메뉴 건너뛰기




Volumn 9, Issue 1, 2004, Pages 179-189

Emerging oral drugs for erectile dysfunction

Author keywords

Apomorphine; Drugs; Erectile dysfunction; Sildenafil; Tadalafil; Treatment; Vardenafil

Indexed keywords

AMPRENAVIR; APOMORPHINE; DELAVIRDINE; DOPAMINE 1 RECEPTOR STIMULATING AGENT; DOPAMINE 2 RECEPTOR STIMULATING AGENT; EFAVIRENZ; INDINAVIR; NELFINAVIR; NITRATE; PROSTAGLANDIN E1; RITONAVIR; SAQUINAVIR; SILDENAFIL; TADALAFIL; UK 103320; VARDENAFIL;

EID: 2642577516     PISSN: 14728214     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728214.9.1.179     Document Type: Review
Times cited : (9)

References (83)
  • 1
    • 0002486987 scopus 로고    scopus 로고
    • Recommendations of the 1st international consultation on erectile dysfunction
    • Jardin A, Wagner G, Khouri S, Giuliano F, Padma Nathan H, Rosen R (Eds). Health Publication Ltd, Plymouth, UK
    • JARDIN A, WAGNER G, KHOURI S et al.: Recommendations of the 1st International Consultation on Erectile Dysfunction. In: Erectile Dysfunction. Jardin A, Wagner G, Khouri S, Giuliano F, Padma Nathan H, Rosen R (Eds). Health Publication Ltd, Plymouth, UK (2000):709-726.
    • (2000) Erectile Dysfunction , pp. 709-726
    • Jardin, A.1    Wagner, G.2    Khouri, S.3
  • 2
    • 0029870714 scopus 로고    scopus 로고
    • Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system
    • ARVER S, DOBS AS, MEIKLE AW, ALLEN RP, SANDERS SW, MAZER NA: Improvement of sexual function in testosterone deficient men treated for 1 year with a permeation enhanced testosterone transdermal system. J. Urol. (1996) 155(5):1604-1608.
    • (1996) J. Urol. , vol.155 , Issue.5 , pp. 1604-1608
    • Arver, S.1    Dobs, A.S.2    Meikle, A.W.3    Allen, R.P.4    Sanders, S.W.5    Mazer, N.A.6
  • 3
    • 0034572645 scopus 로고    scopus 로고
    • Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction
    • SCHULTEISS D, HILTL DM, MESCHI MR et al.: Pilot study of the transdermal application of testosterone gel to the penile skin for the treatment of hypogonadotropic men with erectile dysfunction. World J. Urol. (2000) 18:431-435.
    • (2000) World J. Urol. , vol.18 , pp. 431-435
    • Schulteiss, D.1    Hiltl, D.M.2    Meschi, M.R.3
  • 4
    • 0000844423 scopus 로고    scopus 로고
    • Clinical evaluation and the doctor-patient dialogue
    • Jardin A, Wagner G, Khouri S, Giuliano F, Padma Nathan H, Rosen R (Eds). Health Publication Ltd, Plymouth, UK
    • MEULEMAN E, BRODERICK G, MENG TAN H et al.: Clinical evaluation and the doctor-patient dialogue. In: Erectile Dysfunction. Jardin A, Wagner G, Khouri S, Giuliano F, Padma Nathan H, Rosen R (Eds). Health Publication Ltd, Plymouth, UK (2000):115-138.
    • (2000) Erectile Dysfunction , pp. 115-138
    • Meuleman, E.1    Broderick, G.2    Meng Tan, H.3
  • 5
    • 84942949401 scopus 로고
    • Consensus development panel on impotence
    • NIH: Consensus Development Panel on Impotence. JAMA (1993) 270:83-90.
    • (1993) JAMA , vol.270 , pp. 83-90
  • 6
    • 0029073581 scopus 로고
    • Pharmacological management of erectile dysfunction
    • MONTORSI F, GUAZZONI G, RIGATTI P et al: Pharmacological management of erectile dysfunction. Drugs (1995) 50:465-479.
    • (1995) Drugs , vol.50 , pp. 465-479
    • Montorsi, F.1    Guazzoni, G.2    Rigatti, P.3
  • 7
    • 0034126707 scopus 로고    scopus 로고
    • Central neuropharmacological agents and mechanisms in erectile dysfunction: The role of dopamine
    • HEATON JP: Central neuropharmacological agents and mechanisms in erectile dysfunction: the role of dopamine. Neuro. Bio. Rev. (2000) 24:507-516.
    • (2000) Neuro. Bio. Rev. , vol.24 , pp. 507-516
    • Heaton, J.P.1
  • 8
    • 0034992660 scopus 로고    scopus 로고
    • Pharmacology of erectile function and dysfunction
    • ANDERSSON KE: Pharmacology of erectile function and dysfunction. Urol. Clin. North Am. (2001) 28:233-247. This paper is an excellent review of pathophysiology and molecular targets implicated in erectile function and dysfunction.
    • (2001) Urol. Clin. North Am. , vol.28 , pp. 233-247
    • Andersson, K.E.1
  • 9
    • 0036192379 scopus 로고    scopus 로고
    • Is there a common pathophysiology of erectile dysfunction and how does this relate to new pharmacotherapies?
    • STIEF CG: Is there a common pathophysiology of erectile dysfunction and how does this relate to new pharmacotherapies? Int. J. Impact. Res. (2002) 14(Suppl. 1):S11-S16.
