S., and Post R.M. Frequency dependence of antidepressant response to left prefrontal repetitive transcranial magnetic stimulation (rTMS) as a function of baseline cerebral glucose metabolism. Biol. Psychiatry 46 (1999) 1603-1613
69. Kimbrell T.A., Dunn R.T., George M.S., Danielson A.L., Willis M.W., Repella J.D., Benson B.E., Herscovitch P., Post R.M., and Wassermann E.M. Left prefrontal-repetitive transcranial magnetic stimulation (rTMS) and regional cerebral glucose metabolism in normal volunteers. Psychiatry Res. 115 (2002) 101-113
70. Klein E., Kreinin I., Chistyakov A., Koren D., Mecz L., Marmur S., Ben-Shachar D., and Feinsod M. Therapeutic efficacy of right prefrontal slow repetitive transcranial magnetic stimulation in major depression. Arch. Gen. Psychiatry 56 (1999) 315-320
71. Kolbinger H.M., Höflich G., Hufnagel A., Möller H.-J., and Kasper S. Transcranial magnetic stimulation (TMS) in the treatment of major depression-a pilot study. Human Psychopharmacology 10 (1995) 305-310
72. Kole M.H., Fuchs E., Ziemann U., Paulus W., and Ebert U. Changes in 5-HT1A and NMDA binding sites by a single rapid transcranial magnetic stimulation procedure in rats. Brain Res. 826 (1999) 309-312
73. Kozel F.A., Nahas Z., deBrux C., Molloy M., Lorberbaum J.P., Bohning D., Risch S.C., and George M.S. How coil-cortex distance relates to age, motor threshold, and antidepressant response to repetitive transcranial magnetic stimulation. J. Neuropsychiatry Clin. Neurosci. 12 (2000) 376-384
74. Lisanby S.H., Luber B., Perera T., and Sackeim H.A. Transcranial magnetic stimulation: Applications in basic neuroscience and neuropsychopharmacology. Int. J. Neuropsychopharm. 3 (2000) 259-273
75. Lisanby S.H., Gutman D., Luber B., Schroeder C., Sackeim H.A., and Sham T.M.S. intracerebral measurement of the induced electrical field and the induction of motor-evoked potentials. Biol. Psychiatry 49 (2001) 460-463
76. Little J.T., Kimbrell T.A., and Wassermann E.M. Cognitive effects of 1- and 20-hertz repetitive transcranial magnetic stimulation in depression: preliminary report. Neuropsychiatry Neuropsychol. Behav. Neurol. 13 (2000) 119-124
77. Loo C., Mitchell P., Sachdev P., McDarmont B., Parker G., and Gandevia S. Double-blind controlled investigation of transcranial magnetic stimulation for the treatment of resistant major depression. Am. J. Psychiatry 156 (1999) 946-948
78. Loo C.K., Taylor J.L., Gandevia S.C., McDarmont B.N., Mitchell P.B., and Sachdev P.S. Transcranial magnetic stimulation (TMS) in controlled treatment studies: are some "sham" forms active?. Biol. Psychiatry 47 (2000) 325-331
79. Loo C.K., Sachdev P.S., Elsayed H., McDarmont B.N., Mitchell P.B., Wilkinson M., Parker G., and Gandevia S.C. Effects of a 2- to 4-week course of repetitive transcranial magnetic stimulation (rTMS) on neuropsychological functioning, electroencephalogram and auditory threshold in depressed patients. Biol. Psychiatry 49 (2001) 615-623
80. Manes F., Jorge R., Morcuende M., Yamada T., Paradiso S., and Robinson R.G. A controlled study of repetitive transcranial magnetic stimulation as a treatment of depression in the elderly. Int. Psychogeriatr. 13 (2001) 225-231
81. Martin J.L., Barbanoj M.J., Schlaepfer T.E., Clos S., Perez V., Kulisevsky J., and Gironell A. Transcranial magnetic stimulation for treating depression. Cochrane Database Syst. Rev. 2 (2002) CD003493
82. Martis B., Alam D., Dowd S.M., Hill S.K., Sharma R.P., Rosen C., Pliskin N., Martin E., Carson V., and Janicak P.G. Neurocognitive effects of repetitive transcranial magnetic stimulation in severe major depression. Clin. Neurophysiol. 114 (2003) 1125-1132
