In vitro activity differences between proteins of the ADF/cofilin family define two distinct subgroups

Biochemistry

Volumn 43, Issue 22, 2004, Pages 7127-7142

  Chen, Hui ^a,b   Bernstein, Barbara W ^a   Sneider, Judith M ^a   Boyle, Judith A ^a   Minamide, Laurie S ^a   Bamburg, James R ^a  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; DEPOLYMERIZATION; PH EFFECTS; YEAST;

ACTIN FILAMENT; IN VITRO ACTIVITY; NUCLEOTIDES;

PROTEINS;

ACTIN DEPOLYMERIZING FACTOR; ADENOSINE TRIPHOSPHATE MAGNESIUM; COFILIN; RECOMBINANT PROTEIN;

ACTIN FILAMENT; ARTICLE; CHICKEN; DEPOLYMERIZATION; DROSOPHILA; HUMAN; IONIC STRENGTH; NONHUMAN; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; XENOPUS;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; BRAIN; CHICKENS; DESTRIN; GELSOLIN; HUMANS; HYDROGEN-ION CONCENTRATION; MICROFILAMENT PROTEINS; MICROFILAMENTS;

GALLUS GALLUS; METAZOA; PROTISTA;

EID: 2642580847     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi049797n     Document Type: Article

References (104)

