Long-term dietary high protein intake up-regulates tissue specific gene expression of uncoupling proteins 1 and 2 in rats

European Journal of Nutrition

Volumn 44, Issue 7, 2005, Pages 414-421

  Petzke, Klaus J ^a   Friedrich, Maika ^a   Metges, Cornelia C ^b   Klaus, Susanne ^a  

^a GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

^b LEIBNIZ INSTITUTE FOR FARM ANIMAL BIOLOGY FBN   (Germany)

Author keywords

Energy expenditure; Gene expression; High protein diets; Rats; Uncoupling protein

Indexed keywords

CASEIN; FATTY ACID; MESSENGER RNA; OXYGEN; UNCOUPLING PROTEIN 1; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BROWN ADIPOSE TISSUE; CALORIMETRY; CONTROLLED STUDY; CORRELATION COEFFICIENT; ENERGY EXPENDITURE; FATTY ACID BLOOD LEVEL; GENE EXPRESSION REGULATION; LIVER LEVEL; LONG TERM EXPOSURE; MALE; METABOLIC PARAMETERS; NONHUMAN; NORTHERN BLOTTING; OXIDATION; OXYGEN CONSUMPTION; PROTEIN INTAKE; RAT; RNA ANALYSIS; SKELETAL MUSCLE; THERMOGENESIS; TISSUE LEVEL; TISSUE SPECIFICITY; UPREGULATION;

ANIMALS; BLOTTING, NORTHERN; BODY TEMPERATURE REGULATION; CALORIMETRY, INDIRECT; CARRIER PROTEINS; DIETARY PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENERGY METABOLISM; ION CHANNELS; LIVER; MALE; MEMBRANE PROTEINS; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE, SKELETAL; OXYGEN CONSUMPTION; RANDOM ALLOCATION; RATS; RATS, WISTAR; RNA, MESSENGER; UP-REGULATION;

EID: 26244457989     PISSN: 14366207     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00394-004-0545-4     Document Type: Article

References (36)