83. Matsumiya Y., Yamamoto T., Yarita M., Miyauchi S., and Kling J.W. Physical and physiological specification of magnetic pulse stimuli that produce cortical damage in rats. J. Clin. Neurophysiol. 9 (1992) 278-287
84. Mayberg H.S., Silva J.A., Brannan S.K., Tekell J.L., Mahurin R.K., McGinnis S., and Jerabek P.A. The functional neuro-anatomy of the placebo effect. Am. J. Psychiatry 159 (2002) 728-737
85. McConnell K.A., Nahas Z., Shastri A., Lorberbaum J.P., Kozel F.A., Bohning D.E., and George M.S. The transcranial magnetic stimulation motor threshold depends on the distance from coil to underlying cortex: a replication in healthy adults comparing two methods of assessing the distance to cortex. Biol. Psychiatry 49 (2001) 454-459
86. McGarvey K.A., Zis A.P., Brown E.E., Nomikos G.G., and Fibiger H.C. ECS-induced dopamine release: effects of electrode placement, anticonvulsant treatment, and stimulus intensity. Biol. Psychiatry 34 (1993) 152-157
87. Möller H.-J. Methodological aspects in the assessment of severity of depression by the Hamilton Depression Scale. Eur. Arch. Psychiatry Clin. Neurosci. 251 Suppl. (2001) 13-20 2, II
88. Moser D.J., Jorge R.E., Manes F., Paradiso S., Benjamin M.L., and Robinson R.G. Improved executive functioning following repetitive transcranial magnetic stimulation. Neurology 58 (2002) 1288-1290
89. Mosimann U.P., Rihs T.A., Engeler J., Fisch H., and Schlaepfer T.E. Mood effects of repetitive transcranial magnetic stimulation of left prefrontal cortex in healthy volunteers. Psychiatry Res. 94 (2000) 251-256
90. Mosimann U., Marré S.C., Werlen S., Schmitt W., Hess C.W., Fisch H.U., and Schlaepfer T.E. Antidepressant effects of repetitive transcranial magnetic stimulation in the elderly-Correlation between effect size and coil-cortex distance. Arch. Gen. Psychiatry 59 (2002) 560-561
91. Mottaghy F., Keller C., Gangitano M., Ly J., Thall M., Parker J., and Pascual-Leone A. Correlation of cerebral blood flow and treatment effects of repetitive transcranial magnetic stimulation in depressed patients. Psychiatry Res. 115 (2002) 1-14
92. Muller M.B., Toschi N., Kresse A.E., Post A., and Keck M.E. Long-term repetitive transcranial magnetic stimulation increases the expression of brain-derived neurotrophic factor and cholecystokinin mRNA, but not neuropeptide tyrosine mRNA in specific areas of rat brain. Neuropsychopharmacology 23 (2000) 205-215
93. Murase S., Grenhoff J., Chouvet G., Gonon F.G., and Svensson T.H. Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo. Neurosci. Lett. 157 (1993) 53-56
94. Nahas Z., DeBrux C., Chandler V., Lorberbaum J.P., Speer A.M., Molloy M.A., Liberatos C., Risch S.C., and George M.S. Lack of significant changes on magnetic resonance scans before and after 2 weeks of daily left prefrontal repetitive transcranial magnetic stimulation for depression. J. ECT 16 (2000) 380-390
95. Nahas Z., Lomarev M., Roberts D.R., Shastri A., Lorberbaum J.P., Teneback C., McConnell K., Vincent D.J., Li X., George M.S., and Bohning D.E. Unilateral left prefrontal transcranial magnetic stimulation (TMS) produces intensity-dependent bilateral effects as measured by interleaved BOLD fMRI. Biol. Psychiatry 50 (2001) 712-720
96. Nahas Z., Kozel F.A., Li X., Anderson B., and George M.S. Left prefrontal transcranial magnetic stimulation (TMS) treatment of depression in bipolar affective disorder: a pilot study of acute safety and efficacy. Bipolar Disord. 5 (2003) 40-47
97. Nedjat S., and Folkerts H.W. Induction of a reversible state of hypomania by rapid-rate transcranial magnetic stimulation over the left prefrontal cortex. J. ECT 15 (1999) 166-168
