Influence of 5-HT1 receptor agonists on feline stomach relaxation

European Journal of Pharmacology

Volumn 492, Issue 2-3, 2004, Pages 259-267

  Janssen, Pieter ^a,b   Tack, Jan ^c   Sifrim, Daniel ^c   Meulemans, Ann L ^b   Lefebvre, Romain A ^a  

^a GHENT UNIVERSITY   (Belgium)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

^c UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

5 HT1F; Barostat; Proximal stomach; Retching; Sumatriptan

Indexed keywords

1 (2 METHOXYPHENYL) 4 (4 PHTHALIMIDOBUTYL)PIPERAZINE; 5 HYDROXY 3 (1 METHYLPIPERIDIN 4 YL) 1H INDOLE; ALNIDITAN; BRL 54443; FLESINOXAN; N (3 DIMETHYLAMINO 2,3,4,9 TETRAHYDRO 1H CARBAZOL 6 YL) 4 FLUOROBENZAMIDE; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; N [4 METHOXY 3 (4 METHYL 1 PIPERAZINYL)PHENYL] 2' METHYL 4' (5 METHYL 1,2,4 OXADIAZOL 3 YL)[1,1' BIPHENYL] 4 CARBOXAMIDE; N ACETYL 5 HYDROXYTRYPTOPHYL 5 HYDROXYTRYPTOPHANAMIDE; NITRIC OXIDE SYNTHASE INHIBITOR; SEROTONIN 1 AGONIST; SEROTONIN 1 ANTAGONIST; SEROTONIN 1A AGONIST; SEROTONIN 1D AGONIST; SEROTONIN 1F RECEPTOR; SEROTONIN 1F RECEPTOR AGONIST; SUMATRIPTAN; UNCLASSIFIED DRUG; SEROTONIN 1 RECEPTOR; SEROTONIN ANTAGONIST;

ANIMAL TISSUE; ARTICLE; CAT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; MALE; MUSCLE RELAXATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SEDATION; STOMACH; STOMACH VOLUME; VOMITING; ANIMAL; CELL LINE; COMPARATIVE STUDY; DRUG POTENTIATION; HUMAN; METABOLISM; PHYSIOLOGY; PRESSURE; REGRESSION ANALYSIS; SMOOTH MUSCLE; TIME;

ANIMALS; CATS; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH; PRESSURE; RECEPTORS, SEROTONIN, 5-HT1; REGRESSION ANALYSIS; SEROTONIN ANTAGONISTS; STOMACH; SUMATRIPTAN; TIME FACTORS;

EID: 2642530106     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.03.054     Document Type: Article

References (41)

