Novel antitumour metabolites produced by a fungal strain from a sea hare

Tetrahedron Letters

Volumn 38, Issue 47, 1997, Pages 8215-8218

  Numata, Atsushi ^a   Iritani, Masashi ^a   Yamada, Takeshi ^a   Minoura, Katsuhiko ^a   Matsumura, Eiko ^a   Yamori, Takao ^b   Tsuruo, Takashi ^c  

^a OSAKA MEDICAL COLLEGE   (Japan)

^b CANCER CHEMOTHERAPY CENTER   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTINEOPLASTIC ACTIVITY; ARTICLE; COLUMN CHROMATOGRAPHY; CYTOTOXICITY; DRUG ISOLATION; FUNGUS; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; STRAIN DIFFERENCE; TUMOR GROWTH;

ANASPIDEA; APLYSIA KURODAI; FUNGI; LEPUS; PERICONIA;

EID: 0030726263     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)10198-8     Document Type: Article

References (15)

1. a) C. Takahashi, A. Numata, Y. Ito, E. Matsumura, H. Araki and K. Kushida, J. Chem. Soc., Perkin Trans. 1, 1859 (1994);
2. b) C. Takahashi, T. Takada, T. Yamada, K. Minoura, K. Uchida, E. Matsumura and A. Numata, Tetrahedron Lett., 35, 5013 (1994);
3. A. Numata, C. Takahashi, Y. Ito, K. Minoura, Yamada, C. Matsuda and K. Nomoto, J. Chem. Soc. Perkin Trans 1, 239 (1996).
4. T. Sunatsuka, S Takamatsu, Y-P. Kim, T. Hirose, Y. Haritani, M. Hayashi, K. Komiyama, S. Omura, H. Hiraoka, M. Natori, Abstr. 117th Annu. Meet. Pharm. Soc. Japan, Tokyo, 2, p. 182 (1997).
5. 6) δ 52.4 (C8), 57.6 (C6), 67.0 (C3), 68.6 (C4), 75.4 (C5), 130.3 (C1), 141.8 (C2), 168.2 (C7).
6. 6) δ 51.9 (C8), 61.2 (C9), 69.3 (C3), 69.7 (C4), 72.5 (C5), 76.7 (C6), 130.2 (C1), 141.7 (C2), 166.6 (C7).
7. +, Δ - 0.2 mmu.
8. H. Oikawa, I. Matsuda, T. Kagawa, A. Ichihara and K. Kohmoto, Tetrahedron, 50, 13347 (1994).
9. The proton chemical shift difference between the (+) and (-)-MTPA esters of 3: Δδ (Hz) +41.3 (C6), +18.1(C7), - 13.3 (C9), - 8.1 (C18), +11.4 (C12), +11.3 (C13), - 27.4 (C15), - 16.8 (C17).
10. S. Takamatsu, Y-P. Kim, M. Hayashi, H. Hiraoka, M. Natori, K. Komiyama and S. Omura, J. Antibiotics, 49, 95 (1996).
11. + Δ 1.9 mmu.
12. +, Δ - 0.2 mmu.
13. +, Δ - 0.7 mmu.
14. A. Numata, P. Yang, C. Takahashi, R. Fujiki, M. Nabae and E. Fujita, Chem. Pharm. Bull., 37, 648, (1989).
15. Mice were inoculated intraperitoneally (i.p.) with P388 leukemia cells on day 0, and administered i.p. with 25 mg/kg of 1 on days 1 and 5. The median survival days of non-treated mice and 1-treated mice were 10.7 and 13.0, respectively, suggesting antitumour activity of this compound.