Inhibition of mixed-lineage kinase (MLK) activity during G2-phase disrupts microtubule formation and mitotic progression in HeLa cells

Cellular Signalling

Volumn 18, Issue 1, 2006, Pages 93-104

  Cha, Hyukjin ^a   Dangi, Surabhi ^a   Machamer, Carolyn E ^b   Shapiro, Paul ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF PHARMACY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cell cycle; MAP kinase; Mitosis; Mixed lineage kinase; Phosphorylation

Indexed keywords

CEP 11004; ENZYME INHIBITOR; HISTONE H3; MITOGEN ACTIVATED PROTEIN KINASE; MIXED LINEAGE KINASE; PROTEIN SERINE THREONINE KINASE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL CYCLE G2 PHASE; CELL DISRUPTION; CELL NUCLEUS MEMBRANE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HELA CELL; HUMAN; HUMAN CELL; METAPHASE; MICROTUBULE ASSEMBLY; MITOSIS INDEX; MITOSIS INHIBITION; MITOSIS SPINDLE; NERVE CELL NECROSIS; PARKINSON DISEASE; PRIORITY JOURNAL; PROPHASE; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN TARGETING; SIGNAL TRANSDUCTION;

ANIMALS; CARBAZOLES; CELL CYCLE; CELL DIVISION; CELL LINE; CELL PROLIFERATION; ENZYME INHIBITORS; G2 PHASE; HELA CELLS; HISTONES; HUMANS; INDOLES; MAP KINASE KINASE KINASES; MICE; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; NIH 3T3 CELLS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES;

EID: 26244436978     PISSN: 08986568     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cellsig.2005.03.028     Document Type: Article

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