98. Nemeroff C.B., and Evans D.L. Thyrotropin releasing hormone (TRgH), the thyroid axisand affective disorders. Ann. NY Acad. Sci. 533 (1989) 304-310
99. Nibuya M., Morinobu S., and Duman R.S. Regulation of BDNF and trkB mRNA in rat brain by chronic electroconvulsive seizure and antidepressant drug treatments. J. Neurosci. 15 (1995) 7539-7547
100. Padberg F., and Möller H.J. Repetitive transcranial magnetic stimulation: does it have potential in the treatment of depression?. CNS Drugs 17 (2003) 383-403
101. Padberg F., Zwanzger P., Thoma H., Kathmann N., Haag C., Greenberg B.D., Hampel H., and Möller H.-J. Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMS. Psychiatry Res. 88 (1999) 163-171
102. Padberg F., Juckel G., Präßl A., Zwanzger P., Mavrogiorgou P., Hegerl U., Hampel H., and Möller H.-J. Facial expressions and mood after transcranial magnetic stimulation of the prefrontal cortex. J. Neuropsychiatry Clin. Neurosci. 13 (2001) 206-212
103. Padberg F., di Michele F., Zwanzger P., Romeo E., Bernardi G., Schüle C., Baghai T.C., Ella R., Pasini A., and Rupprecht R. Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depression. Neuropsychopharmacology 27 (2002) 874-878
104. Neuropsychopharmacology 28 (2003) 610-611 corrigendum in
105. Padberg F., Schüle C., Zwanzger P., Baghai T., Ella R., Mikhaiel P., Hampel H., Möller H.-J., and Rupprecht R. Relation between responses to repetitive transcranial magnetic stimulation and partial sleep deprivation in major depression. J. Psychiatr. Res. 36 (2002) 131-135
106. Padberg F., Zwanzger P., Keck M.E., Kathmann N., Mikhaiel P., Ella R., Rupprecht P., Thoma H., Hampel H., Toschi N., and Möller H.-J. Repetitive transcranial magnetic stimulation (rTMS) in major depression: Relation between efficacy and stimulation intensity. Neuropsychopharmacology 27 (2002) 638-645
107. Parker G., Hadzi-Pavlovic D., Brodaty H., Austin M.P., Mitchell P., Wilhelm K., and Hickie I. Sub-typing depression, II. Clinical distinction of psychotic depression and non-psychotic melancholia. Psychol. Med. 25 (1995) 825-832
108. Pascual-Leone A., Catalá M.D., and Pascual-Leone A. Lateralized effect of rapid-rate transcranial magnetic stimulation of the prefrontal cortex on mood. Neurology 46 (1996) 499-502
109. Pascual-Leone A., Rubio B., Pallardó F., and Catalá M.D. Rapid-rate transcranial magnetic stimulation of left dorsolateral prefrontal cortex in drug-resistant depression. Lancet 348 (1996) 233-237
110. Paus T., Jech R., Thompson C.J., Comeau R., Peters T., and Evans A.C. Transcranial magnetic stimulation during positron emission tomography: a new method for studying connectivity of the human cerebral cortex. J. Neurosci. 17 (1997) 3178-3184
111. Paus T., Castro-Alamancos M.A., and Petrides M. Cortico-cortical connectivity of the human mid-dorsolateral frontal cortex and its modulation by repetitive transcranial magnetic stimulation. Eur. J. Neurosci. 14 (2001) 1405-1411
112. Post A., and Keck M.E. Transcranial magnetic stimulation as a therapeutic tool in psychiatry: what do we know about the neurobiological mechanisms?. J. Psychiatr. Res. 35 (2001) 193-215
113. Post A., Müller M.B., Engelmann M., and Keck M.E. Repetitive transcranial magnetic stimulation in rats-evidence for a neuro-protective effect in vitro and in vivo. Eur. J. Neurosci. 11 (1999) 3247-3254
114. Post R.M., Gerner R.H., Carman J.S., Gillin J.C., Jimerson D.C., Goodwin F.K., and Bunney W.E.J. Effects of a dopamine agonist piribedil in depressed patients: relationship of pretreatment homovanillic acid to antidepressant response. Arch. Gen. Psychiatry 35 (1978) 609-615