    • (2002) Int. J. Impact. Res. , vol.14 , Issue.SUPPL. 1
    • Stief, C.G.1
  • 10
    • 0026093557 scopus 로고
    • Effects of nitric oxide synthase inhibitor NG-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit
    • HOLMQUIST F, STIEF CG, JONAS U et al.: Effects of nitric oxide synthase inhibitor NG-nitro-L-arginine on the erectile response to cavernous nerve stimulation in the rabbit. Acta Physiol. Scand. (1991) 143:299-304.
    • (1991) Acta Physiol. Scand. , vol.143 , pp. 299-304
    • Holmquist, F.1    Stief, C.G.2    Jonas, U.3
  • 11
    • 0027523365 scopus 로고
    • Nitric oxide and cGMP: Mediators of pelvic nerve-stimulated erection in dogs
    • TRIGO-ROCHA F, ARONSON WJ, HOHENFELLNER M et al.: Nitric oxide and cGMP: mediators of pelvic nerve-stimulated erection in dogs. Am. J. Physiol. (1993) 264:H419-H422.
    • (1993) Am. J. Physiol. , vol.264
    • Trigo-Rocha, F.1    Aronson, W.J.2    Hohenfellner, M.3
  • 12
    • 0026513870 scopus 로고
    • Endothelium derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone
    • AZADZOI KM, KIM N, BROWN ML et al.: Endothelium derived nitric oxide and cyclooxygenase products modulate corpus cavernosum smooth muscle tone. J. Urol. (1992) 147:220-225.
    • (1992) J. Urol. , vol.147 , pp. 220-225
    • Azadzoi, K.M.1    Kim, N.2    Brown, M.L.3
  • 13
    • 0034750923 scopus 로고    scopus 로고
    • Expression of different phosphodiesterase genes in human cavernous smooth muscle
    • KUTHE A, WIEDENROTH A, MAGERT HJ et al.: Expression of different phosphodiesterase genes in human cavernous smooth muscle. J. Urol. (2001) 165:280-283. This basic science research elucidates distribution of PDE genes in corpus cavemosum, indicating a role of these enzymes in penile erection regulation.
    • (2001) J. Urol. , vol.165 , pp. 280-283
    • Kuthe, A.1    Wiedenroth, A.2    Magert, H.J.3
  • 14
    • 0034086679 scopus 로고    scopus 로고
    • Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis
    • KUTHE A, MAGERT H, UCKERT S et al.: Gene expression of the phosphodiesterases 3A and 5A in human corpus cavernosum penis. Eur. Urol. (2000) 38:108-114.
    • (2000) Eur. Urol. , vol.38 , pp. 108-114
    • Kuthe, A.1    Magert, H.2    Uckert, S.3
  • 15
    • 0035257809 scopus 로고    scopus 로고
    • Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction
    • ÜCKERT S, KUTHE A, STIEF CG et al.: Phosphodiesterase isoenzymes as pharmacological targets in the treatment of male erectile dysfunction. World J. Urol. (2001) 19:14-22.
    • (2001) World J. Urol. , vol.19 , pp. 14-22
    • Ückert, S.1    Kuthe, A.2    Stief, C.G.3
  • 16
    • 0034673250 scopus 로고    scopus 로고
    • Expression of three isoforms of cGMP binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum
    • LIN CS, LAU A, TU R et al.: Expression of three isoforms of cGMP binding cGMP-specific phosphodiesterase (PDE5) in human penile cavernosum. Biochem. Biophys. Res. Commun. (2000) 268:628-635.
    • (2000) Biochem. Biophys. Res. Commun. , vol.268 , pp. 628-635
    • Lin, C.S.1    Lau, A.2    Tu, R.3
  • 17
    • 0036194396 scopus 로고    scopus 로고
    • New directions for erectile dysfunction therapies
    • ANDERSSON KE, HEDLUND P: New directions for erectile dysfunction therapies. Int. J. Impot. Res. (2002) 14(Suppl. 1):S82-S92.
    • (2002) Int. J. Impot. Res. , vol.14 , Issue.SUPPL. 1
    • Andersson, K.E.1    Hedlund, P.2
  • 18
    • 0032516296 scopus 로고    scopus 로고
    • Oral sildenafil in the treatment of erectile dysfunction
    • GOLDSTEIN I, LUE TF, PADMA-NATHAN H et al.: Oral sildenafil in the treatment of erectile dysfunction. N. Engl. J. Med. (1998) 338:1397-1404.
    • (1998) N. Engl. J. Med. , vol.338 , pp. 1397-1404
    • Goldstein, I.1    Lue, T.F.2    Padma-Nathan, H.3
  • 19
    • 0032622397 scopus 로고    scopus 로고
    • Sildenafil citrate for SSRI-induced sexual side effects
    • ROSENBERG KP: Sildenafil citrate for SSRI-induced sexual side effects. Am. J. Psychiatry (1999) 156:157.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 157
    • Rosenberg, K.P.1
  • 21
    • 0001221211 scopus 로고    scopus 로고
    • Pharmacokinetics of sildenafil (Viagra), a selective cGMP PDE5 inhibitor, after single oral doses in fasted and fed healthy volunteers
    • MUIRHEAD GJ, ALLEN MJ, JAMES GC et al.: Pharmacokinetics of sildenafil (Viagra), a selective cGMP PDE5 inhibitor, after single oral doses in fasted and fed healthy volunteers. Br. J. Clin. Pharmacol (1996) 42:268.