1. Bamburg, J. R. (1999) Proteins of the ADF/Cofilin family: essential regulators of actin dynamics, Annu. Rev. Cell Dev. Biol. 15, 185-230.
2. Bamburg, J. R., and Bray, D. (1987) Distribution and cellular localization of actin depolymerizing factor, J. Cell Biol. 105, 2817-2825.
3. Yonezawa, N., Nishida, E., Koyasu, S., Maekawa, S., Ohta, Y., Yahara, I., and Sakai, H. (1987) Distribution among tissues and intracellular localization of cofilin, a 21kDa actin-binding protein, Cell Struct. Funct. 12, 443-452.
4. Moon, A. L., Janmey, P. A., Louie, K. A., and Drubin, D. G. (1993) Cofilin is an essential component of the yeast cortical cytoskeleton, J. Cell Biol. 120, 421-435.
5. Nagaoka, R., Kusano, K., Abe, H., and Obinata, T. (1995) Effects of cofilin on actin filamentous structures in cultured muscle cells. Intracellular regulation of cofilin action, J. Cell Sci. 108, 581-593.
6. Gunsalus, K. C., Bonaccorsi, S., Williams, E., Verni, F., Gatti, M., and Goldberg, M. L. (1995) Mutations in twinstar, a Drosophila gene encoding a cofilin/ADF homologue, result in defects in centrosome migration and cytokinesis, J. Cell Biol. 131, 1243-1259.
7. Abe, H., Obinata, T., Minamide, L. S., and Bamburg, J. R. (1996) Xenopus laevis actin-depolymerizing factor/cofilin: a phosphorylation-regulated protein essential for development, J. Cell Biol. 132, 871-885.
8. Lappalainen, P., and Drubin, D. G. (1997) Cofilin promotes rapid actin filament turnover in vivo, Nature 388, 78-82.
9. Rosenblatt, J., Agnew, B. J., Abe, H., Bamburg, J. R., and Mitchison, T. J. (1997) Xenopus actin depolymerizing factor/cofilin (XAC) is responsible for the turnover of actin filaments in Listeria monocytogenes tails, J. Cell Biol. 136, 1323-1332.
10. Carlier, M. F., Laurent, V., Santolini, J., Melki, R., Didry, D., Xia, G. X., Hong, Y., Chua, N. H., and Pantaloni, D. (1997) Actin depolymerizing factor (ADF/cofilin) enhances the rate of filament turnover: implication in actin-based motility, J. Cell Biol. 136, 1307-1322.
11. Loisel, T. P., Boujemaa, R., Pantaloni, D., and Carlier, M. F. (1999) Reconstitution of actin-based motility of Listeria and Shigella using pure proteins, Nature 401, 613-616.
12. Condeelis, J. S. (2001) How is actin polymerization nucleated in vivo? Trends Cell Biol. 11, 288-293.
13. Dawe, H. R., Minamide, L. S., Bamburg, J. R., and Cramer, L. P. (2003) ADF/cofilin controls cell polarity during fibroblast migration, Curr. Biol. 13, 252-257.
14. McGough, A., Pope, B., Chiu, W., and Weeds, A. (1997) Cofilin changes the twist of F-actin: implications for actin filament dynamics and cellular function, J. Cell Biol. 138, 771-781.
15. Galkin, V. E., Orlova, A., Lukoyanova, N., Wriggers, W., and Egelman, E. H. (2001) Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits, J. Cell Biol. 153, 75-86.
16. Hayden, S. M., Miller, P. S., Brauweiler, A., and Bamburg, J. R. (1993) Analysis of the interactions of actin depolymerizing factor with G- and F-actin, Biochemistry 32, 9994-10004.
17. Nishida, E., Maekawa, S., and Sakai, H. (1984) Cofilin, a protein in porcine brain that binds to actin filaments and inhibits their interactions with myosin and tropomyosin, Biochemistry 23, 5307-5313.
18. Hawkins, M., Pope, B., Maciver, S. K., and Weeds, A. G. (1993) Human actin depolymerizing factor mediates a pH-sensitive destruction of actin filaments, Biochemistry 32, 9985-9993.
19. Blanchoin, L., and Pollard, T. D. (1998) Interaction of actin monomers with Acanthamoeba actophorin (ADF/cofilin) and profilin, J. Biol. Chem. 273, 25106-25111.
20. Ressad, F., Didry, D., Xia, G. X., Hong, Y., Chua, N. H., Pantaloni, D., and Carlier, M. F. (1998) Kinetic analysis of the interaction of acfin-depolymerizing factor (ADF)/cofilin with G- and F-actins. Comparison of plant and human ADFs and effect of phosphorylation, J. Biol. Chem. 273, 20894-20902.
21. Yonezawa, N., Nishida, E., Iida, K., Yahara, I., and Sakai, H. (1990) Inhibition of the interactions of cofilin, destrin, and deoxyribonuclease I with actin by phosphoinositides, J. Biol. Chem. 265, 8382-8386.
