Stereoselective and carrier-mediated transport of monocarboxylic acids across Caco-2 cells

Pharmaceutical Research

Volumn 13, Issue 12, 1996, Pages 1828-1832

  Ogihara, Takuo ^a,b   Tamai, Ikumi ^a   Takanaga, Hitomi ^a   Sai, Yoshimichi ^a   Tsuji, Akira ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b MOCHIDA PHARMACEUTICAL CO   (Japan)

Author keywords

Caco 2 cells; Carrier mediated transport; Lactic acid; Monocarboxylic acid; Stereoselectivity

Indexed keywords

CARBOXYLIC ACID; IBUPROFEN; LACTIC ACID;

ACTIVE TRANSPORT; ARTICLE; CELL STRAIN CACO 2; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG TRANSPORT; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; STEREOCHEMISTRY; TRANSCYTOSIS;

BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE PERMEABILITY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; HYDROGEN-ION CONCENTRATION; IBUPROFEN; KINETICS; LACTATES; MANDELIC ACIDS; SODIUM; STEREOISOMERISM;

EID: 0030444801     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1016081007981     Document Type: Article

References (15)

1. D. E. Drayer. Clin. Pharmacol. 40:125-133 (1986).
2. R. Kato. Xenobio. Metabol. Dispos. 2:177-182 (1987).
3. A. Tsuji, M. T. Simanjuntak, I. Tamai, and T. Terasaki. J. Pharm. Sci. 79:1123-1124 (1990).
4. M. T. Simanjuntak, T. Terasaki, I. Tamai, and A. Tsuji. J. Pharmacobio-Dyn. 14:501-508 (1991).
5. A. Tsuji, H. Takanaga, I. Tamai, and T. Terasaki. Pharm. Res. 11:30-37 (1994).
6. H. Takanaga, I. Tamai, and A. Tsuji. J. Pharm. Pharmacol. 46:567-570 (1994).
7. I. Tamai, H. Takanaga, T. Ogihara, M. Yoneda, and A. Tsuji. Pharm. Res. 12:1727-1732 (1995).
8. J. M. Harig, K. H. Soergel, J. A. Barry, and K. Ramaswamy. Am. J. Physiol. 260:G776-G782 (1991).
9. C. Tiruppathi, D. F. Balkovetz, V. Ganapathy, Y. Miyamoto, and F. H. Leibach., Biochem. J. 256:219-223 (1988).
10. B. B. Brodie, and C. A. M. Hogben. J. Pharm. Pharmacol. 9:345-380 (1957).
11. O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. J. Randall. J. Biol. Chem. 193:265-275 (1951).
12. K. Yamaoka, Y. Tanigawara, T. Nakagawa, and T. Uno. J. Pharmacobio-Dyn., 4:879-885 (1981).
13. I. Tamai, H. Takanaga, H. Maeda, Y. Sai, T. Ogihara, H. Higashida, and A. Tsuji. Biochem. Biophys. Res. Commun., 214:482-489 (1995).
14. H. Takanaga, I. Tamai, S. Inaba, Y. Sai, H. Higashida, H. Yamamoto, and A. Tsuji. Biochem. Biophys. Res. Commun., 217:370-377 (1995).
15. C.-K. Garcia, J. L. Goldstein, R. K. Pathak, R. G. W. Anderson, and M. S. Brown. Cell, 76:865-873 (1994).