    • (1996) Br. J. Clin. Pharmacol. , vol.42 , pp. 268
    • Muirhead, G.J.1    Allen, M.J.2    James, G.C.3
  • 22
    • 0033058382 scopus 로고    scopus 로고
    • Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man
    • WALKER DK, ACKLAND MJ, JAMES GC et al.: Pharmacokinetics and metabolism of sildenafil in mouse, rat, rabbit, dog and man. Xenobiotica (1999) 29:297-310.
    • (1999) Xenobiotica , vol.29 , pp. 297-310
    • Walker, D.K.1    Ackland, M.J.2    James, G.C.3
  • 23
    • 0034029120 scopus 로고    scopus 로고
    • In vitro biotrasformation of sildenafil (Viagra): Identification of human cytochromes and potential drug interactions
    • WARRINGTON JS, SHADER RI, VON MOLTKE LL et al.: In vitro biotrasformation of sildenafil (Viagra): identification of human cytochromes and potential drug interactions. Drug Metab. Dispos. (2000) 28:392-397.
    • (2000) Drug Metab. Dispos. , vol.28 , pp. 392-397
    • Warrington, J.S.1    Shader, R.I.2    Von Moltke, L.L.3
  • 24
    • 0033046143 scopus 로고    scopus 로고
    • Efficacy and safety of fixed-dose oral sildenafil in the treatment of erectile dysfunction of various etiologies
    • MONTORSI F, MCDERMOTT T, MORGAN R et al.: Efficacy and safety of fixed-dose oral sildenafil in the treatment of erectile dysfunction of various etiologies. Urology (1999) 53:1011-1018.
    • (1999) Urology , vol.53 , pp. 1011-1018
    • Montorsi, F.1    Mcdermott, T.2    Morgan, R.3
  • 25
    • 0033661495 scopus 로고    scopus 로고
    • Sildenafil: Clinical toxicology profile
    • KRENZELOK EP: Sildenafil: clinical toxicology profile. J. Toxicol. Clin. Toxicol. (2000) 38:645-651.
    • (2000) J. Toxicol. Clin. Toxicol. , vol.38 , pp. 645-651
    • Krenzelok, E.P.1
  • 26
    • 0032898904 scopus 로고    scopus 로고
    • Sildenafil treatment of serotonin reuptake inhibitor-induced sexual dysfunction
    • ASHTON AK, BENNET RG: Sildenafil treatment of serotonin reuptake inhibitor-induced sexual dysfunction. J. Clin. Psychiatry (1999) 60:194-195.
    • (1999) J. Clin. Psychiatry , vol.60 , pp. 194-195
    • Ashton, A.K.1    Bennet, R.G.2
  • 27
    • 0032962101 scopus 로고    scopus 로고
    • Sildenafil for iatrogenic serotoninergic antidepressant medication-induced sexual dysfunction in 4 patients
    • NURNBERG HG, LAURIELLO J, HENSLEY PL et al.: Sildenafil for iatrogenic serotoninergic antidepressant medication-induced sexual dysfunction in 4 patients. J. Clin. Psychiatry (1999) 60:33-35.
    • (1999) J. Clin. Psychiatry , vol.60 , pp. 33-35
    • Nurnberg, H.G.1    Lauriello, J.2    Hensley, P.L.3
  • 28
    • 0032622397 scopus 로고    scopus 로고
    • Sildenafil citrate for SSRI-induced sexual side effects
    • ROSENBERG KP: Sildenafil citrate for SSRI-induced sexual side effects. Am. J. Psychiatry (1999) 156:157.
    • (1999) Am. J. Psychiatry , vol.156 , pp. 157
    • Rosenberg, K.P.1
  • 29
    • 0033528482 scopus 로고    scopus 로고
    • Possible interaction between sildenafil and HIV combination therapy
    • NANDWANI R, GOURLAY Y: Possible interaction between sildenafil and HIV combination therapy. Lancet (1999) 353:840.
    • (1999) Lancet , vol.353 , pp. 840
    • Nandwani, R.1    Gourlay, Y.2
  • 30
    • 0033864694 scopus 로고    scopus 로고
    • Pharmacokinetic interaction between sildenafil and saquinavir/ritonavir
    • MUIRHEAD GJ, WULFF MB, FIELDING A et al.: Pharmacokinetic interaction between sildenafil and saquinavir/ritonavir. Br. J. Clin. Pharmacol. (2000) 50:99-107.
    • (2000) Br. J. Clin. Pharmacol. , vol.50 , pp. 99-107
    • Muirhead, G.J.1    Wulff, M.B.2    Fielding, A.3
  • 31
    • 0036124906 scopus 로고    scopus 로고
    • A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction
    • MILLIGAN PA, MARSHALL SF, KARLSSON MO: A population pharmacokinetic analysis of sildenafil citrate in patients with erectile dysfunction. Br. J. Clin. Pharmacol. (2002) 53:S45-S52.
    • (2002) Br. J. Clin. Pharmacol. , vol.53
    • Milligan, P.A.1    Marshall, S.F.2    Karlsson, M.O.3
  • 32
    • 0030154874 scopus 로고    scopus 로고
    • Sildenafil: An orally active Type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction
    • BOOLELL M, ALLEN MJ, BALLARD SA et al.: Sildenafil: an orally active Type 5 cyclic GMP-specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int. J. Impot. Res. (1996) 8:47-52.
