Chromosome aberrations induced by high-LET carbon ions in radiosensitive and radioresistant tumour cells

Cytogenetic and Genome Research

Volumn 104, Issue 1-4, 2004, Pages 221-226

  Virsik Kopp P ^a,b   Hofman Huether, H ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b NONE   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; ION;

CELL STRAIN; CELL STRAIN MCF 7; CHROMOSOME ABERRATION; CHROMOSOME ANALYSIS; COLOR; COMPARATIVE STUDY; CONFERENCE PAPER; CONTROLLED STUDY; ENERGY; FLUORESCENCE IN SITU HYBRIDIZATION; HUMAN; HUMAN CELL; IRRADIATION; PRIORITY JOURNAL; RADIATION DOSE; RADIOSENSITIVITY; STANDARD; TUMOR CELL; TUMOR CELL LINE; X RAY;

ADENOCARCINOMA; BREAST NEOPLASMS; CARBON; CELL LINE, TUMOR; CHROMATIDS; CHROMOSOME ABERRATIONS; CHROMOSOME BREAKAGE; CHROMOSOMES, HUMAN; COLONIC NEOPLASMS; DNA REPAIR; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; HUMANS; IN SITU HYBRIDIZATION, FLUORESCENCE; IONS; LINEAR ENERGY TRANSFER; RADIATION TOLERANCE; TRANSLOCATION, GENETIC;

MINK CELL FOCUS-FORMING VIRUS;

EID: 2642580753     PISSN: 14248581     EISSN: None     Source Type: Journal    
DOI: 10.1159/000077493     Document Type: Conference Paper

References (31)

