Coexpression of Ah receptor and CYP1A1 in hepatocytes of C57BL/6J and DBA/2J mice

Toxicology and Applied Pharmacology

Volumn 142, Issue 1, 1997, Pages 69-78

  Forkert, Poh Gek ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

3 METHYLCHOLANTHRENE; AROMATIC HYDROCARBON RECEPTOR; CYTOCHROME P450 ISOENZYME;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ENZYME LOCALIZATION; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; LIVER CELL; LIVER MICROSOME; MALE; MOUSE; NONHUMAN;

EID: 0031018740     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.7962     Document Type: Article

References (40)

1. Abbott, B. D., Perdew, G. H., and Birnbaum, L. S. (1994). Ah Receptor in embryonic mouse palate and effects of TCDD on receptor expression. Toxicol. Appl. Pharmacol. 126, 16-25.
2. Benedict, C. M., Ren, L., and Clawson, G. A. (1995). Nuclear multicatalytic proteinase α subunit RRC3: Differential size, tyrosine phosphorylation and susceptibility to antisense oligonucleotide treatment. Biochemistry 34, 9587-9598.
3. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Chem. 72, 248-254.
4. Burbach, K. M., Poland, A., and Bradfield, C. A. (1992). Cloning of the Ah-receptor cDNA reveals a distinctive ligand activated transcription factor. Proc. Natl. Acad. Sci. USA 89, 8185-8189.
5. Denison, M. S., Harper, P. A., and Okey, A. B. (1986). Ah receptor for 2,3,7,8-tetrachlorodibenzo-p-dioxin: Contribution of unoccupied receptor with cytosolic marker enzymes during fractionation of mouse liver, rat liver and cultured Hepa-1c1 cells. Eur. J. Biochem. 155, 223-229.
6. Forkert, P. G., Mirehouse-Brown, P., Park, S. S., and Gelboin, H. V. (1988). Distribution and induction sites of phenobarbital-and 3-methylcholanthrene-inducible cytochromes P450 in murine liver: Immunohistochemical localization with monoclonal antibodies. Mol. Pharmacol. 34, 736-743.
7. Forkert, P. G., Redza, Z. M., Mangos, S., Park, S. S., and Tam, S.-P. (1994). Induction and regulation of CYP2E1 in murine liver after acute and chronic acetone administration. Drug Metab. Dispos. 22, 248-253.
8. Forkert, P. G. (1995). CYP2E1 is preferentially expressed in Clara cells of murine lung: Localization by in situ hybridization and immunohistochemical methods. Am. J. Resp. Cell. Mol. Biol. 12, 589-596.
9. Forkert, P. G., Chen, S., and Jackson, A. C. (1995). In situ hybridization analysis of hepatic cytochrome P450 2E1 messenger ribonucleic acid in mice. Lab. Invest. 72, 92-99.
10. Fujisawa-Sehara, A., Sogawa, K., Yamane, M., and Fuji-Kuriyama, Y. (1987). Characterization of xenobiotic response elements upstream from the drug metabolizing cytochrome P450c gene: A similarity to glucocorticoid response elements. Nucleic Acids Res. 15, 4179-4191.
11. Gonzalez, F. J., and Nebert, D. W. (1987). P-450 genes: Structure, evolution and regulation. Annu. Rev. Biochem. 56, 945-993.
12. Gudas, J. M., Karenlampi, S., and Hankison, O. (1986). Intracellular localization of the Ah receptor. J. Cell Physiol. 128, 441-448.
13. Harper, P. A., Golas, C. L., and Okey, A. B. (1991). Ah receptor in mice genetically "nonresponsive" for cytochrome P4501A1 induction: Cytosolic Ah receptor, transformation to the nuclear binding state, and induction of aryl hydrocarbon hydroxylase by halogenated and nonhalogenated aromatic hydrocarbons in embryonic tissues and cells. Mol. Pharmacol. 40, 818-826.
14. Hattori, M., Tugores, A., Veloz, L., Karin, M., and Brenner, D. A. (1990). A simplified method for the preparation of transcriptionally active liver nuclear extracts. DNA Cell Biol. 9, 777-781.
15. 3H]tetrachlorodibenzo-p-dioxin. J. Biol. Chem. 264, 18463-18471.
16. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
17. 1-450 by 3-methylcholanthrene. Mol. Pharmacol. 35, 823-830.