    • (1996) Int. J. Impot. Res. , vol.8 , pp. 47-52
    • Boolell, M.1    Allen, M.J.2    Ballard, S.A.3
  • 33
    • 0034851036 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors
    • GUAY AT, PEREZ JB, JACOBSON J et al.: Efficacy and safety of sildenafil citrate for treatment of erectile dysfunction in a population with associated organic risk factors. J. Androl. (2001) 22:793-797.
    • (2001) J. Androl. , vol.22 , pp. 793-797
    • Guay, A.T.1    Perez, J.B.2    Jacobson, J.3
  • 34
    • 0033522208 scopus 로고    scopus 로고
    • Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease
    • CONTI CR, PEPINE CJ, SWEENEY M: Efficacy and safety of sildenafil citrate in the treatment of erectile dysfunction in patients with ischemic heart disease. Am. J. Cardiol. (1999) 83:C29-C34.
    • (1999) Am. J. Cardiol. , vol.83
    • Conti, C.R.1    Pepine, C.J.2    Sweeney, M.3
  • 35
    • 0031861609 scopus 로고    scopus 로고
    • Clinical safety of sildenafil citrate (Viagra) in the treatment of erectile dysfunction
    • MORALES A, GINGELL C, COLLINS M et al.: Clinical safety of sildenafil citrate (Viagra) in the treatment of erectile dysfunction. Int. J. Impot. Res. (1998) 10:69-73.
    • (1998) Int. J. Impot. Res. , vol.10 , pp. 69-73
    • Morales, A.1    Gingell, C.2    Collins, M.3
  • 36
    • 0033522211 scopus 로고    scopus 로고
    • Tissue distribution of phosphodiesterase families and effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro
    • WALLIS RM, CORBIN JD, FRANCIS SH et al.: Tissue distribution of phosphodiesterase families and effects of sildenafil on tissue cyclic nucleotides, platelet function, and the contractile responses of trabeculae carneae and aortic rings in vitro. Am. J. Cardiol. (1999) 83(Suppl. 5A):3C-12C.
    • (1999) Am. J. Cardiol. , vol.83 , Issue.SUPPL. 5A
    • Wallis, R.M.1    Corbin, J.D.2    Francis, S.H.3
  • 37
    • 0008635513 scopus 로고    scopus 로고
    • Efficacy and safety of oral Viagra® (sildenafil citrate) for the treatment of erectile dysfunction in Latin America
    • Bueno Aires, Argentina
    • LINA S: On behalf of the Mexico and Brazil Sildenafil Study Group: efficacy and safety of oral Viagra® (sildenafil citrate) for the treatment of erectile dysfunction in Latin America. Congreso del la Confederacion Americana de Urologia, Bueno Aires, Argentina (2000).
    • (2000) Congreso del la Confederacion Americana de Urologia
    • Lina, S.1
  • 39
    • 0033833755 scopus 로고    scopus 로고
    • Asian sildenafil efficacy and safety study (ASSESS-1): A double-blind, placebo-controlled, flexible-dose study of oral sildenafil in Malaysian, Singaporean, and Filipino men with erectile dysfunction
    • TAN HM, CHANG MOH CL, MENDOZA JB et al.: For the ASSESS-1 Study Group. Asian sildenafil efficacy and safety study (ASSESS-1): a double-blind, placebo-controlled, flexible-dose study of oral sildenafil in Malaysian, Singaporean, and Filipino men with erectile dysfunction. Urology (2000) 56:635-640.
    • (2000) Urology , vol.56 , pp. 635-640
    • Tan, H.M.1    Chang Moh, C.L.2    Mendoza, J.B.3
  • 40
    • 0038023526 scopus 로고    scopus 로고
    • Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction in Chinese patients
    • Beijing, China
    • YINGLU G: Efficacy and safety of oral sildenafil in the treatment of erectile dysfunction in Chinese patients. 5th Asian Congress in Urology, Beijing, China (2000).
    • (2000) 5th Asian Congress in Urology
    • Yinglu, G.1
  • 41
    • 0033811958 scopus 로고    scopus 로고
    • Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction
    • MCMAHON CG, SAMALI R, JOHNSON H: Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. J. Urol. (2000) 164:1192-1196.
    • (2000) J. Urol. , vol.164 , pp. 1192-1196
    • Mcmahon, C.G.1    Samali, R.2    Johnson, H.3
  • 42
    • 0035088339 scopus 로고    scopus 로고
    • Three-year update of sildenafil citrate (Viagra®) efficacy and safety
    • SADOVSKY R, MILLER T, MOSKOWITZ M et al.: Three-year update of sildenafil citrate (Viagra®) efficacy and safety. Int. J. Clin. Pract. (2001). 55:115-128.
    • (2001) Int. J. Clin. Pract. , vol.55 , pp. 115-128
    • Sadovsky, R.1    Miller, T.2    Moskowitz, M.3
  • 43
    • 0030926566 scopus 로고    scopus 로고
    • The international index of erectile function (IIEF): A multidimensional scale for assessment of erectile dysfunction
    • ROSEN RC, RILEY A, WAGNER G et al.: The international index of erectile function (IIEF): a multidimensional scale for assessment of erectile dysfunction. Urology (1997) 49:822-830. This paper represents the first published report of the IIEF, a widely used validated-self assessment scale that investigates, not only ED but all the areas of male sexual life.