1. Anderson RM, Marsden SJ, Wright EG, Kadhim MA, Goodhead DT, Griffin CS: Complex chromosome aberrations in peripheral blood lymphocytes as a potential biomarker of exposure to high-LET alpha-particles. Int J Radiat Biol 76:31-42 (2000).
2. Bauchinger M, Schmid E: LET dependence of yield ratios of radiation-induced intra- and interchromosomal aberrations in human lymphocytes. Int J Radiat Biol 74:17-25 (1998).
3. Durante M, Furusawa Y, George K, Gialanella G, Greco O, Grossi G, Matsufuji N, Pugliese M, Yang TC: Rejoining and misrejoining of radiation-induced chromatin breaks. IV. Charged particles. Radiat Res 149:446-454 (1998).
4. Durante M, Yamada S, Ando K, Furusawa Y, Kawata T, Majima H, Nakano T, Tsujii H: X-rays vs. carbon-ion tumor therapy: cytogenetic damage in lymphocytes. Int J Radiat Oncol Biol Phys 47:793-798 (2000).
5. Durante M, George K, Wu H, Cucinotta FA: Karyotypes of human lymphocytes exposed to high-energy iron ions. Radiat Res 158:581-590 (2002).
6. Goodhead DT: Microscopic features of dose from radionuclides, particularly emitters of alpha-particles and Auger electrons. Int J Radiat Biol 60:550-553 (1991).
7. Goodwin E, Blakely E, Ivery G, Tobias C: Repair and misrepair of heavy-ion-induced chromosomal damage. Adv Space Res 9:83-89 (1989).
8. 238Pu alpha-particles and detected by fluorescence in situ hybridization using single chromosome-specific probes. Int J Radiat Biol 67:431-439 (1995).
9. Grigorova M, Brand R, Xiao Y, Natarajan AT: Frequencies and types of exchange aberrations induced by X-rays and neutrons in Chinese hamster splenocytes detected by FISH using chromosome-specific DNA libraries. Int J Radiat Biol 74:297-314 (1998).
10. Haberer T, Becher W, Schardt D, Kraft G: Magnetic scanning system for heavy ion therapy. Nuc Inst and Methods in Phys Res A 330:296-305 (1993).
11. Heilmann J, Taucher-Scholz G, Haberer T, Scholz M, Kraft G: Measurement of intracellular DNA double-strand break induction and rejoining along the track of carbon and neon particle beams in water. Int J Radiat Oncol, Biol, Phys 34:599-608 (1996).
12. Hofman-Huether H: Wirkung schwerer Ionen auf strahlenresistente und strahlensensitive Tumorzellen. PhD Thesis, University of Göttingen, Göttingen (2002).
13. Hoglund E, Stenerlow B: Induction and rejoining of DNA double-strand breaks in normal human skin fibroblasts after exposure to radiation of different linear energy transfer: possible roles of track structure and chromatin organization. Radiat Res 155:818-825 (2001).
14. Ofuchi T, Suzuki M, Kase Y, Ando K, Isono K, Ochiai T: Chromosome breakage and cell lethality in human hepatoma cells irradiated with X rays and carbon-ion beams. J Radiat Res (Tokyo) 40:125-133 (1999).
15. Olive PL, Banath JP, MacPhail HS: Lack of a correlation between radiosensitivity and DNA double-strand break induction or rejoining in six human tumor cell lines. Cancer Res 54:3939-3946 (1994).
16. Pinto M, Prise KM, Michael BD: Double strand break rejoining after irradiation of human fibroblasts with X rays or alpha particles: PFGE studies and numerical models. Radiat Prot Dosimetry 99:133-136 (2002).
17. Ritter S, Nasonova E, Gudowska-Novak E: Effect of LET on the yield and quality of chromosomal damage in metaphase cells: a time-course study. Int J Radiat Biol 78:191-202 (2002).
18. Rydberg B: Clusters of DNA damage induced by ionizing radiation: formation of short DNA fragments. II. Experimental detection. Radiat Res 145:200-209 (1996).
19. Rydberg B, Löbrich M, Cooper PK: DNA double-strand breaks induced by high-energy neon and iron ions in human fibroblasts. I. Pulsed-field gel electrophoresis method. Radiat Res 139:133-141 (1994).
20. Simpson PJ, Savage JR: Identification of X-ray-induced complex chromosome exchanges using fluorescence in situ hybridization: a comparison at two doses. Int J Radiat Biol 66:629-632 (1994).
21. Stenerlow B, Blomquist E, Grusell E, Hartman T, Carlsson J: Rejoining of DNA double-strand breaks induced by accelerated nitrogen ions. Int J Radiat Biol 70:413-420 (1996).
22. Stenerlow B, Hoglund E, Carlsson J, Blomquist E: Rejoining of DNA fragments produced by radiations of different linear energy transfer. Int J Radiat Biol 76:549-557 (2000).
23. Stenerlow B, Hoglund E, Carlsson J: DNA fragmentation by charged particle tracks. Adv Space Res 30:859-863 (2002).
24. Suzuki M, Kase Y, Kanai T, Ando K: Correlation between cell death and induction of non-rejoining PCC breaks by carbon-ion beams. Adv Space Res 22:561-568 (1998).
25. 56Fe ions. Radiat Res 155:432-439 (2001).
26. Taucher-Scholz G, Heilmann J, Kraft G: Induction and rejoining of DNA double-strand breaks in CHO cells after heavy ion irradiation. Adv Space Res 18:83-92 (1996).
27. Testard I, Dutrillaux B, Sabatier L: Chromosomal aberrations induced in human lymphocytes by high-LET irradiation. Int J Radiat Biol 72:423-433 (1997).
28. Virsik-Peuckert P, Rave-Fränk M, Schmidberger H: Further studies on the possible relationship between radiation-induced reciprocal translocations and intrinsic radiosensitivity of human tumor cells. Radiother Oncol 40:111-119 (1996).
29. Visser AE, Aten JA: Chromosomes as well as chromosomal subdomains constitute distinct units in interphase nuclei. J Cell Sci 112:3353-3360 (1999).
30. Wu H, Durante M, George K, Yang TC: Induction of chromosome aberrations in human cells by charged particles. Radiat Res 148:102-107 (1997).
31. Zink D, Cremer T, Saffrich R, Fischer R, Trendelenburg MF, Ansorge W, Stelzer EH: Structure and dynamics of human interphase chromosome territories in vivo. Hum Genet 102:241-251 (1998).