115. Post R.M., Kimbrell T., Frye M., George M., McCann U., Little J., Dunn R., Li H., and Weiss S.R.B. Implications of kindling and quenching for the possible frequency dependence of rTMS. CNS Spectrums 2 (1997) 54-60
116. Post R.M., Kimbrell T.A., McCann U.D., Dunn R.T., Osuch E.A., Speer A.M., and Weiss S.R.B. Repetitive transcranial magnetic stimulation as a neuropsychiatric tool: present status and future potential. J. ECT 15 (1999) 39-59
117. Pridmore S. Rapid transcranial magnetic stimulation (rTMS) and normalisation of the dexamethasone suppression test (DST). Psychiatry Clin. Neurosci. 53 (1999) 33-37
118. Pridmore S. Substitution of rapid transcranial magnetic stimulation treatments for electroconvulsive therapy treatments in a course of electroconvulsive therapy. Depress. Anxiety 12 (2000) 118-123
119. Pridmore S., Rybak M., Turnier-Shea Y., Reid P., Bruno R., and Couper D. A naturalistic study of response in melancholia to transcranial magnetic stimulation (TMS). German J. Psychiatry 2 (1999) 13-21
120. Pridmore S., Bruno R., Turnier-Shea Y., Reid P., and Rybak M. Comparison of unlimited numbers of rapid transcranial magnetic stimulation (rTMS) and ECT treatment sessions in major depressive episode. Int. J. Neuropsychopharmacol. 3 (2000) 129-134
121. Rampello L., Nicoletti G., and Raffaele R. Dopaminergic hypothesis for retarded depression: a symptom profile for predicting therapeutical responses. Acta Psychiatr. Scand. 84 (1991) 552-554
122. Reid P.D., and Pridmore S. Dexamethasone suppression test reversal in rapid transcranial magnetic stimulation-treated depression. Australian and New Zealand. J. Psychiatry 33 (1999) 274-277
123. Reul J.M., Stec I., Soder M., and Holsboer F. Chronic treatment of rats with the antidepressant amitriptyline attenuates the activity of the hypothalamic-pituitary-adrenocortical system. Endocrinology 133 (1993) 312-320
124. Reul J.M., Labeur M.S., Grigoriadis D.E., De Souza E.B., and Holsboer F. Hypothalamic-pituitary-adrenocortical axis changes in the rat after long-term treatment with the reversible monoamine oxidase-A inhibitor moclobemide. Neuroendocrinology 60 (1994) 509-519
125. Romeo E., Strohle A., Spalletta G., Di Michele F., Hermann B., Holsboer F., Pasini A., and Rupprecht R. Effects of anti-depressant treatment on neuroactive steroids in major depression. Am. J. Psychiatry 155 (1998) 910-913
126. Rupprecht R., Di Michele F., Hermann B., Strohle A., Lancel M., Romeo E., and Holsboer F. Neuroactive steroids: molecular mechanisms of action and implications for neuropsychopharmacology. Brain Res. 37 (2001) 59-67
127. Rush A.J., and Trivedi M.H. Treating depression to remission. Psychiatric Annals 25 (1995) 704-705
128. Sachdev P.S., McBride R., Loo C.K., Mitchell P.M., Malhi G.S., and Croker V. Effects of Different Frequencies of Transcranial Magnetic Stimulation (TMS) on the Forced Swim Test Model of Depression in Rats. Biol. Psychiatry 51 (2002) 474-479
129. Sackeim H.A., Rush A.J., George M.S., Marangell L.B., Husain M.M., Nahas Z., Johnson C.R., Seidman S., Giller C., Haines S., Simpson R.K.J., and Goodman R.R. Vagus nerve stimulation (VNS) for treatment-resistant depression: efficacy, side effects, and predictors of outcome. Neuropsychopharmacology 25 (2001) 713-728
130. Schüle C., Baghai T., Bidlingmaier M., Strasburger C., and Laakmann G. Endocrinological effects of mirtazapine in healthy volunteers. Prog. Neuropsychopharmacol. Biol. Psychiatry 26 (2002) 1253-1261
131. Schüle C., Baghai T., Zwanzger P., Ella R., Eser D., Padberg F., Möller H.-J., and Rupprecht R. Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapine. Psychopharmacology (Berl) 166 (2003) 271-275