1. Abrahamsson H., Thoren P. Vomiting and reflex vagal relaxation of the stomach elicited from heart receptors in the cat. Acta Physiol. Scand. 88:1973;433-439
2. Adham N., Kao H.T., Schecter L.E., Bard J., Olsen M., Urquhart D., Durkin M., Hartig P.R., Weinshank R.L., Branchek T.A. Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase. Proc. Natl. Acad. Sci. U. S. A. 90:1993;408-412
3. Azpiroz F., Malagelada J.R. Intestinal control of gastric tone. Am. J. Physiol. 249:1985;G501-G509
4. Azpiroz F., Malagelada J.R. Importance of vagal input in maintaining gastric tone in the dog. J. Physiol. 384:1987;511-524
5. Baxter G.S., Murphy O.E., Blackburn T.P. Further characterization of 5-hydroxytryptamine receptors (putative 5-HT2B) in rat stomach fundus longitudinal muscle. Br. J. Pharmacol. 112:1994;323-331
6. Bloom S.R. Neurotransmission and the central nervous system. Hardman J.G., Limbird L.E. The Pharmacological Basis of Therapeutics. 1996;271 McGraw-Hill, New York
7. Briejer M.R., Akkermans L.M., Lefebvre R.A., Schuurkes J.A. Novel 5-HT2-like receptor mediates neurogenic relaxation of the guinea-pig proximal colon. Eur. J. Pharmacol. 279:1995;123-133
8. Brown A.M., Avenell K., Young T.J., Ho M., Porter R.A., Vimal M., Middlemiss D.N. BRL 54443, a potent agonist with selectivity for human cloned 5-ht1E and 5-HT1F receptors. Br. J. Pharmacol. 123:1997;233P
9. Buchheit K.H., Buhl T. Stimulant effects of 5-hydroxytryptamine on guinea pig stomach preparations in vitro. Eur. J. Pharmacol. 262:1994;91-97
10. Caulfield M.P. Muscarinic receptors-characterization, coupling and function. Pharmacol. Ther. 58:1993;319-379
11. Chang H.Y., Mashimo H., Goyal R.K. Musings on the wanderer: what's new in our understanding of vago-vagal reflex? IV. Current concepts of vagal efferent projections to the gut. Am. J. Physiol.: Gasterointest. Liver Physiol. 284:2003;G357-G366
12. Cleveland W.S. Robust locally weighted regression and smoothing scatterplots. J. Am. Stat. Assoc. 74:1979;386-829
13. Cohen M.L., Schenck K. Contractile responses to sumatriptan and ergotamine in the rabbit saphenous vein: effect of selective 5-HT(1F) receptor agonists and PGF(2alpha). Br. J. Pharmacol. 131:2000;562-568
14. Coulie B., Tack J., Sifrim D., Andrioli A., Janssens J. Role of nitric oxide in fasting gastric fundus tone and in 5-HT1 receptor-mediated relaxation of gastric fundus. Am. J. Physiol. 276:1999;G373-G377
15. Dahlof C.G. Sumatriptan: pharmacological basis and clinical results. Curr. Med. Res. Opin. 17(Suppl. 1):2001;s35-s45
16. Dechant K.L., Clissold S.P. Sumatriptan. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy in the acute treatment of migraine and cluster headache. Drugs. 43:1992;776-798
17. 1B/D receptors in canine gastric accommodation: effect of sumatriptan and 5-HT1B/D receptor antagonists. Am. J. Physiol.: Gasterointest. Liver Physiol. 285:2003;G96-G104
18. Gommeren W., Renders J., Van Gompel P., Lesage A., Leysen J.E., Jurzak M. Extensive pharmacological study of the G-protein coupled fraction of human 5-HT receptors using agonist radioligand binding. Naunyn-Schmiedeberg's Arch. Pharmacol. 358:1998;R113
19. Hoyer D., Hannon J.P., Martin G.R. Molecular, pharmacological and functional diversity of 5-HT receptors. Pharmacol. Biochem. Behav. 71:2002;533-554
20. Janssen P., Prins N.H., Meulemans A.L., Lefebvre R.A. Smooth muscle 5-HT(2A) receptors mediating contraction of porcine isolated proximal stomach strips. Br. J. Pharmacol. 137:2002;1217-1224
21. Janssen P., Prins N.H., Moreaux B., Meulemans A.L., Lefebvre R.A. In vivo characterization of 5-HT1A receptor-mediated gastric relaxation in conscious dogs. Br. J. Pharmacol. 140:2003;913-920
22. King G.L. Animal models in the study of vomiting. Can. J. Physiol. Pharm. 68:1990;260-268
