Induction therapy with low-dose intravenous cyclophosphamide, oral mizoribine, and steroids for severe lupus nephritis in children

Pediatric Nephrology

Volumn 20, Issue 10, 2005, Pages 1500-1503

  Fujinaga, Shuichiro ^a   Kaneko, Kazunari ^b   Ohtomo, Yoshiyuki ^a   Murakami, Hitohiko ^a   Takada, Masaru ^a   Akashi, Shunji ^a   Hira, Mayako ^c   Yamashiro, Yuichiro ^c  

^a SAITAMA CHILDREN'S MEDICAL CENTER   (Japan)

^b KANSAI MEDICAL UNIVERSITY   (Japan)

^c JUNTENDO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Induction therapy; Low dose intravenous cyclophosphamide; Lupus nephritis; Mizoribine; Steroids

Indexed keywords

CYCLOPHOSPHAMIDE; METHYLPREDNISOLONE; MIZORIBINE; PREDNISOLONE; STEROID;

AMENORRHEA; ARTICLE; BACTERIAL INFECTION; CASE REPORT; CLINICAL FEATURE; DISEASE SEVERITY; DOSE RESPONSE; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG MEGADOSE; FEMALE; HEMORRHAGIC CYSTITIS; HISTOPATHOLOGY; HUMAN; IMMUNOFLUORESCENCE TEST; KIDNEY BIOPSY; LABORATORY TEST; LOW DRUG DOSE; LUPUS ERYTHEMATOSUS NEPHRITIS; MALE; NEPHROTIC SYNDROME; PHYSICAL EXAMINATION; PRIORITY JOURNAL; REMISSION; SCHOOL CHILD; SIDE EFFECT; TREATMENT OUTCOME; URINALYSIS;

ADMINISTRATION, ORAL; CHILD; CYCLOPHOSPHAMIDE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; FEMALE; GLUCOCORTICOIDS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, INTRAVENOUS; KIDNEY; LUPUS NEPHRITIS; MALE; METHYLPREDNISOLONE; PREDNISOLONE; REMISSION INDUCTION; RIBONUCLEOSIDES; SEVERITY OF ILLNESS INDEX;

EID: 26044459718     PISSN: 0931041X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00467-005-1983-9     Document Type: Article

References (21)

1. Niaudet P (2000) Treatment of lupus nephritis in children. Pediatr Nephrol 14:158-166
2. Bartosh SM, Fine RN, Sullivan EK (2001) Outcome after transplantation of young patients with systemic lupus erythematosus: A report of the North America pediatric renal transplant cooperative study. Transplantation 72:973-978
3. Sonda K, Takahashi K, Fchinoue S, Hayasaka Y, Kawaguchi H, Teraoka S, Toma H, Oka K (1996) Clinical pharmacokinetic study of mizoribine in renal transplantation patients. Transplant Proc 28:3643-3648
4. Yoshioka K, Ohashi Y, Sakai T, Ito H, Yoshikawa N, Nakamura H, Tanizawa T, Wada H, Maki S (2000) A multicenter trial mizoribine compared with placebo in children with frequently relapsing nephrotic syndrome. Kidney Int 58:317-324
5. Kaneko K, Nagaoka R, Ohtomo Y, Yamashiro Y (1999) Mizoribine for childhood IgA nephropathy. Nephron 83:376-377
6. Nagaoka R, Kaneko K, Ohtomo Y, Yamashiro Y (2002) Mizoribine treatment for childhood nephropathy. Pediatr Int 44:217-223
7. Tanaka H, Tsugawa K, Tsuruga K, Nakahata T, Ito E, Waga S (2004) Mizoribine for the treatment of lupus nephritis in children and adolescents. Clin Nephrol 62:412-417
8. Yoshidome K, Takei S, Imanaka H, Maeno N, Ohkawa T, Kawano Y (2004) Efficacy of mizoribine in the treatment of systemic lupus erythematosus in children. Pediatr Int 46:444-449
9. Weening JJ, Agati DD, Schwartz MM, Seshan SV, Alpers CE, Appel GB, Balow JE, Bruijin JA, Cook T, Ferrario F, Fogo AB, Ginzler EM, Hebert L, Hill G, Hill P, Jennete JC, Kong NC, Lesavre P, Lockshin M, Looi LM, Makino H, Moura LA, Nagata M (2004) The classification of glomerulonephritis in systemic lupus erythematosus revisited. Kidney Int 65:521-530
10. Austin HA 3rd, Kipple JH, Balow JE, le Riche NG, Steinberg AD, Plotz PH (1986) Therapy of lupus nephritis: Control trial of predonisone and cytotoxic drugs. N Eng J Med 314:614-619
11. Boumpas DT, Austin HA 3rd, Vaughan EM, Kipple JH, Steinberg AD, Yarboro CH (1992) Controlled trial of pulse methylpredonisolone versus two regimens of pulse cyclophosphamide in severe lupus nephritis. Lancet 340:741-745
12. Gourley MF, Austin HA 3rd, Scott D, Yarboro CH, Vaughan EM, Muir J (1996) Methylpredonisolone and cyclophosphamide, alone or in combination, in patients with lupus nephritis. Ann Intern Med 125:549-557
13. Illei GG, Austin HA, Crane M, Collinins L, Gourley MF, Yarboro CH (2001) Combination therapy with pulse cyclophosphamide plus pulse methylpredonisolone improves long-term renal outcome without adding toxicity in patients with lupus nephritis. Ann Intern Med 135:248-257
14. Lehman TJ, Sherry DD, Wagner L, McCurdy DK, Emery H, Magilavy DB (1989) Intermittent intravenous cyclophosphamide therapy for lupus nephritis. J Pediatr 114:1055-1060
15. Lehman TJ, Onel K (2000) Intermittent intravenous cyclophosphamide arrests progression of the renal chronicity index in childhood systemic lupus erythematousus. J Pediatr 136:243-247
16. Houssiau FA, Vasconcelos C, D'Cruz D, Sebastiani GD, Garrido ER, Danieli MG (2002) Immunosupressive therapy in lupus nephritis: The Euro-lupus nephritis trial. A randomized trial of low-dose versus high-dose intravenous cyclophosphamide. Arthritis Rheum 46:2121-2131
17. Kusaba R, Otubo O, Sugimoto H, Takahashi I, Yamada Y, Yamauchi J, Akiyama N, Inou T (1981) Immunosuppressive effect of bredinin in the management of patients with renal transplantation. Proc Eur Dial Transplant Assoc 18:420-425
18. Yokota S (2002) Mizoribine: Mode of action and effects in clinical use. Pediatr Int 44:196-198
19. Chan TM, Li FK, Tang CSO, Wong RWS, Fang GX, Ji YL, Lau CS, Wong AKM, Tong MKL, Chan KW, Lai KN (2000) Efficacy of mycophenolate mofetil in patients with diffuse proliferative lupus nephritis. N Eng J Med 343:1156-1162
20. Tucker LB, Menon S, Schaller JG, Isenberg DA (1995) Adult- and childhood-onset systemic lupus erytematosus: A comparison of onset, clinical features, serology, and outcome. Br J Rheumatol. 34:866-872
21. Contreras G, Pardo V, Leclercq B, Lenz O Tozman E, O'Nan P, Roth D (2004) Sequential therapy for proliferative lupus nephritis. N Eng J Med 350:971-980