A mechanism for the potential proarrhythmic effect of acidosis, bradycardia, and hypokalemia on the blockade of human ether-a-go-go-related gene (HERG) channels

American Journal of Therapeutics

Volumn 12, Issue 4, 2005, Pages 328-336

  Lin, Congrong ^a   Cvetanovic, Ivana ^a   Ke, Xiaogang ^a   Ranade, Vasant ^a   Somberg, John ^a  

^a RUSH UNIVERSITY   (United States)

Author keywords

Acidosis; Bradycardia; HERG channel; Hypokalemia; Quinidine

Indexed keywords

POTASSIUM; POTASSIUM CHANNEL HERG; QUINIDINE;

ACIDIFICATION; ACIDOSIS; ANIMAL CELL; ARTICLE; BRADYCARDIA; CARDIOTOXICITY; CARDIOVASCULAR RISK; CONTROLLED STUDY; DRUG EFFECT; DRUG INHIBITION; ELECTRODE; HEART PACING; HEART PROARRHYTHMIA; HYPOKALEMIA; ISCHEMIC HEART DISEASE; MEMBRANE POTENTIAL; NONHUMAN; OOCYTE; PH; PRIORITY JOURNAL; REPOLARIZATION; STEADY STATE; VOLTAGE CLAMP; XENOPUS;

ACIDOSIS; ANIMALS; ANTI-ARRHYTHMIA AGENTS; ARRHYTHMIA; BRADYCARDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHER-A-GO-GO POTASSIUM CHANNELS; EXTRACELLULAR FLUID; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOKALEMIA; MEMBRANE POTENTIALS; OOCYTES; PATCH-CLAMP TECHNIQUES; POTASSIUM; QUINIDINE; XENOPUS LAEVIS;

EID: 25844523798     PISSN: 10752765     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mjt.0000143698.53038.1b     Document Type: Article

References (34)