    • (1997) Urology , vol.49 , pp. 822-830
    • Rosen, R.C.1    Riley, A.2    Wagner, G.3
  • 44
    • 0034780576 scopus 로고    scopus 로고
    • Sildenafil citrate for the treatment of erectile dysfunction in men wiith Type II diabetes mellitus
    • BOULTON AJM, SELAM JL, SWEENEY M et al.: Sildenafil citrate for the treatment of erectile dysfunction in men wiith Type II diabetes mellitus. Diabetologia (2001) 44:1296-1301.
    • (2001) Diabetologia , vol.44 , pp. 1296-1301
    • Boulton, A.J.M.1    Selam, J.L.2    Sweeney, M.3
  • 45
    • 0036755020 scopus 로고    scopus 로고
    • The efficacy of sildenafil citrate (Viagra) in clinical populations: An update
    • CARSON CC, BURNETT AL, LEVINE LA et al: The efficacy of sildenafil citrate (Viagra) in clinical populations: an update. Urology (2002) 60(2, Suppl. 2):12-27.
    • (2002) Urology , vol.60 , Issue.2 SUPPL. 2 , pp. 12-27
    • Carson, C.C.1    Burnett, A.L.2    Levine, L.A.3
  • 46
    • 0033890352 scopus 로고    scopus 로고
    • Switching from intracavernous prostaglandin E1 injections to oral sildenafil citrate in patients with erectile dysfunction: Results of a multicenter European study
    • GIULIANO F, MONTORSI F, MIRONE V et al.: Switching from intracavernous prostaglandin E1 injections to oral sildenafil citrate in patients with erectile dysfunction: results of a multicenter European study. J. Urol. (2000) 164:708-711.
    • (2000) J. Urol. , vol.164 , pp. 708-711
    • Giuliano, F.1    Montorsi, F.2    Mirone, V.3
  • 47
    • 0033817436 scopus 로고    scopus 로고
    • Sildenafil versus intracavernous injection therapy: Efficacy and preference in patients on intracavernous injection for more than 1 year
    • HATZICHRISTOU DG, APOSTOLIDIS A, TZORTZIS V et al.: Sildenafil versus intracavernous injection therapy: efficacy and preference in patients on intracavernous injection for more than 1 year. J. Urol (2000) 164:1197-1200.
    • (2000) J. Urol. , vol.164 , pp. 1197-1200
    • Hatzichristou, D.G.1    Apostolidis, A.2    Tzortzis, V.3
  • 48
    • 34248403280 scopus 로고    scopus 로고
    • Oral sildenafil (Viagra™) in male erectile dysfunction: Use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital
    • SAIRAM K, KULINSKAYA E, HANBURY D et al.: Oral sildenafil (Viagra™) in male erectile dysfunction: use, efficacy and safety profile in an unselected cohort presenting to a British district general hospital. BMC Urol. (2002) 2:4.
    • (2002) BMC Urol. , vol.2 , pp. 4
    • Sairam, K.1    Kulinskaya, E.2    Hanbury, D.3
  • 49
    • 0012624097 scopus 로고    scopus 로고
    • Sildenafil (Viagra™) for male erectile dysfunction: A meta-analysis of clinical trial reports
    • MOORE RA, EDWARDS JE, MCQUAY HJ: Sildenafil (Viagra™) for male erectile dysfunction: a meta-analysis of clinical trial reports. BMC Urol. (2002) 2:6.
    • (2002) BMC Urol. , vol.2 , pp. 6
    • Moore, R.A.1    Edwards, J.E.2    Mcquay, H.J.3
  • 50
    • 0037166642 scopus 로고    scopus 로고
    • Sildenafil for male erectile dysfunction. A systematic review and meta-analysis
    • FINK HA, MACDONALD R, RUTKS IR et al.: Sildenafil for male erectile dysfunction. A systematic review and meta-analysis. Arch. Intern. Med (2002) 162:1349-1360.
    • (2002) Arch. Intern. Med. , vol.162 , pp. 1349-1360
    • Fink, H.A.1    Macdonald, R.2    Rutks, I.R.3
  • 51
    • 0034996374 scopus 로고    scopus 로고
    • Efficacy, safety, and use of sildenafil in urologic practice
    • FAGELMAN E, FAGELMAN A, SHABSIGH R: Efficacy, safety, and use of sildenafil in urologic practice. Urology (2001) 57:1141-1144.
    • (2001) Urology , vol.57 , pp. 1141-1144
    • Fagelman, E.1    Fagelman, A.2    Shabsigh, R.3
  • 52
    • 0035035922 scopus 로고    scopus 로고
    • Patient and parmer satisfaction with Viagra (sildenafil citrate) treatment as determined by the Erectile Dysfunction Inventory of Treatment Satisfaction Questionnaire
    • LEWIS R, BENNET CJ, BORKON WD et al.: Patient and parmer satisfaction with Viagra (sildenafil citrate) treatment as determined by the Erectile Dysfunction Inventory of Treatment Satisfaction Questionnaire. Urology (2001) 57:960-965.
    • (2001) Urology , vol.57 , pp. 960-965
    • Lewis, R.1    Bennet, C.J.2    Borkon, W.D.3
  • 53
    • 0033119838 scopus 로고    scopus 로고
    • Edits: Development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction
    • ALTHOF SE, CORTY EW, LEVINE SB: Edits: development of questionnaires for evaluating satisfaction with treatments for erectile dysfunction. Urology (1999) 53:793-799.