132. Schüle C., Zwanzger P., Baghai T., Mikhaiel P., Thoma H., Möller H.-J., Rupprecht R., and Padberg F. Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up study. J. Psychiatr. Res. 37 (2003) 145-153
133. Schutter D., van Honk J., d'Alfonso A., Postma A., and de Haan E. Effects of slow rTMS at the right dorsolateral prefrontal cortex on EEG asymmetry and mood. Neuroreport 12 (2001) 445-447
134. Sesack S.R., and Pickel V.M. Prefrontal cortical efferents in the rat synapse on unlabeled neuronal targets of catecholamine terminals in the nucleus accumbens septi and on dopamine neurons in the ventral tegmental area. J. Comp. Neurol. 320 (1992) 145-160
135. Sgro J.A., Ghatak N.R., Stanton P.C., Emerson R.G., and Blair R. Repetitive high magnetic field stimulation: the effect upon rat brain. In: Levy W.J., Cracco R.Q., Barker A.T., and Rothwell J. (Eds). Magnetic Motor Stimulation: Basic Principles and Clinical Experience (EEG Suppl. 43) (1991), Elsevier, Amsterdam 180-185
136. Shajahan P.M., Glabus M.F., Steele J.D., Doris A.B., Anderson K., Jenkins J.A., Gooding P.A., and Ebmeier K.P. Left dorsolateral repetitive transcranial magnetic stimulation affects cortical excitability and functional connectivity, but does not impair cognition in major depression. Neuro-Psychopharmacology and Biological Psychiatry 26 (2002) 945-954
137. Smesny S., Volz H.P., Liepert J., Tauber R., Hochstetter A., and Sauer H. [Repetitive transcranial magnetic stimulation (rTMS) in the acute and long-term therapy of refractory depression-a case report] (Article in German). Nervenarzt (2001,72) 734-738
138. Speer A.M., Kimbrell T.A., Wassermann E.M., D Repella J., Willis M.W., Herscovitch P., and Post R.M. Opposite effects of high and low frequency rTMS on regional brain activity in depressed patients. Biol Psychiatry 48 (2000) 1133-1141
139. Speer A.M., Repella J.D., Figueras S., Deminan N.K., Kimbrell T.A., Wasserman E.M., and Post R.M. Lack of adverse cognitive effects on 1 Hz and 20 Hz repetitive transcranial magnetic stimulation at 100% of motor threshold over left prefrontal cortex in depression. J. ECT 17 (2001) 259-263
140. Steward O., Kelley M.S., and Torre E.R. The process of re-innervation in the dentate gyrus of adult rats: temporal relationship between changes in the levels of glial fibrillary acidic protein (GFAP) and GFAP mRNA in reactive astrocytes. Exp. Neurol. 124 (1993) 167-183
141. Strafella A.P., Paus T., Barrett J., and Dagher A. Repetitive transcranial magnetic stimulation of the human prefrontal cortex induces dopamine release in the caudate nucleus. J. Neurosci. 21 (2001) RC157
142. Szuba M., O'Reardon J.P., Rai A.S., Snyder-Kastenberg J., Amsterdam J.D., Gettes D.R., Wassermann E.M., and Evans D.L. Acute mood and TSH effects of transcranial magnetic stimulation in major depression. Biol. Psychiatry 50 (2001) 22-27
143. Taber M.T., and Fibiger H.C. Electrical stimulation of the prefrontal cortex increases dopamine release in the nucleus accumbens of the rat: modulation by metabotropic glutamate receptors. J. Neurosci. 15 (1995) 3896-3904
144. Teneback C.C., Nahas Z., Speer A.M., Molloy M., Stallings L.E., Spicer K.M., Risch S.C., and George M.S. Changes in prefrontal cortex and paralimbic activity in depression following two weeks of daily left prefrontal TMS. J. Neuropsychiatry Clin. Neurosci. 11 (1999) 426-435
145. Thase M.E. How should efficacy be evaluated in randomized clinical trials of treatments for depression?. J. Clin. Psychiatry 60 Suppl. 4 (1999) 23-31
146. Thomas D.N., Nutt D.J., and Holman R.B. Effects of acute and chronic electroconvulsive shock on noradrenaline release in the rat hippocampus and frontal cortex. Br. J. Pharmacol. 106 (1992) 430-434
