Mizoribine: Mode of action and effects in clinical use

Pediatrics International

Volumn 44, Issue 2, 2002, Pages 196-198

  Yokota, Shumpei ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

Author keywords

Immunosuppressive drugs; Mizoribine; Renal transplantation; Rheumatic diseases

Indexed keywords

AZATHIOPRINE; CYCLOSPORIN A; DRUG METABOLITE; GUANINE NUCLEOTIDE; GUANOSINE MONOPHOSPHATE SYNTHASE; IMIDAZOLE; INOSINE MONOPHOSPHATE SYNTHETASE; MIZORIBINE; MIZORIBINE 5' MONOPHOSPHATE; NUCLEIC ACID; PREDNISOLONE; SYNTHETASE; UNCLASSIFIED DRUG;

ANTIVIRAL ACTIVITY; CELLULAR IMMUNITY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG DISTRIBUTION; DRUG EFFECT; DRUG ELIMINATION; DRUG MECHANISM; DRUG SELECTIVITY; ENZYME INHIBITION; HUMAN; HUMORAL IMMUNITY; IMMUNOSUPPRESSIVE TREATMENT; KIDNEY TRANSPLANTATION; LUPUS ERYTHEMATOSUS NEPHRITIS; NEPHROTIC SYNDROME; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; RHEUMATOID ARTHRITIS; SHORT SURVEY;

ANIMALS; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY TRANSPLANTATION; RHEUMATIC DISEASES; RIBONUCLEOSIDES;

EID: 0036119395     PISSN: 13288067     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1328-8067.2002.01536.x     Document Type: Short Survey

References (13)

1. Immunosuppressive effect of bredinin on cell-mediated and humoral immune reactions in experimental animals
2. Synergistic effect of cyclosporine and mizoribine on survival of dog renal allografts
3. Absorption, distribution, metabolism and excretion of bredinin in rats
4. Comparison of the effects of mizoribine with those of azathio-prine, 6-mercaptopurine, and mycophenolic acid on T lymphocyte proliferation and purine ribonucleotide metabolism
5. Dual inhibitory effect of bredinin
6. Pharmacology of 6-thioguanine in man
7. Alminum fluoride induces phosphatidylinoditol turn-over, elevation of cytoplasmic free calcium, and phosphorylation of the T cell antigen receptor in murine T cells
8. Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: Effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression
9. Guanine ribonucleotide depletion inhibits T cell activation. Mechanism of action of the immunosuppressive drug mizoribine
10. Effectiveness of a new drug, bredinin, on canine kidney allotransplantation survival
11. A clinical study of renal transplant recipients receiving triple-drug therapy - Cyclosporine A, mizoribine, and prednisolone
12. Antiviral activities of mizoribine and other inosine monophosphate dehydrogenase inhibitors against several ortho- and paramyxoviruses
13. Effects of cyclosporine, azathioprine, mizoribine and prednisolone on replication of human cytomegarovirus