23. Koek W., Patoiseau J.F., Assie M.B., Cosi C., Kleven M.S., Dupont-Passelaigue E., Carilla-Durand E., Palmier C., Valentin J.P., John G., Pauwels P.J., Tarayre J.P., Colpaert F.C. F 11440, a potent, selective, high efficacy 5-HT1A receptor agonist with marked anxiolytic and antidepressant potential. J. Pharmacol. Exp. Ther. 287:1998;266-283
24. Kuemmerle J.F., Murthy K.S., Grider J.R., Martin D.C., Makhlouf G.M. Coexpression of 5-HT2A and 5-HT4 receptors coupled to distinct signaling pathways in human intestinal muscle cells. Gastroenterology. 109:1995;1791-1800
25. Leysen J.E., Gommeren W., Heylen L., Luyten W.H., Van D.W.I., Vanhoenacker P., Haegeman G., Schotte A., Van Gompel P., Wouters R., Lesage A.S. Alniditan, a new 5-hydroxytryptamine1D agonist and migraine-abortive agent: ligand-binding properties of human 5-hydroxytryptamine1D alpha, human 5-hydroxytryptamine1D beta, and calf 5-hydroxytryptamine1D receptors investigated with [3H]5-hydroxytryptamine and [3H]alniditan. Mol. Pharmacol. 50:1996;1567-1580
26. Lightowler S., Stean T., Upton N., Vimal M., Kennett G.A., Porter R., Brown A.M. Effect of BRL 54443 (3-(-1-Methylpiperidin-4-YL)-1H-INDOL-5-OL), a 5-HT1E/1F receptor agonist, on general behaviour and maximal electroshock seizure threshold in the rat. Br. J. Pharmacol. 123:1997;237P
27. Lucot J.B. Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. Eur. J. Pharmacol. 253:1994;53-60
28. Lucot J.B., Crampton G.H. 8-OH-DPAT suppresses vomiting in the cat elicited by motion, cisplatin or xylazine. Pharmacol. Biochem. Behav. 33:1989;627-631
29. Mawe G.M., Branchek T.A., Gershon M.D. Peripheral neural serotonin receptors: identification and characterization with specific antagonists and agonists. Proc. Natl. Acad. Sci. U. S. A. 83:1986;9799-9803
30. Mawe G.M., Branchek T.A., Gershon M.D. Blockade of 5-HT-mediated enteric slow EPSPs by BRL 24924: gastrokinetic effects. Am. J. Physiol. 257:1989;G386-G396
31. Meulemans A.L., Helsen L.F., De Ridder W.J.E., Schuurkes J.A. Effects of sumatriptan on the guinea-pig isolated stomach. Neurogastroenterol. Motil. 8(2):1996;A183
32. Mitsikostas D.D., Sanchez D.R., Waeber C. 5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis. Cephalalgia. 22:2002;384-394
33. Neter J., Kutner M.H., Nachtsheim C.J., Wasserman W. Applied Linear Statistical Models. 4th edn. 1996;Irwin Publishers, Chicago
34. Paterson C.A., Anvari M., Tougas G., Huizinga J.D. Nitrergic and cholinergic vagal pathways involved in the regulation of canine proximal gastric tone: an in vivo study. Neurogastroenterol. Motil. 12:2000;301-306
35. Phebus L.A., Johnson K.W., Zgombick J.M., Gilbert P.J., Van Belle K., Mancuso V., Nelson D.L., Calligaro D.O., Kiefer A.D. Jr., Branchek T.A., Flaugh M.E. Characterization of LY344864 as a pharmacological tool to study 5-HT1F receptors: binding affinities, brain penetration and activity in the neurogenic dural inflammation model of migraine. Life Sci. 61:1997;2117-2126
36. Prins N.H., van Der Grijn A., Lefebvre R.A., Akkermans L.M., Schuurkes J.A. 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study. Br. J. Pharmacol. 132:2001;1941-1947
37. Read N.W., Gwee K.A. The importance of 5-hydroxytryptamine receptors in the gut. Pharmacol. Ther. 62:1994;159-173
38. Tack J., Piessevaux H., Coulie B., Fischler B., De Gucht V., Janssens J. A placebo-controlled trial of buspirone, a fundus-relaxing drug, in functional dyspepsia: effect on symptoms and gastric sensory and motor function. Gastroenterology. 166:1999;A325
39. Tack J., Coulie B., Wilmer A., Andrioli A., Janssens J. Influence of sumatriptan on gastric fundus tone and on the perception of gastric distension in man. Gut. 46:2000;468-473
40. Villalon C.M., Centurion D., Terron J.A. GR127935 antagonizes the 5-HT1-like receptor-mediated external carotid vasoconstriction in vagosympathectomized dogs. Ann. N.Y. Acad. Sci. 812:1997;207-208
41. Vingerhagen S., Hausken T., Gilja O.H., Berstad A. Influence of a 5HT1 receptor agonist on gastric accommodation and initial transpyloric flow in healthy subjects. Neurogastroenterol. Motil. 12:2000;95-101