Synthetic study toward antitumour natural product pericosine A

Chemistry Letters

Volumn 34, Issue 7, 2005, Pages 1062-1063

  Usami, Yoshihide ^a   Ueda, Yasuko ^a  

^a OSAKA MEDICAL COLLEGE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 26044483854     PISSN: 03667022     EISSN: None     Source Type: Journal    
DOI: 10.1246/cl.2005.1062     Document Type: Article

References (23)

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16. 3OD) δ 1.81 (1H, dd, J = 13.5, 11.7 Hz, H-2β), 2.19 (1H, dd, J = 13.5, 5.0 Hz, H-2α), 3.45 (1H, dd, J = 9.6, 3.0 Hz, H-4), 3.78 (3H, s, COOMe), 3.98 (1H, ddd, J = 11.7, 9.6, 5.0 Hz, H-3), 4.10 (1H, dd, J = 3.0, 2.8 Hz, H-5), 4.49 (1H, d, J = 2.8 Hz, H-6). Observation of the NOESY cross peaks H-6/H-4, H-6/H-2β, and H-4/H-2β in 19 supported the conformation shown below. These results elucidated the stereochemistry of C-6 in 5 or C-5 in 6. (Chemical Equation Presented) 6 19 Figure 2.
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22. +, 223.0372; Found, 223.0360.
23. +, 223.0372; Found, 223.0379.