1. Camm AJ, Janse MJ, Roden DM, et al. Congenital and acquired long QT syndrome. Eur Heart J. 2000;21:1232-1237.
2. Roden DM. Drug-induced prolongation of the QT interval. N Engl J Med. 2004;350:1013-1022.
3. Vincent GM. Long QT syndrome. Cardiol Clin. 2000;18:309-325.
4. Wang Z, Fermini B, Nattel S. Delayed rectifier outward current and repolarization in human atrial myocytes. Circ Res. 1993;73:276-285.
5. Sanguinetti MC, Jurkiewicz NK. Two components of cardiac delayed rectifier K+ current. Differential sensitivity to block by class III antiarrhythmic agents. J Gen Physiol. 1990;96:195-215.
6. Kr) in AT-1 cells: concentration-, time-, voltage-, and use-dependent effects. Circulation. 1995;91:1799-1806.
7. Van Opstal JM, Leunissen JD, Wellens HJ, et al. Azimilide and dofetilide produce similar electrophysiological and proarrhythmic effects in a canine model of torsade de pointes arrhythmias. Eur J Pharmacol. 2001;412:67-76.
8. Woosley RL, Chen Y, Freiman JP, et al. Mechanism of the cardiotoxic actions of terfenadine. JAMA. 1993;269:1532-1536.
9. Drolet B, Khalifa M, Daleau P, et al. Block of the rapid component of the delayed rectifier potassium current by the prokinetic agent cisapride underlies drug-related lengthening of the QT interval. Circulation. 1998;97:204-210.
10. Roden DM, Woosley RL, Primm RK. Incidence and clinical features of the quinidine-associated long QT syndrome: implications for patient care. Am Heart J. 1986;111:1088-1093.
11. Malik M, Camm AJ. Evaluation of drug-induced QT interval prolongation: implications for drug approval and labelling. Drug. 2001;24:323-351.
12. Roden DM, Hoffman BF. Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ Res. 1985;56:857-867.
13. r: implications for torsades de pointes and reverse use-dependence. Circulation. 1996;93:407-411.
14. + current in rabbit ventricular myocytes. Cardiovasc Drugs Ther. 1993;7(suppl 3):599-604.
15. Trudeau MC, Warmke JW, Ganetzky B, et al. HERG, a human inward rectifier in the voltage-gated potassium channel family. Science. 1995;269:92-95.
16. Kr potassium channel. Cell 1995;81:299-307.
17. Paul AA, Witchel HJ, Hancox JC. Inhibition of the current of heterologously expressed HERG potassium channels by flecainide and comparison with quinidine, propafenone and lignocaine. Br J Pharmacol. 2002;136:717-729.
18. Lees-Miller JP, Duan Y, Teng GQ, et al. Molecular determinant of high affinity dofetilide binding to HERG1 expressed in Xenopus oocytes: involvement of S6 sites. Mol Pharmacol. 2000;57:367-374.
19. Sanchez-Chapula JA, Ferrer T, Navarro-Polanco RA, et al. Voltage-dependent profile of human ether-a-go-go-related gene channel block is influenced by a single residue in the S6 transmembrane domain. Mol Pharmacol. 2003;63:1051-1058.
20. Po SS, Wang DW, Yang IC, et al. Modulation of HERG potassium channels by extracellular magnesium and quinidine. J Cardiovasc Pharmacol. 1999;33:181-185.
21. Roden DM, Iansmith DH. Effects of low potassium or magnesium concentrations on isolated cardiac tissue. Am J Med. 1987;82:18-23.
22. Jo SH, Youm JB, Kim I, et al. Blockade of HERG channels expressed in Xenopus oocytes by external H+. Pflugers Arch. 1999;438:23-29.
23. Vereecke J, Carmeliet E. The effect of external pH on the delayed rectifying K+ current in cardiac ventricular myocytes. Pflugers Arch. 2000;439:739-751.
24. Anumonwo JM, Horta J, Delmar M, et al. Proton and zinc effects on HERG currents. Biophys J. 1999;77:282-298.
25. Jiang M, Dun W, Tseng GN. Mechanism for the effects of extracellular acidification on HERG-channel function. Am J Physiol 1999;277:H1283-H1292.
26. Lee KS, Hume JR, Giles W, et al. Sodium current depression by lidocaine and quinidine in isolated ventricular cells. Nature. 1981;291:325-327.
27. Roden DM, Bennett PB, Snyders DJ, et al. Quinidine delays IK activation in guinea pig ventricular myocytes. Circ Res. 1988;62:1055-1058.
28. Furukawa T, Tsujimura Y, Kitamura K, et al. Time- and voltage-dependent block of the delayed K+ current by quinidine in rabbit sinoatrial and atrioventricular nodes. J Pharmacol Exp Ther. 1989;251:756-763.
29. Imaizumi Y, Giles WR. Quinidine-induced inhibition of transient outward current in cardiac muscle. Am J Physiol. 1987;253:H704-H708.
30. Balser JR, Roden DM, Bennett PB. Single inward rectifier potassium channels in guinea pig ventricular myocytes. Effects of quinidine. Biophys J. 1991;59:150-161.
31. Garlick PB, Radda GK, Seeley PJ. Studies of acidosis in the ischaemic heart by phosphorus nuclear magnetic resonance. Biochem J. 1979;184:547-554.
32. Khuri SF, Flaherty JT, O'Riordan JB, et al. Changes in intramyocardial ST segment voltage and gas tensions with regional myocardial ischemia in the dog. Circ Res. 1975;37:455-463.
33. Orchard CH, Cingolani HE. Acidosis and arrhythmias in cardiac muscle. Cardiovasc Res. 1994;28:1312-1319.
34. Choy AM, Lang CC, Chomsky DM, et al. Normalization of acquired QT prolongation in humans by intravenous potassium. Circulation. 1997;96:2149-2154.