22. Bernstein, B. W., and Bamburg, J. R. (1982) Tropomyosin binding to F-actin protects the F-actin from disassembly by brain actin-depolymerizing factor (ADF), Cell Motil. 2, 1-8.
23. Nishida, E., Muneyuki, E., Maekawa, S., Ohta, Y., and Sakai, H. (1985) An actin-depolymerizing protein (destrin) from porcine kidney. Its action on F-actin containing or lacking tropomyosin, Biochemistry 24, 6624-6630.
24. Bryce, N. S., Schevzov, G., Ferguson, V., Percival, J. M., Lin, J. J., Matsumura, F., Bamburg, J. R., Jeffrey, P. L., Hardeman, E. C., Gunning, P., and Weinberger, R. P. (2003) Specification of actin filament function and molecular composition by tropomyosin isoforms, Mol. Biol. Cell 14, 1002-1016.
25. Agnew, B. J., Minamide, L. S., and Bamburg, J. R. (1995) Reactivation of phosphorylated actin depolymerizing factor and identification of the regulatory site, J. Biol. Chem. 270, 17582-17587.
26. Smertenko, A. P., Jiang, C. J., Simmons, N. J., Weeds, A. G., Davies, D. R., and Hussey, P. J. (1998) Ser6 in the maize actin-depolymerizing factor, ZmADF3, is phosphorylated by a calcium-stimulated protein kinase and is essential for the control of functional activity, Plant J. 14, 187-193.
27. Blanchoin, L., Robinson, R. C., Choe, S., and Pollard, T. D. (2000) Phosphorylation of Acanthamoeba actophorin (ADF/cofilin) blocks interaction with actin without a change in atomic structure, J. Mol. Biol. 295, 203-211.
28. Arber, S., Barbayannis, F. A., Hanser, H., Schneider, C., Stanyon, C. A., Bernard, O., and Caroni, P. (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase, Nature 393, 805-809.
29. Yang, N., Higuchi, O., Ohashi, K., Nagata, K., Wada, A., Kangawa, K., Nishida, E., and Mizuno, K. (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization, Nature 393, 809-812.
30. Sumi, T., Matsumoto, K., Takai, Y., and Nakamura, T. (1999) Cofilin phosphoylation and actin cytoskeletal dynamics regulated by Rho- and Cdc42-actiated LIM-kinase 2, J. Cell Biol. 147, 1519-1532.
31. Maekawa, M., Ishizaki, T., Boku, S., Watanabe, N., Fujita, A., Iwamatsu, A., Obinata, T., Ohashi, K., Mizuno, K., and Narumiya, S. (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase, Science 285, 895-898.
32. Amano, T., Tanabe, K., Eto, T., Narumiya, S., and Mizuno, K. (2001) LIM-kinase 2 induces formation of stress fibres, focal adhesions and membrane blebs, dependent on its activation by Rho-associated kinase-catalysed phosphorylation at threonine-505, Biochem. J. 354, 149-159.
33. Toshima, J., Toshima, J. Y., Amano, T., Yang, N., Narumiya, S., and Mizuno, K. (2001) Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation, Mol. Biol. Cell 12, 1131-1145.
34. Toshima, J., Toshima, J. Y., Takeuchi, K., Mori, R., and Mizuno, K. (2001) Cofilin phosphorylation and actin reorganization activities of testicular protein kinase 2 and its predominant expression in testicular Sertoli cells, J. Biol. Chem. 276, 31449-31458.
35. Toshima, J., Toshima, J. Y., Amano, T., Yang, N., Narumiya, S., and Mizuno, K. (2001) Cofilin phosphorylation by protein kinase testicular protein kinase 1 and its role in integrin-mediated actin reorganization and focal adhesion formation, Mol. Biol. Cell 12, 1131-1145.
36. Gohla, A., and Bokoch, G. M. (2002) 14-3-3 regulates actin dynamics by stabilizing phosphorylated cofilin, Curr. Biol. 12, 1704-1710.
37. Birkenfeld, J., Betz, H., and Roth, D. (2003) Identification of cofilin and LIM-domain-containing protein kinase 1 as novel interaction partners of 14-3-3 zeta, Biochem. J. 369, 45-54.
38. Toshima, J. Y., Toshima, J., Watanabe, T., and Mizuno, K. (2001) Binding of 14-3-3beta regulates the kinase activity and subcellular localization of testicular protein kinase 1, J. Biol. Chem. 276, 43471-43481.
39. Niwa, R., Nagata-Ohashi, K., Takeichi, M., Mizuno, K., and Uemura, T. (2002) Control of actin reorganization by Slingshot, a family of phosphatases that dephosphorylate ADF/cofilin, Cell 108, 233-246.
40. Ohta, Y., Kousaka, K., Nagata-Ohashi, K., Ohashi, K., Muramoto, A., Shima, Y., Niwa, R., Uemura, T., and Mizuno, K. (2003) Differential activities, subcellular distribution and tissue expression patterns of three members of Slingshot family phosphatases that dephosphorylate cofilin, Genes Cells 8, 811-824.