    • (1999) Urology , vol.53 , pp. 793-799
    • Althof, S.E.1    Corty, E.W.2    Levine, S.B.3
  • 54
    • 0002752368 scopus 로고    scopus 로고
    • Dose-normalized pharmacokinetics of single dose-tadalafil (IC351) in healthy volunteers
    • Abstract 14
    • PATTERSON B, BEDDING A, JEWELL H et al.: Dose-normalized pharmacokinetics of single dose-tadalafil (IC351) in healthy volunteers. Int. J. Impot. Res. (2001) 13(Suppl. 5):S62 (Abstract 14).
    • (2001) Int. J. Impot. Res. , vol.13 , Issue.SUPPL. 5
    • Patterson, B.1    Bedding, A.2    Jewell, H.3
  • 55
    • 0001273937 scopus 로고    scopus 로고
    • IC351 enhances NO-mediated relaxation of human arterial and trabecular penile smooth muscle
    • Abstract 415
    • ANGULO J, GADAU M, FERNANDEZ A et al.: IC351 enhances NO-mediated relaxation of human arterial and trabecular penile smooth muscle. Eur. Urol. (2001) 39:106 (Abstract 415).
    • (2001) Eur. Urol. , vol.39 , pp. 106
    • Angulo, J.1    Gadau, M.2    Fernandez, A.3
  • 57
    • 0001064956 scopus 로고    scopus 로고
    • Cialis (IC351) provides prompt response and extended period of responsiveness in the treatment of men with erectile dysfunction (ED)
    • PADMA-NATHAN H, ROSEN RC, SHABSIGH R et al.: Cialis (IC351) provides prompt response and extended period of responsiveness in the treatment of men with erectile dysfunction (ED). J. Urol. (2001) 165(Suppl.):A923.
    • (2001) J. Urol. , vol.165 , Issue.SUPPL.
    • Padma-Nathan, H.1    Rosen, R.C.2    Shabsigh, R.3
  • 58
    • 0035070379 scopus 로고    scopus 로고
    • On demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction
    • PADMA-NATHAN H, MCMURRAY JG, PULLMAN WE et al.: On demand IC351 (Cialis) enhances erectile function in patients with erectile dysfunction. Int. J. Impot. Res. (2001) 13:2-9.
    • (2001) Int. J. Impot. Res. , vol.13 , pp. 2-9
    • Padma-Nathan, H.1    Mcmurray, J.G.2    Pullman, W.E.3
  • 59
    • 0001784061 scopus 로고    scopus 로고
    • Daily IC351 treatment of ED
    • PORST H: Daily IC351 treatment of ED. Int. J. Impot. Res. (2000) 12(Suppl. 3):S76, A-B13.
    • (2000) Int. J. Impot. Res. , vol.12 , Issue.SUPPL. 3
    • Porst, H.1
  • 60
    • 1642518530 scopus 로고    scopus 로고
    • The effect of as-needed tadalafil (IC351) treatment of erectile dysfunction in men with diabetes
    • SAENZ DE TEJADA I, EMMICK J, ANGLIN G et al.: The effect of as-needed tadalafil (IC351) treatment of erectile dysfunction in men with diabetes. Int. J. Impot. Res. (2001) 13(Suppl. 4):A128.
    • (2001) Int. J. Impot. Res. , vol.13 , Issue.SUPPL. 4
    • Saenz De Tejada, I.1    Emmick, J.2    Anglin, G.3
  • 61
    • 0036668536 scopus 로고    scopus 로고
    • The International Index of Erectile Function (IIEF): A state-of-the-science review
    • ROSEN RC, CAPPELLERI JC, GENDRANO N 3rd: The International Index of Erectile Function (IIEF): a state-of-the-science review. Int. J. Impot. Res. (2002) 14:226-244.
    • (2002) Int. J. Impot. Res. , vol.14 , pp. 226-244
    • Rosen, R.C.1    Cappelleri, J.C.2    Gendrano III, N.3
  • 62
    • 2642539623 scopus 로고    scopus 로고
    • Tadalafil in the treatment of erectile dysfunction following bilateral nerve-sparing radical retropubic prostatectomy: A randomized, double-blind, placebo-controlled trial
    • Submitted
    • MONTORSI F, MCCULLOUGH A, BROCK GB et al.: Tadalafil in the treatment of erectile dysfunction following bilateral nerve-sparing radical retropubic prostatectomy: a randomized, double-blind, placebo-controlled trial. J. Urol. (2004) (Submitted). This research underlines the efficacy and safety of tadalafil in a difficult to treat population represented by patients affected by localised prostate cancer who underweat nerve-sparing radical prostatectomy.
    • (2004) J. Urol.
    • Montorsi, F.1    Mccullough, A.2    Brock, G.B.3
  • 63
    • 0001860823 scopus 로고    scopus 로고
    • The effect of intrinsic and extrinsic factors on the pharmacokinetic properties of tadalafil (IC351)
    • PATTERSON B, BEDDING A, JEWELL H et al.: The effect of intrinsic and extrinsic factors on the pharmacokinetic properties of tadalafil (IC351). Int. J. Impot. Res. (2001) 13(Suppl. 4):A120.