1. German Nutrition Society (2000) Reference values for nutrient intake, Umschau/Braus, Frankfurt am Main, Germany
2. Metges CC, Barth CA (2000) Metabolic consequences of a high dietary protein intake in adulthood: Assessment of the available evidence. J Nutr 130:886-889
3. Eisenstein J, Roberts SB, Dallal G, Saltzman E (2002) High-protein weight-loss diets: are they safe and do they work? A review of the experimental and epidemiologic data. Nutr Rev 60:189-200
4. rd amino acid assessment workshop. J Nutr 134:1555S-1557S
5. Lacroix M, Gaudichon C, Martin A, Morens C, Mathe V, Tome D, Huneau JF (2004) A long-term high-protein diet markedly reduces adipose tissue without major side-effects in Wistar male rats. Am J Physiol Regul Integr Comp Physiol 287:R934-R942
6. Thonney ML, Ross DA (1987) Composition of gain of rats fed low or high protein diets and grown at controlled rates from 80 to 205 grams. J Nutr 117:2135-2141
7. Daenzer M, Ortmann S, Klaus S, Metges CC (2002) Prenatal high protein exposure decreases energy expenditure and increases adiposity in young rats. J Nutr 132:142-144
8. Marsset-Baglieri A, Fromentin G, Tome D, Bensaid A, Makkarios L, Even PC (2004) Increasing the protein content in a carbohydrate-free diet enhances fat loss during 35 % but not 75 % energy restriction in rats. J Nutr 134:2646-2652
9. Jean C, Rome S, Mathe V, Huneau JF, Aattouri N, Fromentin G, Achagiotis CL, Tome D (2001) Metabolic evidence for adaptation to a high protein diet in rats. J Nutr 131:91-98
10. Petzke KJ, Eisner A, Proll J, Thielecke F, Metges CC (2000) Long-term high protein intake does not increase oxidative stress in rats. J Nutr 130:2889-2896
11. Schrauwen P, Hesselink M (2002) UCP2 and UCP3 in muscle controlling body metabolism. J Exp Biol 205:2275-2285
12. Dulloo AG, Samec S (2001) Uncoupling proteins: their roles in adaptive thermogenesis and substrate metabolism reconsidered. Br J Nutr 86:123-139
13. Boss O, Hagen T, Lowell BB (2000) Uncoupling proteins 2 and 3, potential regulators of mitochondrial energy metabolism. Diabetes 49:143-156
14. Erlanson-Albertson C (2003) The uncoupling proteins in the regulation of metabolism. Acta Physiol Scand 173:405-412
15. Klaus S (2001) Brown adipose tissue: physiological regulation of thermogenic function. In: Klaus S (ed) Adipose tissues. Eurekah.com/Landes Bioscience, Medical Intelligence Unit. Austin, Texas USA, pp 56-81
16. th rev. ed., National Academy Press, Washington, DC, pp 11-79
17. Klaus S, Münzberg H, Trüloff C, Heldmaier G (1998) Physiology of transgenic mice with brown fat ablation: obesity is due to lowered body temperature. Am J Physiol 274:R287-R293
18. Weir JB (1949) New methods for calculating metabolic rate with special reference to protein metabolism. J Physiol 109:1-9
19. Frenz U (1995) Bestimmung der Energie- und Makronährstoff-Verwertung bei Ratten unter Diäten mit leicht unterschiedlichen Aminosä uregehalten - Neue optimierte Methoden der indirekten Kalorimetrie, PhD thesis (Determination of the energy and macronutrient utilization of rats fed with diets containing small differences in amino acids - New optimized methods of the indirect calorimetry.) Verlag Dr. Köster, Berlin, Germany
20. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159
21. Boeuf S, Klingenspor M, van Hal N, Schneider T, Keijer J, Klaus S (2001) Differential gene expression in white and brown preadipocytes. Physiol Genomics 7:15-25
22. Klaus S, Seivert A, Boeuf S (2001) Effect of the beta-3-adrenergic agonist Cl316.243 on functional differentiation of white and brown adipocytes in primary cell culture. Biochim Biophys Acta (Mol Cell Res) 1539:85-92
23. Rippe C, Berger K, Boiers C, Ricquier D, Erlanson-Albertsson C (2000) Effect of high-fat diet, surrounding temperature, and enterostatin on uncoupling protein gene expression. Am J Physiol Endocrinol Metab 279:E293-E300
24. Kozak LP, Harper ME (2000) Mitochondrial uncoupling proteins in energy expenditure. Annu Rev Nutr 20:339-363
25. Liu X, Rossmeisl M, McClaine J, Riachi M, Harper ME, Kozak LP (2003) Paradoxical resistance to diet-induced obesity in UCP1-deficient mice. J Clin Invest 111:399-407
26. Sivitz WI, Fink BD, Donohoue PA (1999) Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140:1511-1519
27. Murase T, Nagasawa A, Suzuki J, Wakisaka T, Hase T, Tokimitsu I (2002) Dietary alpha-linolenic acid-rich diacyl-glycerols reduce body weight gain accompanying the stimulation of intestinal beta-oxidation and related gene expressions in C57BL/KsJ-db/db mice. J Nutr 132:3018-3022
28. Harper AE, Zapalowski C (1981) Metabolism of branched chain amino acids. In: Waterlow JC, Stephen JML (eds) Nitrogen metabolism in man. Appl Sci Publ, London, New Jersey, pp 97-115
29. Pitot HC, Peraino C (1964) Studies on the induction and repression of enzymes in rat liver I. Induction of threonine dehydrase and ornithine-delta-transaminase by oral intubation of casein hydrolysate. J Biol Chem 239: 1783-1788
30. Forslund AH, Hambraeus L, van Beurden H, Holmback U, El-Khoury AE, Hjorth G, Olsson R, Stridsberg M, Wide L, Akerfeldt T, Regan M, Young VR (2000) Inverse relationship between protein intake and plasma free amino acids in healthy men at physical exercise. Am J Physiol Endocrinol Metab 278:E857-E867
31. Lanni A, Moreno M, Lombardi A, Goglia F (2003) Thyroid hormone and uncoupling proteins. FEBS Lett 543:5-10
32. Brun S, Carmona MC, Mampel T, Vinas O, Giralt M, Iglesias R, Villarroya F (1999) Uncoupling protein-3 gene expression in skeletal muscle during development is regulated by nutritional factors that alter circulating non-esterified fatty acids. FEBS Lett 453:205-209
33. Busquets S, Carbo N, Almendro V, Figueras M, Lopez-Soriano FJ, Argiles JM (2001) Hyperlipemia: a role in regulating UCP3 gene expression in skeletal muscle during cancer cachexia? FEBS Lett 505:255-258
34. Samec S, Seydoux J, Dulloo AG (1998) Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids? Diabetes 47:1693-1698
35. Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, Levi-Meyrueis C, Bouillaud F, Seldin MF, Surwit RS, Ricquier D, Warden CH (1997) Uncoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15:269-272
36. Pecqueur C, Alves-Guerra MC, Gelly C, Levi-Meyrueis C, Couplan E, Collins S, Ricquier D, Bouillaud F, Miroux B (2001) Uncoupling protein 2, in vivo distribution, induction upon oxidative stress, and evidence for translational regulation. J Biol Chem 276:8705-8712