41. Bamburg, J. R., and Wiggan, O. P. (2002) ADF/cofilin and actin dynamics in disease, Trends Cell Biol. 12, 598-605.
42. Maciver, S. K., Pope, B. J., Whytock, S., and Weeds, A. G. (1998) The effect of two actin depolymerizing factors (ADF/cofilins) on actin filament turnover: pH sensitivity of F-actin binding by human ADF, but not of Acanthamoeba actophorin, Eur. J. Biochem. 256, 388-397.
43. Bernstein, B. W., Painter, W. B., Chen, H., Minamide, L. S., Abe, H., and Bamburg, J. R. (2000) Intracellular pH modulation of ADF/cofilin proteins, Cell Motil. Cytoskeleton 47, 319-336.
44. Lappalainen, P., Kessels, M. M., Cope, M. J., and Drubin, D. G. (1998) The ADF homology (ADF-H) domain: a highly exploited actin-binding module, Mol. Biol. Cell 9, 1951-1959.
45. Iida, K., Moriyama, K., Matsumoto, S., Kawasaki, H., Nishida, E., and Yahara, I. (1993) Isolation of a yeast essential gene, COF1, that encodes a homologue of mammalian cofilin, a low-M(r) actin-binding and depolymerizing protein, Gene 124, 115-120.
46. Ono, S., and Benian, G. M. (1998) Two Caenorhabditis elegans actin depolymerizing factor/cofilin proteins, encoded by the unc-60 gene, differentially regulate actin filament dynamics, J. Biol. Chem. 273, 3778-3783.
47. Vartiainen, M. K., Mustonen, T., Mattila, P. K., Ojala, P. J., Thesleff, I., Partanen, J., and Lappalainen, P. (2002) The three mouse actin-depolymerizing factor/cofilins evolved to fulfill cell-type-specific requirements for actin dynamics, Mol. Biol. Cell 13, 183-194.
48. Yeoh, S., Pope, B., Mannherz, H. G., and Weeds, A. (2002) Determining the differences in actin binding by human ADF and cofilin, J. Mol. Biol. 315, 911-925.
49. Dai, S., Sarmiere, P. D., Wiggan, O., Bamburg, J. R., and Zhou, D. (2004) Efficient Salmonella entry requires activity cycles of host ADF and cofilin, Cell Microbiol. 6, 459-471.
50. Pardee, J. D., and Spudich, J. A. (1982) Purification of muscle actin, Methods Enzymol. 85 Pt. B, 164-181.
51. Kinosian, H. J., Selden, L. A., Estes, J. E., and Gershman, L. C. (1993) Nucleotide binding to actin. Cation dependence of nucleotide dissociation and exchange rates, J. Biol. Chem. 268, 8683-8691.
52. Gershman, L. C., Selden, L. A., Kinosian, H. J., and Estes, J. E. (1989) Preparation and polymerization properties of monomeric ADP-actin, Biochim. Biophys. Acta 995, 109-115.
53. Giuliano, K. A., Khatib, F. A., Hayden, S. M., Daoud, E. W., Adams, M. E., Amorese, D. A., Bernstein, B. W., and Bamburg, J. R. (1988) Properties of purified actin depolymerizing factor from chick brain, Biochemistry 27, 8931-8938.
54. Adams, M. E., Minamide, L. S., Duester, G., and Bamburg, J. R. (1990) Nucleotide sequence and expression of a cDNA encoding chick brain actin depolymerizing factor, Biochemistry 29, 7414-7420.
55. Abe, H., Ohshima, S., and Obinata, T. (1989) A cofilin-like protein is involved in the regulation of actin assembly in developing skeletal muscle, J. Biochem. 106, 696-702.
56. Nagaoka, R., Abe, H., and Obinata, T. (1996) Site-directed mutagenesis of the phosphorylation site of cofilin: its role in cofilin-actin interaction and cytoplasmic localization, Cell Motil. Cytoskeleton 35, 200-209.
57. Houk, T. W. J., and Ue, K. (1974) The measurement of actin concentration in solution: a comparison of methods, Anal. Biochem. 62, 66-74.
58. Gill, S. C., and von Hippel, P. H. (1989) Calculation of protein extinction coefficients from amino acid sequence data, Anal. Biochem. 182, 319-326.
59. Pope, B. J., Gooch, J. T., and Weeds, A. G. (1997) Probing the effects of calcium on gelsolin, Biochemistry 36, 15848-15855.
60. 2+ ions to the regulatory binding sites of gelsolin, Eur. J. Biochem. 262, 330-334.
61. Huang, C. Y. (1982) Determination of binding stoichiometry by the continuous variation method: the Job plot, Methods Enzymol. 87, 509-525.
62. Laemmli, U. K. (1970) Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature 227, 680-685.