    • (2001) Int. J. Impot. Res. , vol.13 , Issue.SUPPL. 4
    • Patterson, B.1    Bedding, A.2    Jewell, H.3
  • 64
    • 0036197133 scopus 로고    scopus 로고
    • IC351 (tadalafil, Cialis): Update on clinical experience
    • PORST H: IC351 (tadalafil, Cialis): update on clinical experience. Int. J. Impot. Res. (2002) 14(Suppl. 1):S57-S64.
    • (2002) Int. J. Impot. Res. , vol.14 , Issue.SUPPL. 1
    • Porst, H.1
  • 65
    • 0242460582 scopus 로고    scopus 로고
    • Cardiovascular effects of tadalafil in patients on common antihypertensive therapy
    • KLONER RA, MITCHELL M, EMMICK JT: Cardiovascular effects of tadalafil in patients on common antihypertensive therapy. Am. J. Cardiology (2003) 92(Suppl. 1):47-57. As shown by this paper, tadalafil is provided with an excellent profile in terms of safety which was also found in patients affected by hypertension who were treated with oral therapy.
    • (2003) Am. J. Cardiology , vol.92 , Issue.SUPPL. 1 , pp. 47-57
    • Kloner, R.A.1    Mitchell, M.2    Emmick, J.T.3
  • 66
    • 0242552045 scopus 로고    scopus 로고
    • Time course of the interaction between tadalafil and nitrates
    • KLONER RA, HUTTER AM, EMMICK JT et al.: Time course of the interaction between tadalafil and nitrates. J. Am. Coll. Cardiol. (2003) 42:1855-1860.
    • (2003) J. Am. Coll. Cardiol. , vol.42 , pp. 1855-1860
    • Kloner, R.A.1    Hutter, A.M.2    Emmick, J.T.3
  • 67
    • 0042236843 scopus 로고    scopus 로고
    • Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones
    • HELLSTROM WJG, OVERSTREET JW, YU A et al.: Tadalafil has no detrimental effect on human spermatogenesis or reproductive hormones. J. Urol. (2003) 170:887-891. This research has clearly underlined the safety profile of tadalafil, in terms of spermatogenesis, as its potential interaction with PDE5-11, found in the testis, had previously raised questions about this issue.
    • (2003) J. Urol. , vol.170 , pp. 887-891
    • Hellstrom, W.J.G.1    Overstreet, J.W.2    Yu, A.3
  • 68
    • 17944364288 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose
    • STARK S, SACHSE R, LIEDL T et al.: Vardenafil increases penile rigidity and tumescence in men with erectile dysfunction after a single oral dose. Eur. Urol. (2001) 40:181-190.
    • (2001) Eur. Urol. , vol.40 , pp. 181-190
    • Stark, S.1    Sachse, R.2    Liedl, T.3
  • 69
    • 0035258442 scopus 로고    scopus 로고
    • Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: A RigiScan and pharmacokinetic study
    • KLOTZ T, SACHSE R, HEIDRICH A et al.: Vardenafil increases penile rigidity and tumescence in erectile dysfunction patients: a RigiScan and pharmacokinetic study. World J. Urol. (2001) 19:32-39.
    • (2001) World J. Urol. , vol.19 , pp. 32-39
    • Klotz, T.1    Sachse, R.2    Heidrich, A.3
  • 70
    • 0034868820 scopus 로고    scopus 로고
    • The efficacy and tolerability of vardenafil, a new, oral selective PDE-5 inhibitor, in patients with erectile dysfunction: First at-home clinical trial
    • PORST H, ROSEN R, PADMA-NATHAN H et al.: The efficacy and tolerability of vardenafil, a new, oral selective PDE-5 inhibitor, in patients with erectile dysfunction: first at-home clinical trial. Int. J. Impot. Res. (2001) 13:192-199.
    • (2001) Int. J. Impot. Res. , vol.13 , pp. 192-199
    • Porst, H.1    Rosen, R.2    Padma-Nathan, H.3
  • 71
    • 0042405173 scopus 로고    scopus 로고
    • Vardenafil, a new phosphodiesterase Type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: A multicenter double-blind placebo-controlled fixed-dose study
    • GOLDSTEIN I, YOUNG JM, FISCHER J et al.: Vardenafil, a new phosphodiesterase Type 5 inhibitor, in the treatment of erectile dysfunction in men with diabetes: a multicenter double-blind placebo-controlled fixed-dose study. Diabetes Care (2003) 26:777-783.
    • (2003) Diabetes Care , vol.26 , pp. 777-783
    • Goldstein, I.1    Young, J.M.2    Fischer, J.3
  • 72
    • 0043194001 scopus 로고    scopus 로고
    • Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical prostatectomy
    • BROCK G, NEHRA A, LIPSHULTZ LI et al.: Safety and efficacy of vardenafil for the treatment of men with erectile dysfunction after radical prostatectomy. J. Urol. (2003) 170:1278-1283.
    • (2003) J. Urol. , vol.170 , pp. 1278-1283
    • Brock, G.1    Nehra, A.2    Lipshultz, L.I.3
  • 73
    • 0037378435 scopus 로고    scopus 로고
    • Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase Type 5 inhibitor, in men with erectile dysfunction: Results of a randomized, double-blind, 26-week placebo-controlled pivotal trial
    • HELLSTROM WJ, GITTELMAN M, KARLIN G et al.: Sustained efficacy and tolerability of vardenafil, a highly potent selective phosphodiesterase Type 5 inhibitor, in men with erectile dysfunction: results of a randomized, double-blind, 26-week placebo-controlled pivotal trial. Urology. (2003) 61(4, Suppl. 1):8-14. This research underlines the efficacy and safety of vardenafil, in a difficult to treat population represented by patients affected by localised prostate cancer who underwent radical prostatectomy.