18. Okey, A. B., and Vella, L. M. (1982). Binding of 3-methylcholanthrene and 2,3,7,8-tetrachlorodibenzo-p-dioxin to a common Ah receptor site in mouse and rat hepatic cytosols. Eur. J. Biochem. 127, 39-47.
19. Parkinson, A., and Gemzik, B. (1991). Production and characterization of antibodies against rat liver P450 enzymes. Methods Enzymol. 206, 233-245.
20. Poland, A., and Glover, E. (1974). Comparison of 2,3,7,8-tetrachlorodibenzo-p-dioxin, a potent inducer of aryl hydrocarbon hydroxylase, with 3-methylcholanthrene. Mol. Pharmacol. 10, 349-359.
21. Poland, A., and Glover, E. (1975). Genetic expression of aryl hydrocarbon hydroxylase by 2,3,7,8-tetrachlorodibenzo-p-dioxin: Evidence for a receptor mutation in genetically nonresponsive mice. Mol. Pharmacol. 11, 389-398.
22. 2-dependent proteolysis of the Ah receptor. Arch. Biochem. Biophys. 261, 103-111.
23. b alleles. Mol. Pharmacol. 38, 306-312.
24. 1450 formation by 2,3,7,8-tetrachlorodibenzo-p-dioxin in mice genetically "nonresponsive" to other aromatic hydrocarbons. J. Biol. Chem. 249, 5599-5606.
25. Poland, A., Glover, E., and Bradfield, C. A. (1991). Characterization of polyclonal antibodies to the Ah receptor prepared by immunization with a synthetic peptide hapten. Mol. Pharmacol. 39, 20-26.
26. Poland, A., Glover, E., and Taylor, B. A. (1987). The murine Ah locus: A new allele and mapping to chromosome 12. Mol. Pharmacol. 32, 471-478.
27. Poland, A., Glover, E., and Kende, A. S. (1976). Stereospecific high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. J. Biol. Chem. 251, 4936-4946.
28. Poland, A., and Knutson, J. C. (1982). 2,3,7,8-Tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: Examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554.
29. Pollenz, R. S., Sattler, C. A., and Poland, A. (1994). The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by immunofluorescence microscopy. Mol. Pharmacol. 45, 428-438.
30. Pollenz, R. S. (1996). The aryl-hydrocarbon receptor, but not the aryl-hydrocarbon receptor nuclear translocator protein, is rapidly depleted in hepatic and nonhepatic culture cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Mol. Pharmacol. 49, 391-398.
31. Prokipcak, R. D., and Okey, A. B. (1988). Physicochemical characterization of the nuclear form of Ah receptor from mouse hepatoma cells exposed in culture to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Arch. Biochem. Biophys. 267, 811-828.
32. 3H]tetrachlorodibenzo-p-dioxin. Biochem. Biophys. Res. Commun. 172, 698-704.
33. Reyes, H., Reisz-Porszasz, S., and Hankinson, O. (1992). Identification of the Ah receptor nuclear translocator protein (Arnt) as a component of the DNA binding form of the Ah receptor. Science (Washington, DC) 256, 1193-1195.
34. Rivett, A. J. (1993). Proteasomes: Multicatalytic proteinase complexes. Biochem. J. 291, 1-10.
35. Smith-Gill, S. J., Wilson, A. C., Potter, M., Prager, E. M., Feldmann, R. J., and Mainhart, C. R. (1982). Mapping the antigenic epitope for a monoclonal antibody against lysozyme. J. Immunol. 128, 314-322.
36. Sordahl, L. A., Johnson, C., Blailock, Z. R., and Schwartz, A. The mitochondrion. In Methods in Pharmacology (A. Schwartz, Ed.), pp. 247-286. Appleton-Century-Crofts, Meredith Corp., New York.
37. Watson, A. J., and Hankison, O. (1992). Dioxin and Ah receptor-dependent protein binding to xenobiotic response elements and G-rich DNA studied by in vivo footprinting. J. Biol. Chem. 266, 6874-6878.
38. Whitlock, J. P., Jr. (1986). The regulation of cytochrome P-450 gene expression. Annu. Rev. Pharmacol. Toxicol. 26, 333-369.
39. Whitlock, J. P., Jr. (1990). Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action. Annu. Rev. Pharmacol. Toxicol. 30, 251-277.
40. Whitlock, J. P., Jr., and Galeazzi, D. R. (1984). 2,3,7,8-Tetrachlorodibenzo-p-dioxin in wild type and variant mouse hepatoma cells. J. Biol. Chem. 259, 980-985.