63. McLeod, J. F., Kowalski, M. A., and Haddad, J. G., Jr. (1989) Interactions among serum vitamin D binding protein, monomeric actin, profilin, and profilactin, J. Biol. Chem. 264, 1260-1267.
64. Moriyama, K., and Yahara, I. (1999) Two activities of cofilin, severing and accelerating directional depolymerization of actin filaments, are differentially affected by mutations around the actin-binding helix, EMBO J. 18, 6752-6761.
65. Coluccio, L. M., and Tilney, L. G. (1984) Phalloidin enhances actin assembly by preventing monomer dissociation, J. Cell Biol. 99, 529-535.
66. Ralston, G. (1993) in Introduction to analytical ultracentrifugation, Beckman Instruments, Inc., Fullerton, CA.
67. Cantor, C. R., and Schimmel, P. R. (1980) in Biophysical chemistry, W. H. Freeman and Co., San Francisco.
68. Ressad, F., Didry, D., Egile, C., Pantaloni, D., and Carlier, M. F. (1999) Control of actin filament length and turnover by actin depolymerizing factor (ADF/Cofilin) in the presence of capping proteins and ARP2/3 complex, J. Biol. Chem. 274, 20970-20976.
69. Pollard, T. D., and Cooper, J. A. (1986) Actin and actin-binding proteins. A critical evaluation of mechanisms and functions, Annu. Rev. Biochem. 55, 987-1035.
70. Head, J. F., Swamy, N., and Ray, R. (2002) Crystal structure of the complex between actin and human vitamin D-binding protein at 2.5 A resolution, Biochemistry 41, 9015-9020.
71. Otterbein, L. R., Cosio, C., Graceffa, P., and Dominguez, R. (2002) Crystal structures of the vitamin D-binding protein and its complex with actin: structural basis of the actin-scavenger system, Proc. Natl. Acad. Sci. U.S.A. 99, 8003-8008.
72. Wriggers, W., Tang, J. X., Azuma, T., Marks, P. W., and Janmey, P. A. (1998) Cofilin and gelsolin segment-1: molecular dynamics simulation and biochemical analysis predict a similar actin binding mode, J. Mol. Biol. 282, 921-932.
73. Cooper, J. A., Blum, J. D., Williams, R. C. J., and Pollard, T. D. (1986) Purification and characterization of actophorin, a new 15,000-dalton actin-binding protein from Acanthamoeba castellanii, J. Biol. Chem. 261, 477-485.
74. Quirk, S., Maciver, S. K., Ampe, C., Doberstein, S. K., Kaiser, D. A., VanDamme, J., Vandekerckhove, J. S., and Pollard, T. D. (1993) Primary structure of and studies on Acanthamoeba actophorin, Biochemistry 32, 8525-8533.
75. McKim, K. S., Matheson, C., Marra, M. A., Wakarchuk, M. F., and Baillie, D. L. (1994) The Caenorhabditis elegans unc-60 gene encodes proteins homologous to a family of actin-binding proteins, Mol. Gen. Genet. 242, 346-357.
76. Mabuchi, I. (1983) An actin-depolymerizing protein (depactin) from starfish oocytes: properties and interaction with actin, J. Cell Biol. 97, 1612-1621.
77. Aizawa, H., Sutoh, K., Tsubuki, S., Kawashima, S., Ishii, A., and Yahara, I. (1995) Identification, characterization, and intracellular distribution of cofilin in Dictyostelium discoideum, J. Biol. Chem. 270, 10923-10932.
78. Rosenblatt, J., Peluso, P., and Mitchison, T. J. (1995) The bulk of unpolymerized actin in Xenopus egg extracts is ATP-bound, Mol. Biol. Cell 6, 227-236.
79. Maciver, S. K., and Weeds, A. G. (1994) Actophorin preferentially binds monomeric ADP-actin over ATP-bound actin: consequences for cell locomotion, FEBS Lett. 347, 251-256.
80. Koffer, A., Edgar, A. J., and Bamburg, J. R. (1988) Identification of two species of actin depolymerizing factor in cultures of BHK cells, J. Muscle Res. Cell Motil. 9, 320-328.
81. Devineni, N., Minamide, L. S., Niu, M., Safer, D., Verma, R., Bamburg, J. R., and Nachmias, V. T. (1999) A quantitative analysis of G-actin binding proteins and the G-actin pool in developing chick brain, Brain Res. 823, 129-140.
82. Estes, J. E., Selden, L. A., Kinosian, H. J., and Gershman, L. C. (1992) Tightly-bound divalent cation of actin, J. Muscle Res. Cell Motil. 13, 272-284.
83. 2+i, and cytotoxicity in rat hepatocytes, J. Biol. Chem. 267, 6654-6663.
84. Zaffran, Y., Lepidi, H., Bongrand, P., Mege, J. L., and Capo, C. (1993) F-actin content and spatial distribution in resting and chemoattractant-stimulated human polymorphonuclear leucocytes. Which role for intracellular free calcium? J. Cell Sci. 105, 675-684.