    • (2003) Urology , vol.61 , Issue.4 SUPPL. 1 , pp. 8-14
    • Hellstrom, W.J.1    Gittelman, M.2    Karlin, G.3
  • 74
    • 0037021566 scopus 로고    scopus 로고
    • The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease
    • THADANI U, SMITH W, NASH S et al.: The effect of vardenafil, a potent and highly selective phosphodiesterase-5 inhibitor for the treatment of erectile dysfunction, on the cardiovascular response to exercise in patients with coronary artery disease. J. Am. Coll. Cardiol. (2002) 4(40):2006-2012.
    • (2002) J. Am. Coll. Cardiol. , vol.4 , Issue.40 , pp. 2006-2012
    • Thadani, U.1    Smith, W.2    Nash, S.3
  • 75
    • 0036193167 scopus 로고    scopus 로고
    • Vardenafil: Update on clinical experience
    • PRYOR JP: Vardenafil: update on clinical experience. Int. J. Impot. Res. (2002) 14(Suppl. 1):S65-S69.
    • (2002) Int. J. Impot. Res. , vol.14 , Issue.SUPPL. 1
    • Pryor, J.P.1
  • 76
    • 0037238721 scopus 로고    scopus 로고
    • Central oxytocinergic neurotransmission: A drug target for the therapy of psychogenic erectile dysfunction
    • MELIS MR, ARGIOLAS A: Central oxytocinergic neurotransmission: a drug target for the therapy of psychogenic erectile dysfunction. Curr. Drug Targets (2003) 4:55-66.
    • (2003) Curr. Drug Targets , vol.4 , pp. 55-66
    • Melis, M.R.1    Argiolas, A.2
  • 77
    • 0029565582 scopus 로고
    • Neuromodulation of penile erection: An overview of the role of neurotransmitters and neuropeptides
    • ARGIOLAS A, MELIS MR: Neuromodulation of penile erection: an overview of the role of neurotransmitters and neuropeptides. Progr. Neurobiol. (1995) 47:235-255.
    • (1995) Progr. Neurobiol. , vol.47 , pp. 235-255
    • Argiolas, A.1    Melis, M.R.2
  • 78
    • 0034800547 scopus 로고    scopus 로고
    • Efficacy of apomorphine SL in erectile dysfunction
    • MIRONE VG, STIEF CG: Efficacy of apomorphine SL in erectile dysfunction. BJU Int. (2001) 88(Suppl. 3):25-29.
    • (2001) BJU Int. , vol.88 , Issue.SUPPL. 3 , pp. 25-29
    • Mirone, V.G.1    Stief, C.G.2
  • 79
    • 0034916235 scopus 로고    scopus 로고
    • Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction
    • DULA E, BUKOFZER S, PERDOK R et al.: Double-blind, crossover comparison of 3 mg apomorphine SL with placebo and with 4 mg apomorphine SL in male erectile dysfunction. Eur. Urol. (2001) 39:558-564.
    • (2001) Eur. Urol. , vol.39 , pp. 558-564
    • Dula, E.1    Bukofzer, S.2    Perdok, R.3
  • 80
    • 0036186468 scopus 로고    scopus 로고
    • Sequential administration enhances the effect of apomorphine in men with erectile dysfunction
    • HEATON JP, DEAN J, SLEEP DJ: Sequential administration enhances the effect of apomorphine in men with erectile dysfunction. Int. J. Impot. Res. (2002) 14:61-64.
    • (2002) Int. J. Impot. Res. , vol.14 , pp. 61-64
    • Heaton, J.P.1    Dean, J.2    Sleep, D.J.3
  • 81
    • 0038715226 scopus 로고    scopus 로고
    • Tolerability and safety of apomorphine SL (Ixense (TM))
    • MONTORSI F: Tolerability and safety of apomorphine SL (Ixense (TM)). Int. J. Impot. Res. (2003) 15(Suppl. 2):S7-S9.
    • (2003) Int. J. Impot. Res. , vol.15 , Issue.SUPPL. 2
    • Montorsi, F.1
  • 82
    • 0034786840 scopus 로고    scopus 로고
    • Safety and tolerability of apomorphine SL in patients with erectile dysfunction
    • BUVAT J, MONTORSI F: Safety and tolerability of apomorphine SL in patients with erectile dysfunction. BJU Int. (2001) 88(Suppl. 3):30-35.
    • (2001) BJU Int. , vol.88 , Issue.SUPPL. 3 , pp. 30-35
    • Buvat, J.1    Montorsi, F.2
  • 83
    • 1642565818 scopus 로고    scopus 로고
    • A comparative, crossover study of the efficacy and safety of sildenafil and apomorphine in men with evidence of arteriogenic erectile dysfunction
    • PERIMENIS P, GYFTOPOULOS K, GIANNITSAS K et al.: A comparative, crossover study of the efficacy and safety of sildenafil and apomorphine in men with evidence of arteriogenic erectile dysfunction. Int. J. Impot. Res. (2004) 16:2-7.
    • (2004) Int. J. Impot. Res. , vol.16 , pp. 2-7
    • Perimenis, P.1    Gyftopoulos, K.2    Giannitsas, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.