147. Triggs W.J., McCoy K.J.M., Greer R., Rossi F., Bowers D., Kortenkamp S., Nadeau S.E., Heilman K.M., and Goodman W.K. Effects of left frontal transcranial magnetic stimulation on depressed mood, cognition, and corticomotor threshold. Biol. Psychiatry 45 (1999) 1440-1446
148. Uzunova V., Sheline Y., Davis J.M., Rasmusson A., Uzunov D.P., Costa E., and Guidotti A. Increase in the cerebrospinal fluid content of neurosteroids in patients with unipolar major depression who are receiving fluoxetine or fluvoxamine. Proc. Natl. Acad. Sci. USA 95 (1998) 3239-3244
149. Wassermann E.M. Risk and safety of repetitive transcranial magnetic stimulation: report and suggested guidelines from the International Workshop on the Safety of Repetitive Transcranial Magnetic Stimulation, June 5-7, 1996. Electroenceph. Clin. Neurophysiol. (1998) 1-16
150. Wassermann E.M., and Lisanby S.H. Therapeutic application of repetitive transcranial magnetic stimulation: a review. Clin. Neurophysiol. 112 (2001) 1367-1377
151. Wu J., Buchsbaum M.S., Gillin J.C., Tang C., Cadwell S., Wiegand M., Najafi A., Klein E., Hazen K., Bunney W.E.J., Fallon J.H., and Keator D. Prediction of antidepressant effects of sleep deprivation by metabolic rates in the ventral anterior cingulate and medial prefrontal cortex. Am. J. Psychiatry 156 (1999) 1149-1158
152. Yoshida K., Higuchi H., Kamata M., Yoshimoto M., Shimizu T., and Hishikawa Y. Single and repeated electroconvulsive shocks activate dopaminergic and 5-hydroxytryptaminergic neurotransmission in the frontal cortex of rats. Prog. Neuropsychopharmacol. Biol. Psychiatry 22 (1998) 435-444
153. Zangen A., and Hyodo K. Transcranial magnetic stimulation induces increases in extracellular levels of dopamine and glutamate in the nucleus accumbens. Neuro Report 13 (2002) 2401-2405
154. Zetterstrom T.S., Pei Q., and Grahame-Smith D.G. Repeated electroconvulsive shock extends the duration of enhanced gene expression for BDNF in rat brain compared with a single administration. Brain Res. Mol. Brain Res. 57 (1998) 106-110
155. Zetterstrom T.S., Pei Q., Madhav T.R., Coppell A.L., Lewis L., and Grahame-Smith D.G. Manipulations of brain 5-HT levels affect gene expression for BDNF in rat brain. Neuropharmacology 38 (1999) 1063-1073
156. Zis A.P., Nomikos G.G., Brown E.E., Damsma G., and Fibiger H.C. Neurochemical effects of electrically and chemically induced seizures: an in vivo microdialysis study in the rat hippocampus. Neuropsychopharmacology 7 (1992) 189-195
157. Zobel A.W., Yassouridis A., Frieboes R.M., and Holsboer F. Prediction of medium-term outcome by cortisol response to the combined dexamethasone-CRH test in patients with remitted depression. Am. J. Psychiatry 156 (1999) 949-951
158. Zobel A.W., Nickel T., Sonntag A., Uhr M., Holsboer F., and Ising M. Cortisol response in the combined dexamethasone/CRH test as predictor of relapse in patients with remitted depression. a prospective study. J. Psychiatr. Res. 35 (2001) 83-94
159. Zwanzger P., Ella R., Keck M.E., Rupprecht R., and Padberg F. Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depression. Biol. Psychiatry 51 (2002) 602-603
160. Zwanzger P., Baghai T.C., Padberg F., Ella R., Minov C., Mikhaiel P., Schüle C., Thoma H., and Rupprecht R. The combined dexamethasone-corticotropin-releasing-hormone test (DEX/CRH test) before and after treatment with repetitive transcranial magnetic stimulation in major depression. Psychoneuroendocrinology 28 (2003) 376-385
161. Zyss T., Gorka Z., Kowalska M., and Vetulani J. Preliminary comparison of behavioral and biochemical effects of chronic transcranial magnetic stimulation and electroconvulsive shock in the rat. Biol. Psychiatry 42 (1997) 920-924