85. Kitazawa, T., Shuman, H., and Somlyo, A. P. (1982) Calcium and magnesium binding to thin and thick filaments in skinned muscle fibres: electron probe analysis, J. Muscle Res. Cell Motil. 3, 437-454.
86. Llinas, R., Sugimori, M., and Silver, R. B. (1992) Microdomains of high calcium concentration in a presynaptic terminal, Science 256, 677-679.
87. Nyitrai, M., Hild, G., Belagyi, J., and Somogyi, B. (1997) Spectroscopic study of conformational changes in subdomain 1 of G-actin: influence of divalent cations, Biophys. J. 73, 2023-2032.
88. Fuller, N., and Rand, R. P. (1999) Water in actin polymerization, Biophys. J. 76, 3261-3266.
89. Ichetovkin, I., Han, J., Pang, K. M., Knecht, D. A., and Condeelis, J. S. (2000) Actin filaments are severed by both native and recombinant Dictyostelium cofilin but to different extents, Cell Motil. Cytoskeleton 45, 293-306.
90. Blanchoin, L., Pollard, T. D., and Mullins, R. D. (2000) Interactions of ADF/cofilin, Arp2/3 complex, capping protein and profilin in remodeling of branched actin filament networks, Curr. Biol. 10, 1273-1282.
91. Carlier, M. F., Ressad, F., and Pantaloni, D. (1999) Control of actin dynamics in cell motility. Role of ADF/cofilin, J. Biol. Chem. 274, 33827-33830 (review, 62 refs).
92. Mangs, H., Sui, G. C., and Wiman, B. (2000) PAI-1 stability: the role of histidine residues, FEBS Lett. 475, 192-196.
93. Linder, M., Nevanen, T., and Teeri, T. T. (1999) Design of a pH-dependent cellulose-binding domain, FEBS Lett. 447, 13-16.
94. Pope, B. J., Zierler-Gould, K. M., Kuhne, R., Weeds, A. G., and Ball, L. J. (2004) Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor, J. Biol. Chem. 279, 4840-4848.
95. Bowman, G. D., Nodelman, I. M., Hong, Y., Chua, N. H., Lindberg, U., and Schutt, C. E. (2000) A comparative structural analysis of the ADF/Cofilin family, Proteins 41, 374-384.
96. Lappalainen, P., Fedorov, E. V., Fedorov, A. A., Almo, S. C., and Drubin, D. G. (1997) Essential functions and actin-binding surfaces of yeast cofilin revealed by systematic mutagenesis, EMBO J. 16, 5520-5530.
97. Ono, S., McGough, A., Pope, B. J., Tolbert, V. T., Bui, A., Pohl, J., Benian, G. M., Gernert, K. M., and Weeds, A. G. (2001) The C-terminal tail of UNC-60B (actin depolymerizing factor/cofilin) is critical for maintaining its stable association with F-actin and is implicated in the second actin-binding site, J. Biol. Chem. 276, 5952-5958.
98. Okada, K., Obinata, T., and Abe, H. (1999) XAIP1: a Xenopus homologue of yeast actin interacting protein 1 (AIP1), which induces disassembly of actin filaments cooperatively with ADF/cofilin family proteins, J. Cell Sci. 112, 1553-1565.
99. Okada, K., Blanchoin, L., Abe, H., Chen, H., Pollard, T. D., and Bamburg, J. R. (2002) Xenopus actin-interacting protein 1 (XAip1) enhances cofilin fragmentation of filaments by capping filament ends, J. Biol. Chem. 277, 43011-43016.
100. Balcer, H. I., Goodman, A. L., Rodal, A. A., Smith, E., Kugler, J., Heuser, J. E., and Goode, B. L. (2003) Coordinated regulation of actin filament turnover by a high-molecular-weight Srv2/CAP complex, cofilin, profilin, and Aip1, Curr. Biol. 13, 2159-2169.
101. Mohri, K., and Ono, S. (2003) Actin filament disassembling activity of Caenorhabditis elegans actin-interacting protein 1 (UNC-78) is dependent on filament binding by a specific ADF/cofilin isoform, J. Cell Sci. 116, 4107-4118.
102. Aizawa, H., Sutoh, K., and Yahara, I. (1996) Overexpression of cofilin stimulates bundling of actin filaments, membrane ruffling, and cell movement in Dictyostelium, J. Cell Biol. 132, 335-344.
103. Chan, A. Y., Bailly, M., Zebda, N., Segall, J. E., and Condeelis, J. S. (2000) Role of cofilin in epidermal growth factor-stimulated actin polymerization and lamellipod protrusion, J. Cell Biol. 148, 531-542.
104. Zebda, N., Bernard, O., Bailly, M., Welti, S., Lawrence, D. S., and Condeelis, J. S. (2000) Phosphorylation of ADF/Cofilin abolishes EGF-induced actin nucleation at the leading edge and subsequent lamellipod extension, J. Cell Biol. 151, 1119-1128.